Approximate Solubilities of USP and NF Articles

SOLUBILITIES

Approximate Solubilities of USP and NF Articles Name and Volume, in mL, of Solvent

Solute (1 g) WaterBoilingWater Alcohol Chloroform Ether Other

Acenocoumarol 67,000 280 130 1800 Acetaminophen 20 10 1 N sodium

hydroxide, 15Acetohexamide 230 210Acetylcysteine 5 4Acetyldigitoxin 6100 62.5 12 >10,000Ammonium Alum 7 0.5Aluminum Chloride 0.9 4Aluminum Sulfate 1Amantadine Hydrochloride

2.5 5.1 18 polyethylene glycol 400, 70

Amaranth 15Aminocaproic Acid 3 methanol, 450Aminohippuric Acid 45 50 3 N hydrochloric

acid, 5Aminosalicylate Sodium 2Ammonium Carbonate 4Amodiaquine Hydrochloride

25 78 >10,000 >10,000 benzene, 10,000

Anethole1 2

Anileridine >10,000 2 1Anileridine Hydrochloride

5 80 >10,000 >10,000

Antimony Potassium Tartrate

12 3 glycerin, 15

Apomorphine Hydrochloride

50 50 water at 80 , 20

Apraclonidine Hydrochloride

34 74 >10,000 methanol, 13; ethyl acetate, >10,000; hexanes, >10,000

Ascorbic Acid 3 40Ascorbyl Palmitate >1000 125 >1000 >1000Aspirin 300 5 17 10 to 15Atropine 460 2 1 25 water at 80 , 90Atropine Sulfate 0.5 2.5 5 glycerin, 2.5Bendroflumethiazide 23 200Benoxinate Hydrochloride

0.8 2.6 2.5 >10,000

Benzalkonium Chloride (anhydrous)

100 benzene, 6

Gamma Benzene Hexachloride

3.5 40 dehydrated alcohol, 20

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Benzethonium Chloride <1 <1 <1 6000Benzocaine 2500 5 2 4 almond oil or olive

oil, 30–50Benzoic Acid 300 3 5 3Benzonatate <1 <1 <1 <1Betadex 54Betamethasone 5300 65 325 warm alcohol, 15;

methanol, 3Betamethasone Acetate

2000 9 16

Betamethasone Sodium Phosphate

2 470 >10,000 >10,000

Betamethasone Valerate

10,000 16 <10 400

Bisacodyl >10,000 210 2.5 275Boric Acid 18 4 18 boiling alcohol, 6;

glycerin, 4Bromodiphenhydramine Hydrochloride

<1 2 2 3500 isopropyl alcohol, 31

Brompheniramine Maleate

5 15 15

Busulfan acetone, 45Butabarbital Sodium 2 7 7000 10,000Butamben 7000Butylated Hydroxyanisole

4.0 2.0 1.2

Butylated Hydroxytoluene

4.0 1.1 1.1

Caffeine (hydrous) 50 75 6 600Calcium Chloride 0.7 0.2 4 boiling alcohol, 2Calcium Gluconate 30

(slowly)5

Calcium Hydroxide 630 1300Calcium Lactate 20Calcium Pantothenate 3Calcium Sulfate 375 485Camphor 800 1 0.5 1Carbinoxamine Maleate <1 1.5 1.5 8300Carisoprodol 2083 2.5 2.3 acetone, 2.5Cephaloridine 5 1000 10,000 10,000Cetylpyridinium Chloride

4.5 2.5 4.5

Chloral Betaine 1 4 >10,000 >10,000 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1

Chloral Hydrate 0.25 1.3 2 1.5Chlorambucil acetone, 2Chloramphenicol 400



Chlordiazepoxide >10,000 50 6250 130Chlorobutanol 125 1 glycerin, 10Chlorocresol 260 0.4Chloroprocaine Hydrochloride

20 100

Chlorpheniramine Maleate

4 10 10

Chlorpromazine 3 2 3 benzene, 2Chlorpromazine Hydrochloride

1 1.5 1.5

Chlortetracycline Hydrochloride

75 560

Cholesterol 100 (slowly)

dehydrated alcohol, 50

Citric Acid 0.5 2 30Clindamycin Palmitate Hydrochloride

3 ethyl acetate, 9

Clindamycin Phosphate 2.5 >1000 >1000 >1000Clioquinol >100,000 3500 120 4500Cocaine 600 7 1 3.5 olive oil, 12; liquid

petrolatum, 80–100Cocaine Hydrochloride 0.5 3.5 15Codeine 120 2 0.5 50Codeine Phosphate 2.5 325 boiling alcohol, 125;

water at 80 , 0.5Codeine Sulfate 30 1300 water at 80 , 6.5Colchicine 25 220Cortisone Acetate 350 4 acetone, 75;

dioxane, 30Cupric Sulfate 3 0.5 500 glycerin, 3Cyanocobalamin 80Cyclizine Hydrochloride 115 115 75Cyproheptadine Hydrochloride

