U . 5. DEPARTMENT OF

H EALTH, EDUCATION, AND WELFARE

Prince Hitachi of Japan And His Wife Visit NIH

Friday, April 7, NIH had two very special visitors- Prince Masa­hito Hitach i of Japan and his wife, Princess Hanako Hitachi.

His Imperial Highness was in Washington to attend the 69th an­nual meeting of the American As-

Using the model of the NIH campus in Bldg. 1 , Dr. Fredrickson explains various research programs and facili­ties to Prince Hitachi, as well as Princess Hitachi, Ambassador Togo, and other members of the party of visitors,

sociation for Cancer Research. Last year he was made an honorary member of that Association.

Prince Hitachi and his wife had previously visited NIH in Septem­ber 1971.

On their arrival at NIH, Their Imperial Highnesses and members of their party were greeted by NIH Director Dr. Donald S. Fredrickson and Dr. Arthur C. Upton, Director of the National Cancer Institute.

As the guests viewed the model of the NIH campus, Dr. Fredrick­son explained the growth of NIH and its facilities, plans for expan­sion of the Clinical Center and of the N ational Library of Medicine, the Metro facilities now under con­struction, and the Uniformed Serv­ices University of the Health Sci­ences now being built across Rock­ville Pike.

The second son of Emperor Hiro­hito, Prince Hitachi is the princi­pal author of numerous papers, including two published in the Journal of the National Cancer In-

(Continued on Page 9)

FILE COPY

April 18, 1978 Vol. XXX, No. !!

Seven N/H'ers Recognized by Califano In Department Honor Awards Ceremony

Seven NIH staff members were recognized by HEW Secretary J oseph A. Califano, Jr., at th<• Department Honor Awards Ceremony held on Tuesday, April 11, in the Hubert H. Humphrey Building Lobby.

The DHEW Distinguished Service Award, the highest Departmental honorary recognition conferred on civilian employees, was presented to Vernice D. 1-'erguson, chief of the Nursing Department at the Clinical Center.

The Distinguished Ser vice Medal, the Department's highest award to PHS Commissioned Officers, was presented to D1·. Robert H. Pur cell, head of the Hepatitis Virus Section, Laboratory of Infectious Diseases, Na­tional Institute of Allergy and Infectious Diseases, and Dr. Alan S. Rab­son, director of the Division of Cancer Biology and Diagnosis, National Cancer Institute.

Jacob Seidenberg, chief of the Audit Resolution Section, Financial Ad­visory Services Branch, Division of Contracts and Grants, OD, and Ruth C. Smith, chief of the Library Branch, Division of Research Services, were recipients of the Departmental Manage­ment Award-Senior Management Citat ion.

This honor award recognizes individuals who have demonstrated extraordinary initiative while performing their duties in the field of management in an outstanding manner. Special Citation Awarded to Mrs. Porns

Secretary Califano presented the Secretary's Special Citation for Ten Outstanding Em­ployees of the Year Award to Marion F. Porns, secretary in t he Laboratory of Central Nervous System Studies, National Inst it ute of Neuro­logical and Communicative Disorders and Str oke.

(See A WARDS, Page 5)

Dr. Purcell Dr. Rabson

Mrs. Smith Mrs. Poms

Mrs. Ferguson

Mr. Seidenberg

Dr. Hoel

NATIONAL INSTITUTES OF HEALTH

Sen. Edward M. Kennedy Talks on Goals, Funding Of Biomedical Research

Senator Kennedy addressed proble ms of allocation of research resourtes. public expectations of research . and the exclusion o f women from profes­sional advanceme nt.

On April 3 Senator Edward M. Kennedy presented a Special Let­tu re, ~ponsored by t he Foundation for Advanced Education in the Sci­<1nees, to un overflow audi<1 nc-e in t he Clinical Center's :-.1asur and 14th F loor Audito riums. Senator Kcnn('(fy said, in part:

" . Over the past 30 yean, t his country has poured tens of billions of dollars into biomedical and be­havioral resear ch and t raining-.

" ... that investment has yielded incredible dividends that have far surpassed our expectatiom, . . . therapeutic triumphs which would have been impossible, perhaps in­conceivable 25 years ago ....

Apprec iates Medical Miracles

"My f amily, more than most, un­derstands the value of your work. If you had seen my son Teddy climbing the Great Wall in China earlier this year, you would know what I mean when I say a prayer of g ratit ude each day for the mira­cles of modern American medicine.

"It comes as no surprise that the American people would rather spend their science dollars on health than any other area, or that they continue . .. to regard NIH as the embodiment of scientific in­tegrity and excellence ....

". . . Congress and the public have begun . . . asking complex questions about benefits received compared to costs of research ...

(See SEN. KENNEDY, Page 8)

Page% April 18, 1978 THE NIH RECORD

Published biweekly at Bethesda, Md., by the Editorial Oper ations Branch, Division of Public Information, for the information of employees of the National Institutes of Health, Department of Health, Education, and Welfare, and circulated by request to interested writers and to investi­gator s in the field of biomedical and related research. The content is reprintable without permission. Pictures are available on request. The N IH R ecord r eserves the right to make corrections, changes, or de­letions in submitted copy in conformity with the policies of the paper and the Department of Health, Education, and Welfare.

NIH Record Office .... . .. . Bldg. 31 , Room 2B-03. Phone 496- 2125

Editor

Associate Editor

.. . Frances W. Davis

. . Heather Banks

Staff Correspondents

ADA, Judy Fouche; CC, Susan Gerhold; DCRT, Mary Hodges; DRG, Sue Meadows; DRR, Jerry Gordon; DRS, Arthur F. Moore; FIC, George Presson; NCI, Dr . Robert M. Hadsell; NEI, Julian Morris; NHLBI, Bill Sanders; N IA, Ann Shalowitz; NIAID, Jeanne Winnick; N IAMDD, Pat Sheridan; NICHD, Tina McIntosh; NIDR, Sue Burroughs; NIEHS, Hugh J. Lee; NIGMS, Wanda Warddell; NIMH, Betty Zubovic; NIN CDS, Carolyn Holstein; NLM, Roger L. Gilkeson.

June Arts and Crafts Festival-Sign Up Now For Exhibition Space

The R&W Association will spon­sor an Arts and Crafts Festival during the month of June. To par­ticipate, reserve space now by sending your name, building/ room and telephone numbers to the R& W Office, Bldg. 31, Room 1A17, de­scribing your handiwork.

All types of crafts are eligible­pottery, macrame, woodwork, weav­ing, photography, art work, etc.

Watch for further information in the R&W newsletter.

Sales, Display Opportunity

YOU are necessary to make this venture a success. You have an op­portunity to display and sell your own work as well as earning some money for t he Patient Emergency Fund.

R& W Sponsors May 20 Trip to Kings Dominion

The Recreation & Welfare As­sociation is sponsoring a day at Kings Dominion on Saturday, May 20. Buses will leave Bldg. 31C at 8 a.m.

Carouse among the many attrac­tions, such as the Rebel Yell, the King Kobra, the Apple Turnover, and 30 other rides.

Price Includes Shows, L11nch

The package price of $16.50 in­cludes transportation, entrance to the park, and all the entertaining musicals and sideshows. Watch Broadway musicals and travel through the Happy Land of Hanna­Barbera where Yogi-Bear leads children through a fantasy world.

Stocked Poolesville Lake Open Saturdays in R& W Fishing Contest Season

The Recreation & Welfare As­sociation is going fishing ... and you have an opportunity to become the R&W fisherman of the year!

Starting April 29, the Poolesville Animal Farm will be open on spec­ified days for your fishing fun. Bring along the family for a lazy Saturday by a lake stocked with blue gills, bass, and catfish, and take home your catch.

Fishing, supervised by an R&W guard, will be permitted on April 29, May 6, May 13, May 27, June 7, June 17, and July 15, from 7 a.m. to 6 p.m.

10, But No License Needed

The farm, located near Pooles­ville, is approximately 30 miles from the NIH campus. A fishing license is not necessary, but NIH ID and an R&W membership card are required.

The person catching the largest fish during the season will receive a trophy. Weekly winner s will re­ceive an NIH T-shirt.

Stop by the R&W Activities Desk in Blclg. 31 to pick up fishing rules and a map.

Also included in the package is an Old Fashioned Buffet with southern fried chicken, ham, baked beans, lemonade, and a keg of beer for NIH'ers.

Sign Up by May 12

Sign up by May 12 at the Ac­tivities Desk, Bldg. 31, Room 1A18, or at the R&W store in the West­wood Bldg.

Some of ,the NIH'ers on the Ski Club Trip included ( I to r): Brian Mclaughlin . Meredith Horan. Lynn Ann Cloeckler, Mitsuru lmuta , Or. Robert Scow, Or. Eve lyn Ralston, Or. Heikki Hervonen, James Kiefer and Or. Craig Edelbrock.

Ski Club Enioys Visit To Quebec in March

Arriving at Mont Tremblant Lodge in Quebec, Canada, on March 5, the R&W-sponsored NIH Ski Club took to the slopes for a week of skiing. Excellent weather conditions allowed everyone to ski either downhill or cross-country all 7 days.

The NIH group also won the hearts of everyone at the Lodge with performances at the Thursday evening talent show.

A slalom race culminated the week's parties and skiing. Dr. Heikki Hervonen received a silver medal for his time, and Dr. Craig Edelbrock, Dr. Evelyn Ralston, and Brian McLaughlin won bronze medals.

Mr. McLaughlin and Dr. Edel­brock organized the trip.

