ANTIMICROBIAL AGENTS ANDCHEMOTHERAPYVOLUME 26 * DECEMBER 1984 * NUMBER 6

Leon H. Schmidt, Editor in Chief (1985)University ofAlabama in BirminghamBirmingham

Herbert L. Ennis, Editor (1987)Roche Institute of Molecular BiologyNutley, New Jersey

Robert L. Hamill, Editor (1985)Eli Lilly & Company, Inc.Indianapolis, Indiana

George A. Jacoby, Jr., Editor (1985)Massachusetts General HospitalBoston

Robert C. Moellering, Jr., Editor (1987)New England Deaconess HospitalBoston, Massachusetts

Christine C. Sanders, Editor (1989)Creighton University School of MedicineOmaha, Nebraska

Peter G. Welling, Editor (1988)Warner-Lambert Co.Ann Arbor, Michigan

John A. Washington II, Editor (1986)Mayo ClinicRochester, Minnesota

EDITORIAL BOARDNorris Allen (1986)Vincent T. Andriole (1984)John P. Anhalt (1984)Bascom F. Anthony (1985)George R. Aronoff (1986)Robert Austrian (1986)Richard H. Baltz (1984)Rashmi H. Barbhaiya (1986)Arthur L. Barry (1986)John D. Bartlett (1984)Michael Barza (1985)John E. Bennett (1984)Richard F. Bergstrom (1985)Gerald P. Bodey (1986)Lawrence E. Bryan (1985)Ward Bullock (1984)Tsun Chang (1986)Anthony Chow (1985)C. Glenn Cobbs (1986)Paul S. Cohen (1986)William A. Craig (1984)Naomi Datta (1984)Lawrence E. Day (1986)William E. Dismukes (1984)R. Gordon Douglas, Jr. (1986)John C. Drach (1984)Theodore Eickhoff (1985)Gertrude B. Elion (1984)

Arthur English (1986)Robert J. Fass (1985)Stuart Feldman (1985)Sydney Finegold (1985)Robert J. Fitzgerald (1986)Martin Forbes (1986)Dale N. Gerding (1985)David Gilbert (1984)Anthony J. Glazko (1984)Irving H. Goldberg (1985)Richard H. Gustafson (1984)Jack Gwaltney (1986)Scott M. Hammer (1986)W. Lee Hand (1986)H. Hunter Handsfield (1986)Maurice W. Harmon (1984)Joseph Hawkins, Jr. (1985)Michael Higgins (1986)Richard Hornick (1986)George Gee Jackson (1986)James H. Jorgensen (1984)William J. Jusko (1986)A. W. Karchmer (1985)Donald Kaye (1985)George S. Kobayashi (1985)Donald J. Krogstad (1986)Felix Leitner (1986)Stephen A. Lerner (1986)

Matthew E. Levison (1984)Stuart B. Levy (1986)Friedrich C. Luft (1984)Joan Lusk (1986)R. Luthy (1986)Francis L. Macrina (1985)Gerald L. Mandell (1986)Gary R. Matzke (1986)George H. McCracken (1984)Gerald Medoff (1986)Michael Miller (1984)Barbara Minshew (1985)Bernard Moss (1984)Thomas P. Moyer (1986)Barbara E. Murray (1984)John D. Nelson (1986)Harold C. Neu (1986)James T. Park (1985)James E. Pennington (1986)T. J. Perun (1986)Lance R. Peterson (1985)Burton M. Pogell (1984)Michael Rein (1986)W. H. G. Richards (1986)Richard Roberts (1985)Ian M. Rollo (1985)Richard Root (1986)John P. Rosazza (1986)

Jon E. Rosenblatt (1985)Merle Sande (1985)W. Eugene Sanders (1984)W. Michael Scheld (1986)Jerome J. Schentag (1985)Raymond F. Schinazi (1986)Fritz D. Schoenknecht (1986)F. C. Sciavolino (1985)William M. Shannon (1986)Charles Shipman, Jr. (1985)Robert W. Sidwell (1984)P. Frederick Sparling (1984)Harold Standiford (1985)David A. Stevens (1986)R. Sutherland (1985)Vera L. Sutter (1984)Morton N. Swartz (1985)Richard B. Sykes (1985)Francis P. Tally (1984)Alexander Tomasz (1985)Ralph Tompsett (1985)Francis L. S. Tse (1986)Michael Waring (1984)Bernard Weisblum (1985)Richard M. Welch (1986)Richard Wise (1986)Lowell Young (1985)Pauline K. W. Yu (1985)

Helen R. Whiteley, Chairman, Publications BoardLinda M. Illig, Managing Editor, Journals

Walter G. Peter III, Director of PublicationsDeborah J. Shuman, Production Editor

Antimicrobial Agents and Chemotherapy (ISSN 0066-4804), an interdisciplinary publication of the American Society for Microbiology,1913 I St., NW, Washington, DC 20006, is devoted to the dissemination of knowledge relating to all aspects of antimicrobial, antiparasitic, andanticancer agents and chemotherapy. Instructions to authors are published in the January issue each year; reprints are available from theeditors and the Publications Department. Antimicrobial Agents and Chemotherapy is published monthly, and the twelve numbers are dividedinto two volumes per year. The nonmember subscription price is $157 per year; single copies are $21. The member subscription price is $31(foreign, $41 [surface rate]) per year; single copies are $7. Correspondence relating to subscriptions, reprints, defective copies, availability ofback issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM PublicationsDepartment, 1913 I St., NW, Washington, DC 20006 (phone: 202 833-9680).