275 35 26 methanol, 1.5

Dehydrocholic Acid 100 35 2200 (15 )

acetic acid at 15 , 135; acetone at 15 , 130; benzene at 15 , 960; ethyl acetate at 15 , 135

Demeclocycline 200 methanol, 40Demeclocycline Hydrochloride

60 methanol, 50

Denatonium Benzoate 20 2.4 2.9 5000Desipramine Hydrochloride

12 14 3.5 >10,000

Dexamethasone Sodium Phosphate

2

Dexbrompheniramine Maleate

1.2 2.5 2 3000



Dexchlorpheniramine Maleate

1.1 2 1.7 2500

Dextroamphetamine Sulfate

10 800

Dextromethorphan Hydrobromide

65

Dextrose 1 100Diazepam 333 16 2 39Dibucaine 4600 0.7 0.5 1.4Dicyclomine Hydrochloride

13 5 2 770 glacial acetic acid, 2

Diethylpropion Hydrochloride

0.5 3 3

Digitoxin 150 40Dihydroergotamine Mesylate

125 90 175 2600

Dimercaprol 20Dimethisterone 3 0.7Diphenhydramine Hydrochloride

1 2 2 acetone, 50

Disulfiram >5000 30 15Docusate Calcium 3300 >1 >1 >1Docusate Sodium 70

(slowly)Doxapram Hydrochloride

50

Doxylamine Succinate 1 2 2 370Droperidol 10,000 140 4 500Dyclonine Hydrochloride

60 24 2.3 >10,000 hexane, >10,000

Dydrogesterone >10,000 40 2 200Echothiophate Iodide 1 dehydrated alcohol,

25; methanol, 3Edrophonium Chloride 0.5 5Enalaprilat 200 >1000 dimethylformamide,

40; methanol, 68Ephedrine 20 0.2Ephedrine Hydrochloride

3 14

Ephedrine Sulfate 1.3 90Epinephrine Bitartrate 3Ergotamine Tartrate 500 500Erythromycin 1000Erythromycin Estolate 20 10 acetone, 15Estradiol 28 435 150Estradiol Cypionate >10,000 40 7 2800Estrone 250

(15 )110 (15 ) boiling alcohol, 50;

boiling chloroform,



80; acetone at 50 , 50; boiling acetone, 33; boiling benzene, 145

Estropipate >2000 >2000 >2000 >2000 warm alcohol, 500Ethacrynic Acid 1.6 6 3.5

Ether1 12

Ethyl Vanillin 100 (50 ) 2Ferrous Gluconate 5Ferrous Sulfate 1.5 0.5Flumethasone Pivalate >10,000 89 350 2800Fluocinolone Acetonide >1000 45 25 350Fluorometholone >10,000 200 2200 >10,000Fluphenazine Enanthate

<1 <1 2

Fluphenazine Hydrochloride

1.4 6.7

Flurandrenolide 72 10 methanol, 25Flurazepam Hydrochloride

2 4 90 5000 methanol, 3; isopropanol, 69; benzene, 2500; petroleum ether, 5000

Fluroxene 220Fructose 15 methanol, 14Gentian Violet 10 glycerin, 15Glyceryl Monostearate 10.0 100.0 methanol, 100;

isopropyl alcohol, 33Glycine 4 1254 water at 50 , 2.6; at

75 , 1.9; at 100 , 1.5Glycopyrrolate 4.2 30 260 35,000Guaifenesin 60–70Halazone >1000 140 >1000 >2000Haloperidol >10,000 60 15 200Heparin Sodium 20Histamine Phosphate 4Homatropine Hydrobromide

6 40 420

Hydralazine Hydrochloride

25 500

Hydrocortisone 40 acetone, 80Hydrocortisone Acetate 230 200Hydrocortisone Sodium Phosphate