Dr. Walker, Well Known Author, Will Discuss His Sailing Experiences

On April 27 at 8 p.m. in Bldg. 30, Room 117, Dr. Stuart Walker of Annapolis, Md., will present a free lecture to the NIH Sailing Club.

Dr. Walker has written several books on techniques of sailing, in­cluding Advanced Racing Tactics and Wind and Stt-ategy.

Known as Story Te ller Known as a fine story teller and

rule book interpreter, and sought all over the world as a strategist for races, Dr. Walker was involved in racing International 14's until 1960, when he became an active Soling sailor.

He will discuss his experience of the Chesapeake Bay weather sys­tem, how to make short-term weather predictions, and how to utilize wind shifts in sailing.

Visitors and guests are welcome to attend this free lecture and to join Dr. and Mrs. Walker before­hand for dinner at the San Fran­cisco East Restaurant in Bethesda at 6 p.m.

NIH Ski Club Plans Party On April 22- Bring Slides

The NIH Ski Club will hold a party Saturday, April 22, at 8 :30 p.m. at the Halpine View Party Lodge (Twinbrook Parkway). Refreshments, mu­sic, and dancing are planned. All ski enthusiasts are invited and encouraged to bring slides of their ski trips. Admission is $2.

Directions are available at the R&W Activities Desk, Bldg. 31.

Singles Cocktails Tonight, Other Parties Planned For Month of May

Singles! Tonight (April 18) is the night for a buy-your-own-drinks cocktail party starting at 6 :30 p.m. at the Paradise Restaurant, Hal­pine Road and Rockville Pike, Rockville, Md. Call Chris Aylmer, 496-1000, for further information.

Monday night, May l, at 6:30 p.m., come to a pot luck supper at River Road Unitarian Church. Bring a favorite food or pay $2 toward general expenses. Contact Heather Banks, 496-2125, who is coordinating this event-to avoid a glut of potato chips and chocolate cake.

Friday, May 12, a cookout is planned on the NIH campus near the NIH Apartment House (Bldg. 20 at the intersection of Center Drive and West Drive). Bring your own food, and call Rose Staley, 946-1770, for information.

A picnic is also planned for May 23 and a dance on June 2. Call Pete Eddy, 496-2146, if you are interested in the dance party as a minimum of 40 reservations are necessary.

Is Your Family Situation Stressful?

Call 496-2738 Employee Auistance Program

THE NIH RECORD

NIH Photo Contest Is May 8-Win Prizes In B&W, Color, Slides

Calling all camera buffs! It's time to dust off your best slides and negatives or get busy taking your best pictures ever.

The F irst Annual NIH E m­ployees Photographic Competition, sponsored by the NIH Camera Club, will be held May 8.

As many as four ent ries in each of the three categories-slides, color prints, a nd black and white prints-may be submitted by each NIH employee, member of the NIH Camera Club or R&W, and their immediate families. There is an entry fee of $1.50 per category.

Entries should be submitted by the photographer/ entrant between noon and 6 p .m. at any of three locations: Bldg. 31, Conference Room 4 ; Linda Robbins, Westwood Bldg., Room 205; John Horm, Lan­dow Bldg., Room 5A-04.

Prints may be commer cially processed and must be mounted on a mat no larger than 16x20 inches. Slides must be in 2x2-inch mounts with an orientation mark in the lower lefthand corner when the slide is viewed correctly ( hand held).

All entries must have the photog­rapher's name and photograph title on the back ( side opposite orienta­tion mark for slides) .

Cash prizes will be awarded to first, second, and third place win­ners in each category. Honorable mentions will receive an award certificate.

A selection of t he winning photo­graphs will also be published in the N I II Record.

Judging-open to the public­will begin at 7 :30 p.m. in Bldg. 31, Conference Room 4.

The highly qualified and experi­enced judges are Marshall H. Cohen, a prize-winning portrait and travel photographer; Ollie Fife, an award-winning photo­journalist; and Silom Horwitz, au­thor of over 200 articles on photog­raphy and an Associate of the Royal Photographic Society (Great Britain).

Photographs may be picked up immediately after judging or on May 9 from t he location where they were turned in. Photos entered in Conference Room 4 may be picked up in Bldg. 31, Confe,·ence Room 6

(6th floor, C Wing) between 12:30 and 6 p.m.

Although due care will be taken in handling the entries, the NIH Camera Club will not be responsi­ble for losses or damage.

F or further details, contact the R&W Office, Bldg. 31, Room 1A18 ( 496-4600) and check the March

April 18, 1978

Health's Angels Run for Fun, Good Times

NOT FIRST, BUT NOT LAST EITHER! Betty Boone ( I) of FDA was a happy finisher of the 2-mile run in the Cherry Blossom Classic. Ms. Boone, a victim of polio, is a dedicated runner with the NIH Health's Angels. Dr. Marc Lippman of NCI (r) crosses the finish line in the 10-mile race. Dozens of NIH'ers competed with the more than 4000 runners in the two events.

It was a sunny but windy day (April 2) as more than 4,000 run­ners took their places for the start of the 2-mile and 10-mile runs in the Cherry Blossom Classic.

Dozens of NIH'ers were among the entrants in each event. The first NIH'er to reach the finish line in the 10-mile contest was Dr. Charles Schulz of NIMH ( a member of the Washington Running Club) in 58.00 minutes. The second and third NIH'ers were Dr. James L. Rein­ertsen of NIAMDD in 57 minutes,

Re-register for Parking­Decals Required May 29

The Parking Section began re­registration of all vehicles parking on the N IH reservation-with the exception of carpoolers-yesterday, April 17.

Through May 17 the Parking Section will be setting up tempo­rary re-registration sites at vari­ous locations on the r eservation and off-campus buildings.

Coordinators Contact Individuals

If you have not already been contacted by the re-registration co­ordinator for your Bureau/Insti­tute/ Division, you soon will be.

Each coordinator has the date, time, and location for employees in their respective areas and will be forwarding the information on to you.

Those re-reg istering a vehicle must present an NIH employee or company identification card and the vehicle registration card (or xerox copy thereof) for each vehicle be­ing registered.

All vehicles parking on the NIH reservation beginning Monday, May 29, MUST have a new parking de­cal properly displayed on the wind­shield.

27 R&W Smoke Signals. Or call Ken Edwards ( 496-6750) or Gail Planck (881- 1378).

35 seconds, and Dr. Richard Schwarz of NHLBI in 58 :10. All three runners are among those training for the next big chal­lenges: the marathons in Boston on April 17 and in Frederick, Md.

For occasional joggers and less ambitious runners, the Beginner's 1-Mile and 3-Mile Series Runs began last week and are continuing each Wednesday at 5 :30 p.m., start­ing from Bldg. 1. Tomorrow eve­ning, April 19, there will also be a clinic--open to all--on how to se­lect and properly fit running shoes.

The Institute Relay on May 24 is fast approaching. Five-member teams representing B/ 1/D's, pro­i.rams, labs, or offices will compete, with each person running half a mile.

Contact Dr. Peter Pentchev, Bldg. 10, Room 3D-14, regarding teams already formed or interest in officiating.

OMS Urges Employees: lmmunixe Your Children Against Seven Diseases

Complying with President Car­ter's goal of having every preschool child in the country immunized against seven childhood diseases­polio, diphtheria, whooping-cough, tetanus, measles, mumps, and ru­bella-NIH is urging each em­ployee to check his/her child's im­munizations.

Since these often debilitating diseases have not been eliminated, it is essential and prudent to pro­tect all children through safe and effective vaccination.

NIH does not administer these vaccinations to children, but perti­nent information regarding immu­nizations has been provided on bul­letin boards, posters, and table tent cards.

A Parents Guide to Childhood Immunizations is also available

Page 3

Don't Take Chances! High Blood Pressure Can Be Controlled

The only way to know you have high blood pressure is to have your blood pressure checked. You can feel and look fine and still have high blood pressure because it can strike anyone, regard,less of age, sex, or race.

F ortunately, high blood pressure can be controlled in almost all cases to reduce your risk of heart attack, stroke, and kidney diseases. It's an easy, painless, free health check, and it might save your life.

Between May and November 1978, the Occupational Medical Service will offer a blood pressure check to NIH employees on a building-by-building basis.

This voluntary screening is part of a comprehensive OMS blood pressure program to help hyper­tensive employees get their blood pressure under adequate control for a longer and healthier life.

Any employee with consistently high blood pressure readings dur­ing screening will be offered refer­ral services to his or her private physician.

If an employee does not have a private physician, OMS will pro­vide a referral list to assist the employee in contacting physicians or facilities providing health care in the immediate area.

In cooperation with the employee and the private physician, OMS health units will also offer hyper­tensive employees free blood pres­sure checks and individualized counseling.

Watch the NIH Record for an­nouncements on the scr eening schedule. For specific times and rooms, look for the smiling face on posters and flyers.

Get your blood pressure checked. Don't take chances.

free at all Occupational Medical Service Health Units and Informa­tion Desks in Bldgs. 10 and 31.

Please contact your private doc­tor or health department if your child needs immunization.

Page 4 April 18, 1978

Role ol Pathogens in Diarrheal Diseases Of 'Young' Animals Aids Human Studies

Diarrheal dfaeases of the young are caused by similar pathogens whether "the young" are calves, piglets, or human babies. A conference to exchange information about these organisms and the diseases they cause was held March 7-8 at Wilson Hall.

Participants included physi­cians, veterinarians, microbiolo­gists, and pathologists from the United States and three foreign countries who have an active inter­est in the clinical and research as­pects of diarrheal diseases.

