969

INDEX

Volume 193, APRIL-JUNE 1975

Abboud, F. M., see Heistad, 1). 1)., 941Acetanilides, effects on irmvertebrate neurons cor-

related with analgesic activity in vertebrates,

892

Acetazolammi ide

effect on ervt hrocvte 2 , 3-diphosphoglyeerateconten t and nmetaboiism , 639

effect Ofl estrogen-induced eiectrographic spike-wave discharge, 647

Ace t vlchol incdesensitization of adrenergic neurons of isolated

rabbit ear artery to, 138

effect omm cyclic guanosine 3’,.Y-monophosphateiii amitononmic gangiia, possible role in synaptictransniissioim, 474

intestinal stimulatory effects, influence of iso-

proterenol, prostaglandin E, and theophyllineon, 884

ii� ravent ridular, ant inociceptive activity inmice, 845

release by rat brain cortical slices, effects of

etimammol, 824synthesis iii vim in guinea-pig tissues, distribu-

tiomm and nmetabolisnm of intravenous choline[nmethvl-’H] and, 246

vasoconstriction of isolated rabbit ear artery(atmSed by, 128

Acetylsaiicylic acid, and conmbinations with co-deimme , self-adnmin ist rat ion in rhesus monkeys,870

Acetylst rophaimthidin -induced bradycardia, neu-ml nmechanisnms involved tim, 336

Ackerimman, N. H. and Beebe, J. B. : Effects of

pharnmacoiogic ageimts on release of lysosomal

enzvnmes frommmalveolar mononuclear cells, 603Adanms, (. K., see 1)ianmond, L., 2�(i -

Adanms, H. II. and ;oodnman, F. H. : 1)ifferentialinhibitory effect of neomycin on contractileresponses of various canine arteries, 393

Adrenal glaimd (s)immedulla , boy inc , cale join -independeim t c at e -

cholanmine secret ioim from, 513tinme course of effect of reserpine on tyrosine hy-

droxvlase activity in, 533

Adrenergic blocking agentsbeta, effects on erythropoietin production in rab-

bits exposed to hypoxia, 176

effects on release of iysosonmal enzymes from al-

veolar mononuclear cells, 603

effect of chronic ganglion blockade and chronic

choiinesterase inhibition on sensitivity of rab-bit stonmaeh muscularis to, 739

Adrenergic neuronsof isolated rabbit� ear artery, desensitizatioim to

nicotinic agonists, 138vasoconstriction of isolated rabbit ear artery

caused by nieotinic agonists acting on, 128

Adrenergic receptor(s)

agonists, beta, role of cyclic 3’,S’-adenosinenmoimophosphate in induction of tyrosine hy-

droxylase in normal and decentralized synmpa-thetie ganglia elicited by, 95

alpha , interact ions with methoxan me -st imu-lated adeimosine 3’,S’-nmonophosphate fornma-tion in rat cerebral cortical slices, 549

beta, blockade, effect on initiation and perpetu-

ation of ouabain-induced ventricuiar tachyar-rhythnmia, 327

mechanical response in wall of ovarian folliclesmediated by, 460

Adrenocorticotropin , analogs (ACTH4,) , correla-

tion between structure, behavioral activityand rate of biotransformation of, 853

Aghajanian, G. K., see Gallagher, D. W., 785Ajmaiine, effects in experimental and clinical ar-

rhythmias and their relation to some eleetro-physiological parameters of heart, 182

Albuquerque, E. X., see Warnick, J. E., 232Aidosterone, release in rat, mediated by angioten-

sin, 166Altura, B. M. : 1)ose-response relationships for

arginine vasopressin and synthetic analogs cmi

three types of rat blood vessels: Possible evi-dence for regional differences in vasopressinreceptor sites within a mammal, 413

Altura, B. M. : Sex and estrogens and responsive-imess of terminal arterioles to neurohypo-physeal hormones and eatecholamines, 403

y-Aminobutyric acid, release by rat brain corticalslices, effects of ethanol, 824

Amninogimanidine, inhibition of granimlat ion t issue

growth by, 910Ammminophenazone, and combinat ions with codeine,

self-adrninist rat ion in rhesus monkeys , 870Aminopyrine, hepatic nmetabolism in rat, role of

neonatal androgen, 621

Amobarbital, effects of thyrot ropin-releasing hor-

mone on actions of, 11

Amphetanmine

-induced norepinephrine release in rat cerebral

970 INi)iX Vol. 193

acetylchoiine in nmice , 845

APailtakil , F . 0. , Baunmgarten , C. I�.I . and Ten

(on cx , effec t s of 6-imvd roxvdopmmnmine amidreserpine on, 64

interrespoimse t inme (hallges as fund iou of, 701

(I- and /-Anmphetanmiime, blood lressure and heartrate respoimses III pithed rat to, 149

Analgesia, nmorphuiie, iIifluen(e of i.-t ryptophan

oil, 35

Analgesics nut ipyret ic , :umd (oimmbinat ioflS withcodeine, seif-adnminist ret ion irm rhesus nmon-

keys, 870

AImaigei4ic act ivitvof :wetanilides in vertebrates, correlated with

effects on invertebrate neurons , 892

of nmorphine, reiationship to brain levels in

acutely t rented immice and rats :umd pellet -mm-

planted mice, 876Analogs

of hat rachotoxin , pharin:aoiogy, 232synthet iC , of vasopressin , dose-response rela-

tionsimips oil rat blood vessels, evidence forregional differences in vasopressin receptorsites, 143

An(irogen , imeonat al , role in (leveiopnment of hepatic

In ic roma)nmal (�Irug-nmet 1(1)01 IZ inc enzyiiies , 621

.&ngiotensin

effect of Imypoxenmia on responses of (oN)Imary

aimd immuscular vessels to, 941effect of sex and estrogens on responsiveness of

terimmirmal arterioles to, 403-immediated aldosteroime release in rat , 166

Angiotensin I , conversion to angiotemisin I I in rat,

effects of chronic oral (ontra(�eptive treatnmentoil, 160

Angioteimsin I I , jut racerebrovent ricular, effect onrabbit operant behavior, 1

Antiarthrit iC drugs, clinically effect lye, inhibitionof prinmary lesion of adjtmvant -induced poly-

arthritis (18-hour arthritis test) in rats for de-tectn)n of, 918

Antiasthnmatic agent , potential, Sch 15280, 256

Antibiotics, effects oii fixation of (�):m i)\’ rat livermitochondria, 720

Antidepressaimt drug, (inmipranmitme) , act ioims on

vol tage -cia.nmped �1! yxicola gian t axon , 669Antiepileptic drugs, effects on estrogen-induced

eleetrographic spike-wave (liscimarge, 647An t i hype rtensive d rugs

effect on tyrosine hvdroxylase act ivitv and iior-

epitmephriime (oncent rat ions in spontaeonsly

hypertensive rat , 443

vasodilat ing, aidosterone release in rat in-

duced ifl’, 166

Anti-inflainnmatory compounds, effect oim release of

lysosonmal enzynmes fronm aiveoia r immonontmciear

cells, 603

Antinoricept ive liCt iVitV, of mt ravent ricular

Eick, R. E. : Effect of beta receptor blockade011 the initiation and perpetuation of ouabaiii-irmduced vent ricuiar tachyarrhythnmia, 327

Aortas, effect of 5-hydroxykyntmrenanmiime , sero-

tonin nmetabolite, 011, 385

Arginirme vasopressin , dose-response relationshipson three types of rat blood vessels, evidence

for regiommai differences iii vasopressin receptor

sites, 413Arrhythnmias, experinmental armd clinical, effects of

ajnmaline and their relation to soimme electro-physiological paranmeters of heart , 182

Arteries

canine, effect of neomycin on contractile re-

spouses of, 393isolated , canine, characterization by cyprohep-

tadine of dopamine-indtmced contract ion in,

43;-)isolated canine cerebral , imicot iime-induced re-

laxation in, 376

isolated cerebral , effect of 5-hydroxykvnurena-mine, serotonin metaholite, on, 385

isolated , rabbit ear, adrenergic neurons , deseimsi-

tization to nicotinic agonists, 138isolated rabbit ear, vasoconstriction caused by

nicotinic agonists acting on adrenergic iieu-rons, 128

Arterioles, ternminal, responsiveimess to imeurohypo-

physeal hormones and catecholanmines, effect of

sex and estrogens, 403Arthritis test (18-hour), as reliable sereening pro-

cedtmre for clinical effective antiarthritic

drugs, 918At na, effect of 5-hydroxykynurenanmine, serotonimm

metabolite, on, 38:-)

At ropine, effects oim morphine dependence in rat, 44

Baboon, effects of nmorphine on schedule-controlled

behavior in, contrasted with chimpanzee, 861Bacitraciim, effect on fixation of CO2 by rat liver

mitochondria, 720Bakhle, Y. S., see Bell, C., 160Barbiturate, enantiomers, brain levels, correia-

tion with differences in duration of sleep, 664

Barker, J. L. and Levitan, H. : Acetaniiides:

Effects on invertebrate neurons correlatedwith analgesic activity in vertebrates, 892

Barnes, E., see Cubeddu, L., X., 105Bartholini , (1. , Constant inidis, J. , Puig, M. , Tis-

sot, 11. and Pletscher, A. : The stereoisomersof 3,4-dihydroxyphenylserine as precursors of

norepinephrine, 523Baskiim, F. aimd Rosenberg, IL N. : l)ecreased 6-

mnercaptopurine retention by two resistantvariants of mouse neuroblastoma with normal

hypoxan t hine - guanine - phosphoribosylt rans-ferase activities, 293

Batrachotoxin , analogs, pharnmacology , 232Baumgarten, C. M., see Apaimtaku, F. 0. , 327

in, 941

1975 INJ)EX 971

Beard , J. 1)., see Sargent, W. Q., 336

Beebe, J. IL, see Ackernmaim, N. 11,603

Behavior

after ACTH4 analogs, correlation with struc-

ture and rate of biotransfornmation of, 853

operant, rabbit, effect of intraeerebroventricu-

lar bradykirmin and related peptides on, 1schedule -cont roiled , effects of morphine on,

contrasted iii chinmpanzee and baboon, 861wet shake, regional sensitivity of rat brain to in-

hibitorv effects of morphine on, 56

Bell, C. and Bakhle, Y. S. : Effects of chronic oraleontraceptive treatment on the conversioim of

angiotensin I to angiotensin II in the rat, 160Belier, (1. A. amid Simmith,T. W. : Digitalis toxicity

dtmring acute hypoxia in intact conscious dogs,963

Benzquinanmide , effects on mmmultipie fixed-ratio,fixed-interval schedule perfornmance, 689

Berkowitz, B. A., see Kohier, C.,443

Bethaimechol, effects oii cyclic guanosiime 3’,3’-mmmonophosphate in autononmic ganglia, possiblerole iii synaptic transnmission, 474

