Applied Health Sciences Programme - Ireland's Health … · Applied Health Sciences Programme...

Applied Health Sciences

Programme

Proposal for

Medical Device Company (MDC)

By: National Institute of Health Sciences

2009

Applied Health Sciences –

Contents

Introduction Objectives Design Content Delivery Assessment Accreditation Costings Appendix 1


Introduction

A need for greater understanding of basic medical science and the practical issues

associated with the use of medical devices exists amongst professionals at Medical

Device Company Ltd. A programme to compliment successful product engineering and

development knowledge of modern medical practice relevant to medical device

application is required.

Through the National Institute of Health Sciences, it is proposed to further develop and

deliver a bespoke program in applied health sciences to meet such requirements.


Objectives

The course participants in the proposed programme are predominantly Engineering

Professionals. The primary aim of the programme is to equip the participants with the

following skills:

• General core competency in Cardiology and Vascular Science

• Specific core competency in Human Disease and Treatment Strategies

• Specific core competency in Drug Development and Drug Delivery Systems

In addition the program will provide:

• Basic knowledge of human anatomy and physiology

• Basic knowledge of blood physiology and haemodynamics

• Broad overview of diagnostic procedures

• Basic understanding of cell biology, pharmacology and immunology


Design

The program will be run by the National Institute of Health Sciences and led by a

Consultant Professor. The program will be delivered over an approximate 5-month

period. Lectures, in-situ theatre sessions, and laboratory assessment visits will be the

modes of program delivery. In addition to in-program assignments, there will be a

formal assessment and the end of the program which will be processed in two parts, i)

Written assessment and ii) Viva.

The overall study: tuition ratio is estimated at 3:1.


Content

Anatomy and Physiology

• The human body, cells and tissues

• Cardiovascular anatomy and physiology I

• Cardiovascular anatomy and physiology II

• Vascular procedure observation

• Cardiology procedure observation

Disease Classification, Diagnosis & Treatment

• What is disease? Disease classifications.

• Cardiovascular diagnostics – ECG, ECHO, Coronary angiography

• Cardiovascular Haemodynamics – Fluid mechanics

• Endovascular repair of aortic aneurysms

• Restenosis and treatments - peripheral vascular system and endovascular repairs

• ECG / ECHO procedure observation

Biology, Pharmacology and Immunology

• Pharmacology / Drug Eluding

• Cell Biology – cell structure / division / proliferation / drug delivery across

membranes

• Immunology – basic immunology

• Immunology – immune responses to xenotransplanataion of products

• Pathology laboratory visit

• Radiology laboratory visit

• Tutorial


Delivery

The program will be delivered in four locations:

• Designated Hospital

• University of Limerick

• South Court Hotel, Limerick

Lecturers delivering the program:

• Consultant Physicians

• Consultant Surgeons

• University Researchers

The program co-ordinators will be:

• National Institute of Health Sciences

Susan O’ Reilly

Tel: 061-483929

e-mail: [email protected]

• Medical Device Company.

Contact Point

Tel:

e-mail:


Assessment

Recommended reading will be suggested in advance of each set of lectures. This will

endeavour to achieve a minimum degree of comprehension of the lecture topics

amongst the course participants.

Assessment breakdown:

In-program assignments* will account for 35% of the final score

Final written assessment will account for 50% of the final score

Viva assessments will account for 15% of the final score

*Assignments

One shared assignment plus two individual assignments will be set during the program and will be

tailored to broadly apply to MDC products and processes.

Confidentiality surrounding the content of the assignments will be strictly adhered to. In addition, any

relative intellectual property associated with the assignments, will be considered the property of MDC.


Accreditation

The program will be accredited by University of Limerick.