Veterinarians' Aid Noted

Dr. Milo D. Leavitt, Director of F IC, and Dr. Kenneth E. Sell, sci­entific director of the National In­stitute of Allergy and Infectious Diseases, welcomed the partici­pants. They noted the contributions of veterinarians in discovering and defining the role of various patho­gens in diarrheal diseases of ani­mals , providing a groundwork for similar studies in human beings.

NIAID intramural scientists, in particular, have been working closely with veterinarians in State and Federal agricultural organiza­tions studying diarrhea in calves and piglets.

Calves' Vaccine Licensed

One widespr ead cause of diarrhea in human infants and other young animals is the rotavirus. Scientists have already developed for calves a vaccine licensed hy the USDA.

Lambs have been experimentally protected by feeding serum and colostrum-derived anti-body- an example of passive, short-term im­munity. The possibility of protect­ing human infants and young chil­dren can be explored using knowl­edge gained from these experiences with animals.

Other common causes of diarrhea include parvoviruses ( cat distem­per), co.rona viruses, and a variety of bacteria including toxigenic and invasive E. coli, Salm<mella, and Cryptoposidia.

The participants agreed that neo­nates succumb to diarrheal dis­eases, not because of the viral or bacterial agent, but more often be­ca use of the Joss of electrolytes and water with consequential dehydra­tion, acidosis, and shock.

Prevention Emphasized

Therefore, any program devel­oped to control diarrheal diseases must emphasize preventive meas­ures and supportive treatment.

This was one of a series of con­ferences sponsored by the Ameri­can Veterinary Medical Association and was jointly sponsored by FIC; NIAID; the Bureau of Biologics, FDA; Animal Research Service, and Animal and Plant Health In­spection Service, USDA; and sev­eral commercial companies.

NIDR Plans Workshop On Feedback Control

The National Institute of Dental .Research, in cooperation with the American Academy of Dental Ra­diology and the Bureau of Radio­logical Health, wiJI sponsor an open workshop on F eedback Control of Exposure Geometry in Dental Ra­diography.

The pr incipal objective of the 1-day conference/workshop, to be held May 16 at the School of Den­t istry of the University of Con­necticut, Farmington, Conn., is to exchange ideas on the use of an on-line feedback control system to establish r eproducible bases for de­termining projection geometry.

The sessions are planned to en­courage communication between technical experts and clinicians in­terested in dental r adiology and are directed toward improving the diagnostic process from existing and new radiological resources.

Dr. Richard L. Webber (496-4934), Diagnostic Methodology Section, NIDR, is the conference coordinator.

Sam Yep, an electronics engineer in the Communications Engineering Branch of the NLM's liste r Hill Na­tional Ce nter for Biomedical Commu­nications, recently won a prize in a nationwide design contest organized to help uncover novel applications for three ne w families of BiFET opera­tional amplifiers introduced last year by Tex.as Instruments. Mr. Yep's win­ning entry was an imaginative ap­proach for an Amplitude Frequency Equalizer, which may have audio and telecommunications applications.

Apprenticeship Training Program Starts in Fall

Attending the signing of the National Apprenticeship Standards ( I to r) are: Edgar S. Barnett, National Appre nticeship representativ.e, Department of Labor; Mr. Murphy; Mr. Schwartz ; and W . Elbert Wilson, Jr., chief , Career Develop­ment Branch, DPM.

The recent signing of National Apprenticeship Standards signalled the end of the long planning period to coordinate a training program between t he Department of Labor and NIH.

This new Apprenticeship Train­ing Program, the first such pro­gram within H EW, covers the fol­lowing eight trades: carpenter, electrician, plumber, painter, sta­tionary engineer (boiler plant op­erator), refrigeration and air con­ditioning mechanic, sheet metal wo1·ker, and welder (ind us trial).

In brief remarks during the sign­ing, both Leon M. Schwartz, Asso­ciate Director for Administration, NIH, and Hugh C. Murphy, Ad­ministrator, Bureau of Apprentice­ship and Training, Department of

Labor, commented that NIH now has an op port unity to establish an exemplary program, creating effec­tive opportunities for members of minority groups and for women.

An integral part of the program will be participation of apprentices in classroom training related to their particular trade. Successful finishing of related training as well as successful performance in on­the-job training is required for completion of the program.

Work is continuing on the devel­opment of selection criteria for each of the trades.

The selection of employees for the first apprenticeship class is scheduled for early fall 1978. Addi­tional facts about the program will be published in coming months.

THE NIH RECORD

Lab Safety Courses On Bioha.zard Control Offered Tuition Free

Laboratory safety training courses for 1978 are being con­ducted by the University of Minne­sota School of Public Health under contract with the National Cancer Institute Office of Research Safety.

Courses on Biohazard and In­jury Control in the Biomedical Laboratory will be presented at NIH Dec. 12-13; at State Univer­sity of New York, Stony Brook, June 13-15; and University of Washington, Seattle, Sept. 6-8.

Viral Oncology Stressed

Emphasis in these courses­aimed at senior scientists and tech­nicians working in fields related to cancer virology-is on biohazards in viral oncology research.

Two courses on Biohaza rd Con­tainment and Control for Recom­binant DNA Molecules will also be held. They ;re set for Oct. 24-25 at the F rederick Cancer Research Center; and Sept. 19-20, Univer­sity of California, San Diego.

These courses are directed at principal investigators, scientists, and senior technicians working with genetic recombinants.

Lectures and workshops empha­size interpr etation of NIH Guide­lines for Recombinant DNA Re­search.

Support from NCI enables the University to offer both courses tuition free. Participants pay only for travel and living expenses. En­rollment is limited, and early ap­plication is recommended.

Information on the courses can be obtained from Dr. Donald Ves­ley, Associate Professor, School of Public Health, 1158 Mayo Memo­rial Bldg., 420 Delaware St. SE, University of Minnesota, Minne­apolis, Minn. 55455, or telephone ( 612) 373-5943.

21,000 Federal Workers Counseled; Many Helped

Almost 21,000 F ederal workers were counseled last year for alco­holism, drug abuse, and emotional or similar problems.

Of these, 12,069 were for emo­tional or similar problems with 85 percent termed "helped." Some 8,073 were counseled for alcoholism wi th 76 percent helped, and 747 for drug problems with 62 percent helped.

HEW Response Cood

Since the Alcohol and Drug Abuse Program's inception 5 years ago, nearly 30,000 persons have received counseling under the Pro­gram.

The agencies in which the Pro­gram showed the best rate of r e­sponse were the departments of State; Health, Education, and Welfare; and Navy.

THE NIH RECORD April 18, 1978 Page 5

Sixth Annual Minority Biomedical Support Symposium

The Sixth Annual Minority Biomedical Support Program Symposium, cospon­sored by the Division of Research Resources and Atlanta University Center in Atlanta on Ma rch 27-29, featured some 400 scientific papers by student­researchers from 80 unive rsities, colleges, and junior colleges ( see the N IH Record, Mar. 21, p. 4 ) as well as presentations by several e mine nt scientists. L to r : Dr. Thomas C. Bowery , DRR Director, presents a special commendation to Dr. Joyce Corrington, MBS Director at Xavier University, for her role in

beginning the MBS Symposium and serving as coordinator for the first five symposiums. Or. W a lter Sullivan, this year's symposium coordinator, looks over the program with several MBS students. Dr. Benjamin Alexander, Chicago State University preside nt, talks with Dr. Geraldine Woods, NIH consultant, before the Symposium banquet. This year, Dr. Woods, a biologist, was honored for helping to launch the MBS program, and Dr. Alexander paid her tribute during his speech at the banquet.

r

L .... .. :al

AWARDS · (Continu ed from Page 1)

The award recognizes outstand­ing performance by employees in clerical, administrative, technical, professional, and general support positions.

On behalf of the Department, Secretary Califano also recognized the accomplishments of Dr. David G. Hoel, National Institute of En­vironmental Health Sciences, who was the recipient of the Mortimer Spiegelman Gold Medal A ward, a major non-HEW award.

He was recognized "for being

The Symposium attracted a wide variety of the news media. From left clockwise: NIH Deputy Director Dr. Thomas E. Malone (back to camera ) , Dr. Alexander, and Dr. Ciriaco Conzales, director of ORR's MBS Program, are interviewed by two newsmen during an Atlanta radio program. Or. George Lythcott, administrator of the Health Services Administration, PHS. talks to a write r for Urban Health magazine. Drs . Alexander and Woods, appearing on a television program, are interviewed by Walter Elder (I ) . Dr. Sullivan (r) speaks with a medical writer of the Atlanta Journal. Three native Africans are now MBS Pro­gram directors. L to rare: Dr. Obi Emeh, Savannah State; Dr. Joseph C. Wutoh. University of Maryland- Eastern Shore; and Or. Fred Christian, Southern University, being interview ed by Bill Clitx, DRR, for an article for Topic, an International Communication Agency (formerly USIA ) magazine distributed in Africa.

one of the first statisticians to rea­listically approach the development of practical analytical tools for treating the problem of human health risk assessment."

Excellent Nursing Cited

M1·s. Ferguson was cited for "dy­namic leadership which created a Nursing Department that is recog­nized for excellent nursing prac­tice, educational programs and opportunities for professional growth."

Dr. Purcell's citation read "for distinguished leadership in the de­tection and prevention of viral

hepatitis." Dr. Rabson received the Medal

for "outstanding accomplishments as a diagnostic patholog ist and as a sen ior executive and scientist­managH in the National Cancer Institute."