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Author IndexAlcock, Stephen R., 833Alexander, Donald P., 845Allen, Harry R., 802Andrews, J. M., 876Aulicino, Taryn M., 933

Barriere, Steven L., 845Bodey, Gerald P., 941Brajtburg, Janina, 892Brewer, Lois A., 887Brown, Ronald J., 802Buccini, Frank, 850

Calhoun, Patricia, 944Caufield, Page W., 807Cherubin, Charles, 850Chiodini, Rodrick J., 930Citron, Diane M., 947Clark, Donald S., 819Corey, Lawrence, 887Corti, A., 917Coutu, Jessica A., 930Cross, C., 876

Deforest, Denise, 928De Schepper, Paul J., 881Dudley, Michael N., 811

Egger, Hermann-Josef, 898Elberg, Svetlana, 892Eng, Robert H. K., 850Eppstein, Deborah A., 937

Fancher, M. J., 924Fasching, Claudine E., 935Fontijne, P., 829Fraser-Smith, Elizabeth B., 937Friis, Janice M., 802

Gaede, Paul, 819

Gambertoglio, John G., 845Gastaldo, L., 917Geraci, Joseph E., 909Gerding, Dale N., 837, 935Goering, Richard V., 797Goessens, W. H. F., 829Goldstein, Ellie J. C., 947Gombert, Myles E., 933Gwaltney, Jack M., Jr., 928

Hamill, M. Bowes, 793Harris, Cynthia, 837Hayden, Gregory F., 928Hendley, J. Owen, 928Hendrickx, Bea, 881Hickingbotham, J. Mark, 811Hodges, Glenn R., 903Hughes, Carolyn E., 837Hutson, Duane, 944

Indrelie, Jeffrey A., 909Inoue, Matsuhisa, 863Ishikawa, Fumiyasu, 939Itoh, Zen, 863

Jaxel, Christine, 857Jones, Paula G., 941

Kato, H., 841Kemner, John M., 903Kenward, Melvin A., 833Klastersky, J., 870Kobayashi, G. S., 824Kobayashi, George S., 892Koldin, M., 824Kuhrt, M. F., 924

Lafferty, William E., 887Lagast, H., 870Lakings, Duane B., 802

Le Goffic, Francois, 857Lennert, S. D., 924Levi, Joe U., 944Levitz, Robert E., 811Little, J. R., 824Little, K. D., 824Livingstone, Alan, 944

Malinin, Theodore I., 944Marsh, Y. Vivienne, 937Martinez, Octavio V., 944Matsumoto, Joseph Y., 909Matthews, Thomas R., 937McKay, Ian C., 833McKeough, Mark, 819McKinlay, M. A., 924Medoff, Gerald, 892Medoff, Judith, 892Merkal, Richard S., 930Meunier, F., 870Michel, M. F., 829Mitsuhashi, Susumu, 863Moreau, Nicole, 857

Nakaya, Mitsuo, 863Nichol, Kristin L., 935Nightingale, Charles H., 811Nozawa, R. T., 841

Oishi, Kunio, 939Osato, Michael S., 793

Pelletier, Lawrence L., Jr., 815Peterson, Lance R., 837, 935Piccart, M., 870Plut, E., 824

Quintiliani, Richard, 811

Reed, James S., 903Robertson, Fredrika, 819

Ronen, Dvora, 913Rosenbaum, Beverly, 941

Sanders, Christine C., 797Sanders, W. Eugene, Jr., 797Schlessinger, David, 892Smith, Sharon M., 850Somma, S., 917Spruance, Spotswood L., 819Stoeckel, Klaus, 898Sugibayashi, Kenji, 819Suzuki, Tomoaki, 863Swabb, Edward A., 941

Teitz, Yael, 913Thayer, Walter R., 930Tjandramaga, Budya, 881

Van Hecken, An, 881Van Kruiningen, Herbert J., 930Van Laethem, Y., 870Van Melle, Pascale, 881Verbesselt, Rene, 881Verbist, Ludo, 881Verhaegen, Jan, 881

Wakayama, Sachio, 939Wannemuehler, Yvonne, 807Washington, John A., II, 909Weerts, D., 870Weidekamm, Erhard, 898Werner, Vicki, 797Wilhelmus, Kirk R., 793Wilson, Walter R., 909Wise, R., 876Worley, Samuel E., 903

Yokota, T., 841

Zeppa, Robert, 944Ziegler, Walter H., 898

ACKNOWLEDGMENT

The following have served as invited special reviewers for the journal during 1984, and their help is greatly appreciated.

N. R. BachurStephen BarnesArnold BayerW. H. BeggsWilliam M. BennettJohn BesseKaren K. BironPatrick J. BrennanR. Wallace BrockmanDavid A. BrodieArthur BrownBob BrummettIan ChopraG. Robert CoatneyWilliam A. CramerB. Louise CrandallGeorge Cuchural, Jr.Arnold L. DemainRobert B. DiasioGeorge L. DrusanoR. G. EagonD. I. Edwards

Richard P. ElanderGeorge EliopoulosD. S. FeingoldP. A. FurmanJ. A. FyfeJohn N. GalgianiH. E. GillelandFrances D. GillinMelvin R. GlickP. GoldmanDonald GoldmannRobert S. GordeeC. J. HackbarthMargaret HammerschlagRobert E. W. HancockWilliam L. HansonFrederick G. HaydenGladys L. HobbyP. HochsteinP. HoeprichC. E. HoffmannDavid Hooper

Nilda JacobusDavid JanickeG. JuG. KaczorowskiRobert KammerJ. KapusnikJohn E. KasikGeorge E. KennyJordan KoniskyDennis KopeckoR. LesterH. B. LevineJoseph LiGesina L. LongeneckerJ. Joseph MarrAntone MedeirosMarcia MillerHarry MobleyP. MorrelRoy MundyHenry W. MurrayBurt Myers

Hiroshi NikaidoThomas F. O'BrienDennis J. PillionPhilip PizzoRichard PlattDavid W. PlothA. PortnerRobin D. PowellStephen W. QueenerEdward D. RalphL. Barth RellerJack S. RemingtonFrank RhameMark RichmondGlenn D. RobertsAllan RonaldEugene D. RosenblumGordon RossRobert RubinLee SabathDennis SchabergStephen Schimpff

S. ShadomyB. G. SprattAnne SummersM. G. TauberDiane TaylorCharles ThoenR. VinceK. VosbeckRichard J. Wallace, Jr.Lawrence G. WayneRobert WeaverPeter WellerBurt WestD. C. WhiteC. C. WhitneyRobert L. WolenJohn WolfsonDavid J. WylerRaymond C. YaoStephen Zinner

AUTHOR INDEX

VOLUME 26

Adams, Cynthia, 401Adams, Katherine F., 31Ahmad, Fareeduddin, 424Alarc6n, Balbino, 702Alcock, Stephen R., 833Aldridge, Kenneth, 145Aldridge, Kenneth E., 410Alexander, Donald P., 845Allegra, Carmen J., 656Allen, Harry R., 802Alonso, A. G6mez, 787Amico, Leonard A., 778Amos, William P., 601Andrews, J. M., 876Ansehn, Steffan, 22Anthony, Bascom F., 689Araujo, Visi, 766Argast, Manfred, 263Arioli, Vittorio, 462Arnaud, Jean-Pierre, 428Aronoff, Stephen C., 318, 580Auger, Francois, 686, 775Aulicino, Taryn M., 933Ayisi, Nana K., 762