Biarmchi, C. ia.,see Kroeger, E. A., 309

Biochemical effects, of optical isomers of p-chloro-

anmphetamine, correlat ion with brain levels,835

Biochemical studies

of catecholamine in superior cervical gamiglia inorgaim culture, 489

of stereoisonmers of 3 , 4 -dihvd roxyphenylserine

as precursors of norepinephrine, 523of synmpathec toimmy produced by administ rat ion

of guanethidine to newborn rats, 503Biosvnthet ic capacity, for 3-hydroxytryptamine

in rat brain, effects of lithium chloride on, 812Bishop, V. S., see Carrier, (1. 0., 218Blancuzzi,V.,seePerper, 11.J.,594-

Bleidt, B., see 1)ianmond, L., 236Blood pressure responses, to d- and l-anmphetaimmine

in pithed rat, 149Blood vessels

coroimary and nmuscular, effect of hypoxemia onresponses to norepirmephrine and angiotensin

rat, dose-response relationships for argininevasopressin amid syn t het ic analogs on , evidencefor regional differences in vasopressin receptor

sites, 413Bojorges, 11., Pastelin, G., Sanchez-Perez, S.,

Mendez, 11. amid Kabeia, E. : The effects of

ajnmaline in experinmental and clinical arrhyth-

nmias and their relation to some eleetrophysio-

logical parameters of the heart, 182

Boilinger, J. N., see Van Auken, 0. W., 729

Bradveardia, acetylst rophanthidin-indueed , imen-

r�d nmechanisimms involved in, 336

Bradvkinin, intracerebroventrieular, related pep-

tides and, effect on rabbit operant behavior, 1

Brain

arteries, canine, nicot inc-induced relaxation in,376

arteries, isolated, effect of 5-hydroxykynurena-nmiime, serotonin mmmetaboiite, 0mm,383

dopanmine, blockade by reserpine of methyl-phen idate -iimduced release of , 359

levels of barbiturate enanthiomers, (orrelat ion��ith differences in duration of sleep, 664

levels of Ol)t icai isomers of p-chioroamphet a-

mine, correlation with biochemical effects, 835

nmorphine levels, relationship to analgesic ac-tivity in acutely treated nmice and rats and

pellet -inmplarmted nmice, 876immouse, comparison of effects of mmmorphine and

forced running on incorporation of ‘4C-tyro-sine into ‘4C-catecholammmine irm, 364

rat, cortical slices, effects of ethanol on imeuro-

transmitter release by, 824rat , effects of 6-hydroxydopamine and reserpilme

on anmphetanmine -induced norepinephrine re -

lease in, 64rat, effects of lithium chloride on biosynthetic

capacity for 3-hydroxyt ryptanmine iim, 812rat , effect of a-nmethyldopa on dopanmine synthe-

siR and release in vitro in, 73rat , effects of reserpine on act ivit ies and amounts

of tyrosine hydroxylase and dopanmine-�-hy-

droxylase in eateeholamine netmronal systems

in, 775rat, regional sensitivity to inhibitory effects of

nmorphiime on wet shake behavior of, 36

rat , stimulation of adenosine 3’ , 5’-monophos-phate formation by nmethoxamine in, interac-

tioim with alpha adrenergie receptor, 549

rat , stereoisomers of 3 , 4 -dihydroxyphenylserine

as precursors of norepinephrine in, 523rat, synaptosomes, serotonin uptake into, 3-(p-

trifluoromethylphenoxy)-N-nmethyl-3-phenyl-

propylamine as new selective inhibitor of, 804

serotonin , depict ion by 4-chloroamphetamine,

effec t of 3 - (p-t rifluoromethyiphenoxy) -N -

methyl-3-phenylpropylamine on, 796

Brase, I). A., see Ho, I. K., 35

Breese, U. it, Cott, J. M., Cooper, B. 11., Prange,A. J., Jr., Liptoim, M. A. and Plotnikoff, N. P.:Effect 5 of t hv rot ropin -releasing hormone

(THH) on the actions of pentobarbital andother centrally actingdrugs, 11

Bretyliunm , elect rophysioiogical effects and uptakeand binding in normal and immunosympathee-

tomized rat hearts, 194Brooks, S. N., see Campbell, W. B., 166Brown, 11. M. and Seiden, L. S. : Interresponse

time changes as a function of water depriva-

tion and amphetamine, 701

Btmrimamide, effect on gastric secretion stimulated

by histamine and methyl derivatives, 614

Burke, J., see Riekert, I). E., 585

972 INDEX Vol. 193

effect of thyrotropin-releasing hormone on ac-

tions of, 11

Burks, T. F., see (rubb, M. N., 884Bushing, J. A., see Sekerke, H. J., 835

Butoxaimmine , effect s on ervthropoiet in j)roduc t iou

in rabbits exposed to hypoxia, 176

Bynmaster, F. j)#{149},5CC Woimg, 1). T., 804Byrd, 14. 1). : Contrastiimg effects of nmorphine on

schedule-cont roiled hehaviorin the (hinmpanzee

and baboon, 861

( ‘ale juimu-independent (atecholanmine secret ion fronm ho-

vine adrenal immedulla, 313

nmetaholisnm, alteratioii irm, as mmmeclmanisnm forpy ridine aldoxiimme nmethoehloride cardiac ac -

tion in rabbit atria, 218nmovemmments iii rat niyometriunm, effect of iso-

proterenol afl(l I)-600, 309Caimmpbell, W. B., Pettinger, W. A., Keeton, K.

and Brooks, S. N. : Vasodilating aumtihyper-

tensive drug-induced aldosterone release-Astudy of endogenotis angiotensin -nmediated

aidosterone release in the rat, 166Cantor, E., see Johnsoum, E. M., Jr., 503

Carbachol, vasoconstriction of isolated ral)hit ear

artery caused by, 128Carboim dioxide, fixatiomm by rat liver immitochondria,

effects of glucagon aumd other peptides oum, 720Carbon immoumoxide, lethality, influence of carbon

monoxide, hypoxic hypoxia or potassitmnm cya-nide pretreatnment on, 713

Carbon tetraehloride, alteration by phenobarbitaland 2-methylcholanthrene of functional and

structural changes in rat liver dime to inhala-tion of, 281

Carbonic anyhdrase , inimihit ion , effect mm erythro-cyte 2 , 3 -diphosphoglycerate (olmten t and

metabolism , (139

Carison, (1. li., see Shah, H. C., 281Carnmichael, F. J. and Israel, V. : Effects of ethanol

on netmrotransmitter release by rat brain corti-

(al slices, 824Carrier, (1. 0., Peters, T. and Bishop, V. S. : Al-

teratioum in calcitmm nmetaboiisnm as a nmecha-II ism for py ridine aldoxinme nmethochloride(2-PAM) cardiac action in rabbit atria, 218

Castration, in rats, infitmence of snmooth muscle onsynmpathetic nerve innervating internal sexorgans after, 424

Cat(s)blockade by reserpine of nmethylphenidate-in-

duced release of brain dopanmirme in, 539effects of antiepiieptic drugs on estrogen-iimduced

elec trographic spike -wave discharge in , 647

effect of potential antiastimmatic agent, Sch15280, in, 256

neural nmechanisnms involved in acetylstrophan-

thidin-indtmced bradvcardia in, 336

respiratory stimulant effects of ethanmivan and

picrotoxin in, (�7

spleerm, eimhaneed release of norepinephrine and

dopaimmiime-iS-hydroxylase by nerve st inmulationfronm, associated with granular effect of reser-

pine-like conmpound, 757spleen, possible role for cyclic adenosine mono-

phosphate in release of norepinephrine and

dopanmine-�3-hydroxylase by nerve st imula-tion, 105

Catecholamine (s)effect of sex and estrogens on respommsiveness of

terminal arterioles to, 403in superior cervical ganglia in orgamm culture, bio-

chenmical and histofluorescence studies, 489

nmetabolism in spontaneously hypertensive rat,effects of reserpine and hydralazine, 443

piasnma, in rat, effects of ganglionic blockade,

reserpine and vinblastine on, 748secretion fronm bovine adrenal nmedtmlla, (aiciunm-

independent, 513m4CCatecholamines, incorporation of ‘4C-tyrosine

iii nmouse brain, heart and spleen into, compari-son of effects of nmorphine and forced running,

364Cells, alveolar mononuclear, effects of pharma-

cologic agents on release of lysosonmal ermzymesfrom, 603

Cephalothin, effects orm fixation of Ct)2 by rat liver

mitoehondria, 720Chase, 0. J., see Uretsky, N. J., 73

Chastril, J. and Wilson, J. T. : 4-Nitrocatechol

production from p-nitrophenol by rat liver,(131

Chitmeh, C. C. and Moore, K. E. : Blockade by

reserpine of methylphenidate-indtmced releaseof brain dopamine, 559

Chimpanzeedrug-induced alteration in renal excretion of

uric acid in, comparison with Cehus nmonkeyand nman, 363

effects of morphine on schedule-controlled be-havior in, contrasted with babooum, 804

Chlorai hydrate, effects of thyrotropium-releasing

hornmone on actions of, 11Chlorimipramine, lysergic acid diethylaimmide and,

effects on efflimx of precursor-formed 3H-sero-tonium correlated with serotonergic inmpulseflow, 785

Chlorisoumdam inc-induced ganglionic blockade in

rat, effects on plasnma eatechoiamiimes anddopamine-f3-hydroxylase, 748

4 -Chloroamphetamine , effec t of 3 -(p-t rifluoro-

nmethylphenoxy)-N-methyl-3-phenylpropyla-nmine on depletion of brain serotoniim by, 796

p-Chloroanmphetamine , optical isomers , correla-

tioii between brain levels and biochenmicai

effects of, 835Chlorpromaz me

1975 INDEX 973

tioums of, 11

effect on multiple fixed-ratio, fixed-immterval

schedule performance, 689Chlorprothixene, effect on multiple fixed-ratio,

fixed -interval schedule performance , fiSt)

Choline, effect on nmorphine depermdence in rat, 44

Cholinelmethyl-’Hl , intravenous , distribution aumdnmetabolism in guinea-pig tissues, synthesis of

in vivo of acetylcholine and, 246Cholinergic agents

effects on release of lysosoimmal enzymes fronm al-veolar mononuclear cells, 603

effects of chronic ganglion blockade and chronic

cholinesterase inhibition on sensitivity ofrabbit stommmach niuscularis to, 739

Cholinesterase inhibition, chronic, effects on sen-sitivity of rabbit stomach muscularis to cho-linergic and adrenergic agonists, 739

Chung, L. W. K., Raymond, (L and Fox, S. : Boleof neonatal androgen in the development of

hepat ie nmicrosonmal drtmg-metaboliz ing en -

zynmes, 621

Ciancy, M. M., see (liilis, 11. A., 336Coagulating gland, castrated rat, influeumce of

snmooth muscle on synmpathetic nerurons in-nervating. 424

Cocaine , nmet hyiphetmidate and, choice procedure

to conmpare reinforcing efficacy in rhesus nmon-keys, 676

Code, C. F., see Preiss, 1)-U., 614Codeine, and conmbinations with antipyretic aimal-

gesics, self-adnministration in rhesus ummonkeys,

870Cohen, L., Lapkin, It. and Kaloyanides, (L J.:

Effect of gentammiicin on renal function in therat , 264

Colchiciume, effects on release of lysosomal enzymesfrormm alveolar mmmononuclear cells, 603

Constantinidis, J., see Bartholini, (1., 523Contractility, niyocardial, effects of verapaimmil on,