Mr. Seidenberg's citation was "for contributing to the accom­plishment of Public Health Service programs through improving rec­ord keeping and management by grantees."

Mrs. Smith's Senior Management Citation was for "innovative man­agement approaches in the library science field through application of

new techniques in a biomedical re­search environment."

Mrs. Porns' citation was for " sus­tained outstanding levels of per­formance durirg the more than 19 years of secretarial, administrative, and editorial service to the NINCDS program in the Labora­tory of Cent ral Nervous System Studies which is now a worldwide recognized branch of the NIH."

Reception for Recipients

A reception for HEW, PHS, and NIH officials and award r ecipients and their family members followed the ceremony.

Page 6

Clinical Trial To Examine Laser, Drug Treatment For Diabetic Retinopathy

A new n ationwide clinical trial of early treatment for diabetic retinopathy, a common eye compli­cation of diabetes and a leading cause of blindness in the United States, was announced yester day (April 17) by the National Eye Institute.

The Early Treatment for Dia­betic Retinopathy Study (ETDRS ), involving 22 research cent er s, will examine the use of laser treatment and drug therapy for the disease.

Blood Veuels Change

Diabetic retinopathy is a pro­gressive disorder which causes harmful changes in the blood ves­sels in the retina-the light-sensi­tive tissue at the back of the eye.

These vessels may become blocked or grow abnormally, a stage which is called proliferative retinopathy.

Visual impairment may result when these abnormal vessels break and bleed into the vitreous, the clear gel that fills the center of the eye. This blood may clear , but scar tissue is frequently formed.

Scar Ti$$Ue Causes Blindness

In very severe cases, t he scar tissue may cause the retina to be­come detached from underlying tissue layers, frequently causing blindness.

Data f rom a previous NEI-sup­ported trial, the Diabetic Reti­nopathy Study (DRS), showed that laser treatment can reduce the risk of blindness in patients in the pro­liferative stage of this disease.

In the DRS, however, some pa­tients' eyes become blind in spite of treatment, and in some, harmful s ide effects of treatment were noted, such as mi ld blurring of vision and narrowing of side vision.

The new study seeks to deter­mine whether treatment at an earlier stage of retinopathy may be of greater value in reducing the risk of blindness and, if so, whether this benefit outweighs the risk of adverse side effects.

Check Use of Laser

Investigator s in the ETDRS also hope to find out whether laser treatment may be effective against macular edema, an abnormal ac­cumulation of fluid in the retina. It frequently accompanies diabetic retinopathy and may cause blurred central vis ion.

A third objective of the study is to deter mine whether aspirin, either alone or in combination with another drug, may be useful in treating diabetic retinopathy.

In diabetics, there is an in­creased tendency for blood platelets to clump. This may affect the flow of blood through small vessels, such as those present in the retina, and

April 18, 1978

Computer Is Being Developed To Help Physicians Diagnose Patient's Disease

Drs. Myers (left ) and Pople discuss the video information display resulting from a hypothetical medical problem posed to their INTERNIST system.

Sitting in front of a small computer terminal, a family physician in a remote Pennsylvania town pr ovides information to a central computer in Pittsburgh based on a history and physical examination he has jus t obtained on a patient.

The computer digests the infor­mation and questions the physician concerning the pa t ient. In the course of asking questions, the com­puter tells the physician what diag­noses it is considering and how an­swers to t he questions will help reach a final decision.

After several minutes, the com­puter gives the physician its diag­nosis.

Not Just a Dream

If that sounds like something medicine is only dreaming about, guess again. Two Universit y of Pittsburgh professors are well on t he road to making it a reality. Their system, called INTERNIST because it deals only with diseases pertaining to internal medicine­t he broadest and largest medical specialty-is still being completed

contribute to the development of retinopathy.

Because aspirin interferes with clumping of blood platelets, it may be effective in preventing blockage of the retinal vessels in diabetic r etinopathy.

Will Enroll 3,000 Patients

Patient enrollment in the new ETDRS will begin following a planning stage of about 1 year. Eventually, 3,000 patients are ex­pected to participate.

It is expected t hat each will be followed for 5 years to provide long-term information on the r isks and benefits of both kinds of treat­ment being examined. The average cos t of the projected 7- to 8-year study is an estimated $3 million per year.

The Center for Disease Control in Atlanta, Ga., plans to provide,

and refined, but the researchers hope to have it working in the clin­ical environment within 5 years.

The two Pittsburgh researchers, Dr. Jack Myers, a physician, and Dr. Harry Pople, who received his P h.D. degree in the University's Graduate School of Business, have developed their medical diagnostic system with the help of high tech­nology equipment funded by the Biotechnology Resources Program of the Division of Research Re-sources.

The Prog ram assures the avail­ability of resources that apply t he physical sciences, mathematics, and engineering to biology and medi­cine.

Includes 350 Diseases

According to Drs. Myers and Pople, the knowledge base under­lying INTERNIST is based on two types of information- disease en­t ities and disease manifestations. The system includes approximately 350 diseases and 2,800 manifesta­tions.

"Each disease entity has an asso­ciated list of manifestations known to occur in that disease recorded along with an estimate on a scale of one to five of the frequency of occurrence," Dr. Myers says.

"The inverse of this relation also

through an interagency agreement, a central laboratory for the study to monitor drug t reatment of pa­tients.

The University of Maryland School of Medicine Department of Social and Preventive Medicine, Baltimore, will be the Coordinating Center, and the University of W is­consin Medical School Department of Ophthalmology will be the Fun­dus Photograph Reading Center.

THE NIH RECORD

is recorded explicitly ... thus, each manifestation is associated with a list of diseases in which the mani­festation is known to occur with a weighing factor on a zero to five scale intended to reflect the strength of the association."

The system uses a hierarchy of disease categories, organized pri­marily around the concept of organ systems.

Categories at the top level in­clude diseases such as "heart dis­ease," "lung disease," and "liver disease." Each of t hese a r eas is di­vided into more specific categor ies, which may be further divided until t hey reach the final level made up of specific disease entities.

Formulate Problems

The task of I NTERNI ST is one of problem formulation, not prob­lem solving, according to Dr. Myers.

"INTERNIST is really a simula­tion of the mental processes of a physician in analyzing a complex case," Dr. Pople says. "It generates and tests hypotheses, much as a clinician would formulate a model as a basis for clinical problem solv­ing.,.

The computer informs the physi­cian what data it is disregarding for the time being and on what it intends to focus.

Computer Questions Users

It questions the user about other observations and laboratory tests, with t he computer retiring occa­sionally to b riefly reflect on the additional information.

Each time it returns, the com­puter lets the user know the lead­ing diagnostic contender s which it is considering. Eventually, it will inform the physician either that the considered disease has been con­firmed or that it is now consider ing a new hypothesis.

"One of the most important things we've taught the machine is to deal with the least costly t hings first," Dr. Myers says.

Another benefit of the INTERN­IST syst em is the development of a new medical textbook, according to its developers.

DRR Funds SUMEX System

The INTERNIST system utilizes the large SUMEX-AIM computer facility of Stanford University, Stanford, Calif., another DRR­funded project.

The SUMEX system has been de­veloped to provide a national shared computer facility for medical re­search concentrating on the appli­cation of artificial intelligence to medicine.

The Bureau of Health Manpower also provided funding for the de­velopment of INTERNIST.

Tranquility is nothing else than the good ordering of t he mind.­Marcus Aurelius

T HE N IB RECORD April 18, 1978 Page 7

Director of NIA Dr. Butler Cites Myth Of Sexual Capacity Loss in the Elderly

According to Dr. Robert N. Butler, Director of the National Institute on Aging, elderly people have been victims of a wealth of myths sur­rounding their sexuality.

"Men and women do not lose the capacity for sexual fulfillment. The need for sex is basic to all human beings and desexualization is age­ism in it.~ most extreme form."

Speaking before the American Association of Sex Educators, Counselors, and Therapists on March 31 in Washington, D.C., Dr. Butler emphasized that older peo­ple display- and are entitled t<r­an active interest in continuing their sex lives.

Dr. Butler explained that " Psy­chologically, the sex act offers many older people affirmative evidence that the body is still reliable and functional. It is a means of self­assertion in a society where most traditional means of assertion are denied to older people."

Dr. Butler stressed that sex edu­cation should be readily available to the elderly. He told the audience of researchers and counselors in t he field of sex education that nor­mal physiological changes accom­panying aging must be explained so that neither men nor women regard them as indicative of a loss of sexuality.

Dr. Butler went on to point out

White House Challenges NIH Gashouse Gang-PEF Softball Benefit May 7

The third annual Patient Emer­gency Fund softball game between the White House team and the NIH Gashouse Gang will be played Sunday, May 7, at 2 p.m. at the Georgetown Prep School field, Rockville Pike (about 3 miles from NIH).

For the first time, three women will be playing on each team.

It's a family outing- free admis­sion, with food and drink available. All donations and proceeds go di­rectly to the Patient Emergency Fund.

Door prizes include: tickets to a Washington Capitals game and a team autographed hockey stick; tickets to a Washington Bullets game and a team autographed basketball; tickets to a Washington Diplomats game and a team auto­graphed soccer ball.

Also, two free dinners at Bish Thompson's Seafood Restaurant, five pairs of tickets to Ringling Brothers, Barnum and Bailey Cir­cus, and a ride on a hot air balloon. There will also be special prizes for kids.