Bach, Phillip R., 314Baggett, Jane W., 322, 730Bailey, Judith M. G., 13Baker, Robert L., 231Baltch, Aldona L., 417, 519Bannatyne, R. M., 604Bansal, Madhu B., 606, 785Barefoot, Susan F., 328Baron, P., 335Barriere, Steven L., 845Barry, Arthur L., 949Bartley, Elizabeth Ann, 493Barza, Michael, 104, 170Basker, M. J., 734Bassey, Christine M., 417Bastow, Kenneth F., 283Bathala, M. S., 119Baughn, Robert E., 401Bayer, Arnold S., 220, 260Beaubien, Arthur R., 87Beck, Christoph F., 263Beggs, William H., 699Beretta, Grazia, 462Berry, Alison, J., 730Bertram, Miriam A., 272, 277Bihl, Julie A., 585Binswanger, U., 368Bitsura, Jo Ann M., 160Blair, Andrew D., 535Blaser, Martin J., 351Blickle, Jean-Frederic, 428Blumer, Jeffrey L., 78, 318Bodey, Gerald P., 295, 421, 455,941

Bohe, Montserrat, 766Bolivar, Ricardo, 295Bonet, Montserrat, 766Bopp, B. A., 431Borgers, Marcel, 527Brady, Eileen, 65Brajtburg, Janina, 892Bregman, Dennis J., 101

Brewer, Lois A., 887Brion, Nils, 373Brisson, Anne-Marie, 513Britt, Eugene M., 97Brogard, Jean-Marie, 428Brown, Ronald J., 802Bruckner, David A., 277Brumfitt, W., 757Bryan, L. E., 181, 250, 485Bryan, Larry E., 665Bryskier, Andre, 513Buccini, Frank, 850Burns, Noah J., III, 466Bustamante, Carlos, 715Bustamante, Carlos I., 678Busuttil, Ronald W., 673

Caine, Virginia A., 683Calder, Margaret A., 424Calhoun, David L., 364Calhoun, Patricia, 944Canonico, Peter G., 476Caplan, Ellis S., 686Carbon, Claude, 373Carr, Bernice, 280Carrasco, Luis, 702Caufield, Page W., 807Cavalieri, Stephen J., 97Cavalleri, Bruno, 462Chaffin, Donald O., 235Chambers, Henry F., 61Chan, Lydia, 539Chandrasekar, Pranatharthi H.,

280Chen, Ming S., 778Chen, P. T., 599Chen, Pat T., 441Cheng, Yung-Chi, 283Cherubin, Charles, 42, 850Cheung, R., 604Cheung, Rose, 91Chin, Nai-Xun, 174Chiodini, Rodrick J., 930Chiou, Jwo-Farn, 283Chuah, See-Kean, 606Chung, Menger, 522Citron, Diane, 343Citron, Diane M., 947Clark, Donald S., 819Cleary, Timothy, 145Clyde, Wallace A., Jr., 591Coen, Donald M., 382Cofsky, Richard D., 110Cole, M., 335Commes, J. R., 787Conley, Patricia E., 417, 519Connamacher, R., 306Contrepois, Alain, 373Coovadia, Yacoob M., 770Corey, Lawrence, 887Corti, A., 917Couch, Robert B., 200Counts, George W., 535Coutu, Jessica A., 930Crane, Lawrence R., 557Creger, Richard J., 643Cremieux, Anne-Claude, 373

Cross, C., 876Croughan, Michael J., 424Cuchural, George J., Jr., 145

Daikos, George K., 245Daldoss, C., 289Dame, John B., 656Dandu, Vijay R., 775Dean, A. V., 119de Clercq, Erik, 155De Clercq, Erik, 762Deforest, Denise, 928DeHertogh, Deborah, 575Delaportas, Dino, 715Demetriades, J. L., 707Dent, J., 17, 208De Schepper, Paul J., 881Desjardins-Giasson, Suzanne, 87Devlin, Richard G., 493DeYoung, Donald R., 94Dhruv, R., 20DiGiore, Charles, 522Dolzani, Lucilla, 405Dominguez-Gil, A., 787Douglas, Gail F., 310Douzinas, Emanouel, 245Drake, James C., 656Drezner, A. David, 347Dromer, Francoise, 373Drusano, George L., 339, 388,

678, 686, 715, 775duBouchet, Lorraine, 110Dubovi, Edward J., 591Dudley, Michael N., 347, 811Duma, Richard J., 730DuPont, Herbert L., 160Dutschman, Ginger E., 283

Easton, Christopher J., 358Edmondson, R. A., 734Egger, Hermann-Josef, 898El-On, Joseph, 745Elberg, Svetlana, 892Elmer, Gary W., 552Eng, Robert H. K., 42, 850Eppstein, Deborah A., 937Ericsson, Charles D., 160Espinel-Ingroff, Ana, 5Eustice, David C., 53Everett, D. W., 119

Faergemann, Jan, 773Fainstein, Victor, 295, 421, 455Falkowski, Andrew J., 643Fancher, M. J., 924Faro, Sebastian, 410Farr, Barry M., 31Fasching, Claudine E., 935Fass, Robert J., 231, 660Ferber, F., 707Ferrer, Magin, 766File, Thomas M., 652File, Thomas M., Jr., 310Finegold, Sydney M., 145, 343Fiore, Cynthia, 170Fiore, Dario, 686, 775Fitzpatrick, Brian, 339, 388

Fitzpatrick, Brian C., 228Fleming, H. Edward, Jr., 382Fong, I. W., 115Fontijne, P., 829Forrest, Alan, 686, 715Forrester, Gene D., 594Foulds, George, 683Fourtillan, Jean-Bernard, 513Frank, Karl B., 283Franklin, Italia, 757Fraser-Smith, Elizabeth B., 937Freundt, E. A., 112Friedhoff, L. T., 20Friedman-Kien, Alvin E., 65Friis, Janice M., 802Fuksa, Milan, 419Fuster, Armando Pichardo, 741

