APLA SYNDROME

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Phospholipid Antibody Syndrome Myriad Presentation Dr.Anita Dr.K.S.V.Chalam,Dr.A.Lalitha,D r.A.P.Naveen Kumar,Dr.D.V.N.Sharma, Dr. M.K.Tripathy

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Transcript of APLA SYNDROME

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APLA SYNDROME - Anti Phospholipid Antibody Syndrome

Myriad PresentationDr.Anita

Dr.K.S.V.Chalam,Dr.A.Lalitha,Dr.A.P.Naveen Kumar,Dr.D.V.N.Sharma, Dr. M.K.Tripathy

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• Polyarthritis and rash• Gangrene of tips of fingers• Treated with LMWH and then acitrom• Recovered completely• ANA , DsDNA , Anti Cardiolipin positive• On follow up

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• 28 yr. female• Recurrent abortions• Anti cardiolipin antibodies positive• Started on anticoagulants• Delivered a female baby with LMWH

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ACA SYNDROME

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• 34 yr. female• Polyarthritis and skin rash• Developed swelling of leg• Doppler showed DVT• ANA,DsDNA,Smith and Anti cardiolipin Ab.

positive

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• Presented with septicemia and MODS• Recovered completely except for thrombocytopenia• ANA positive – treated with steroids• After 1 yr. developed swelling of abdomen• U/S s/o Budd Chiari• Investigations confirmed APLA

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• 12 yr. girl• Recurrent abdominal pain• Confirmed as pancreatitis• Later symptoms of rash and arthritis• Investigations for SLE and APLA positive• On immunomodulants and acitrom• Developed CNS lupus and recovered

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• Presented with convulsions• MRI brain – large bleed• Thrombocytopenia• MR Venogram – Sup. Saggital sinus thrombosis• APLA workup positive

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