Applied Biosystems

Enterprise Informatics Enterprise Informatics Discovery through ManufacturingDiscovery through Manufacturing

May 17th, 2005

Increased Value for Our CustomersCore Enabling Technology / End-to-End Solution

SampleCollection

SampleBarcode

ChemicalProcessing

SamplePrep

ProcessValidation

DataCollection& Storage

DataAnalysis

ResultsReporting

RequiredQualityTest

PerformDiagnosticMethod

CalculateNormalizedOperatingPoints

NormalizeOP

ControlRules

QCStrategy

Data /RiskAnalysis

ResultsReporting

ProcessIndustries

Forensics CaseManagement

QuestionScientificSolutionHypothesis

SampleCollection

SamplePreparation

SampleAnalysis

DataCollection& Storage

DataAnalysis

ResultsReporting

LifeScience

Reducing Time to Results, Increasing ProductivityApplied Biosystems offers highly advanced informatics solutions capable of

integrating disparate data and research applications. We:Quickly reach an understanding of the customer’s process with the goal of increasing productivity, improving quality and reducing costsOrganize processes across facilities and integrate to outside servicesImplement large scale experiment/process design templates to maximize impactFacilitate large-scale distributed process management & optimize workflowSatisfy demanding information management requirements

Value-Add Services Built Upon Enabling Technologies & Professional Services

AB Instrument Platforms

AB Toolkits

Support Services

EnablingTechnologies

VerticalValue-Add

Services

HorizontalProfessional

ServicesTechnology Services

Consulting ServicesEnd to EndSolutions

Vertical Services

Pharma

Manufacturing (Q

A/Q

C)

Proteomics Expression Studies

Gene Expression Studies

Genom

ics Sequencing Analysis

Forensics Case M

anagement

Diagnostics

Drug Targets & Validation

Next G

eneration Service

SQL*LIMS®

v5 Software• Web / Browser client, JAVA applet / servlet

based(Windows, Linux, Unix – IE, Netscape, Firefox)

• J2EE, Web services extensible framework(Oracle/Apache exposed services for SOAP, WSDL, .NET, COM and other common application framework technologies)

• Server & Client are configuration based, build workflows, calculations; define specifications, attach SOP’s, documents, build user logic loopback directly from configuration / setup screens

• Deploy and manage easily in single lab or across the globe, securely, standards based LDAP and encryption to allow hosting across firewalls

SQL*LIMS® v5 Software and Oracle®

TechnologyArchitecture

ClientWeb browser

Client• Configure for a small lab or large, global operation

• Easily scale to global system with minimal need for re-validation

• Multi-tiered

• Simplifies Applied Biosystems instrument and application integration

Application server

Web ServicesWeb ServerBusiness Intelligence

Database

SQL*LIMS® v5 SofwareRich use of graphical controls to navigate to log a sample, perform an analytical task , result entry, review and approve data or run report

A Configuration Setup Screen for an Instrument Calibration / Reagent Tracking routineBuilding a definition or activity is mostly a mouse click to add a node, fill in a blank or selection from a list of values

Systems IntegrationOther Enterprise

Systems

•Accounting•Inventory•Quality•Document Mgmt

3rd Party Applications

SQL*LIMS® v5 Software

MRP Systems

Instrument IntegrationRoboticsABI Instruments

SQL*LIMS® v5 Software

3rd Party Instruments

SQL*LIMS v5 tightly integrates Oracle Reports And easily integrates with ANY 3rd party reporting tool, statistical package or desktop application that is ODBC compliant

• Out-of-the-box: Printer, File, Browser, E-Mail, Oracle10gAS Portal

• OTN: WebDAV, FTP, Oracle9iAS Wireless

• Standards-based deployment

• JSP and Servlet

• Open Java-API to add your own destinations and notifications

Built-inReporting Capabilitieswith Flexible

Formatting

Web

PDF & Printer XML

RTF

Excel

Northwest Analytical charting packageIntegrates directly with SQL*LIMS

Applied Biosystems & SQL*LIMS® SoftwareA history of innovation and commitment to providing laboratory informatics solutions

SL v4 ArchiverSL v4

Archiver

First Commercial LIMS

LIMS 2000

First Commercial LIMS

LIMS 2000

SQL*GTSQL*GT

SQL*LIMS v1.1Oracle v5.1

SQL*LIMS v1.1Oracle v5.1

‘82 ‘84 ‘86 ‘88 ‘92 ‘94 ‘96 ‘98 ’02 ‘04

SQL*LIMS v2.0Oracle v6

SQL*LIMS v2.0Oracle v6

SQL*LIMS v2.1SQL*LIMS v2.1 SQL*LIMS v3.1Y2K

SQL*LIMS v3.1Y2K

SQL*LIMS v3.0Oracle v7

SQL*LIMS v3.0Oracle v7

SQL*LIMS v4.0Oracle v8i

SQL*LIMS v4.0Oracle v8i

SQL*LIMS v4.1SQL*LIMS v4.1

SQL*LIMS v5iOracle 10g

SQL*LIMS v5iOracle 10g

SQL*StabilitySQL*Stability SQL*QASQL*QA

SQL*ScheduleSQL*Schedule LifeScience

LIMS

LifeScience

LIMS

SL*SolutionSAP

SL*SolutionSAP

v5 v6 v7

Validation ServicesStreamlining the process

Industry Proven and FDA Approved Validation Services• Validation Manual Sets, including IQ & OQ Scripts.

• Save Months and Important Resources by not having to build your own scripts.

• Lowers total cost of validation.

• Complete IQ/OQ/PQ services and assistance available.• Directly from ABI or approved Third Party

• On-site Vendor Site Audits.

• Dedicated Quality Assurance Staff (8 people)

• Source Code Escrow Accounts

Licensing/TrademarksCopyright © 2005 Applied Biosystems. All rights reserved. Thisdocument or parts thereof may not be reproduced in any form without the written permission of the publisher.

Information in this document is subject to change without notice. Applied Biosystems assumes no responsibility for any errors that may appear in this document. This document is believed to be complete and accurate at the time of publication. In no event shall Applied Biosystems be liable for incidental, special, multiple, or consequential damages in connection with or arising from the use of this document.

Applied Biosystems and SQL*LIMS are registered trademarks, and AB (Design), Applera, SL Solution, SQL*QA, SQL*Protocol, SQL*Stability, and SQL*Schedule are trademarks of Applera Corporation or its subsidiaries in the U.S. and/or certain othercountries.

Oracle is a registered trademark of Oracle Corporation and/or its affiliates.

Java is a trademark of Sun Microsystems, Inc.

All other trademarks are the sole property of their respective owners.