Gabay, Elizabeth, 343Gaede, Paul, 819Gal, Joseph, 303Galanakis, Nearchos, 245Galgiani, John N., 108, 364Galindo, Emma, 160Gambertoglio, John G., 845Garcia, Ibrahim, 421Garcia, J., 787Gastaldo, L., 917Gatell, Jose M., 766Gay, J. Douglas, 94Gebhart, Ronald J., 5Gengo, Francis M., 228Gennaro, Renato, 405George, W. Lance, 343Georgopoulos, Apostolous, 149Geraci, Joseph E., 909Geratz, J. Dieter, 591Gerding, Dale N., 214, 256, 837,

935Giamarellou, Helen, 245Gilbert, Brian E., 200Gilbertson, J. R., 306Glette, Johan, 489Glew, Richard H., 378Godfrey, A. J., 181, 485Goering, Richard V., 797Goessens, W. H. F., 829Goi, Hitoshi, 722Goldman, Anne I., 136Goldstein, Ellie J. C., 947Gombert, Myles E., 933Gonzalez, Marco A., 741Gonzalez, Maria Eugenia, 702Gorbach, Sherwood L., 145Gordon, Paul, 74Grady, Deidre, 757Grant, Christopher, 546Gravallese, D. A., 707Graves, Patricia M., 656Graziosi, Giorgio, 405Greenblatt, Charles L., 745Grill, Susan P., 283Guenthner, Sharon H., 268Guibert, J., 368Gundrum, JoAnn, 408Gural, Richard, 522Gurusiddaiah, S., 394

i

ANTIMICROB. AGENTS CHEMOTHER.

Gwaltney, Jack M., Jr., 31, 928Gyr, K., 35

Haase, David A., 481Hall, Wendell H., 192Hamill, M. Bowes, 793Hamilton-Miller, J. M. T., 757Hancock, Robert E. W., 48, 539,

546Handsfield, H. Hunter, 683Haneberg, Bjmrn, 489Hara, Tetsuro, 722Harakeh, Hani, 426Harding, Godfrey K. M., 481Harris, Cynthia, 837Harrod, Linda G., 292Hashimoto, Tadayo, 74Hatlelid, L., 181Hattori, Yukio, 187Hay, Mary, 295Hayden, Frederick G., 31Hayden, Gregory F., 928Helsel, Valerie L., 660Helstad, Arlan G., 601Hendley, J. Owen, 928Hendrickx, Bea, 881Heppleston, Carol, 13Hickingbotham, J. Mark, 811Hill, G., 335Hill, Gail, 145Hirano, Fumiya, 722Hrianinen, Ulla, 69Ho, D. H. W., 455Ho, Dah Hsi, 421Hodges, Glenn R., 903Hof, Herbert, 498Hollick, Gary E., 408Hooton, Thomas M., 535Hsieh, J. Y.-K., 707Hsiung, G. D., 354Hudes, Ellen, 493Huggins, John W., 476Hughes, Carolyn E., 837Hughes, Herbert, 762Hughes, Walter T., 436Hull, Sheila I., 594Huovinen, Pentti, 82, 300Husson, M., 224Hutchinson, Margaret A., 601Hutson, Duane, 944Huupponen, Risto K., 300

lannini, Paul, 145Ikeda, Chieko, 204Ikeda, Tomiki, 139Iliffe, A., 757Indrelie, Jeffrey A., 909Inoue, Matsuhisa, 863Inouye, Shigeharu, 722Ishikawa, Fumiyasu, 939Ita, C. E., 119Ita, Callixtus E., 127, 132Itoh, Zen, 863

Jacobs, Geoffrey P., 745Jacobs, Michael R., 580Jacobus, Nilda V., 104, 145Jadavji, Taj, 91Jadeja, Leena, 295Janney, Aillen, 410Janssen, Paul A. J., 527Jaxel, Christine, 857Jimenez de Anta, Maria T., 766

Jin, Byoung Won, 270Johenning, Sharon, 580John, Joseph F., Jr., 781Johnson, Lynette A., 310Jones, K. H., 707Jones, Paula G., 455, 941Jones, Ronald N., 949

Kadosawa, Hiroyuki, 722Kaley, Lori, 65Kanno, Harushige, 789Kantarian, Hagop, 426Kater, Nancy A., 101Kato, H., 841Kawaharajo, Katsumi, 722Kazuno, Yuzo, 722Keating, Michael, 295Keim, G. R., 132Kemner, John M., 903Kendal, Alan P., 101Kennedy, James K., 481Kenward, Melvin A., 833Kerkering, Thomas M., 322Kerridge, David, 570Kersey, John, 136Khan, Noroze J., 585Kim, H., 446Kim, Hong-Ki, 522Kim, Kwang Sik, 689Kirby, Barbara D., 343Kirsi, Jorma J., 466Klaenhammer, Todd R., 328Klastersky, J., 224, 870Klein, Richard J., 65Kline, Berry J., 322Klinge, Erik, 69Klinger, Jeffrey D., 318Knight, Vernon, 200, 450Knott, S. J., 734Knowles, Jeremy R., 358Kobayashi, Fujio, 187Kobayashi, G. S., 824Kobayashi, George S., 892Koldin, M., 824Komiya, Masayuki, 204Konishi, Konosuke, 647Koshi, Tomoyuki, 187Krajden, Sigmund, 419Kripalani, K. J., 119Kuhrt, M. F., 924Kurzynski, Terrence A., 601

Laber, Georg, 149Labia, R., 335Labthavikul, Pornpen, 174Lacroix, Jean-Michel, 694Lafferty, William E., 887Lagast, H., 870Laishley, Edward J., 665Lakings, Duane B., 802Lam, Charles, 149Lam, Kitty, 260Lamothe, Franqois, 694Landesman, Sheldon H., 110Langkamp, H. H., 306Latham, Robert H., 670Lavillaureix, Jean, 428Lawrence, L., 119LeBlanc, Barbara, 421Lecaillon, J. B., 368Lee, Albert, 419LeFrock, Jack L., 280, 585Le Goffic, Franqois, 857

Lennert, S. D., 924Lerner, A. Martin, 557Lesko, Lawrence J., 775Leslie, James, 388, 715Lev, Meir, 211Levi, Joe U., 944Levitz, Robert E., 811Leyhausen, G., 752Lin, C., 446Lin, Chin-Chung, 522Lindberg, Raija L. P., 300Little, J. R., 824Little, K. D., 824Livingstone, Alan, 944Lockerby, Deirdre L., 665Lockley, R., 17Lockley, R. M., 208Loebenberg, D., 446Loh, Bernadette, 546Lovering, A. M., 10Low, Henry B., 347Lozano, F., 787