317Coimt rast nmedia (nmeglunmine diatrizoate) , renal

vascular effects, 932Cooper, B. H., see Breese, (1. 11., 11Copp, F. C., see Nanmm, I). H., 194

Costa, E., see Hanbauer, 1., 95

Cott, ,J.M., see Breese, (‘i. IL, 11

ad renal nmedulia , calcium -independent cute -

cholamine secretion from, 313

ovarian follicles , nmechanicai response nmediated

by adrenergic receptors in, 460

superior cervical ganglion , possible role for cyclic

guanosine 3 ‘ , 3’ -monophosphate in synaptic

traimsnmission in, 474

Creven, H. M., see Witter, A., 853

Ctmbeddu, L., X., Barnes, B., and Weiner, N. : He-

lease of norepinephrine and dopamine-�-hy-

droxylase by nerve stimulation. IV. An evalu-

atiomm of a role for (Vcli( adenosine nmonophos-phate, 103

Cubeddu, L., X., and Weirmer, N. : Release of nor-

epiumephrine and dopanmiume-#{231}3-hydroxyiase bynerve stinmulation. V. Enhanced release asso-

ciated with a granular effect of a benzoquino-iizine derivative with reserpine-like proper-

ties, 757dl-Cvclazociuie , conmparisomm of oxilorphan , new

synthetic narcotic antagonist , to, 23Cyclic adenosiime 3’,3’-nmonophosphate

cardiac, effects of verapamii on, 317formation in rat cerebral cortical slices stinmim-

lated by nmethoxanmine, interaction with alpha

adrenergic receptor, 549possible role in release of norepinephriume and

dopamine -f3-hydroxylase by nerve stimulation

103role in induction of tyrosine hydroxylase elicited

by beta adrenergic receptor agonists in normaland decentralized sympathetic ganglia, 95

Cyclic guanosine 3’ ,5’-monophosphate, muscariniccholinergic regulation in autonomic ganglia,

possible role in synaptic transmission, 474Cyclic nucleotides, effects on release of lysosomal

enzymes from alveolar mononuclear cells, 603

1 - N - Cyclopropyinmethyl - 3, 14 - dihydroxymor-phinamm (oxilorphan) , new synthet ic narcotic

antagonist, 23Cyproheptadine

characterization of dopamine-induced contrac-

tion in canine isolated arteries by, 433-induced depletion of insulin in rat, 583

Cytochalasin B, effects on release of lysosomal en-zymmmes fronm alveolar nmononuclear cells, 603

D-600, effect on calciunm nmovenments in rat nmyo-

nmetriunm, 309

1)aly, J., see Warnick, J. B., 232l)aly, J. W., see Skolmmick, P., 349

1)anielson, M. G., see Julien, H. M., 647

1)anilo, J)�, Jr., see Rosen, M. H., 2091)avis, F. A., see Schauf, C. L., 669

Dewey, W. L.

see Patrick, (l. A., 876see Pedigo, N. W., 845

de Wied, 1)., see Witter, A., 853

Diabetes, in rats, influence of alteration in en-dogenous insulin levels and state of nourish-

nment on isoproterenol- and epinephrine-in-dtmced changes in blood glucose and tissue

glycogen levels in, 576

1)ianmond, L. , Adams, G. K., Bleidt, B. and

Williams, B.: Experimental sttmdyof a poten-

tial aimtiasthnmatic agent : Sch 13280, 256

1)iazepam

effect of thyrotropin-releasing hormone on ac-

974 INI)FX Vol. 193

ternminal arterioles t o, 43()

effect on est rogen -induced elect rographic spike -wave discharge, 647

I)ibona, (1. F., see Norby, L. H., 932

l)igitalis, toxicity during acute hypoxia iii iimtact

conscious dogs, 963

3 ,4-l)ihydroxyphenylseriume , stereoisonmers , as pre-

cursors of norepineplmrine, 5232 , 3-I )iphosphoglycerate , eryt hrocyte content and

nmetabol isnm , effec t of acetazolaun ide amid car-houmic anhydrase inhibit ioum on, 639

i)isodiunm cronmoglycate, specificity in inhibition of

passive cutaneous aimaphylaxis react ion in

nmice and rats by, 594

Dog(s)antagonisnm of intestinal st iimmulatory effects of

niorphine by isoproterenol , prostaglandin B,

and theophyiline in, 884arteries, effect of neonmycin on cciii met ile re-

sponses of, 393cardiac Purkinje fibers, effects of UM-272 on

elect rophysiological properties of, 209effect of ajimmaline in experimental aumd clinical

arrhythnmias and their relation to sonme dcc-

trophysiological parameters of heart iii, 182effect of beta receptor blockade Ofl initiation and

perpetimat ion of ouabaum-induced vent rictmla.r

tachyarrhythmia i n , 327effect of burirnamide auid nmetiamide on gastric

secretion stinmuiated by histanmiume and its

nmethyl derivatives iii, 614

effect of 5-hydroxvkvnurenanm inc , serotoninimmetabolite, on isolated cerebral arteries, 385

effect of hypoxemia on responses to norepiumeph-

rine and angiotensin in coronary amid nmtiscularvessels of, 941

forelimbs , pressure -depen(Ien t factors i ii edenma

formation in, 454heart, alteration iii oxyheimmoglobin equilibriimm

and inyocardial oxygen consunmption by nitro-glycerum in, 346

intact cOnseiOtms, digitalis toxicity durimig actmtehypoxia iii, 963

intact, nmyocardial uptake of ouahain in, 951isolated arteries , characterizat ion by cypro-

heptadine of dopanmine-iuiduced (ont raet ioniii, 435

isolated cerebral arteries , nicat me-inducedrelaxation in, 376

renal henmodynanmics atid elect rolvte excret ions

after reserpine and ethanol in, 356

renal vascular effects of nmegiuiimine diatrizoate

iii, 932

I )opammmiume

brain , blockade by reserpine of niethylpheni -

date-induced release of, 559

effect of sex and estrogens on responsiveness of

ii, superior cerVical ganglia, I)iochenmical and

histofluorescence studies, 489-i imduced coumt raction in canine isolated arteries,

charac terizat ion by cyproheptadine , 435release by rat brain cortical slices, effects of

ethanol, 824role of cyclic 3’,S’-adenosine monophosphate in

induction of tyrosine hydroxylase in normaland decentralized synmpathetic ganglia elicitedby, 93

synthesis and release iii rat striatunm in vitro,

effect of a-methyldopa on, 73

uptake into rat brain synaptosomes, inhibitedby 3-(p-trifluoronmethylphenoxy)-N -nmethyi-3-phenylpropylamine, 804

I )opanmine-�9-hydroxylase

activity aumd anmount in catecholamine neuronalsystems in rat brain, effects of reserpine, 775

plasma, iii rat, effects of ganglionic blockade,reserpine and vinblastine on, 748

release by nerve stinmulation, associated with

grammiar effec t of reserpi ne -like eonmpound,

757release by nerve stimulation, possible role for

cyclic adenosine monophosphate, 105

l)opaminergic agents, increased sensit ivity ofmice to, after chronic umeuroleptic treatment,

88

1)otmglas,J. H.,Jr.,seeJohnsoim,E.M.,Jr.,303l)tmnn, M. J. and Hunt, W. : The effects of harma-

line on sOditiifl transport in human erythro-cytes: Evidence in favor of action at interiorsoditim-seiisitive sites, 903

Edema, fornmation in canine forelinmbs, pressure-

dependent factors, 454Edvinsson, L., see Walles, H., 460Electrographic spike-wave discharge , est rogeim-

induced, effects of antiepileptic drugs on, 647Electrolytes, exeret ions , renal henmodynammmics and,

after reserpine and ethanol, 356

Electrophysiological effects, uptake aimd bindingand, of bretylium in nornmal and immmmmmunosynm-

pathectonmized rat hearts, 194Elect rophysiological properties

heart, effects of ajmaline in experinmental and

clinical arrhythmnias and their relation to, 182of canine cardiac Purkinje fibers, effect of UM-

272, 209

Ellis, S., see Potter, 1). B., 576

El-Sayad, S., see Narnm, I). H., 194

Enzymatic derivative double isotope assay, fornmeasuring tissue levels of taurine, 301

Enzynmeshepat ie microsonmal drug-nmetabolizing, role of

neonatal androgen in development of, 621in catecholanmine neuronal systems in rat brain,

effects of reserpine, 775

‘975 INDEX 975

lysosonmal , release frommm alveolar nmoimommimclear

cells, effects of pharnmacoiogic agents, 603

i4)inephrimme

effect of sex ammd estrogens on responsiveimess ofteriimiiiai arterioles to, 403

-induced (hanges mm blood glucose and tissueglycogen levels in nornmal and diabetic rats,influence of alterat ion i n endogenous insulin

and state of nourishimment , 576role of (V(lic 3’ ,5’-adenosinme mmmonophosphate in

induction of tvrosine hvdroxylase in normal

amid decent ralized syimmpathetic ganglia elicited1)\ , 95

i’rvthrocyteseffect of acetazoiaimmide arid carbonic anhydrase

inhibit ion mm 2 , 3-diphosphoglycerate content

in , 639

lmtiiiman, effects of harimmaline on sodiuimm transport

iii, 903

Erythropoiet in , product ion iii rabbits exposed to

hypoxia, effects of be/a adrenergic blocking

agents on, 176

Eserimme, effects onm morphine dependence in rat, 44lstrogen

effect (iii responsiveness of ternminai arterioles to

neurohypophyseal hornmommes and catechola-nmines, 403

-induced elect rographic spike-wave discharge,

effects of antiepileptic drugs, (147Ethanmivan, respiratory stimulant effects of, 657

Ethanoleffects Ofl neurotransmitter release by rat brain

cortical slices, 824reserpine amid, renal henmodynanmics and electro-

lyte excretions after, 356

Et hosuxini ide , effects on est rogen-indtmced dec -t rographic spike-wave discharge, 647

Etimylimmorphine, hepatic nmetabolism in rat , role ofneonatal aimdrogeim, 621

Evans, I). H., see (1illis, H. A., 336

Famielli, (1. M., Jr. and Weimmer, I. M. : Species

variations ammmong priimmates in responses to

drugs which alter the renal excretion of uric

acid, 363

Fink, (1. 1)., Paulo, L. (. and Fisher, J. W. : Effect

of beta adrenergic blocking agents oim erythro-

poietin production in rabbits exposed to hy-

pOXIR, 176

Fischer, L. J., see flickert, 1). E., 583

Fisher, J. W., see Fink, (l. 1)., 176

Fluorodichloromethane , funct ional and structural

changes in isolated rabbit liver mitochondria

induced by, 729

Fltmphenazine , effects on nmultiple fixed-ratio,

fixed-interval schedule performance , 689

Forelinmbs, �anume , pressure-dependemit factors in

edenma fornmatioim in, 434

Fowier, (L W., see Julien, 11. �I., 647Frederickson, II. C. A. and Pimisky, C. : Effects of

cholinergic and anticholinergic drugs and a

partial cholinergic agonist on the develop-ment and expression of physical dependemiceon morphine in rat, 44

Freon 21 (see Fhmorodichloronmethaime)