Costings

€ Design & Implementation -

Co-ordination -

Preparation -

Delivery -

Assignments -

In-situ visits -

Assessments -

Lecture theatre & equipment -

€ -

Suggested Payment Schedule

One payment 100%


Appendix 1

Week 1

Wednesday 25th January 2006

5.00 – 8.00 pm

• Anatomy & Physiology

o Human body, cells and tissues

Advance reading: Ross & Wilson: Anatomy & Physiology in

Health and Illness.

Churchill Livingston – 8th edition

(Sections 1 & 2)

Clancy & McVicar: Physiology and

Anatomy – A Homeostatic Approach

Edward Arnold

(Chapters 1 – 4)

Lecture content: A series of 4 sessions involving small

groups, problem-solving, discussion and a

lecture.

The sessions are entitled:

1. Introduction to the body as a whole

2. The role of the cell in homeostasis

3. The chemical basis of life

4. Tissues

Recommended text: As above


Learning outcomes: To have an understanding of cells and

tissues, and to develop a basic knowledge

of the organisation of the human body.

Wednesday 25th January 2006

Hospital

10:30 am

• Vascular Procedure – Students #1 & #2

10:30 am

• Cardiology Procedure – Students #11 & #12


Week 2

Wednesday 1st February 2006

Hospital

10:30 am


10:30 am



Week 3

Wednesday 8th February 2006

4:30 – 7:30 pm

• Cardiovascular anatomy & physiology I

Lecture content: Lecture will be delivered in 2 parts:

i. Gross anatomy and physiology of the

heart

ii. Gross anatomy and physiology of

circulation – arteries, veins, lymphatics.

Recommended text: Ross & Wilson: Anatomy & Physiology in

Health and Illness.

Churchill Livingston – 8th edition

- good basic overview of anatomy & physiology

Martini: Fundamentals of Anatomy and

Physiology. Prentice Hall

- detailed overview of human anatomy and

physiology

Learning outcomes: Should have a basic understanding of

anatomy and physiology of the heart and

vascular system.



Hospital

10:30 am


10:30 am



Week 4


4:30 – 7:30 pm

• Cardiovascular anatomy & physiology II

o Cardiology

Advance reading: The Sympathetic Nervous System &

Hypertension – Schroder

Colour Atlas of Physiology - Despopdulos

Lecture content: Blood vessel structure

Vessel structure as it relates to physiology

Key homeostatic systems in vessel

function

Blood vessel dysfunction and disease

Recommended text: Textbook of Medical Physiology –

Guyton & Hall

Nitric Oxide – Louis Ignarro

Learning outcomes: An understanding of how blood vessel

dysfunction contributes to disease.

• Assignment 1



Hospital

10:30 am


10.30 am



Week 5

Wednesday 22nd February 2006

Hospital

10:30 am


10:30 am



Week 6

Wednesday 1st March 2006

Hospital

10:30 am


10:30 am



Week 7

Wednesday 8th March 2006

Limerick

• Disease Classification, Diagnosis & Treatment

o What is disease?

o Classifications of disease

Advance reading: Pathological Basis of Disease, 6th Edition

– Robbins

Principles of Internal Medicine, 14th

edition – Harrison

Lecture content: Definitions

Historical classifications

Current classifications

Disorders and related topics

Current diagnostic trends

Future treatments and diagnostic

approaches to disease


Learning outcomes: To understand why diseases are classified

The role of science in classification and

diagnosis

Brief introduction of main diagnostic

elements of disease

Introduction to pathophysiology of the

major diseases



o Cardiovascular diagnostics

o Cardiovascular therapies

Advance reading: Lecture notes in Cardiology

Davidson Principles of Medicine –

Cardiology Section

Pocket Consultant, Cardiology by R.H.

Swanton

Booklets published by Irish Heart

Foundation and BSCI

Lecture content: Introduction.