Dr. Mortimer Lipsett, Clinical Center Director, will throw out the first ball, and the game will be MC'ed by Sonny Jurgenson and Frank Herzog of WTOP-TV. Everyone is invited-bring friends and family, too.

that older p'eople themselves often accept society's negative sexual stereotypes. The distorted body im­ages and self-hatred engendered in older people by these attitudes not only impair sexual functioning, but also further discourage sexual ac­t ivity.

Tests conducted at NIA's Geron­tology Research Center in Balti­more show that men who were sex­ually active throughout their lives tend to remain so in old age.

A study of 188 males aged 60 to 79 has ident ified some previously unrecognized factors which appear to influence sexual functioning.

Much sexual inactivity of the older male stems from apathy or indifference to stimuli which pre­viously caused erotic reactions.

Sexually inactive s ubjects felt no pressure to perform, and t he vast majority had never sought help for their condition.

One of the most distressing myths surrounding sex and the el­derly is the belief that "sex i s bad for your heart." Many heart pa­t ient s, particularly older ones, are afraid that coitus is too strenuous and can provoke a heart attack.

Dr. Butler stressed that studies conducted on male cardiac patients show that they can enjoy coital activities several weeks after a heart attack and after moderate physical activities have been re­sumed. A cardiac patient should check with his doctor before resum­ing sexual activities.

Index to Health AV Serials Now Published

The Medical Library Association plans to publish in cooperation with the National Library of Medicine a new quartel'ly publication titled Index to Audiovisual Serials in the Ilea/th Sciences.

This bibliography, derived from the Library's MEDLARS (Medical Literature Analysis and Retrieval System) will cite selected audio­tape and videotape serials sub­jected to peer review cri teria estab­lished by the A~sociation of Ameri­can Medical Colleges.

Initially 31 ser ials will be in­dexed by NLM to produce three quarterly issues and one annual cumulation. Additions are planned for subsequent volumes.

The first volume will be an annual cumulation for 1977 avail­able this spring for $6. Prepay­ment, accompanying all orders, should be sent to the Medical Li­brary Association, 919 North Michigan Ave., Suite 3208, Chi­cago, Ill. 60611.

Westwood Employees Celebrate Success, Express Thanks to WECOPS Organizers

Rejoicing in victory--CSA withdrew proposed charges for parking at the Westwood Bldg.-were Congressman Newton I . Steers, who had supported the employees; NIH Deputy Director Dr, Thomas E. Malone, liaison to WECOPS; and Donna Hube r, the e ner­getic executive secretary of WECOPS.

March 31 was a banner day for NIH employees at the Westwood Rldg.-the day they celebrated their success in convincing the Gen­eral Services Administration to ameliorate conditions in the build­ing and to release to the Westwood Management Corporation parking

charges collected from NIH. The signs used in picketing both

at Westwood and at GSA decorated the walls along with balloons and streamers. Long tables were laden with food contributed by employees, and punch was ladled out to the hundreds of employees who had joined in the effort to negate the parking charges to individuals.

Donna Huber Honored Especially happy-and honored

-were Donna Huber and Christine Davenport, who were presented with orchilds by their fellow em­ployees grateful for their invest­ment of time and energy in orga­nizing the Westwood Employees Committee on the Parking Situa. tion.

Ms. Huber also received a spe­cially inscribed certificate for her dedication to the cause-and a parking lot sign: RESERVED, EXECUTIVE SECRETARY, WE­COPS.

Even Dr. Laszlo Tauber, one of the co-owners of the building, was on hand and joined in the festivi­ties, amusingly describing in how many ways the building's condition and t he parking charges had been brought to his attention.

"Free Parking" said the picket sign carried by a panda cake baked and deco­rated by Lois Valeo for the WECOPS victory celebration. NCl's Division of Cancer Research Resources and Centers, housed in the Westwood Bldg., pre­sented congratulations in the form of a cake decorated w ith a mini-parking lot and cars. More than 1,000 employees at W estwood attended the celebration. Many also contributed food and baked goods ... a joyous afternoon for all.

Dial 496-4608 To Hear Personnel Tapes The Division of Personnel Management is extending the series

on personnel topics via telephone recordings. Dial 496-4608 to hear the following topics on a 24-hour basis during the dates indicated: Dates T opic April 17-April 21 Preparing for a Desk Audit Ap1·il 24-April 28 Special Placement Program May 1-May 5 Designation of Beneficiary May 8-May 12 The Privacy Act May 15-May 19 Within-Grade Increases May 22-May 26 The Classification of Jobs May 29-June 2 Employee Appraisal and Performance Rating June 5-June 9 F reedom of Information Act June 12-June 16 The Employee Assistance Program June 19-June 23 Your Leave Benefits June 26-June 30 AWOL and LWOP- What's the Difference

A listing of topics will be posted on all NIH official bulletin boards.

Page 8

Impact of Hypertension In Spanish-Speaking Community Is Explored · The impact of hypertension in

the Spanish-speaking community was explored at a California Con­ference on High Blood Pressure held April 1-2 in Los Angeles.

The forum for health care pro­viders was cosponsored by the Cali­fornia State Department of Health and the National HBP Education P rogram, coordinated by t he Na­tional Heart, Lung, and Blood In­stitute.

More than 60 experts- repre­senting state and local government, public and private health care pro­viders, consumers, health and medi­c.al care services from the United States and Mexico-spoke and served as panelists during the 2-day conference.

California Most Affected Conference workshops focused on

the medical, social, educational, and legislative issues which are of par­ticular concern to California since 16 percent of its population is Spanish-speaking, with Los Ange­les having the largest concentra­tion of Spanish-speaking people in the United States.

Hold Forums for Other Minorities Because the impact of hyperten­

sion is of importance to other mi­nority populations, NHLBI is sup­porting similar forums for other minority groups.

Conferences on hypertension in Native American, Asian/Pacific and Cuban populations have al­ready been held, and future confer­ences will include Puerto Rican and Black American groups.

F urther information on these conferences may be obtained by writing to the High Blood Pressure Information Center, 120/80, NIH, Bethesda, Md. 20014.

Top recording artist Neil Sedaka has an important message about cigarettes from the American Cancer So­ciety: especially for young Americans-"best tip yet: don't start."

April 18, 1978

An attentive a udience listened to Senator Kennedy and later asked questions, including some which the senator re ferred to NIH Director Dr. Donald S. Fredrickson (center) .

SEN. KENNEDY ( Continued from, Page 1)

Some members of the research com­munity have reacted with great alarm .... I do not share that fear.

" .... But we cannot ignore the very real changes taking place . ... Biomedical research, once the most favored child of Congress, has now become one of many favored chil­dren.

". . . To make this new and still evolving relationship work .. . will require changes in the role and attitudes of the research com­munity and in the Federal Govern­ment and Congress ... We must place greater emphasis on stable and continuing support for health resear ch.

" We have seen too many confus­ing swings in research priorities and funding. . .. It is no wonder that ... Congress is now called the 'Disease of the Month Club.'

" ... But in the future, Congress must recognize that this disease­by-disease approach to Federal support for biomedical research is incapable of working adequately in a period of tight budgets.

"We need standards for deciding how to allocate scar ce research dol­lars ... We also need mechanisms to keep Congress and the public currently informed about bot h pub­lic needs and research opportuni­ties.

"We have discussed these ques­tions repeatedly in hearings before the Senate Health Subcommittee, starting 2 years ago when the President's Biomedical Research Panel reported on its review of the Nation's biomedical research pro­gram ... [and] 9 additional days of hearings [which] we will con­tinue this year.

" ... Over the past 6 years, Con­gress has invested heavily in pro­grams to understand and control cancer . . . As one of the chief authors of the cancer legislation, I can assure you that we never in­tended to promote the cancer effort at the expense of the many other excellent research programs of NIH.

" One of our highest priorities must be to correct this imbalance without curtailing progress in the war on cancer.

"Congress and the Administra­tion must also r eaffirm their com­mitment to the health and vitality of the peer r eview system at NIH ... the foundation of modern bio­medical science in this country.

". . . I am distressed over the escalating work load which NIH study sections have experienced in r ecent years. Despite large in­creases in the n umber of applica­tions for grant support, the num­ber of initial peer review groups has actually decreased since 1973.

"As a result, the average work­load of the r eview committees has doubled. Some study sections now pass on as many as 120 applica­tions during a single 3-day meet­ing.

"We cannot expect peer review groups to work at this pace, and still g ive each application the kind of careful scrutiny it deserves.

"Most important, the public must be accepted as an active partner in the development and evaluation of biomedical research policy in this country.

Taxpayers Are Concerned

"The bulk of health research dollars in this country now come from the pockets of American tax­payers, [who] have a legitimate interest in how their tax dollars are spent.

"For the most part, American taxpayers support biomedical r e­search because they are concerned about finding cures for the dis­eases they fear.

"The public is becoming more sophisticated in its undestanding of biomedical research and its pos­sibilities and limitations. Your r e­sponsibility is to enhance and solidify that understanding by edu­cating the public on the importance of fundamental, non-targeted re­search.

"There is no better way to ac­complish this goal than to include laymen, to the maximum extent possible, in the difficult decisions which determine how our research dollars are spent.

" . .. You at NIH have led the way in some respects in this area. You have lay member s on many of the advisory councils to your Insti­tutes ... Congress and the Admin­istration must fulfill their own re-

THE NIB RECORD

sponsibility in making public par­ticipation work at NIH.

"Too often in the past, politics and patronage have determined who is appointed to public open­ings on the various N IH advisory councils and committees ....