Freudenthal, H. I. and Martin, J. : Correlation of

brain levels of barbiturate enmmntionmers withreported differences in duration of sleep, 664

Fuller, H. W., Perry, K. W. amid Molloy, B. B.:

Effec t of 3 - (p -t rifluoronme t hyiphemmoxy ) -N -

methyl -3 -phenylpropylanm i iie on t he depict iou

of brain serotonin by 4-chloroanmphetanmine,

796

Ftmrchgott, 14. F., see Steinsland, 0. 5., 128, 138

(;allagher, I). W. amid Aghajanian, U. K. : Effectsof chiorinmipramine and lysergic acid diethyl-

amide on efflux of precursor-formmmed ‘H-serotonin : Correlations with serotonergic mm-

pulse flow, 785

( anglia

atitonoimmic , immuscaruiic cholinergic regulat ion ofcyclic guanosine 3’,5’-mmmonophosphate imi,

possible role in synaptic transnmissiomi, 476

blockade, chronic, effects Ofl semisitivity of rab-

bit stomach nmuscularis to cholinergic and

adrenergic agents, 739blockade, effects on plasnma catecholammmines and

dopamine-$-hydroxylase in rat , 748superior cervical, in organ culture, hiochemnical

and histofluorescence sttmdies of catechola-

nmmnes in, 459sympathetic, nornmal and decentralized, role of

cyclic 3’ , 5’-adenosimme nmonophosphate in in-

due tion of tyrosine hydroxylase die it ed by

beta adrenergic receptor agonists in, 95(larcia, A. (1., see Wakade, A. IL, 424

Garg, L. C., see Hoif, L. L., Jr., (139Gastric secretion, stimulated by histammmiume and its

nmethyl derivatives, effects of hurinmmanmide and

metianmide on, 614Gentanmicin, effect 011 renal fumictiomi in rat, 264

Gerbil, effects of thyrotropin-releasiumg hornmoneon actions of pentobarbital in, 11

Giant axon, Myxieola, voltage-clanmped, actiomis ofimipranmimme on, 669

Gilbert, J.-C. and Goldberg, L. 1. : Characteriza-

tion by cyproheptadine of the dopanmiime-induced contraction in canine isolated ar-

teries, 433Gillis, IL A., Quest, J. A., Thibodeaux, H., Ciancy,

M. M. and Evans, 1). E. : Neural nmechanismsinvolved in acetylst rophant hidin -indtmcedbradycardia, 336

976 INDEX Vol. 193

see Patrick, G. A., 876

( ilucagon, effects on fixation of (X)� by rat liver

mitochondria, 720Glutamate, release by rat I)raiui cortical slices,

effects of etimamiol, 824Goldberg, 14.1.,see Gilbert, J.-C., 435

(;oodnmami, F. H., see Adanms, II. it, 393Graeff, F. (1., sec �Ielo, J. C., 1( 1 reen , Ft . i ) . , see Lefever , ( . S . , 739

(;reengard, P., see Kebahian, J. W., 474(lrega, (1. J., see Kline, H. L., 434

Gross, G. .J. and 1!ardnman, ii . F. : Alteration in

oxyhenmoglobin equilibriunm (P-SO) amid nmyo-

cardial oxygen consunmption (MV(),) by nitro-

glycerin ((1TN ) , 346Grubb, M. N. and Btirks, T. F. : Selective an-

tagonisiim of the iimtestiumal stimulatory effectsof niorphine by isoproterenol , prost aglandi ii

F�1 amid theophyiline, 884

(itmanethidine-induced svmmmpmtthectonmv in mmewbornrats, hiocheimmical and ftmnct ional evaluat ionof, 5�3

Guidotti, A., see Ilmtiihatier, I . , 95

Giminea pigeffect of pharmacologic agents on release of

lysosoimmal enzynmes froimm alveolar mommo-

nuclear cells of, 603

effects of t hy rot ropi Ii -releasi ng hormmmoime on

actions of pentobarbital in, 11tissues, distribution amid nmietabolisnm of immtrmi-

venous choline [methyl-’Hl amid synthesis iii

,‘wo of a(etylcholine, in , 246

Gylys, J. A., see Pircio, A. W., 23

H,-receptor antagonists (hurinmanmide and nmeti-

anmide), effect ott gastri( secretion stimimlated

I)y histaimmine and its iiiethyl derivatives, 614

iladdy, F. J., see Kline, R. L., 434

Ilaloperidolchrommic t reatmmment in immice , increased sensitivity

to (lopaIflinergic agents after, 55

effect on nmultiple fixed-ratio, fixed-interval

schedule perforimiamice , 659

increased sensitivity in mice to dopanminergic

agents after, 55

Hanmster, effects of t hyrotropin-releasing hornmone

on actiomis of l)eumtobmtrhital in, 11Ilanbauer, 1., Kopin, I. J., (luidotti, A. and Costa,

E. : Imiductioum of tvrosimme hydroxylase elicitedby bela adrenergic receptor agonists in nornmai

and decent ralized symmipat het ic ganglia : Holeof cyclic 3’,S’-adenosine immonophosphate, 95

Hardman, H. F., see Gross, G. J., 346Harmaline, effects on sodium trammsport in human

erythrocytes, 903

Harper, J. F., see Snmith, I. M., 720

Harris, L. S.

see Pedigo, N. W., 845

Hauhrich, I). IL, Wang, P. F. L. and Wedeking,P. W. : 1)istribution and nmetabolism of intra-venously admimmistered choline [methyl-’H]ammd synthesis in vivo of acetylcholine in van-

ous tissues of guinea pigs, 246

Haynes, 11. C., Jr., see Snmith, I. M., 720Heart

cont ract ili ty, adenosiume 3 ‘ , 5’-monophosphateand phosphorylase, effects of verapamil, 317

dog, alteration in oxyhemoglobin equilibrium

aumd myocardial oxygen consumption by nitro-

glycerin iii, 346dog, ouabain-i nduced ventricular tachyarrhyth-

nmia, effect of beta receptor blockade on initia-tioum and perpetuation of, 327

effects of ajmaline in experimental and clinicalarrhythmias and their relation to some elec-trophysiological parameters of, 182

intact dog and man, uptake of ouabain in, 951

mouse, comparison of effects of morphine andforced running on incorporation of “C-tyro-

siume into 14C-catecholamines in, 564rabbit, action of pynidine aidoxime methochlo-

ride on, alteration in calcium metabolism asmechanism for, 218

rat, mmormal and immunosympathectomized,

electrophysiological effects and uptake andbiumding of bretylium in, 194

rat, stereoisomers of 3 ,4-dihydroxyphenyl-serine as precursors of mmorepinephnine in, 523

rate responses, to d- and i-amphetamine inpithed rat, 149

Heistad, 1). 1)., Abboud, F. M., Mark, A. L. ammdSchmid, P. G. : Effect of hypoxemia on re-

sponses to norepinephnine and angiotensin incoroumary and muscular vessels, 941

Heimdersoim, A. 0., see Van Auken, 0. W., 729Hess, M. E., see Shaimfield, J., 317

Hexobarbital, hepatic metabolism, in rat, role ofneonatal andnogen, 621

Hirsch, K. and Wang, S. C. : Respiratory stimulanteffects of ethamivan and picrotoxin, 657

Histami tieinhibition of granulation tissue growth by, 910Iflethyl derivatives and, effect of bunimamide

and metiamide on gastric secretion stimulatedby, 614

Histochenmical studies, of stereoisomers of 3,4-dihydroxyphenylserine as precursors of nor-

epinephrine, 523

Histofluorescence studies , of catecholami nes in

superior cervical ganglia in orgaum culture, 489

Ho, I. K., Brase, D. A., Loh, H. H., and Way,

E. L. : Influence of L-tryptophan on morphine

analgesia, tolerammce and physical dependence,

35

1975 INDEX 977

Isoproteretmoi

Hoffnmeister, F. and Wuttke, W. : Further studies

on seif-adnministrationm of antipyretic anal-

gesics and combinations of antipyretie anal-

gesics with codeine in rhesus monkeys, 870

Hornmones, neurohypophyseal, effect of sex andestrogens on respommsiveness of terminal an-tenioles to, 403

Horng, J. S., see Wong, 1). T., 804Hunt, \V., see 1)tmnn, NI. J., 903Hydralazi tie

effect on tyrosiime hydroxylase activity and

norepi nephrine concentrations in spontane-ously hypertensive rat, 443

-induced aldosterone release in rat, mediated by

amigiotensiim, 166

6-Hydroxydopamine, effects on amphetamimme-induced mmorepinephnine release in rat cerebral

cortex, 64

5-Hydroxykynurenamine (serotonin metabolite),

effect ommisolated cerebral arteries, aortas andatria, 385

5-Hydroxytryptamine (see also Serotonin), bio-synthetic capacity in rat brain for, effects of

lithium chloride, 812Hypoxanthine - guanine - phosphoribosyltransfer-

ase activities, miormal, decreased 6-mercapto-punine retention by two resistant variants ofmouse neuroblastoma with, 293

Hypoxenmia, effect on responses to norepiimephnine

and angiotensin in coronary and muscularvessels, 941

Hypoxia

hypoxic, lethality, influence of carbomm mon-oxide, hypoxic hypoxia on potassium cyanide

pretreatment on, 713in intact conscious dogs, digitalis toxicity

dunimig, 963rabbits exposed to, effects of beta adrenergic

agents on erythropoietin production in, 176

Imniprami tie, actions on voltage-clamped Myxicola

giant axon, 669Insulin

cyproheptadine-induced depletion in rat of, 585

levels, eumdogenous, influeimce on isoproterenol-and epimiephnine-induced changes in bloodglucose and tissue glycogen levels in normal

and diabetic rats, 576Iimterresponse time, changes, as function of water

deprivation and amphetamine, 701

Intestitme, stinmulatory effects of morphimme, an-tagomiisnm i)y isoproterenol, prostaglaimdin E�and theophylline, 884

Invertebrates, neurons, effects of acetanilides on,

correlated with analgesic activity in verte-

brates, 892

antagonism of intestinal stinmulatory effects of

morphine by, 884

effect on calcium nmovenments iii rat myonme-

tnium, 309

-induced changes in hlood glucose aimd tissueglycogen levels in normal and diabetic rats,influence of alteration in endogenoims imisulinand state of nourishmemit, 576

Israel, Y., see Carmichael, F. J., 824

Jacobowitz, 1). M., see Webb, J. G., 489Jansson, 5.-B., see Warnick, J. E., 232

Joh, T. H., see Reis, D. J., 775Johanson, C. E. and Schuster, C. li. : A choice

procedure for drug reimiforcers: Cocaiume amid

methylphenidate iii the rhesus mnomikey, 676Johnson, E. M., Jr., Cantor, H. and Douglas, J.