Symptoms of heart disease / Examination

in brief / Cardiac investigation /

Therapeutic procedures / Ischaemic

(coronary) heart disease – Aetiology and

risk factors, Angina – symptoms,

treatment and investigation, Myocardial

infarction (heart attack) – symptoms,

treatment and investigations. / About

coronary angiograms, angioplasty and

stenting / Open session for questions /

Closing remarks

Recommended text: Davidson: Principles of Medicine,

Cardiology Section

Test Book of Medicine, B. J. Kumar,

Cardiology Section


Learning outcomes: Participants will have a basic

understanding of, and will be able to

define:

Relevant cardiovascular and heart diseases

Diagnostic approaches

Basic recommended treatments


Hospital

10:30 am

• Electrocardiography & Echocardiography Procedures

– Students #1, #2 & #3


Week 8


Limerick

4:30 – 7:30 pm


o Cardiovascular Fluid Mechanics

Advance reading: McDonalds Flow in Arteries – Nicolas,

W.W., O’ Rourke, M.F., 1998. Arnold

Publishers London

Physics of Pulsatile Flow – Zamir, M.,

2000. Springer-Verlag, New York.

Introduction to Bioengineering – Berger,

S.A., Goldsmith, W. and Lweis, E.R.,

1996. Oxford University Press.

Lecture content:

i. Flow in a liquid

ii. Properties of arteries

iii. Pulsatile flow

iv. Arterial systems

v. Disease in the vasculature

vi. Flow behaviour in implant devices



Learning outcomes: An overview of blood flow properties in

humans. An introduction to the effects of

disease on vascular flow and an understanding

of how and why flow properties alter

following insertion of implant devices


o Endovascular Repair of Aortic Aneurysms

Advance Reading: Clinical Surgery 2nd Ed. Cuschreri, Grace,

Darzi Blacknell Publishing Oxford 2003

Chaper 37 Cardiovascular disorders.

Vascular Surgery: A comprehensive review

Gredtro Saunders Philadelphia 2002 Moore

WS

Minimal Access Therapy for Vascular

Disease. Leahy AL, Bell RF, Katzen BT,

Martin Dunitz London 2002

Lecture Content:

i. Anatomy of the thoracic and abdominal

aorta

ii. Pathophysiology of aneurysm formation

iii. Surgical options: open repair and its

problems

iv. History of endovascular repair

v. Anatomical Considerations

vi. Challenges in stent graft design and

comparison between grafts

vii. Problems & solutions: endoleak and

migration

viii. Recent evidence from randomised trials


ix. Current guidelines and future

considerations


Learning Outcomes:

A basic understanding of aortic anatomy and

aneurysm pathophysiology. An understanding of

surgical options and the background to the

development of endovascular repair. An

understanding of endovascular problems and

challenges to stent graft design. A basic

knowledge of results to date and likely future

developments.


Hospital

10:30 am


– Students #4 #5 & #6


Week 9

Wednesday 22nd March 2006

4:30 – 7:30 pm


o Stenosis, Restenosis & Treatments

Advance reading: Interventional Radiology of the Peripheral

Vascular System – Anna-Maria Belli

Lecture content: Stenosis, Restenosis & Treatments in

Vascular and Venous Terretories

(excluding cardiac)

i. Basic applied vascular anatomy

ii. Pathogenesis of occlusive and

stenosis/restenosis of vessels in arterial

and venous tree (incl. Carotid, renal,

peripheral and venous)

iii. Clinical cases

iv. Interventional techniques for evaluation

and treatment

v. Factors that affect stenosis

Recommended text: Vascular Surgery. Edit - Robert B.