MacGregor, Rob Roy, 715Machinist, J. M., 431Mack, D. G., 26Mack, Karl D., 235MacLeod, Catherine M., 493Madsen, P. O., 20Maidhof, A., 752Malinin, Theodore I., 944Malouin, Frangois, 694Mafia, Juan, 766Mandel, Laura J., 563Mannisto, Pekka T., 69Mantyla, Raiji, 69Manocchio, Marian, 689Marco, A., 446Marco, Aliceann, 522Marier, Robert L., 410Marifio, E. L., 787Marks, Melvin 1., 196Marsh, Y. Vivienne, 937Marshall, Rosemarie, 785Martinez, Octavio V., 944Marzari, Roberto, 405Masson, J. M., 335Matsui, Hidefumi, 204Matsumoto, Joseph Y., 909Matthews, Thomas R., 937Mattila, Jyrki, 69Mayo, Donald R., 354McClung, Harvey W., 200McCracken, George H., Jr., 583McCredie, Kenneth, 295McCutchan, Thomas F., 656McEnroe, Amy S., 507McGlave, Philip, 136McGrattan, Marie A., 673McKay, Ian C., 833McKeough, Mark, 819McKernan, Patricia A., 466McKinlay, M. A., 924McLeod, Dwight T., 424McLeod, R., 26Medoff, Gerald, 892Medoff, Judith, 892Meeker, F. S., Jr., 119Mendelman, Paul M., 235Mendiola, Jaime G., 160Merigan, T. C., 599Merigan, Thomas C., 441Merkal, Richard S., 930

Messidi, Morsi El, 245Mett, H., 35Meunier, F., 870Michel, M. F., 829Migdalof, B. H., 119Migdalof, Bruce H., 127, 132Miller, Michael H., 563Millerioux, Laurette, 513Milne, Debra A., 557Minshew, Barbara H., 670Mitsuhashi, Susumu, 187, 863Miyauchi, Keinosuke, 722Mohn, Mary Lou, 214Moisen, Salvador Duran, 741Moody, Julia A., 214, 256Moody, Marcia R., 388Moore, Rebecca V., 200Moore, Richard A., 539Moreau, Nicole, 857Morgan, Donna, 160Morrison, Christine J., 74Morrison, Joan O., 220Mullenax, Jean G., 441Muller, Gregory, 266Muller, W. E. G., 752Mulligan, Maury E., 343Murphy, Ellen, 563Murray, Byron K., 466Musher, Daniel M., 401Myers, Carolyn M., 78

Nakata, Lisa M., 303Nakaya, Mitsuo, 863Nakayama, Koji, 283Nassar, Nabil T., 426Nelson, John D., 578Neu, Harold C., 174Nichol, Kristin L., 935Nightingale, Charles H., 347, 811Nilsson, Lennart, 22, 501Nishino, Takeshi, 722Nkam, M., 289Norden, Carl W., 597Norrby, S. R., 707North, James A., 466Nozawa, R. T., 841

O'Brien, Cheryl A., 318Oda, Takeshi, 187O'Hara, Koji, 250O'Keefe, J. Paul, 145, 275Oishi, Kunio, 939Opfer, Bonnie J., 192Orikasa, Yoshinori, 722Osato, Michael S., 793Otero, M. J., 787Ozawa, Yukio, 647

Painter, Barbara, 741Pallanza, Rosa, 462Papoulias, George, 245Pasternak, Jacyr, 455Patriarca, Peter A., 101Patterson, Pat M., 322Pavuk, Rosemary A., 378Payne, John A., 493Peacock, James E., 575Peeters, Martine, 608Pelletier, Lawrence L., Jr., 815Pennington, James E., 1Peterson, Lance R., 214, 256,

837, 935Peterson, Phillip K., 136

ii AUTHOR INDEX

AUTHOR INDEX iii

Petrikkos, George, 245Piccart, M., 870Pierson, Carl, 145Piot, Peter, 608Platt, D., 306Platt, Thomas B., 730Plut, E., 824Polk, Ron E., 322Ponsford, R. J., 734Ponte, M. C., 39Prabhala, Rao H., 785Prober, Charles G., 91Pulkkinen, Leena, 82

Quakyi, Isabella A., 656Quarles, John M., 200Quinn, D., 431Quintiliani, Richard, 347, 811

Rabin, Harvey R., 665Radwanski, Elaine, 522Raff, Martin J., 292Ramsaroop, Ugendri, 770Ramsay, Norma K. C., 136Rao, Bhavani, 785Rasmussen, L. E., 599Rasmussen, Lucy, 441Reed, James S., 903Reed, Michael D., 318Reeves, D. S., 10Regnier, B., 289Reller, L. Barth, 351Rhame, Frank, 136Richmond, Shirley J., 13Rieffert, Martina, 498Rivera, Giselle, 715Roberts, Glenn D., 94Robertson, Fredrika, 819Robins, Roland K., 466, 476Rodriguez, J. M., 787Rodriguez, J. R. Barbero, 787Rogers, J. D., 707Romeo, Domenico, 405Ronald, Allan R., 481Ronen, Dvora, 913Rosenbaum, Beverly, 941Rosenthal, Karen U., 591Rossan, Richard N., 611Rouan, M. C., 368Rubens, Craig E., 235Rudin, Jennifer E., 597Rudrik, James T., 97Ryan, Patricia, 388

Sacks, Stephen L., 762Saino, Yushi, 187Saito, Hajime, 164, 270Salstrom, Sara-Jane, 310Sandberg, Sverre, 489Sande, Merle A., 61Sanders, Charles V., 410Sanders, Christine C., 797

Sanders, W. Eugene, Jr., 797SanMiguel, Juan Garcia, 766Sato, Katsumasa, 270Sato, Koichiro, 578Savoini, Adriano, 405Schell, Ronald F., 585Schentag, Jerome J., 228Schiff, Jill B., 1Schimpff, Stephen C., 339, 388,