1.5

Hydroflumethiazide >5000 39 >5000 2500Hydromorphone Hydrochloride

3

Hydroquinone 17 4 51 16.5



Hydroxocobalamin 50 100 10,000 10,000Hydroxyzine Hydrochloride

1 4.5 13 >1000

Hydroxyzine Pamoate >1000 700 >1000 >1000 dimethylformamide, 10; 10 N sodium hydroxide, 3.5

Hyoscyamine Hydrobromide

2.5 1.7 2300

Hyoscyamine Sulfate 0.5 5Ichthammol 10Indigotindisulfonate Sodium

100

Indomethacin 50 30 40Iodine 3000 13 carbon disulfide, 4;

glycerin, 80Ipodate Sodium <1 2 dimethylacetamide,

2; dimethylformamide, 3.5; dimethylsulfoxide, 3.5

Isoniazid 8 50Isopropamide Iodide 50 10 5Isopropyl Alcohol <1 <1 <1 <1Isoproterenol Hydrochloride

3 50

Isoproterenol Sulfate 4 >2000 >2000 >2000Isoxsuprine Hydrochloride

500 100 >10,000 >10,000 0.1 N hydrochloric acid, 2500; 0.1 N sodium hydroxide, 100

Ketamine Hydrochloride

4 14 60 >10,000 methanol, 6; absolute alcohol, 60

Lactose 5 (slowly)

2.6

Levorphanol Tartrate 50 120Levothyroxine Sodium 700 300Lisinopril 10 >10,000 >10,000 >10,000 methanol, 70Magnesium Hydroxide >10,000 >10,000 >10,000 >10,000Magnesium Sulfate 0.8 0.5 glycerin, 1 (slowly)Mannitol 5.5Menadione 60 benzene, 10;

vegetable oils, 50Mesoridazine Besylate 1 11 3 6300Methacholine Chloride 1.2 1.7 2.1Methacrylic Acid Copolymer

water in methanol (3 in 100), 10; water

in alcohol ( 3 in 100), 10; water in isopropyl alcohol ( 3



in 100), 10; water in acetone ( 3 in 100), 10

Methacycline Hydrochloride

100 300 >1000 >1000 0.1 N sodium hydroxide, 25

Methdilazine Hydrochloride

2 2 6 >10,000 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1

Methenamine 1.5 12.5 10 320Methenamine Mandelate

10 20 350

Methimazole 5 5 4.5 125Methocarbamol 40 (20 )Methotrimeprazine 10 10 2 methanol, 10Methoxyflurane 500 <1 <1 <1Methsuximide 350 3 <1 2Methyclothiazide >10,000 92.5 >10,000 2700Methylbenzethonium Chloride

0.8 0.9 >10,000 0.7

Methylene Blue 25 65Methylergonovine Maleate

100 175 1900 8400

Methylparaben 400 3 10 water at 80 , 50Methylprednisolone 10,000 100 800 800Methylprednisolone Acetate

1500 400 250 1500

Methylprednisolone Sodium Succinate 1.5 12 >10,000 >10,000Methysergide Maleate 200 165 3400 >10,000Miconazole >100,000 9.5 2 15 isopropyl alcohol, 4;

propylene glycol, 9; methanol, 5.3

Miconazole Nitrate 6250 312 525 50,000 isopropyl alcohol, 1408; propylene glycol, 119; methanol, 75

Morphine Sulfate 16 570 alcohol at 60 , 240; water at 80 , 1

Nalidixic Acid >1000 910 29 >1000Neomycin Sulfate 1Niacin 60Niacinamide 1.5 10 5.5Nifedipine >10,000 acetone, 10Nitrofurazone 4200 590 propylene glycol,

350Nitromersol >2000 >2000 >2000 >2000Norepinephrine Bitartrate

2.5 300

Norethindrone Acetate >10,000 10 <1 18 dioxane, 2



Nortriptyline Hydrochloride

90 30 20 methanol, 10

Oxandrolone 5200 57 <5 860 acetone, 69Oxazepam >10,000 220 270 2200Oxtriphylline 1Oxymetazoline Hydrochloride

6.7 3.6 862

Oxymetholone >10,000 40 5 82 dioxane, 14Oxymorphone Hydrochloride

4 100 >1000 >1000 methanol, 25

Oxytetracycline 4150 >10,000 6250 absolute alcohol, 66Oxytetracycline Calcium

>1000 >1000 >1000 >1000 0.1 N sodium hydroxide, 15

Papaverine Hydrochloride

30 120

Paraldehyde1 10 17

Paramethasone Acetate

50 methanol, 40

Paromomycin Sulfate <1 >10,000 >10,000 >10,000Pectin 20Penicillin G Benzathine 5000 65Sterile Penicillin G Procaine