Rutherford

Vascular and Endovascular Surgery. J. Beard

& P. Gaines


Learning outcomes: Basic understanding of arterial and vascular

stenosis and occlusion

Basic understanding of mechanisms of

treatment, patient selection and outcome for

treated patients

• Assignment 2 & Group Assignment

Wednesday 22nd March 2006

Hospital

10:30 am


– Students #7, #8 & #9


Week 10


Hospital

10:30 am


– Students #10, #11 & #12


Week 11

Wednesday 5th April 2006

4:30 – 7:30 pm

• Biology & Pharmacology

o Pharmacology / Drug Eluding

Advance reading: Appropriate supplementary notes will be provided at the beginning of the lecture

Lecture content: Pharmacology: the science and study of drugs. Basic pharmacological terminology & principles. Pharmacokinetics and pharmacodynamics. Drug absorption, distribution, metabolism and elimination. Toxicology: the study of poisons and their effects on the body. Xenobiotics and xenobiotic metabolism. Phase I and II reactions. The drug development process. Pre-clinical and clinical studies, pharmacological and toxicological assessments undertaken during pre-clinical & clinical trials. Drugs delivered as part of a medical device.

Recommended text: Lecture notes & appropriate supplementary reading will be provided during the lecture.

Learning outcomes: Overview understanding of the basic

principles of the disciplines of pharmacology and toxicology. Overview understanding of terminology such as pharmacokinetics, ADME and pharmacodynamics

Overview understanding of the drug development process and where/how/why


pharmacological/toxicological studies are undertaken during pre-clinical and clinical trials.


Hospital

10:30 am


- Students #1, #2, #3, #4, #5 & #6

• Radiology visit

- Students #7, #8, #9, #10,#11 & #12


Week 12


4:30 – 7:30 pm

• Biology & Pharmacology

o Cell biology

Advance reading: Essential Cell Biology: An Introduction to the Molecular Biology of the Cell: Bruce Alberts, Dennis Bray, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts and Peter Walter, ISBN 0–8153–2045–0 1998

The Virtual Cell Web Page: http://personal.tmlp.com/Jimr57/textbook/chapter3/chapter3.htm

Lecture content: Introduction to Cells, How Cells Obtain Energy from Food, Cell Membrane, Cell Communication, Cell Division and Cell Death, Drug Delivery Across Membranes.

Recommended text: The Alberts et al. text is superb but is undoubtedly in far greater detail than is required for this course. I will provide Power Point Slide copies and references to Web sites that should prove more immediate.

Learning outcomes: An understanding of cells as the functional units of life. Understanding of the importance of cell membrane structure as the cellular gatekeeper. An appreciation of the cell cycle and of the role of disturbances in cell cycle control in cancer, cell death and cell suicide.


http://personal.tmlp.com/Jimr57/textbook/chapter3/chapter3.htm

http://personal.tmlp.com/Jimr57/textbook/chapter3/chapter3.htm


Hospital

10:30 am


- Students #7, #8, #9, #10, #11& #12

• Radiology visit

- Students #1, #2, #3, #4,#5 & #6


Week 13


4:30 – 7:30 pm

• Basic Immunology

Recommended Text: Immunobiology: The immune system in Health and Disease: Janeway, C.A., Jr.,Travers, P. Walport,M., and Capra, J.D. Fifth Edition 2004. Current Biology/Garland London.

Lecture content: Concept of immunity, Natural & Acquired Immunity, Active and Passive Immunity, Cells and Organs of the Immune System, Cell and Antibody Mediated Immunity,

Learning Outcomes: An understanding of the components of

the immune system.


Week 14


4:30 – 7:30 pm

• Immune Responses

Recommended Text: Immunobiology: The immune system in Health and Disease: Janeway, C.A., Jr.,Travers, P. Walport,M., and Capra, J.D. Fifth Edition 2004. Current Biology/Garland London.

Lecture content: Cells of the Immune system, B cells and Antibody Synthesis, T Cells and Immune Regulation, Vaccination, Immune Response to Grafts & Implants.

Learning Outcomes: An appreciation immune responses and

an understanding of immune reactions to grafts and implants.


Week 15

Tuesday 2nd May 2006

Medical Device Company

3.30 – 4.30 pm

• End of program tutorial

• Formal feedback


Week 16

Friday 9th June 2006

University of Limerick

• Written Assessment 10 – 12.30 am

• Vivas 2 – 5 pm


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