II., Jr. : Biochemical and functional evaluation

of the sympathectomy produced by the ad-ministration of guatmethidine to miewbonmi rats,503

Julien, R. M., Fowler, (1. W. and Danielson, I�I. G.:The effects of antiepileptic drugs on estrogen-

induced electrographic spike-wave discharge,

647

Kabela, E., see Bojorges, H., 182Kaiisker, A., Waymire, J. C. and Rutledge, C. 0.:

Effects of 6-hydroxydopamine amid reserpineon amphetamine-induced release of nor-

epinephnine in rat cerebral cortex, 64

Kaloyanides, G. J., see Cohen, L., 264Kauker, M. L. : Tracer microinjeetion studies of

prostagiadnin E, tranmsport in the rat nephron,

274

Kebahian, J. W., Steiner, A. L. aimd Greengard,P. : Muscarinic cholinergic regulation of cyclic

guanosine 3’ , 5’-monophosphate in autonomicganglia: Possible role in synaptic transmis-sion, 474

Keeton, K., see Campbell, W. B., 166

Kesler, II. L., see Sehauf, C. L., 669Kidney

functiotm, in rat, effect of gentamicin, 264hemodynamics, electrolyte excretions amid, after

reserpine and ethanol, 356nephron, rat, tracer microinjectiomi studies of

prostaglandin E, transport iim, 274species variations among primates in responses

to drugs which alter excretion of uric acid in,

363vascular effects of nmeglumine diatnizoate in, 932

Kirpekar, S. M., see Wakade, A. II., 424Kline, R. L., Sak, 1). P., Haddy, F. J. and Grega,

G. J. : Pressure-dependent factors in edema

formation in cammine forelimhs, 454

Knapp, S. and Mandell, A. J. : Effects of iithitmm

Vol. 193975 INDEX

chloride on parminmeters of I)iosynthetic (ml-

pacity for 5-hydroxvtryptaummine in rat brain,812

h.iiobloch, L. C., see Sofia, It. I)., 918Kohler, C., Berkowitz, B. A. atid Spector, S.:

Aimti hypertensive drugs muid catecholanmi tienmetabolisimm: Effects of reserpine and hydrala-zinc on tyrositme hydroxylase activity amid

norepinephrimie concent rations in the spoti-taneously hypertensive rat , 443

Kopiim, I. J.

see Hanbauer, I. , 95see Reid, J. L., 748see Webb, J. CL, 489

Kroeger, E. A., Marshall, J. M. and Bianchi, C. P.:

Effect of isoproterenoi atid l)-600 on calciunm

nmovenments in rat mmmyotnetrninm, 309

Lapkin, It., see Cohen, L., 264

Leander, J. 1). : Hate-dependent effects of drugs.

II. Effects of somime major tranquilizers on

multiple fixed-ratio, fixed-i nterval schedule

perforimmance, (189Lee, H. T. S., see Van Auketi, 0. W., 729Lefever, (. S. and Greeti, 11. 1). : The effects of

chronic gangiion blockade and chronic chol-

inesterase inhibition on the sensitivity ofrabbit stonmach immuscularis I o cholinergic mind

adrenergic agotmists, 739Levine, N. H., see Shanfield, J., 317

Levitan, H., see Barker, J. L. , 892Lipton, M. A., see Breese, (1. 11., 11Lithiunm chloride, effects oii i)iosynthetic capacity

for 5-hydroxvtrvptamimine iii rat hraimm, 812

Liver

isOlitte(l nmitocimondria, ral)i)it, functional and

st ruct ural chaimges i nduced by fluorodichloro-

methane in, 729mmmicrosonmai drug-iimet aix d i z i rig enzvnmes , role

of neonatal androgen iii developnment of, 621

rat , alteration by phenoharhital and 3-mmmethyl-cholaiithrene of functional and structural

chaimges due to carbon tetrachloride iimhala-

tioii in, 281rat, niitochondria, effects of glucagon amid other

peptides oim fixation of (�)2 i)V, 720rat, 4-mmit rocate(hol product ion fromim p-nit ro-

phenol by, 631Lob, H. H., see Ho, I. K., 35Lonmhardini, J. B. : Aim eimzyimmatic derivative

double isotope assay for measuring tissue

levels of taurine, 301

Lorenzo, A. V., see Uretsky, N. J., 73Losey, B. G., see Von\oigtlander, P. F., 88Lysergic acid diethylanmide, (hloriimmipranmine and,

effects on elilux of precursor-fornmed ‘H-serotoimin correlated with serotonergic iimmpulse

flow, 785

1\Imui

drug-immduced alteration iii renal excretion ofuric acid in, comparison with chimpamizee

and Cebus nmonkey, 363effect of 5-hydroxykynureimamine, serotoni ii

nmetabolite, oil isolated cerebral arteries, 385erythrocytes, effects of harmaiine on sodiunm

transport mm, 903myocardial uptake of oual)ain in, 951

Mandeli, A. J., .�ee Knapp, S., 812Mark, A. L., see Heistad, D. 1).,941

Marshall, J. M., see Kroeger, H. A., 309Martin, J., see Freimdenthal, 11. I., 664Maxwell, 11. A., see Nanmm, I). H., 194

Mecamylamine, effects on immorphine dependencein rat, 44

Meglumine diatrizoate, reimal vascular effects, 932Melo, J. C. and Graeff, F. (1. : Effect of intracere-

broventricular bradykinin and related pep-tides on rabbit operant behavior, 1

Mendez, H., see Bojorges, H., 1826-Mercaptopurine, decreased retention of, by two

resistammt variants of mouse neurobiastoma

wi th nornmai hypoxaimthiime-guanine-phospho-

ribosyltransferase activities, 293

Metabolismcalcium, alteration in, as mechanism for pyri-

dine aldoxime methochloride cardiac action in

rabbit atria, 218of ACTH4#{216} ammalogs, correlation with structure

and behavioral activity, 853of catecholamines in spoimtaneously hyperten-

sive rat, effects of reserpine and hydralazine,

443of 2,3-diphosphoglycerate, effect of acetazola-

mnide and carbonic aimhydrase inhibition on,

639of intravenous choiine[met hyl-’Hj i im guinea-

pig tissues, synthesis in vivo of acetyicholineand, 246

Metabolite, of serotoni n (5-Hydroxykynurena-

mine), effect on isolated cerebral arteries,

aortas amid atria, 385Methoxamnine-stimulated adenosine 3 ‘ , 5’-mono-

phosphate formation in rat cerebral corticalslices, interaction with alpha adrenergic recep-

tor, 549

3-Met hylcholant hrene-indtmced alteration of futme -

tional and structural changes in rat liver dueto carbon tetrachloride inhalation by, 281

a-Methyldopa, effects 0!) dopamine synthesis and

release in rat striatunm in vitro, 73

Methylphenidate

cocaine and, choice procedure to compare rein-

forcing efficacy in rhesims monkeys, 676

-immduced release of brain dopamine, blockade by

reserpine, 359

‘975 INDEX 979

thidin-induced bradycardia, 336

l\tetiainide, effect on gastric secretion stiummulated

h� histamine an(1 nmethvl derivatives, 614

Miceacutely treated and pellet-implanted, relation-

ship of brain morphine levels to analgesicactivity iii, 876

antinociceptive activity of acetylcholine iii, 845brain, heart and spleen, comparison of effects

of nmorphine amid forced rummning ommincorpora-t ion of ‘4C-tvrosimme into ‘4C-catechoianmines in,

564

correlation of brain levels of barbiturate en-antionmers with differences in duratiomm of

sleet) iii, 664effect of oxilorphan, new synthetic narN)tic

:tiitagonist, in, 23effect of thyrotropin-releasing hormone oii ac-

t 10115 of pemmtobarbital amid other centrallyacting drugs 1mm,11

increased semisitivity to dopamiimergie agemitsafter chronic neimroleptic treatment, 88

influence of L-tryptophamm on morphine anal-

gesia, tolerance and physical dependence in,:35

nemiroblastoma, t W() resistant variants withnorimmal hypoxant hine-guaniime -phosphoribo-svlt ransferase act ivit ies , decreased (i-nmer-

captoptmrine retention by, 293specificity in pharnmacological inhibition of

1)mtssive ctmtaneous anapimylaxis reaction iii,

594

t inme course of effect of reserpine on tyrosine

lmvdroxylase activity imivasa deferentia of, 533

Mim)xidil-induced aldosteromie release in rat,mimediated by amigiotensin, 1(1(1

Mit ochondriarabbit liver, isolated, fuumctional and structural

C hanges i nduced by fluorodichioromet hane in,

729rat liver, effects of giucagomm and other pept ides

cii fixation of CO2 by, 720Micra, 1). S., see ibsen, I). S., 209Mollov, B. B.

see Ftmller, 14. W., 796see W’ong, 1). T., 804

Molluse, neuromms, effects of acetanilides on, (Orre-

lation with analgesic activity in vertebrates,

892

Monkey (s)Cebus, drug-induced alteration in renal excre-

tutu of uric acid in, conmpmtrison with chinm-

l)tttlZdd aimd miman , 363rhesus, choice procedure to compare reinforcing

efficacy of drug solutions in, experiments with

cocaine and methylphenidate, 676rhesus , self-administ ration of antipyretic ammal-

gesics and combinations with codeine in, 870Moore, K. B., see Chinch, C. C. , 559

Morphine

analgesia , toieraimce and physical dependence,

influence of m�-tryptophan on, 35brain levels, relationship to analgesic activity in

acutely treated mmmice atmd rats and pellet-implanted mice, 876

effec ts on schedule-con trolled behavior �om -

pared in chimpanzee and baboon, 861forced running and, comparison of effects on

incorporatiomm of ‘4C-tyrosiime into ‘4C-cate-cholanmines in mouse brain, heart and spleen,

564-induced antinocicept ive act ivity in nmice ,

latioti with that of acetylcholinme, 845inhibitory effects on wet shake behavior, re-

gional sensitivity of rat braimm to, 56intestinal stimulator�’ effects, antagonisnm by

isoproterenol, prostaglandin E, and theo-

phylline, 884physical dependence on, in rat, effects of cholin-

ergic and anticholinergic drugs and a partialcholinergic agonist on development andexpression of, 44

Mosinmann, W. F., see Pfeffer, H. I., 422, 533Moss, J., see Webb, J. U., 489

Muscle, smooth, in castrated rat, influence onsympathetic neurons innervat ing internal

sex organs, 424Myonmetrium, rat, effect of isoproterenol and D-

(100 on calcium nmovements in, 309Myxicola, giant axon, voltage-clamped, actiomis of

inmipramine oh, 669

Naloxoime, comparison of oxilorphan, new synithetic narcotic antagonist, to, 23

Naitrexone, comparison of oxilorphan, miew syim-

thetic narcotic antagonist, to, 23Namm, D. H., Wang, C. M., El-Sayad, S., Copp,

F. C. and Maxwell, 11. A. : Effects of bretyliumon rat cardiac muscle: The electrophysiologi-cal effects and its uptake and binding in nor-mmmaland imnmunosynmpathectommmized rat hearts,