250 30 60

Sterile Penicillin G Sodium

40

Penicillin V Benzathine 3200 330 42 910 acetone, 37Penicillin V Potassium 150Pentazocine >1000 11 2 42Pentazocine Hydrochloride

30 20 4 >10,000

Pentobarbital >2000 4.5 4.0 10Pentolinium Tartrate 0.5 475 >1000 >2000Perphenazine 7 acetone, 13Phenazopyridine Hydrochloride

<10 20 59 331 >5000 cold water, 300; glycerin, 100

Phenindamine Tartrate 40 350Phenmetrazine Hydrochloride

0.4 2 2

Phenobarbital 1000 10Phenol 15 mineral oil, 70Phentolamine Mesylate 1 4 700Phenylethyl Alcohol 60 <1 <1 <1 alcohol solution (1 in

2), 2; diethylphthalate, <1; benzyl benzoate, <1

Phenylmercuric Acetate 180 225 6.8 200Phenylmercuric Nitrate 600Phenylpropanolamine 1.1 7.4 4100



HydrochloridePhysostigmine Salicylate

75 16 6 250

Physostigmine Sulfate 4 0.4 1200Pilocarpine Hydrochloride

0.3 3 360

Pilocarpine Nitrate 4 75Piminodine Esylate >1000 6 2 >1000Pimozide >10,000 1000 10 1000 acetone, 100;

methanol, 1000; 0.1 N hydrochloride acid, >1000

Polyethylene Glycol 1540

1 3 absolute alcohol, 100

Polyethylene Glycol 4000

4 2.5 2

Potash, Sulfurated 2Potassium Acetate 0.5 0.2 3Potassium Alum 7 0.3Potassium Benzoate 2 75 alcohol solution (9 in

10), 50Potassium Chloride 2.8 2Potassium Citrate 1 glycerin, 2.5Potassium Gluconate 3Potassium Hydroxide 1 3 glycerin, 2.5Potassium Iodide 0.7 0.5 22 glycerin, 2Potassium Permanganate

15 3.5

Potassium Sodium Tartrate

1

Potassium Sorbate 4.5 35 >1000 >1000Pramoxine Hydrochloride

35

Prednisolone 30 180 acetone, 50Prednisolone Acetate 120Prednisolone Hemisuccinate

4170 6.3 1064 248

Prednisolone Sodium Phosphate

4 methanol, 13

Prednisone 150 200Prilocaine Hydrochloride

3.5 4.2 175

Primaquine Phosphate 15Primidone 2000 200Procaine Hydrochloride 1 15Prochlorperazine Edisylate

2 1500



Prochlorperazine Maleate

1200

Procyclidine Hydrochloride

35 9 6 11,000

Promazine Hydrochloride

3

Propoxycaine Hydrochloride

2 10 >10,000 80

Propoxyphene Napsylate

10,000 15 10

Propylhexedrine >500 0.4 0.2 0.1Propylparaben 2500 400 1.5 3Protriptyline Hydrochloride

2 3.5 2.5 >10,000

Pseudoephedrine Hydrochloride

0.5 3.6 91 7000

Pyrazinamide 67 135 1000 absolute alcohol, 175; methanol, 72

Pyridoxine Hydrochloride

5 115

Pyrilamine Maleate 0.5 3 2 absolute alcohol, 15Pyrimethamine 200 125Pyrrocaine Hydrochloride

1.5 12 8

Quinidine Sulfate 100 10 15Quinine Sulfate 500 120Reserpine 1800 6Resorcinol 1 1Rotoxamine Tartrate 10 100 >10,000 >10,000Saccharin 290 25 31Saccharin Calcium 2.6 4.7Saccharin Sodium 1.5 50Salicylic Acid 460 15 3 45 3 benzene, 135Scopolamine Hydrobromide

1.5 20

Secobarbital 0.5 N sodium hydroxide, 8.5

Selenium Sulfide 161 1667Sennosides 35 2100 3700 6100Silver Nitrate 0.4 0.1 30 boiling alcohol, 6.5

Simethicone2 >10,000 102 102 benzene, 102; absolute alcohol, >10,000

Sodium Acetate 0.8 0.6 19Sodium Ascorbate 1.3Sodium Benzoate 2 75 90 percent alcohol,