"It is equally impor tant for med­cial researchers to take more ini­tiatives themselves in identifying research areas and disciplines which have been neglected in the past.

" . Why, for example, does NIH spend only $20-$40 million a year on nutrition research out of a total of $2.8 billion?

"Why is so little attention paid to behavioral research in the treat­ment and cure of disease? While infectious diseases used to be the most burdensome illnesses, we now see cardiovascular disease, cancer, Jung disease, accidents, homicide, and violence as the major thr eats to life and health. These afflictions have strong behavioral components.

"The National· High Blood Pres­sure Education Program is an ex­ample of what you can accomplish here when the physical and be­havioral sciences work together. No NIH program in your history has done more to improve the health of Americans.

New Institute Proposed

"Recently I introduced the Na­tional Institutes of Health Care Research Act of 1978, S.2466. The intent of this legislation is to make certain that health services re­search, epidemiology, the health re­lated social sciences, and the as­sessment of new clinical technolo­gies get the attention, the prestige, and the stable funding they de­serve.

"I proposed a new Institution .. . because in some respects [these disciplines] lie outside the tradi­tional mission of NIH.

"There must and will continue to be overlap between the mission of NIH and other agencies, and I would be disappointed and dis­turbed if, as a result of new legis­lation, NIH were to deemphasize or discontinue its work in epidemi­ology, in the primary prevention of disease, in clinical trials, or in the behavioral sciences.

"There is one additional legisla­tive issue I would like to mention ... Last month I introduced the Women in Science and Technology Equal Opportunity Act, which es­tablishes a 10-year, $250 million program to help eliminate the edu­cational and institutional barriers which for 50 years have virtually excluded women from careers in science.

"Nationwide, only 25 per cent of our biomedical scientist s are women. Here at NIH, women pro­fessionals and scientists earn only 62 per cent of what men do, and have only 1/7 the chance of receiv­ing a promotion. We must do better t han that in the future ... .''

THE NIH RECORD April 18, 1978 Page 9

PRINCE, PRINCESS HITACHI VISIT NIH

NCI Director Dr. Upton ( I, foreground ) and NIH Director Dr. Fredrickson welcome Prince and Princess Hitachi to NIH as Dr. Takayama, scientific col ­laborator with Prince Hitachi, and Ambassador of Japan Fumihiko Togo look on.

(Contimied from T'ave J) stitute: "Diethylmethyln itrosamine­induced chromosome changes in rat liver cells" (1974), and "Cytologic changes induced in rat liver cells by short-term exposure to chemical substances" ( 1975).

He has Joni?; been interested in comparative oncology and has re­cently been studying spontaneous erythrophoromas ( pigment variant tumors) in goldfish raised by hob­byists in Japan as well as other types of tumors in a variety of tropical and salt-water fishes.

Tour Labs, Clinical Center On this visit to NIH, accompa­

nied by Drs. Tsuyoshi Kakefuda and Robert R. Omata of NCI , Prince Hitachi visited two NCI scientists in their laboratories in Bldg. 37: Dr. Harry Gelboin, chief of the Chemistry Branch, Division of Cancer Cause and Prevention; and Dr. Ira Pastan, chief of the Laboratory of Molecular Biology, Division of Cancer Biology and Diagnosis.

Princess Hitachi, meanwhile, vis-

With CC Rehabilitation Department chief Dr. Cerber, Princess Hitachi vis­ited several areas and talked with patients. such as Tim Martin of Read­ing, Pa. , who rece ntly had his left leg amputated. ltaru Umesu, second sec­retary in the Embassy of Japan (I )

accompanied Princess Hitachi.

ited the Clinical Center. Escorted by the associate direc­

tor of the CC, Dr. Philippe V. Car­don, ,Jr., and Dorothy P. Horlander, chief of the International Visitors Center, Fogarty International Cen­ter, Princess Hitachi visited the Rehabi litation Department.

Dr. N. Lynn Gerber, chief of the Department, explained several kinds of t herapy, prostheses, and orthopedic devices, such as spe­cially designed shoes. Princess Hi­tachi talked with several patients, including recent amputees and some who demonstrated their facility with pro,;theses.

As guests at a luncheon at Stone

At lunch in Stone House, Dr. Clyde J. Dawe { I ) head of the Comparative Oncology Section. Laboratory of Path­ology, Division of Cancer Biology and Diagnosis, NCI , chats with Prince Hi­tachi {r) and Dr. Shoxo Takayama. Dr. Dawe previously visited Prince Hitachi in Japan. Dr. Tak.tyama, for­mer Visiting Scientist in Dr. Dawe's laboratory and a co-author with Prince Hitachi on several papers, is chief of the department of experimental path­ology, Cancer Institute, Tokyo.

House, hosted by Dr. and Mrs. Fredrickson, Their Imperial High­nesses met several additional NCI researcher s and administrators.

In the afternoon, P rince Hitachi planned to visit Dr. John C. Harsh­barger a t the Registry of Tumors in Lower Animals at the Smith• sonian Institution Museum of Nat­ural History. The RTLA is mainly supported by NCI.

Hormone Receptors in Breast Cancer Tissue May Indicate Effective Therapy

The presence of hormone receptor proteins in breast cancer tissue may be a useful indicator of the kind of therapy that would be most effective in treating the disease, according to Drs. Joseph C. Allegra and Marc E. Lippman and their co-workers in the National Cancer Institute's Di­vision of Cancer Treatment and Howard University's Cancer Re­search Center.

They presented their findings of a study with breast cancer patients on April 4 at the 14th Annual Meeting of the American Society of Clinical Oncology in Washington, D.C.

Hormone receptors, which selec­tively bind specific hormones, are being studied in an attempt to dis­cover which breast cancers are hor­mone dependent and, therefore, might be controlled by hormonal therapy.

Used After Surgery

Hormone therapy often is used when breast cancer recurs some time after surgery.

The e,;trogen receptor prolei n was the first of the hormone recep­tors found in brea~t cancer tissue. Since then several other hormone receptors have been discovered.

Ors. Allegr a and Lippman and colleagues analyzed the breast tis­sue of 32H breast cancer patients for four hormone receptors: estro­~en and progesterone, female hor­mones; androgen, a male hormone that is present in minute amounts in females ; and g]ucocorticoid.

Check for Receptors

Estrogen r eceptors were found in 53 percent of the patients, most of whom were postmenopausal. Of these estrogen receptor-positive pa­tients, 65 percent responded to hor­mone therapy.

Only nine percent of patients without the estrogen receptor re­sponded to hormone t herapy.

Patients with both the estrogen and glucocorticoid receptors had a higher response rate of 83 percent.

Patients with estrogen a nd pro­gesternne receptors showed a trend toward an increased response rate,

but the comparison was not statis­tically significant.

The presence of androgen recep­tor with the estrogen receptor was of no significance.

Surprisingly, the presence or ab­sence of hormone r eceptors corre­lated with patients' response rates lo chemotherapy as well as to hor­mone therapy.

Measure Responses

Seventy of the patients who were tested for hormone receptors under­went chemotherapy. Of 45 patients who we,-e estrogen receptor nega­li ve, 34 (76 percent) responded to anticancer drugs.

Of the 25 estrogen receptor posi­tive patients, only 3 (12 percent) responded to chemotherapy.

Director of NCI Discusses Viewpoints at Wed. Forum

Dr. Arthur C. Upton, who was appointed Director of the National Cancer Institute on July 29, 1977, will discuss his Perspectiveg After the First Nine Months at the next meet­ing of the NCI Fourth Wed­nesday Forum. The meeting will be held April 26 from noon to 1 p.m. in Wilson Hall, Bldg. 1.

Since hig appointment, Dr. Upton has conducted a broad review of NCI activities in or­der lo familiarize himself with the structure and programs of the Institute.

He will report on the per­spectives gained through this review, discuss the rationale for changes that have been made, and outline plans for fu­ture directions of the Institute.

After his presentation, Dr. Dpt.on will welcom<.l questions and comments from the audi­ence.

Dr. Fredrickson describes some of the scientific programs at NIH to Their Impe rial Highnesses. Later Prince Hitachi presented a copy of a recent study on pigment tumors in goldfish,

Page 10 April 18, 1978 THE NIH RECORD

Current Fogarty Scholars-in-Residence Meet With Members of Advisory Panel

All eight Scholars-in-Residence currently at NIH gathered for after­noon tea April 3 with members of the Scholars-in-Residence Advisory Panel.

Since the F ogarty Scholars are from many difference countries, visit the campus for varying lengths of time, are sponsored by various In­stitutes, and most-but not all­reside in Stone House, such a meet­ing of the entire group is actually a rather rare occasion.

Sir George Pickering, a specialist in internal medicine, hypertension, and cerebrovascular diseases who has been visiting N IH since J anu­uary, planned to fly back to Oxford the following day. However, he will return to NIH in October and re­main on campus through Decem­ber of this ye.ar.

Dr. Roger Stanier of Canada, visiting from the Pasteur Institute in Paris, was featured in the April 4 issue of the NIH Record (page 8) .

Dr. Paul Zamecnik of Colis P. H untington Laboratories, Massa­chusetts General Hospital, Boston, Mass., known for pioneering studies of in vitro protein synthesis, is visiting NIH from March to June. While at NIH he is working with Dr. Peter J. Fischinger of the Na­tional Cancer Institute, in Bldg. 41, Room 400 ( 496-1200).