194

Narcotic antagonist , synthetic, new (oxilorphan),23

Neill, W. A., see Seldemm, H., 951Neoiimycin, effect on contractile responses of

canine arteries, 393

Nerve stimulation-induced release of norepinephrine and dopa-mine-�1-hydroxylase, associated with granular

effect of reserpine-like compound, 757

possible role of cyclic adenosine monophosphate

in release of norepinephrine and dopamine-�3-

hydroxylase by, 103

Netmral mechanisms , involved in acetyist rophan -

950 INDEX Vol. 193

ethanol, 824

Neuroblastonia, mouse, t wo resistant variants

wit h mmorimmal hypoxanthimme-gtmaimine-phospho-

ribosylt ramisferase act ivit ies , decreased 6-

immercaptopurimme retention by, 293

Neuroleptics, chroimic treatiimemmt of mmmi(e with,increased sensit ivity to dopanminergie agents

after, SM

Neuronsinvertebrate , effects of �wet anilides , correlation

with analgesic activity in vertebrates, 892sympathetic, immnervating internal sex organs

iii rat , iiiflumence of smooth nmuscle after cas-

tration oim,424Neurotranisnmitter release, by rat brain cortical

slices, effects of ethaimol on, 824

desensitization of adrenergic neurons of isolated

rabbit ear artery to, 138

-induced relaxation in isolated carmine cerebralarteries, 376

vasoconstriction of isolated rabbit ear artery

caused by, 128

Nicotinic agonmists

act ion on adrenmergic mieurons, vasoconstrictiommof isolated rabbit ear artery caused by, 128

desensitization of adremmergic mmeurons of isolatedrabbit ear artery to, 138

4 -N it rocatechol, production from p-nitrophenol

by rat liver, 631Nitroglycerin , alterat iomm in oxyhemoglobin equi-

libriunm atid mimyocardial oxygen consumptionby, 341;

p-N it rophenol , 4 -hit roemitecimol product ion by rat

liver from, 631

Norby, L. 1-1. and l)iBona, (�. F. : The renal vascu-

lmir effects of nieglunmine diatrizoate, 932Norepimiephrimme

anmphetanminie-imidiiced release of, in rat cerebral

(ortex , effec t 5 of (1-hydroxydopamine and

reserpine on, (14

con(entrat ioims in spommtammeoimsly hypertensiverat, effects of reserpine aumd hydralazine on,

443

effect of hypoxenmia on responses of coronary

and muscular vessels to, 941

effect of sex aimd estrogens on responsiveness of

terminal arterioles to, 403in simperior cervical gamiglia, biochenmical and

histofluorescence studies, 489plasma, imm rat, effects of ganglionic blockade,

reserpine and vinblastine 0mm, 748

release by nerve stinmulation, associated with

granular effect of reserpine-like commmpound,

757

release by nerve stiniulation, possible role for

cyclic adenosine nmonophosphate, 105

release by rat brain cortical slices, effects of

role of cyclic 3’ ,5’-adenosine mnonophosphate iii

induction of tyroxine hydroxylase in nornmal

and decentralized synmpathetic ganglia elicited

by, 95stereoisonmers of 3 ,4-dihydroxyphenviserimie as

precursors of, 523uptake into rat brain synaptosomes, inhibited

by 3-(p-trifluoronmethylphenoxy)-N -nmethyl-3-

phenylpropylamine, 804

O’Neill, P. J. and Hahwan, H. (1. : Experinmemmtal

evidence for calcium-independent catechola-

mine secretion from the bovine adremmal

medulla, 513Ontmr, 11., see Warnick, J. E., 232Oral contraceptives, chronic treatnment , effects on

(onversion of angiotensimm I to ammgiotensimm II

in rat, 160Orommsky, A. L., see Perper, H. J., 594

Ouabain

effects on neurotransmitter release by rat braincortical slices, 824

-immdimced ventricular tachyarrhythmmmia , effee t of

beta receptor blockade on initiation amid per-

petuation of, 327nmyocardial uptake in intact dog and man, 951

Ovary, follicles, wall, mechanical response niedi-

ated by adrenergie receptors in, 460

Owimman, C., see Walles, B., 460

Oxilorphan (l-N-cyelopropylmethyl-3 , 14-dihy-droxymorphinan) , new synthet ic narcoticmintagonist, 23

Oxprenolol, effect on immitiation amid perpetimationof ouabain -induced ventricular tachyarrhyt h-nmia, 327

Oxygen, consumption, myocardial, alteratioim bynitroglycerin, 346

Oxyhemoglobin, equilibrium, alteration by imitro-

glycerin, 346()xytocin, effect of sex and estrogens on respon-

siveness of terminal arterioles to, 403

Pancreas, rat, effect of cyproheptadine on insulinin, 585

Passive cutaneous anaphylaxis reaction, in miceand rats, specificity of in pharnmacological in-hibition of, 594

Pastelin, G., see Bojorges, B., 182

Patrick, (1. A., I)ewey, W. L., Spaulding, T. C.and Harris, L. S. : Relationship of brainnmorphine levels to ammalgesie activity in

acutely treated mice and rats amid in pellet-inmplanted mice, 876

Paulo, L. G., see Fink, G. I)., 176

Pedigo, N. W., Dewey, W. L. and Harris, L. S.1)etermination and characterization of the

amitinociceptive activity of intraventricularly

administered acetylcholine in nmice, 845

1975 INDEX 981

exposed to hypoxia, effects on beta adrenergic

Peimtoharhit Ill

effect of thyrotropin-releasing hormone on

actiomis of, 11

etmantionmers, brain levels, correlation withdifferences in duration of sleep, 664

Pept ideseffect OIl flxatiomm of CO, by rat liver mito-

chondria, 720intracerebrovent ricular, effect on rabbit operant

behavior, 1Perper, H. J., Orommsky, A. L. and Blancuzzi, V.:

An analysis of the specificity in pharmaco-

logical inhibition of the passive cutaneous

anaphylaxis reaction in mice and rats, 594Perphemmaz inc , effec ts on nmultiple fixed -rat io,

fixed -interval schedule performance , (189

Perry, K. W., see Fuller, H. W., 796Peters, T., see Carrier, (L 0., 218

Pettinger, �‘ A., see Campbell, W. B., 166Pfeffer, 13. 1., Mosinmann, W. F. and Weiner, N.:

Tinme course of the effect of administration of

reserpine on tyrosine hydroxylase activity inadrenal glands mind vasa deferentia, 533

Ph, effects ommaction of batrachotoximm, 232

Phenobarbitaleffects of thyrotropin-releasing hormone on

actions of, 11-induced alteration of functional and structural

changes iii rat liver due to carbon tetrachloride

inhalatiomm, 281Phentolanm imie , effec t on nerve stimimlat ion -mcdi-

ated release of norepinephrine and dopanmine-�3-hydroxylase, 105

Phenylbutazone, and conmbinations with codeine,self-administration in rhesus monkeys, 870

Phenmylephrine, effect of sex and estrogens on re-sponsiveness of terminal arterioles to, 403

Phosphorylase, heart, effects of verapamil on, 317

Physical dependenceoh nmorphine, influence of L-tryptOphafl on, 35

cii mmmorphine in rat, effects of cholinergic and

atiticholinergic drugs and a partial cholinergicagonist on development and expression of, 44

Picrotoxin, respiratory stimulant effects of, 657Pigeons, effects of trammqimilizers on multiple fixed-

ratio, fixed interval schedule performance in,fiSt)

Pinsky, C., see Frederickson, R. C. A., 44Pircio, A. W. ammd Gylys, J. A. : Oxilorphan (i-N-

(yrlopropylmethyl - 3 , 14 - dihydroxymor-

phinamm) : A new synthetic narcotic antagonist,

23

Plasm a, catecholami imes and dopamimme-$-hy-

droxylase, in rat, effects of ganglionic block-

ade, reserpine and vinblastimme on, 748

Pletscher, A., see Bartholini, G., 523

Plotnikoff, N. P., see Breese, 0. R., 11

Polyarthritis, adj uvant-induced, in rats, inhibi-

tion of primary lesion for detectiomi of clini-

(.ally effective antiarthritic drugs, 918Potter, D. F:. and Ellis, S. : Isoproteretiol- and

epinephrine-induced changes in blood glucoseammd tissue glycogen levels in normal and dia-

betic rats: The influence of alteration inendogenous insulimm levels and state of nourish-

ment, 576Practolol, effects on erythropoieti n production in

rabbits exposed to hypoxia, 176

Prange, A. J., Jr., see Breese, G. II., 11Probenecid, effects on renal excretion of uric

acid, species differences among primates, 363

Preiss, D.-U. ammd Code, C. F. : Effect of the H,-

receptor antagonists (burimamide and ineti-amide) on gastric secretiomm stimulated byhistamiume and its nmethyl derivatives, 614

Prochiorperazine, effects omi multiple fixed-ratio,fixed-i nterval schedule performance, 689

Promazine, effects on multiple fixed-ratio, fixed-interval schedule perforniance, 689

Propranolol

dimethyl quaterimary (see UM-272)

effects mm erythropoietin production in rabbits

exposed to hypoxia, 176

Prostaglandin

E1, antagonism of intestimial stimimlatory effectsof morphine by, 884

E,, transport in rat mmephron, tracer nmicroinjec-tion studies, 274

effects OIl release of lysosomal enzymes fromalveolar moimontmclear cells, 603

specificity in inhibition of passive cutaimeousanaphylaxis reaction in mice amid rats by, 594

Proteins, effects on fixation of CO, by rat livermitochondria, 720

Puig, M., see Bartholini, C., 523

Purkinje fibers, canine cardiac, effects of UM-272on eleetrophysiological properties of, 209

Pyrazinoate, effects out renal excretion of uric

acid, species differences among prinmates, 363

Pyridi ne aldoxinme methochioride , cardiac actionjIm rabbit atria, alteratiomm in calciunm nmetabo-

lisnm as nmechanisnm for, 218

Quest, J. A., lee (illis, 11. A., 336

Rabbit(s)

aortas amid atria, effect of 5-hydroxykynmurena-mine, serotonin metaholite, 0mm, 385

atria, alteration in calcium metabolism as

mechanism for pyridine aldoxime metho-

chloride cardiac action in, 218

effects of potemmtial ammtiasthmatic agent, Sch

15280, in, 256

982 INI)EX 10/. 193

of sympathectonmy produced by guanethiditie

iii, 503

blocking ageiits on erythropoietin production

in, 176

isolated ear artery, midrenergic iietmroiis, desensi-

tization to iiicotini( agoiiists, 138isolated ear artery , vasoconst nc tioii caused by

umicot i ilic mtgoiiists acti ng on mi(lrenergi( imetm-

rons, 128liver umitochondria, isolated, ftitictionmil and

st ru(t ural changes i tidniced by fluorodichloro-

methane in, 729

�peraiit behavior, effect of immtracerehroveiitri(u-lar bradykiniti and related peptides on, 1

stonma(h iimusctmlaris, effects of chroni( ganglion

hlockade and (hroliic (holinesterase inhihi-

tioii Oii sensitivity to (holinergir amid adre-

nergic agoiiists of, 739

Rahwati, 11. (1., see O’Neill, P. J., 51:3

Hat(s)acutely treated , relat ionship of 1)rai ii immorphitme

levels to analgesic activity in, 876miiigiotensi n-mmmediated aldosterone release in , 166blood vessels, dose-response relationships for

argi nine vasopressiim aii(I symithetic analogsoil, evidence for regioiial differences iii vaso-

pressin receptor sites, 413L)rain cortical slices, effects of ethanol on neimro-

transnmitter release by, 824brain, eflects of lithiuIil chloride oti biosytithetic