50Sodium Bicarbonate 12

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Sodium Bisulfite 4Sodium Borate 16 1 glycerin, 1Sodium Carbonate 3 1.8Sodium Chloride 2.8 2.7 glycerin, 10Sodium Citrate (hydrous)

1.5 0.6

Sodium Fluoride 25Sodium Formaldehyde Sulfoxylate

3.4 510 175 180

Sodium Hydroxide 1Sodium Iodide 0.6 2 glycerin, 1Sodium Lauryl Sulfate 10Sodium Nitrite 1.5Sodium Phosphate, Dried

8

Sodium Propionate 1 0.65 24 >10,000 >10,000Sodium Thiosulfate 0.5Sorbic Acid 1000 10 15 30 absolute alcohol, 8;

methanol, 8; propylene glycol, 19

Sorbitol 0.45Stanozolol >1000 41 74 370Stearic Acid 20 2 3Stibophen 1 >10,000 >10,000 10,000Succinylcholine Chloride

1 350

Sucrose 0.5 0.2 170Sucrose Octaacetate 1100 11 acetone, 0.3;

benzene, 0.6; toluene, 0.5

Sulconazole Nitrate 3333 100 333 pyridine, 10; methanol, 71; acetone, 130; methylene chloride, 286; toluene, 2000; dioxane, 2000

Sulfacetamide Sodium 2.5Sulfadiazine 13,000 human serum at 37 ,

620Sulfadiazine Sodium 2Sulfadimethoxine 200 2 N hydrochloric

acid, 50Sulfaethidole >3000 75 1300 1700 methanol, 51;

acetone, 13; benzene, 2277

Sulfamethizole 2000 38 1900 1900 acetone, 13Sulfamethoxazole 3400 50 1000 1000 carbon disulfide, 2

(slowly and usually incompletely)



Sulfapyridine 3500 440 acetone, 65Sulfasalazine >10,000 2900 >10,000 >10,000 methanol, 1500Sulfisoxazole 7700 boiling alcohol, 10Sulfisoxazole Acetyl 176 35 1064 methanol, 203Precipitated Sulfur carbon disulfide, 2

(slowly and usually incompletely); olive oil, 100

Tartaric Acid 0.8 0.5 3 250 methanol, 1.7Terpin Hydrate 200 35 13 140 140 boiling alcohol, 3Testolactone 4050Testosterone 2 100 absolute alcohol, 6Tetracaine >1000 5 2 2Tetracycline 2500 50Tetracycline Hydrochloride

10 100

Tetrahydrozoline Hydrochloride

3.5 7.5 >1000 >1000

Theophylline Sodium Glycinate

6

Thiamine Hydrochloride 1 170Thiamine Mononitrate 44Thiethylperazine Maleate

1700 530 >10,000 >10,000

Thimerosal 1 12Thioguanine 7700Thiotepa 13 8.3 1.9 4.1Thiothixene >10,000 2 120 absolute alcohol,

110Thiothixene Hydrochloride

8 280 >10,000 absolute alcohol, 270

Thymol 1000 1 1 1.5 olive oil, 2Tolazoline Hydrochloride

<1 2 3 >10,000

Triamcinolone Diacetate

13 80 methanol, 40

Triamterene formic acid, 30; 2-methoxyethanol, 85

Triazolam >10,000 1000 25 >10,000 0.1 N hydrochloric acid, 600

Trichlormethiazide 1100 48 5000 1400 dioxane, 9.1; dimethylformamide, 4.35

Trichloroethylene >10,000Triethylenemelamine 2.5 13 3.6 methanol, 8;

acetone, 9.5; benzene, 18

Trifluoperazine Hydrochloride

3.5 11 100



Triflupromazine Hydrochloride

<1 <1 1.7

Trimeprazine Tartrate 2 20 5 1800Trimethobenzamide Hydrochloride

2 59 67 720

Trioxsalen 1150 84 methylenedichloride, 43; 4-methyl-2-pentanone, 100

Tripelennamine Hydrochloride

1 6 6 acetone, 350

Triprolidine Hydrochloride

2.1 1.8 1 2000

Tromethamine 1.8 45.5 >10,000Tubocurarine Chloride 20 45Urea 1.5 10 boiling alcohol, 1Vanillin 100 glycerin, 20; water at

80 , 20Xylometazoline Hydrochloride

35

Zinc Acetate 2.5 30Zinc Chloride 0.5 1.5 glycerin, 2Zinc Sulfate 0.6 glycerin, 2.51 Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents.



Approximate Solubilities of USP and NF Articles

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