715Schlessinger, David, 892Schmidt, L. H., 611Schoeller, J. P., 368Schoenknecht, Fritz D., 670Schuessler, David, 522Schutze, Eberhard, 149Schweizer, Ernst H., 498Schwertschlag, Ullrich, 303Scotti, Roberto, 462Seibert, G., 752Selen, Arzu, 741Serran6, Domenico, 405Shadomy, Smith, 5Shanholtzer, Carol J., 214Shaw, J. M., 119Shaw, James M., 127, 132Shelton, Sharon, 578Shinners, Ellen M., 597Sica, Domenic A., 322Signs, Steven A., 652Sikes, R. Keith, 101Singh, S. K., 394Singhvi, S. M., 119Singhvi, Sampat M., 127, 132Slocombe, B., 734Small, Gloria J., 1Smith, Arnold L., 235Smith, Bessie L., 436Smith, Bruce R., 280Smith, John D., 101Smith, Raymond P., 417, 519Smith, Sharon M., 42, 850Smith, Susan M., 730Sobel, Jack D., 266Solberg, Claus O., 489Somma, S., 917Soren, Lars, 501Soriano, F., 39Speelman, Dan J., 778Spruance, Spotswood L., 819Stamm, Walter E., 670Standiford, Harold C., 339, 388,

678, 715Steele, Lorraine C., 594Steigbigel, Neal H., 563Sticht-Groh, Veronica, 498Stoeckel, Klaus, 898Stull, Terrence L., 235Stutman, Harris R., 196Sugibayashi, Kenji, 819Summersgill, James T., 292Sun, Chong-Son, 450

Sundaram, K. Soma, 211Sunstrum, James C., 557Suzuki, Tomoaki, 863Swabb, Edward A., 196, 455,

730, 941Swenson, Jana M., 594Symchowicz, S., 446Symchowicz, Samson, 522Szoka, Francis, 170

Taber, Harry W., 507Tachibana, Akio, 204Takahashi, Kohki, 789Talhouk, Akram, 426Tally, Francis P., 104, 145Tan, James S., 310, 652Tangtatsawasdi, Paktiya, 388Tashjian, Louise, 575Tatarowicz, Walter A., 275Tatem, Beverly, 339, 388, 715Tatem, Beverly A., 678Tazuke, Shigeo, 139Teitz, Yael, 913Thadepalli, Haragopal, 606, 785Thayer, Walter R., 930Thomas, Marion L., 583Thompson, Kenneth D., 275Thomson, Margaret J., 481Thornsberry, Clyde, 949Threlkeld, Norma, 583Tidwell, Richard R., 591Tjandramaga, Budya, 881Toivanen, Paavo, 82Tomasz, Alexander, 414Tomioka, Haruaki, 164Tomkins, K. B., 115Toothaker, Roger D., 552Tremblay, Claude, 170Tuomanen, Elaine, 414Turck, Marvin, 535Twitty, James A., 781

Urias, Barbara A., 481Uribe, Francisco, 741Uwaydah, Marwan, 426

Vachon, F., 289Van Cutsem, Jan, 527Van de Ven, Marie-Anne, 527Van Dyck, Eddy, 608Van Gerven, Frans, 527Van Hecken, An, 881Van Kruiningen, Herbert J., 930Van Laethem, Y., 224, 870Van Melle, Pascale, 881VanWyck, David B., 108Vartivarian, Shahe, 426Venezia, Richard A., 408Verbesselt, Rene, 881

Verbist, Ludo, 881Verhaegen, Jan, 881Vernam, Kathryn, 493Vosbeck, K., 35Vuorio, Eero, 82

Wakayama, Sachio, 939Walker, B. D., 119Wall, Richard A., 762Wallace, Richard J., Jr., 594Wang, Wen-Lan L., 351Wannemuehler, Yvonne, 807Washington, John A., II, 909Watanabe, Tadahiro, 722Webberly, M., 17, 208Weber, Steven J., 585Weerts, D., 870Weidekamm, Erhard, 898Weidner, L. L., 707Weinstein, S. H., 119Welling, Peter G., 741Welsh, Judith A., 656Wenzel, Richard P., 268Werner, Vicki, 797Whelan, William L., 570White, L. O., 10White, S. J., 734Wilhelm, James M., 53Wilhelmus, Kirk R., 793Wilson, Samuel Z., 200, 450Wilson, Walter R., 909Winkelmann, G., 112Winston, Drew J., 673Wise, R., 17, 208, 876Witztum, Eli, 745Wolff, M., 289Wong, Patrick G. W., 48Wong, Sallene, 250Wood, Lindsey V., 160Worley, Samuel E., 903Wu, David H., 519Wyde, Philip R., 450

Yamabe, Shigeru, 580Yamaguchi, Hideki, 139Yokota, T., 841Yoneyama, Toshimi, 164Yoshida, Takashi, 722Young, Lowell S., 272, 277Yu, Victor L., 575

Zacchei, A. G., 707Zak, O., 35Zak, Otokar, 498Zamora, Laura, 766Zeleznik, Dolores, 670Zeppa, Robert, 944Ziegler, Walter H., 898Zuravleff, Jeffrey J., 575

VOL. 26, 1984

SUBJECT INDEX

VOLUME 26

A-16686in vitro activity, 462

Acholeplasma spp.herbicolin A, 112

Actinoplanes teichomyceticusteicoplaninmechanism of action, 917

Activity enhancementduodeno-pancreatic secretions, 35

Acyclovircombinations

arabinosyl hypoxanthine, 557interferon, 557polyriboinosinic acid-polyribocytidy-

lic acid complex, 557vidarabine, 557

herpes simplex virus, 887lymphocyte transformation response,

887AMA- 1080

see Ro 17-2301Amifloxacin

aminoglycoside-resistant P. aeruginosa,275

comparative activityampicillin, 275aztreonam, 275cefotaxime, 275cephalexin, 275cinoxacin, 275gentamicin, 275

gentamicin-resistant bacteria, 781Amikacin

combinationsazlocillin, 256aztreonam, 224cefamandole, 378cefoperazone, 224cefotaxime, 378cefoxitin, 378cephalothin, 378mezlocillin, 256moxalactam, 378piperacillin, 378ticarcillin, 339

comparative activityceftazidime, 339

E. coli, 224Enterobacteriaceae resistance, 378K. pneumoniae, 224P. aeruginosa, 224radioimmunoassay, 87S. marcescens, 224

D-Amino acidsP-lactams, 414

Aminoglycosidesacetylating enzymes, 10antibacterial activity

potentiation by lipids, 306combinations

P-lactams, 535comparative activity

fortimicins, 857cross-resistance

P-lactams, 797quinolones, 797

E. coli resistanceMIC determinations, 501regrowth, 501

endocarditis, 909enterococci, 909

eucaryotic protein synthesis, 53M. avium-intracellulare complex, 841mechanisms of action, 53multiple resistance, 797P. aeruginosa

outer membrane, 546resistance, 250

synergyimipenem, 909P-lactams, 535

Amoxicillincombinations

clavulanate, 580YTR 830, 580

Amphotericin Bactivity enhancement

tetracycline analogs, 837Aspergillus spp., 837candidiasis, 170high-pressure liquid chromatography,