Other current Scholars-in-Resi­dence and their affiliations are:

Dr. G. N. Ramachandran, Insti­tute professor of biophysics of the Molecular Biophysics Unit, Indian Institute of Science, Bangalore, In­dia, has been at NIH since August 1977 and will remain through June of this year. He is internationally known for his work in crystallog­raphy, especially in the areas of proteins and polypeptides. He can be reached at Stone House, 496-2087.

Dr. Michael Schramm of the bio­logical chemistry department, He­brew University of Jerusalem, Is­rael, is visiting NI H for 1 year, beginning in September 1977. He is particularly interested in gland functions, hormone receptors, and metabolic diseases. He is sponsored by Dr. Mart in Rodbell of the Na­tional Institute of Arthritis, Me-

tabolism, and Digestive Diseases, Bldg. 6-B, Room 26.

Dr. Jan G. Waldenstrom of the department of medicine, Malmo, General Hospital, Malmo, Sweden, came to NIH in February and will remain through April. He is chief editor of the Acta Medica Scandi­navica and consulting physician at the Karolinska Hospital in Stock­holm. Three syndromes bear his name, including Waldenstrom's glo­bulinemia. He has made key con­tributions to understanding mye­loma and related diseases. Dr. Waldenstrom may be contacted at Stone House, 496-2027. Organi"e Conference This Week

Drs. Helmut Holzer and Georges N. Cohen also visited NIH last year (see the N IH Record, March 8, 1977) and have returned this year

Dr. Lipsett (,) chats with Sir George Pickering, who says "Being at NIH as a Fogarty Scholar, one can live in a comfortable way, meet some of the most intelligent people in the world . and use two of the best libraries in the world-the National Library of Medicine and the NIH Library."

and have organized an Interna­tional Conference on Limited Pro­teolysis in Microorganisms, being held April 17-19 in Conference Room 6, Bldg. 31.

Dr. Holzer, from the Institute for Physiological Chemistry, Uni-

Fogarty Scholars now on campus include ( I to r) : Dr. Schramm and Dr. Waldenstrom; Dr. Ramachandran, talking w ith Dr. Ne ufeld ( r) and Dr. Cond-

Dr. Neufeld and FIC Director Dr. Leavitt talk with Dr. Schramm, while Dr. Pastan and Dr. Ramachandran converse at the far end of the entrance hall in Stone House.

versity of Freiburg, West Ger­many, will remain -at NIH until May 15, and may be reached at Stone House, 496-2091.

Dr. Cohen, of Biochimie Cellu­laire, Institut Pasteur, Paris, France, will stay through May 30. His sponsor at NIH is Dr. Earl R. Stadtman of the National Heart, Lung, and Blood Institute, Bldg. 31, Room 122 (496-3078).

Pane l Members Listed Members of the Advisory Panel

attending the tea included: Dr. Mortimer B. Lipsett, Director of the Clinical Center; Dr. Elizabeth Neufeld, NIAMDD; Dr. Jack Or­loff', NHLBI ; Dr. Ira Pastan, NCI; and Dr. Joseph E . Rall, NIAMDD.

Dr. Milo D. Leavitt, Jr., Director of the Fogarty International Cen­ter, Dr. Peter Condliffe, chief of the Scholars and Fellowships Branch, FIC, and several FIC staff members were also present.

Other members of the Advisory Panel not able to attend are: Dr. Donald B. Caine, NINCDS; Dr. Edward V. Evarts, NIMH; Dr. J erome Green, NHLBI ; Dr. Ruth Kirschstein, Director of NIGMS; Dr. Melvin L. Kohn, NIMH; Dr. Richard M. Krause, Director of NIAID; Dr. Clare H. Winestock, DRG; and Dr. Sheldon Wolff, New England Medical Center Hospital, Boston, Mass.

NIH Visiting Scientists Program Participants 3/26-Dr. Katsuhisa Tawada,

Japan, Laboratory of Physical Bi­ology. Sponsor: Dr. Richard Podol­sky, NIAMDD, Bg. 6, Rm. 106.

3/26-Dr. Atsushi Togawa, Ja­pan, Laboratory of Microbiology and Immunology. Sponsor: Dr. Joost Oppenheim, NIDR, Bg. 30, Rm. 327.

3/ 27-Dr. Andrej Rotter, United Kingdom, Laboratory of Biochemi­cal Genetics. Sponsor: Dr. Marshall Nirenberg, NHLBI, Bg. 36, Rm. 1C06. NC I Hosts Visitors

4/ 1- Dr. Riccardo Dalla Favera, Italy, Laboratory of Tumor Cell Biology. Sponsor: Dr. Prem Sarin, NCI, Bg. 37, Rm. 6B04.

4/ 1-Dr. Jorma Keski-Oja, Fin­land, Laboratory of Viral Carcino­genesis. Sponsor : Dr. George To­daro, NCI, Bg. 37, Rm. 1B22. Visits Dr. Korn

4/ 1-Dr. Sueo Matsumura, Ja­pan, Laboratory of CelI Biology. Sponsor: Dr. Edward Korn, NHLBI, Bg. 3, Rm. Bl-20.

4/ 1-Dr. Sandip Saha, India, Laboratory of Immunobiology. Sponsor: Dr. Sarkis Ohanian, NCI, Bg. 37, Rm. 2B23.

liffe ( back to camera ) ; Dr. Cohen ( Dr. Orloff, r l : and Drs. Zamecnik and Holzer. Dr. Stanier ( not in photo I also recently came to NIH.

THE NIH RECORD

NICHD Sponsors Science Writers' Seminar, Press Room at NYC Meetings

A science writers' seminar, Ad­vances In Child Health Research, will be held Tuesday, April 25. from 9 a .m. to noon, in the Madison Suite of the New York Hilton.

Organized by the National Inst i­tute of Child Health and Human Development, the seminar is spon­sored jointly by the NI CHD with the Society for Pediatric Research and the American Pediatric Soci­ety.

Speakers, all experts in pediatric research, will outline new develop­ment in three major research areas:

• Nutrition in the Newborn­Breastmilk: Its Role in Immunity; Is Human Milk Best for All Babies?

• Fetal Medicine- New Method for Fetal Evaluation; Advances in Prenatal Diagnosis;

• Environmental Insults Before Bfrth- Fetal A !coho! Syndrome: Effects on Learning and Behavior; Maternal Smoking and Fetal Deaths.

Provides News, Feature Material

The purpose of the seminar is to provide 11ews and feature material for writers who report on child health issues as media staff mem­bers or freelancers.

The seminar will be held during the annual meetings of the Society for Pediatric Research, American Pediatric Society, and Ambulatory Pediatric Association. Throughout t hose meet ings, from April 24 through April 28. a press room will be open in the Morgan Suite of the New York H ilton.

For details on the seminar , con­tact the Office of Resear ch Repo1-t­ing, NICHD, at (301) 496-5133.

He jests at scars that never felt a wound.-Slrakespeare

Norman L. Osinski has been appointed contract officer for the National Li­brary of Medicine. He succeeds Ken­neth C. Styers who has been named assistant director for administration and operations at the Library's At­lanta-based National Medical Audio­visual Center. Mr. Osinski was previ­ously a procurement analyst with the HEW Management and Budget Office.

April 18, 1978

8 Young Science Award Winners Visit NIH

At the NIH Visitors Center, the award winners arc: ( I to r, front ) Robin Eng, Edward Chen, Mary Boylan, Bradley Teague; I I to r, rear ) Marilyn Mayer, Stephen Cornaby, Deborah Bentley, and David Lobach.

From all over the U.S. they came-from Utah, California, Ohio, Penn­sylvania, Oregon, and Florida-eight teenagers who received the 1978 National Exploration Award sponsored by the Boy Scouts of America.

The winners' science projects were selected from more than 250,000 entries.

Their scientific interests range from the growth of fungi, to photo­taxis in tropical fish, mathematics,

Seminar May 5: Issues That Affect Women Biomed. Researchers

The Coordinating Committee for NIH Minority and Women Re­search and Training will sponsor a seminar May 5 on many issues that affect women who aim to enter and contribute to biomedical sci­ence through research and training supported by the Extramural Pro­grams of NIH. Expert speaker s from outside and within NIH will participate in this half-day semi­nar.

The CCMWRT, chaired by Dr. Zora J. Griffo, OD, advises the Of­fice of t he Director, NIH, on civi l rights issues relevant to the Extra­mural Programs of NI H.

NIH Director Dr. Donald S. Fredrickson will welcome the group and present his views and expec­tations.

Topics and Speakers Listed

Topics and speakers will include : the avai lability of women scien­tists, Betty M. Vetter, executive director, Scientific Manpower Com­mission; employment of women scientists, Dr. Elizabeth L. Scott, professor of department of statis­tics, Univers ity of California at Berkeley; minority perspective by Dr. Anna Epps, professor of medi­cine, Tulane University; NIH mis­sion and perspective, Dr. Ruth L. Kirschstein, Director of the Na­tional Institute of General Medical

prototypes of solar furnaces, the role of THC (a psychoactive in­gredient of marijuana) as a fe­male sex hormone, a study of gor­gonians ( sea fans), the effect of noise pollution on rats, and even conditioning an orphan raccoon to successfully hunt in the wild!

After an introduction to NIH at Lhe Visitors Center in Bldg. 31, the young scientists met with Dr. De­Witt Stetten, Jr., NIH Deputy Di­rector for Science, and visited the laboratory of Dr. Ronald Crystal, chief of the Pulmonary Branch, Division of Intramural Research, in the National Heart, Lung, and Blood Institute.