capacity for 5-hydroxytryptanmine in, 812

brain, effects of reserpine on activities and

mtnmotiimts of tyrosine hvdroxylase and dopa-tnirie-$-hvdroxylmise it, (ateciiolatiiiime iieu-

roimal svsteiims in, 775

brain, regional sensit ivity to inhibitory effects

of morphine Oil wet shake behavior of, 56brain synaptosomimes, serotoniti uptake into, 3-(p-

t riflwroimmethylphenoxy ) -N -nmethyl -3 - phenyl -

propylamnitie as new selective inhibitor of, 804castrated, itifluence of smooth nmuscle on synmpa-

thetic iiCItN)i15 ititiervating internal sex orgamis

of, 424

cerebral cortex, effect � of 6-hydroxydopammmi tie

and reserpine on anmphetanmine-itmduced imor-

epinephritie release in, 64

cerebral cortical sh(es, stinmulation of adeno-sine 3’ ,5’-monophosphate formimation by ineth-

oxanmitme in, interaction with alpha adrenergic

receptor, 549

correlation I)etween I)rain levels and i)iocheimmi-(al effects of optiemil isomers of p-chloro-anmphetanmitie iii, 835

correlation hetweeti structure, behavioral ac-

tivity and rate of biotransformation of

ACTH4., analogs iii, 853

cyprohept adine-immduced depletioim of insuliim in,

585

effect of acetazolammmide mind carbonic anhydraseinhibition cii erythrocyte 2 , 3-diphosphogly-cerate nonteiit and nletmil)olisnm in, 639

effect of chlorinmipramine and lysergic acid di-ethylanmide on efilux of precursor-forimmed ‘H-serotonin associated with serotonergic im-

pulse flow in, 785

effect of cholinergic and antichoiinergic drugsand a partial cholinergic agonist on develop-mmment and expression of physical dependence

oh nmorphine in, 44

effect of chronic oral contraceptive treatment

Ot) conversion of angiotensini I to aimgiotemmsitm

II in, 160effect of gentamicin on remmal functiomi in, 264effect of oxilorphan , miew sy tmthet ic narcotic

antagonist, in, 23

effect of sex and estrogens on responsiveness of

ternmi nal arterioles to neurohypophyseal

hornmones and catecholanmines in, 403effect of ganglionic blockade, reserpine and yin-

blastine on plasma catecholamines and dopa-nmine-fl-hydroxylase in, 748

effect of thyrotropiim-releasing hornmone on

actiomms of pentoharbital in, 11effect of 3- (p-trifluoromethylphenoxy ) -N -

nmet hyl-3-phenylpropylam i tie on depletioti ofbrai ii serotoni im by 4-chloroanmphet anmi tie iii,

796

effect of verapamil on nmyocardial contractility,cardiac adenosine 3 ‘ , 5’-monophosphate andheart phosphorylase in, 317

enzymatic derivative double isotope assay formeasuring tissue levels of taurine iim, 301

hearts, tiormimal and inmmnutiosyimipathect ciii ized,

electrophysiological effects atmd uptake andl)inding of bretylium imm, 194

iiiflueimce of L-tryptophan on morphine anal-

gesia, tolerance and physical dependence in,35

inhibition of gramitmlation tissue growth by hista-

nmitie iii,910

inhibition of prinmary lesion of adjuvammt -inducedpolyarthritis for detection of clinically effec-

tive atmtiarthritic drugs iii, 918interresponse time changes as function of water

deprivation and amphetamimiume in, 701liver, alteration by phetmobarbital and 3-nmethyl-

cholaiithrene of functional and structuralchanges due to carbon tetrachloride inhala-tion in, 281

liver mitoehondria, effects of glucagomi and other

peptides on fixatiomm of CO, by, 720liver, 4-nitrocatechol production fronm p-ni tro-

phemmol by, 631

mmmyometriunm, effect of isoproterenol and l)-600on calcium movemetmts in, 309

nephron , tracer microi njection studies of prosta-glandin E2 transport in, 274

newl)orii, biochenmical amid ftmnctional evaluation

1975 INDEX 983

nornmal and decentralized synmpathetie ganglia,role of cyclic 3 ‘ , 5’-adenosine monophosphate

iii imiductioti of tyrosine hydroxylase elicited

by beta adreimergic receptor agonmists iii, 95nornmal mitid diabetic, imifluence of alteration imi

eumdogetious insulitm atid state of mmourishment0 Ii isoproterenol- and epi tmephri mme-induced

changes iii i)lOOd glucose amid tissue glycogenlevels in, 576

phremi ic nerve-diaphragni muscle preparation,effects of hatrachotoxitm amid analogs, 232

pithed, blood pressure and heart rate responsesto d- and l-amphetanmiime in, 149

role of neommatal ammdrogetm imi developnmeiit of

hepat ic immicrosonmal drug-nmet abolizing en -

zynmes iii, 621specifi(ity in pharimmacologieal inhibition of

passive c Ut ammeous anaphylaxis reaction i a , 594

spont aiieotisly hypertensive , effects of reserpiume

atid hydralazine on tyrosine hydroxylase ac-

tivity amid miorepinephrine commeemitrations in,

443stereoisonmers of 3 ,4-dihydroxyphenylserine as

precursors of miorepinephrine imm,523striatunm, effect of a-mmmethyldopa omi dopanmine

synthesis and release in vitro in, 73simperior cervical ganglia in organ culture,

biochem i(al and histofi uorescence studies ofcatecholanmines imm, 489

tinme course of effect of reserpimme on tyrosine

hydroxylase activity in adrenal glammds andvasa deferemitia of, 533

Reid, J. L. and Kopimi, I. J. : The effects of ganglionblockade, reserpitme and vinblastin on plasma(atecholamines and dopamine-�-hydroxylase

iti the rat, 748

Reis, D. J., Joh, T. H. ammd Ross, R. A. : Effects of re-serpine on activities and amounts of tyrosine

hydroxylase amid dopanmine-fl-hydroxyiase incatecholanmine neuronal systems in rat brain,

775Reserpi iie

blockade of nmethylphemmidate-i nduced releaseof hraimm dopamine by, 559

effect of thyrotropin-releasing hormone onactions of, 11

effect ott activities atid amnounts of tyrosine

hydroxylase amid dopanmi ime-$-hydroxylase incatecholamine neuronal systems in rat brain,

775effect cii anmphetanmi ne-i mmduced norepinephrine

release in rat cerebral cortex, 64effect cmi plasma catecholamines and dopanmine-

$-hydroxylase iii rat, 748

effect otm tyrosine hydroxylase activity andimorepi nephrine concentrations i mm spomitane-

ously hypertensive rat, 443ethaiiol and, renal hemodytmamics and electro-

lyte excretions after, 356

-like compound, enhanced release of norepi-

nephrine and dopamine-$-hydroxyiase by

nerve stimulation associated with granulareffect of, 757

time course of effect on tyrosine hydroxylaseactivity in adrenal glamids and vasa deferentia,

533Respiration, stimulant effects of ethamivan and

picrotoxin, 657Rickert, I). E., Burke, J. aimd Fischer, L. J.:

Cyproheptadine-induced depletion of insulinin the rat, 585

Roberts, B. J., see Wilson, J. M., 713

Roif, L. L., Jr. and Garg, L. C. : The effect of

acetazolamide and carbotmic anhydrase inhibi-

tiOIm on erythrocyte 2 ,3-diphosphoglycerate

content and metaboiisnm, 639Rosen, M. B., Miura, D. S. ammd Danilo, P., Jr.:

The effects of dinmethyl quaternary pro-pranolol on the electrophysiologic propertiesof canine cardiac Purkinje fibers, 209

Rosetmberg, B. N., see Baskin, F., 298

Ross, H. A., see Reis, I). J., 775Rutledge, C. 0., see Kalisker, A., 64

Saeki, K., Yokoyama, J. amid Wake, K. : Inhibitionof granulation tissue growth by histanmine, 910

Sak, D. P., see Kline, R. L., 454

Salicylate, effects on renal excretion of uric acid,species differences anmommg primates, 363

Sammchez-Perez, S. , see Bojorges, H. , 182Sanders-Bush, E., see Sekerke, H. J., 835Sargent, W. Q., Sinmpson, J. 11. and Beard, J. D.:

11 enal hemodytmanmics aimd electrolyte excre-

tions after reserpine aimd ethanol, 356Sch 15280 (5[4- (N -methyl)-piperidylidinej5H-

[ll-benzopyrano 12 ,3 , bi-pyridimme nialeate),potential antiasthmatic agent, 256

Schauf, C. L., 1)avis, F. A. and Kesler, It. L.;Actions of the antidepressant drug iimmipra-

nmine on the voltage-clanmped illyxieola giant

axon, (169

Schmid, 1�. G., see Hiestad, 1). 1)., 941

Schuster, C. IL, see Johansomi, C. B., 676

Secobarbi tal

effect of t hyrot ropi H -releasi mig hormone onactions of, 11

enantionmers, brain levels , correlation with

differences in duration of sleep, (164

Seiden, L. S., see Brown, H. M., 701

Sekerke, H. J., Smith, H. E., Bushing, J. A. and

Sanders-Bush, E. : Correlation between brain

levels and biochemical effects of the opticalisomers of p-chloroanmphetanmine, 835

Selden, H. and Neill, W. A. : Myoeardial uptake of

ouabain in intact dog and imman, 951Seminal vesicle, castrated rat, influence of snmooth

muscle on synmpathetic mieurons innervating,424

954 INDEX Vol. 193

Serotonin (see a/n) 5-Hydroxytryptamine)l)rai Ii , depict iou by 4 -chioroamphetamine , effect

of 3-(p-t rifluoromethylphenoxy)-N -methyl-3-

plmenylpropylainiiie cmi , 796effect of sex and estrogens on responsiveness of

t erimminal arterioles to, 403release by rat brain cortical slices, effects of

ethanol, 824uptake imito rat braimm synaptosomes, 3-(p-

trifluoronmethylpheimoxy)-N -methyl-3-phenyl-propylannine as new selective inhibitor of, 804

:iu -Merotonin , precursor-formed, effects of chior-

iniprmimmminme and lysergic acid diethylanmide on

efilux of, correlated with serotonergic inmpulse

flow, 785

Sex, effect on responsiveness of terminal arteriolesto neurohypophyseai hormones and cate-cholanmines, 403

Shah, H. C. and Carison, (�. P. : Alteration by

phenobarbital 1111(1 3-methylcholanthrene of

futictiommal and structural changes in rat liverdue to carbomm tetrachloride inhalation, 281

�hatifield, J., Hess, M. E. and Levine, N. 11.:Effects of verapanmil on myocardial contrac-t ility, cardiac adenosine 3’ ,5’-monophosphateand heart phosphorylase, 317

Sheldon, M. 1., Sorclmer, S. and Smith, C. B. : A

comimparison of the effects of morphine and

forced rummning tmpomm the incorporation of“C-tvrosine into i4C(.atechoiamine in nmousebrain, heart and spleen, 564