314L cells

permeabilization, 892stimulation, 892toxicity, 892

liposome-intercalated, 170pharmacokinetics

animals, 446compared with Sch 28191, 446

specific antibodies, 824Ampicillin

aminoglycoside-resistant P. aeruginosa,275

combinationssulbactam, 580

comparative activityamifloxacin, 275

E. coli, 689H. influenzae

interactions, 91resistance, 235

rifampin interaction, 91traveler's diarrhea, 160

Anaerobic bacteriaciprofloxacin, 785

Antibioticsamphotericin B-specific, 824

Antiplaque agentsA-16686, 462

Antipseudomonal agentscomparative activity

enoxacin, 417P. aeruginosa, 417

Apalcillinbiliary elimination, 428comparative activity

piperacillin, 660E. corrodens, 947gram-negative bacilli, 660P. aeruginosa, 408pharmacokinetics, 578pneuimococcal meningitis, 578

Arabinosyladenineherpes simplex virus, 382

Arabinosyl hypoxanthinecombinations

acyclovir, 557interferon, 557polyriboinosinic acid-polyribocytidy-

lic acid complex, 557vidarabine, 557

herpes simplex virus, 557Arenavirus

ribavirin, 476selenazofurin, 476tiazofurin, 476

Aspergillosisitraconazole, 527

Aspergillus spp.amphotericin B enhancement

tetracycline analogs, 837AT-2266

see enoxacinAtropine

herpesvirus, 702Azlocillin

B. fragilis, 606bone penetrationenhancement by probenecid, 292

combinationsamikacin, 256aztreonam, 519cefoxitin, 256ceftizoxime, 256moxalactam, 256

P. aeruginosa, 519Azone

herpes simplex virus, 819trifluorothymidine penetration, 819

Aztreonamaminoglycoside-resistant P. aeruginosa,

275Bacteroides spp., 39cancer patients

effect on flora, 941combinations

amikacin, 224azlocillin, 519cefoperazone, 224piperacillin, 519

comparative activityamifloxacin, 275cefotaxime, 39

concentration in prostatic tissue, 20difficult-to-treat infections, 245E. coli, 39, 224enterococcal superinfection, 280kinetics

cirrhosis, 493K. pneumoniae, 224P. aeruginosa, 224, 519penetration into cerebrospinal fluid, 730pharmacokinetics, 1%, 455posttreatment follow-up, 245radiolabeled

disposition in animals, 119distribution in rat, 127, 132

S. marcescens, 224

Bacillus subtiliscytochrome aa3 concentration, 507streptomycin accumulation, 507

Bacterial infectionsceftazidime, 318imipenem, 673moxalactam, 310P. aeruginosa, 673piperacillin, 310timentin, 310

BacteriocinsL. acidophilus lactacin B, 328

iv

VOL. 26, 1984 SUBJECT INDEX v

Bacteroides bivius,-lactamase, 6943-lactam-susceptible, 694

Bacteroides fragilisazlocillin, 606clavulanic acid, 606

Bacteroides fragilis groupantimicrobial susceptibility, 145

Bacteroides spp.aztreonam, 39cefotaxime, 391-lactams, 410penicillin G, 410

Bay o 9867see ciprofloxacin

Bile duct obstructioncefamandole, 944

Bioluminescent assaysC. albicans, 22ketoconazole, 22tioconazole, 22

Bis(5-amidino-2-benzimidazoiyl)methanerespiratory syncytial virus, 591

BMY-28142comparative activitycefmenoxime, 585cefoperazone, 585cefotaxime, 585ceftizoxime, 585moxalactam, 585

Bone marrow transplant patientsduration of empirical therapy, 136

Bordetella pertussiscephalosporin derivatives, 604imipenem, 604

Branhamella catarrhalisbronchopulmonary infections, 424susceptibility, 424

BRL 36650antibacterial properties, 734

(E)-5-(2-Bromovinyl)-2'-deoxyuridineherpes simplex virus, 155, 762monophosphates

herpes simplex virus, 778interaction with thymidylate kinases,

778Vero cells, 778

Bronchopulmonary infectionsB. catarrhalis, 424

Bunyavirusribavirin, 476selenazofurin, 476tiazofurin, 476

Camnpylobacter colinitrothiazole, 498susceptibility patternscomparison with C. jejuni, 351

Campylobacterjejuninitrothiazole, 498susceptibility patternscomparison with C. coli, 351

Cancer patientsaztreonam

effect on flora, 941empirical therapy, 870gram-negative bacillary infections, 870granulocytopenia, 870piperacillin, 295vancomycin, 295WIN 49375, 421

Candida albicansbioluminescent assay, 22flucytosine, 3645-fluorocytosine-resistant, 570intracellular ATP levels, 22ketoconazole, 22membrane damage, 22SM-1213, 74tioconazole, 22, 699UMP pyrophosphorylase activity, 570

Candida parapsilosistioconazole, 699

Candidiasisamphotericin B, 170ornithyl amphotericin methyl ester, 108

Cefamandolebile duct obstruction, 944biliary excretion, 944combinations

amikacin, 378Enterobacteriaceae resistance, 378typhoid fever, 426

Cefazolinopen-heart surgery, 347penetration

atrial appendage, 347pericardial fluid, 347

Cefbuperazonecomparative activitycefmenoxime, 585cefoperazone, 585cefotaxime, 585ceftizoxime, 585moxalactam, 585

Cefmenoximecomparative activityBMY-28142, 585cefbuperazone, 585cefpiramide, 585

metabolism, 431pharmacokinetics, 322, 845radiolabeled, 431

Cefmetazolecomparative activityMT-141, 722

periincisional administration, 787Cefodizimelymphocyte stimulation, 752

Cefonicidbone penetrationenhancement by probenecid, 292

open-heart surgery, 347penetration

atrial appendage, 347pericardial fluid, 347

Cefoperazonecombinations

amikacin, 224aztreonam, 224

comparative activityBMY-28142, 585cefbuperazone, 585cefpiramide, 585MT-141, 722

E. coli, 224K. pneumoniae, 224P. aeruginosa, 224S. marcescens, 224

Cefotaximeaminoglycoside-resistant P. aeruginosa,

275Bacteroides spp., 39combinations

amikacin, 378gentamicin, 260

comparative activityamifloxacin, 275aztreonam, 39BMY-28142, 585cefbuperazone, 585cefpiramide, 585MT-141, 722