Sciences, NIH. Also, ability of women scientists

to compete for NIH grants, Anne Krey, grants associate, DRG; uni­versity perspective, Dr. Doris H. Merritt, dean of Research and Sponsored Programs, Indiana-Pur­due Universities; flexible time training, Dr. Sharon H. Penney, associate provost, Yale University; and issues associated with re-entry or reorientation in biomedical pro­grams, Dr. Alice S. Huang, asso­ciate professor, Harvard Medical School.

Seminar Is Open

The seminar will take place in Wilson Hall on May 5 from 8:30 a.m. to 12: 15 p.m. Attendance is open to all as long as seats are available.

Additional information may be obtained from Dr. Jane Showacre, NICHD, who chairs the Steering Committee at 496-1383, or the Spe­cial Programs Office, OD at 496-5358.

Page 11

Dr. De Luca Receives Mead Johnson Award

Dr. Luigi M. De Luca, head of the Differentiation Control Section, Experimental Pathology Branch, National Cancer Institute, was given the Mead Johnson Award for Research in Nutrition of the Amer­ican Institute of Nutrition for his work on the mechanism of action of vitamin A.

The award of $1,000 and an in­scribed scroll is given to an inves­tigator who has not yet reached his 40th birthday.

Dr. De Luca received the award April 12 at the annual meeting of the American Institute of Nutri­tion in Atlantic City.

He obtained a doctor ate in or­ganic chemistry from the Univer­sity of Pavia in Italy in 1964, and joined Dr. George Wolf's labora­tory at MIT to work on the meta­bolic action of vitamin A in main­taining epithelial differentiation.

Dr. De Luca, who joined NCI in 1971 , is the author of approximately 40 sci­entific publications.

His main contribution has been the finding that vitamin A is di­rectly involved in controlling bio­synthesis of specific glycoprotcins.

Such involvement occurs via the formation of a phosphorylated de­rivative of vitamin A, retinyl phos­phate, found in mammalian cell membranes in the free form and as its mannosyl derivative.

Recent work in Dr. De Luca's laboratory has shown that spon­taneously or chemically trans­formed cells regain some of the characteristics of normal cells after culturing in the presence of vitamin A. Their saturation den­sity decreases to that of their nor­mal counterparts, and they become much more adhesive.

Dr. De Luca and his co-workers have found that the transformed cells synthesize phosphorylated de­rivatives of vitamin A. Retinyl phosphate itself increases the ad­hesion of these cells.

Thus, it appears that some of the effects of vitamin A on cancer­ous tissues may occur through gly­cosylation reactions of membranes.

Page 12

Three Scientists Give Administration's View At FASEB Symposium

N IH Director Dr. Donald S. F redr ickson was one of three top science figures who presented "The Administr ation View of Basic Re­search and the Life Sciences" at FASEB's Public Affairs Sympos­ium on April 10.

Meeting Held April 9-14

The 62nd Annual Meeting of the Federation of American Societies for Experimental Biology-at­tended by some 1,000 members­was held in Atlantic City April 9-14.

Other participants in the Sym­posium were Dr. Gilbert S. Omenn, Assistant Director, Office of Science and Technology Policy, and Dr. Donald Kennedy, Commissioner of the Food and Drug Administration.

Dr. Lipsett Chairman of 1978 U.S. Savings Bond Campaign

NIH Director Dr. Donald S. F redrickson has appointed Dr. Mortimer Lipsett, Director of the Clinical Center, as chairman of the 1978 U.S. Savings Bond Campaign at NIH.

Howard Kettl, CC executive offi­cer, will serve as vice chairman, and Steven Groban, chief, CC Out. patient Department, is coordinator.

Kick- Off Is April 2 5

This year's campaign will begin with the kick-off meeting of coordi­nators and canvassers on April 25, at 1 :30 p.m., in the Masur Audi­tor ium.

Blood Donors Are Allowed 4 Hours 'Special' Leave Did you know t hat every

time you donate blood at the Clinical Center Blood Bank you are permitted 4 hours ad­ministrative leave?

This leave covers the time it takes to donate blood, travel time to and from the Blood Bank, as well as the time to recover following the donation.

Supervisors may request that their employees' blood do­nations be postponed during busy workloads; however , the supervisor should check with the Blood Bank on the urgency of the donation.

Also, at the supervisor's re­quest, the Blood Bank will give an employee a record of his or her donation.

For further information on this policy, see the NIH Man­ual, Issuance 3010, listed as Compensation to NIH Em­ployees for Donating Blood.

What science has to teach us is not its techniques but its spirit: the irresistible need to explore.­Jacob Bronowski

April 18, 1978

Ten Nations Participate in Workshop, Evaluate Different Types of Interferon

Interferon workshop participants Drs. Pieter DeSomer (far left ), Rega Institute, Belgium, and Fakhey Assad (second from right), W orld Health Organi%ation , Switzerland, discuss session reports with workshop organi~ers Drs. June K. Dun nick and Ceorge J. Galasso ( far right ) , Development and Applications Branch, NIAID.

Research clinicians from nine foreign Nations and the U.S. participated in a workshop here, on March 21-23, on Clinical Trials with Exogenous Interferon.

Jointly sponsored by the National Institute of Allergy and Infectious Diseases and the National Cancer Institute, the meeting was designed eluding hepatitis B and herpes in­to bring together investigators ac- fections. tively using interferon to treat pa- Studies are now u nder way in tients with a variety of infectious England, Belgium, The Nether­and metastatic diseases. lands, and the United States to de-

Interferon is a naturally occur- termine the usefulness of inter­ring substance that has long been feron for hepatitis B. These studies recognized as playing an important are designed to determine the most role in the body's defenses against effective dose and type of inter­disease. Scientists have now devel- feron. oped methods to produce it outside In addition, interferon is cur­the body, but this exogenous inter- rently under investigation for the feron is costly and difficult to pro- prevention of viral infections fol­duce. lowing 1·enal and bone marrow

Despite these limitations, exoge- transplants. nous interferon- usually produced According to preliminary find­from either human leukocyte or ings, patients with certain types of fibroblast cells- appears promising cancer may benefit from interferon in the t reatment and prevention of therapy. several major illnesses, many of which are caused by viruses. Swedish Study Cited

At the recent workshop, more In one study, conducted by Swed-than 25 speakers presented their ish investigators, patients with findings to evaluate the therapeutic osteogenic sarcoma who received effectiveness of the different types interferon appeared to do as well, of interferon. and, in some cases better than they

Preliminary studies suggest that would have done r eceiving high interferon can be used to treat a dose chemotherapy (methotrexate variety of infectious diseases in- or adriamycin) for treating this

STEP Seminar Topic April 26: Ethics and Immunization Trials

Ethical Balance Associated With Immunization Trials will be the topic of the STEP Continuing Ed­ucat ion Seminar on Wednesday, April 26, from 3 to 5 p.m., in Bldg. 31, Conference Room 4.

Dr. Michael Kaliner of the Na­tional Institute of Allergy and In­fectious Diseases and Canon Mi­chael Hamilton of National Ca­thedral will be the speaker s.

type of cancer. At the M.D. Anderson H ospital

in Houston and at Stanford Uni­versity in California controlled clinical trials are in progress to assess the use of interferon in sev­eral forms of metastatic disease.

During the 3-day meeting, five workshop sessions allowed small groups of investigators to review and discuss patient data and draw up recommendations for future re­search.

In view of the limited supply of exogenous interferon, the partici-

THE NIH RECORD

NLM Board of Regents Has Seven New Members

On March 20, the U.S. Senate confirmed the nomination of seven members to the NLM Board of Regents. The Library had been wit hout appointed Regents since last August, when the term of Dr. J oseph F. Volker expired. Board meet ings scheduled for September 1977 and January 1978 were can­celled.

The new Regents are: Dr. Thomas C. Chalmers, pr esi­

dent and dean, Mount Sinai School of Medicine of the City University of New York;

Dr. Nicholas E . Davies, attend­ing physician, Piedmont Hospital, Atlanta, Ga. ;

Dr. S. Richardson Hill, Jr., president, University of Alabama in Birmingham;

Dr. Doris H. Merritt, dean, Office of Research and Sponsored Pro­grams, Indiana-Purdue University;

Dr. Cecil G. Sheps, professor of social medicine, University of North Carolina;

Dr. Kelly M. West, professor of medicine and of continuing educa­tion, University of Oklahoma;

James F. Williams II, medical librarian, Shiffman Medical Li­brary, Wayne State University.

The Board of Regents, estab­lished by the National Library of Medicine Act of 1956, advises the Director and staff of the Library and makes recommendations to the Secretary of HEW on matters of policy affecting the Library.

Re,riew Grant Applicat ions

The Regents also review appli­cations for grants. The Act stipu­lates that 10 appointed Regents shall be selected from among lead­ers in the fundamental and medical sciences, scientific or medical li­brary work, public affairs, public health, and hospital administra­tion. The Board meets 3 times a year.

I n addition to the 10 appointed members, there are 7 ex officio Regents: the Surgeons General of the PHS, Army, Navy, and Air Force; the chief medical director of the Department of Medicine and Surgery, VA; the assistant director for Biological, Behavorial, and Social Sciences of the National Science Foundation; and the Li­brarian of Congress.

pants suggested that its use be lim­ited to controlled clinical trials, preferably through multicentcr studies, and only for diseases where data exists to justify its use.

In addition, they called for in­creased production of interferon from all available sources, as well as additional studies to delineate differences in the various prepara­tions. All interested persons are invited

to attend. * U.S. GOVERNMENT PRINTING OFFICE: 1978-260·901/15