Sigel, S., see Wei, E., 56Sinmpson, L. L. : Blood pressure and heart rate re-

sp�uises evoked by (1- mind l-amphetaminme inthe pithed rat preparation, 149

Sinmpson, J. 11., see Sargent, W. Q., 356Sinonmenine, inhibition of granulation tissue

growth i)y, 910

Sj#{246}berg, N.-O., see Walles, B., 460

Skolimick, P. and 1)aly, J. W. : Stimulationm of

adenosimme 3’ , 5’-nmommophosphate formation iii

rat cerebral cortical slices by methoxanmine:Immteraction with an alpha adrenergic receptor,:149

Sleep, duratiomm, correlation of brain levels of

barhittmrate enamitionmers with differences in,664

Snmooth imiusele (see Muscle, smooth)Sniith, (‘. B., see Sheldomi, M. I., 564

Sniith, H. B., see Sekerke, 11. J., 835Simmith, I. M., Haynes, H. C., Jr. and Harper, J. F.:

Effects of ghmcagon and other peptides on fixa-

tion of (‘O� by rat liver mnitochondria, 720Snmith, T. W., see Belier, (I. A., 963Sodium, transport in hunman erythrocytes, effects

of harnmaline on, 903

Sofia, 13. 1)., Knobloch, L. C. and Vassar, H. B.:

Inhibition of time prinmary lesion of adjuvant-

induced polyarthritis in rats (18-hour arthritistest) for specific detectiomm of clinically effec-

tive antiarthritis drugs, 918

Sorcher, S., see Sheldon, M. I., 564Spauldimmg, T. C., see Patrick, (. A., 876

Spector, S., see Kohier, C., 443Spleemm

cat, enhanced release of norepinephrine anddopamine-�-hydroxylase by nerve stimnulationfrom, associated with grantmlar effect of re-

serpine-like compound, 757

cat, possible role for cyclic adenosine nmono-

phosphate in release of umorepinephrine amid

dopamine -jl-hydroxylase by nerve stimula-

tion, 105

mouse, conmparison of effects of morphine andforced running on incorporation of ‘4C-tyro-sine into ‘4C-catecholamines in, 564

Steiner, A. L. , see Kebabian, J. W., 474

Steinsland, 0. S. and Furehgott, H. F.:Desensitization of the adrenergie neurons of the

isolated rabbit ear artery to nieotinic agonists,

138

vasoconstriction of the isolated rabbit earartery caused by nicotitmic agonists acting on

adrenergic neurons, 128

Stereoisommmers , of 3 , 4-dihydroxyphenylserine , asprecursors of norepinephrine, 523

Stomach, nmuscularis, rabbit, effects of chronicganglion blockade aumd chronic cholinesteraseinhibitiomi cmi sensitivity to cholinergic and

adrenergic agonists of, 739Svensson, K-U., see Walles, B., 460Sympathec tomy , produced by guammethidine in

newborn rats , biochemical and fuuictional

evaluation of, 503Synaptosonmes, rat brain, serotonin uptake immto,

3 - (p - trifluoronmethylphenoxy) - N - mnethyl -3-

phenylpropylanmine as new selective inhibitor

of, 804

Tachyarrhythnmia, ventricular, ouabain -induced,effect of beta receptor blockade cmi initiationand perpetuation of, 327

Taurine, enzymatic derivative double isotopeassay for measuring tissue levels of, 301

Temm Eick, II. E., see Apantaku, F. 0., 327

Tet rabenazimme, effects on multiple fixed-ratio,fixed-in terval schedule performance , 689

Tet raethylanmmnonium , vasoconstriction of iso-lated rabbit ear artery caused by, 128

Tet rodotoxin , effects on neurot ransmitter releaseby rat brain cortical slices, 824

Theophyllineammtagonistmm of intestinal stinmulatory effects of

mimorphine by, 884specificity in inhibition of passive cutammeous

anaphylaxis reaction in nmice and rats by, 594

1975 INDEX 985

Tyrosine hydroxylase, induced by bela adrenergic Wakade, A. H., Garcia, A. G. and Kirpekar, S. M.:

Thibodeaux, ii., see Gillis, H. A., 336

Thiopentai, effects of thyrotropin-releasing hor-nmone on actions of, 11

Thioridazine, chronic treatnment in nmice, increasedsensitivity to dopaminergic agents after, 88

Thy rotropin -releasing hornmone , effects on actions

of pentobarbital and other centrally acting

drugs, 11

Tissot, 11., see Bartholini, (L, 523Tissue(s) (see also specific tissue)

granulation, growth, inhibition by histamine,910

guirmea pig, distribution and metabolism ofi ntravenous cholimme[methyl-’H] and synthesisin vivo of acetyleholine in, 246

levels of taurine, enzynmatic derivative double

isotope assay for measuring, 301Toda, N. : Analysis of the effect of 5-hydroxy-

kymmtmrenanmine, a serotonin metabolite, on

isolated cerebral arteries, aortas and atria,

385

Toda, N. : Nicotine-induced relaxation in isolatedcanine cerebral arteries, 376

Tokuyama, T., see Warnick, J. E., 232Tolerance, to morphine, influence of L-tryptophan

on, 35

Tracer nmicroinjection studies, of prostaglandin E,

trammsport in rat nephron, 274Tranquilizers, effects on multiple fixed-ratio,

fixed-interval schedule performance, 689

Triezenberg, H. J., see VonVoigtlander, P. F., 88Trifluoperaz me , effects on multiple fixed-ratio,

fixed -interval schedule performance , 689

3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenyl-

propylamimme

effect on depletiomm of brain serotonin by 4-chloroanmphetamine , 796

new selective inhibitor for uptake of serotonininto rat brain synaptosonmes, 804

Triflupromaz me , effects on nmultiple fixed-ratio,fixed -interval schedule performance , 689

Trinmethadione , effects on estrogemi-induced dee-trographic spike-wave discharge, 647

L-Trypt ophan , influence on morphine analgesia,

tolerance and physical dependence, 35‘4C-Ty rosine , incorporat ion into ‘4C-catechola-

mines in mouse brain, heart and spleen, com-pmirison of effects of morphine and forcedrunning on, 564

Tyrosimie hydroxylase

activity and amount in catecholamine neuronal

systems in rat brain, effects of reserpine, 775

activity, in adrenal glands and vasa deferentia,tinme course of effect of reserpine on, 533

act ivity , in spon t aneously hypertensive rat,

effects of reserpine and hydralazine, 443

receptor agonists in nornmai amid decentralized

sympathetic ganglia, role of cyclic 3’,S’-

adenosine monophosphate, 95

U35,777A, chronic treatment in mice, increased

sensitivity to dopaminergic agents after, 88

JJM-272 (dimethyl quaternary propranoiol),

effects on electrophysiological properties of

canine cardiac Purkinje fibers, 209Uretsky, N. J., Chase, 0. J. and Lorenzo, A. V.:

Effect of a-methyldopa on dopamine synthesisand release in rat striatumn in vitro, 73

Uric acid, species variations anmong primates in

responses to drugs which alter renal excretiommof, 363

Van Auken, 0. W., Henderson, A. 0., Lee, It. T. S.,

Wilson, B. H. and Bollinger, J. N. : Functionaland structural changes in isolated rabbit liver

nmitochondria induced by fluorodichlorome-

thane, 729Vancomycin, effects on fixation of CO, by rat liver

mitochondria, 720Vas deferens

castrated rat, influence of snmooth muscle on

sympathetic neurons innervating, 424time course of effect of reserpine on tyrosine

hydroxylase activity in, 533Vasoconstrictor responses

of isolated rabbit ear artery caused by nicotinmicagonists acting on adrenergic neurons, 128

to norepinephrine and angiotensin in coronary

and muscular vessels, effect of hypoxemia, 941Vasopressin

effect of sex and estrogens on responsiveness of

terminal arterioles to, 403synthetic analogs , dose-response relationships

on three types of rat blood vessels, evidencefor regional differences in vasopressimi receptorsites, 413

Vasotocin, effect of sex and estrogens on respon-

siveness of terminal arterioles to, 403Vassar, H. B., see Sofia, B. D., 918

Verapamil , effects on nmyocardial contractility,

cardiac adenosine 3’,S’-monophosphate andheart phosphorylase, 317

Vertebrates, analgesic activity of acetanilides in,correlated with effects on invertebrate neu-rons, 892

Vinblastine, effects on plasnma catecholanmines anddopamine-�3-hydroxylase in rat, 748

VonVoigtlander, P. F., Losey, E. (1. and Triezen-

berg, H. J. : Increased sensitivity to dopa-

minergic agents after chronic neuroleptic

treatment, 88

INDEX IrOl. 193

Yokoyanma, J., see Saeki, K., 910

Effect of (astratioti on the smooth muscle cellsof the internai sex organs of the rat: Influence

of the smooth muscle on the sympathetic

neurons intiervating the vas deferens, seminal

vesicle and coagulating gland, 424Wake, K. , 5CC Saeki, K. , 910Walles, B., Edvinsson, L., ()wman, C., Sj#{246}berg,

N.-O. and Svensson, K-U. : Mechanical re-sponse in the wall of ovarian follicles mediated

by adrenergic receptors, 460

Wang, C. 1�I., see Namnnm, D. H., 194

Wang, j)#{149}� � , see Haubrich, 1). H., 246Wang, S. C., see Hirsh, K., 657

W’arnick, J. F�. , Albuquerque, 1K. X., Onur, 11.,.Jminssoti, 8.-h., 1)aly, J., Tokuyama, T. and

Witkop, B. : The pimarmacology of batracho-toxin . VII . Structure-activity relationships

and the effects ()f p11, 232Water, deprivation, immterresponse time changes as

function of, 701

IVay, E. IA.see ho, I. K., 35

see Wei, E., 56Wayimmire, J. C., see Kalisker, A., 64Webb, J. (;., Moss, J., Kopin, I. J. and Jacobowitz,

I). M. : Biochemical and histofluorescencestudies of catecholanmines in superior cervical

gamiglimi iIi orgamm culttmre, 489

Wedeking, P. W., see Haubrich, I). H., 246

Wei, E., Sigel, S. and Way, E. L. Hegional sensi-

tivity of the rat brain to the inhibitoryeffects of morphine on wet shake behavior, 56

Weiner, I. i�iI., see Fanelli, (I. M., Jr., 363

Weiner, N.see Cubeddu, L., X., 105, 757

see Pfeffer, H. I., 333Willianms, B. , see I)ianmond, IA. , 236Wilson, J. T., see Chastril, J., 631

Wilson, 11. H., see Van Auken, 0. W., 729Winston, J. M. and Hoberts, It. J. : Imiflueuice of

carbon monoxide, hypoxic hypoxia or potas-sium cyanide pretreatumeuit on acute carboimnmonoxide and hypoxic hypoxia lethality, 713

Withdrawal syndrome, from morphiime in rat, in-volvement of cholinmergic disruption in, 44

Witkop, B., see Warnick, J. E., 232

Witter, A., Creven, H. M. and de Wied, 1). : Cor-

relation between structure, behavioral ac-

tivity and rate of biotransfornmation of some

ACTH4, analogs, 853Wong, D. T., Bymaster, F. P., Horng, J. S. and

Molloy, B. B. : A new selective inhibitor for

uptake of serotonin imito synaptosomes ofrat brain : 3-(p-Trifluoronmethylphenoxy)-N-nmethyl-3-phenyipropylatnimie, 804

Wuttke, W. , see Hoffnmeister, F., 870