Apoptosis. Necrosis and Apoptosis Apoptosis Morphological.

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Apoptosis

Transcript of Apoptosis. Necrosis and Apoptosis Apoptosis Morphological.

Page 1: Apoptosis. Necrosis and Apoptosis Apoptosis Morphological.

Apoptosis

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Necrosis and Apoptosis

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Apoptosis Morphological

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Morphological

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Necrosis Biochemical

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Apoptosis Biochemical

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Agarose gel electrophoresis of DNA isolated from promyelocytic leukemia cells (HL-60) were either untreated (Lane 1) or treated with 0.5 mg/ml actinomycin D (Lane 2). DNA Markers (M) were electrophoresed as a base pair reference.

DNA ladder

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nucleosome

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FACS DNA

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Anexin V

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Anexin V

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Necrosis physical

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Apoptosis physical

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Physical significance

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3. Detection of Apoptosis

• Morphological

• DNA electrophoresis

• DNA 断裂的原位末端标记 TUNEL 测定法, Terminal deoxynucleotid

yl transferase(TdT)-mediated dUTP end labeling ,末端脱氧核苷酸移换酶介导的 dUTP缺口末端标记测定法

• Flowmetery

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3.Regulation of Apoptosis

⑴ Genes for proliferation

c-myc

ras

⑵ For survival

bcl-2

c-kit

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⑶ proliferation inhibitors

p53

Rb

⑷ death promotors

Bax

ICE

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4.p53 and apoptosis

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2002 Press Release

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Laureates

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Ap-overview

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