E. coli, 39Enterobacteriaceae resistance, 378group G streptococcilymphocyte stimulation, 752

Cefotiampharmacokinetics, 368, 513

hemodialysis patients, 647renal impairment, 647

CefoxitinC. difficile ingrowth, 343combinations

amikacin, 378azlocillin, 256mezlocillin, 256

comparative activityMT-141, 722

Enterobacteriaceae resistance, 378fecal flora alteration, 343

Cefpimizoleintravenous infusion, 802pharmacokinetics, 802

Cefpiramidecomparative activitycefmenoxime, 585cefoperazone, 585cefotaxime, 585ceftizoxime, 585moxalactam, 585

pharmacokinetics, 578pneumococcal meningitis, 578

Cefsulodinpharmacokinetics, 368

Ceftazidimeactivity-efficacy correlation, 231bacterial infections, 318comparative activity

amikacin, 339ticarcillin, 339

penetration into cerebrospinal fluid, 115pharmacokinetics, 204, 388, 583renal disposition, 373S. aureus endocarditis, 231

Ceftizoximecombinations

azlocillin, 256mezlocillin, 256

comparative activityBMY-28142, 585cefbuperazone, 585cefpiramide, 585

lymphocyte stimulation, 752Ceftriaxone

pharmacokinetics, 204Cephalexin

aminoglycoside-resistant P. aeruginosa,275

comparative activityamifloxacin, 275

Cephalosporinsbroad-spectrumCGP 31523A, 876

derivativesB. pertussis, 604

E. corrodens, 947

vi SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

high-pressure liquid chromatography,652

HR 810, 277Cephalothin

activity-efficacy correlation, 231combinations

amikacin, 378Enterobacteriaceae resistance, 378S. aureus endocarditis, 231S. saprophyticus, 670

CephamycinsMT-141, 722

CGP 31523Aactivity, 876

Chandramycincharacterization, 394production, 394purification, 394

Chlamydia trachomatisimmunofluorescence, 13ofloxacin, 13tetracycline, 13

ChloramphenicolE. coli, 689H. influenzae, 91rifampin interaction, 91

Chlorhexidine gluconateocular antisepsis, 793

CI-919see enoxacin

Cilastatincombinationsimipenem, 715

disposition in humans, 707high-pressure liquid chromatography,

78pharmacokinetics, 715radiolabeling studies, 707

Cinoxacinaminoglyoside-resistant P. aeruginosa,

275comparative activity

amifloxacin, 275Ciprofloxacin

anaerobic bacteria, 597, 785comparative activity

ticarcillin, Itobramycin, I

fecal flora, 757mycobacteria, 94N. gonorrhoeae, 608P. aeruginosa pneumonia, Ipenetration into extravascular spaces,

935pharmacokinetics, 208, 741, 757safety in volunteers, 741

Cirrhosisaztreonam kinetics, 493

Clavulanic acidB. fragilis,, 606combinations

amoxicillin, 580comparative activity

sulbactam, 580YTR 830, 580

Clindamycinmortality inducement

prevention by S. boulardii, 552T. gondii, 26

Clostridium difficileingrowth in fecal flora

cefoxitin, 343Clostridium pasteurianum

ferredoxin, 665metronidazole reduction, 665

Coumermycinpneumococci, 933

Crohn's diseaseMycobacterium spp., 930

Cycloguanil pamoateP. cynomolgi, 611

L-Cycloserine3-ketodihydrosphingosine synthetase

inhibition, 211Cyclosporin A

T. gondii, 26Cytochrome aa3

B. subtilis, 507streptomycin accumulation, 507

Cytomegalovirus9-(1,3-dihydroxy-2-propoxymeth-

yl)guanine, 441interferon, 441, 599

Deoxycoformycinherpes simplex virus, 382

4,4'-DiacetyldiaminodiphenylsulfoneP. cynomolgi, 611

DiaminophenylsulfoneP. carinii pneumonitis, 436

Difficult-to-treat infectionsaztreonam, 245

9-(1,3-Dihydroxy-2-propoxymethyl)-guanine

combinationsinterferon, 441, 937

cytomegalovirus replication, 441herpes simplex virus, 283, 937

Duodeno-pancreatic secretionsactivity enhancement, 35

Eikenella corrodensapalcillin, 947cephalosporins, 947penicillin, 947

Endocarditisaminoglycosides, 909enterococci, 909imipenem, 909nafcillin, 61S. aureus, 61teicoplanin, 61vancomycin, 61

Enoxacincomparative activityantipseudomonal agents, 417

gram-negative bacteria, 97P. aeruginosa, 417pharmacokinetics, 17tissue penetration, 17

Enterobacteriaceaeamikacin, 378cefamandole, 378cefotaxime, 378cefoxitin, 378cephalothin, 378moxalactam, 378piperacillin, 378

Enterococciaminoglycosides, 909aztreonam, 280endocarditis, 909imipenem, 909superinfection, 280

Enzymesaminoglycoside-acetylating, 10

Escherichia coliamikacin, 224aminoglycoside-resistantMIC determination, 501regrowth, 501

ampicillin, 689aztreonam, 39, 224cefoperazone, 224cefotaxime, 39chloramphenicol, 689K-12

penicillin-binding proteins, 335temocillin, 335

Fatty acidsmycobacteria, 164

Flucloxacillinmethicillin-resistant S. aureus, 268

FlucytosineC. albicans, 364high-pressure liquid chromatography,

303Fluoride gels

S. mutans plaque aggregates, 8072'-Fluoro- I-0-D-arabinofuranosylpyrimi-

dinemonophosphates

herpes simplex virus, 778interaction with thymidylate kinases,

778Vero cells, 778

5-FluorocytosineC. albicans, 570UMP pyrophosphorylase activity, 570

Fluoropyrimidinesherpes simplex virus, 354

Fortimicinsbacterial ribosomes, 857comparison with aminoglycosides, 857protein synthesis, 857

Fosfomycinmethicillin-resistant S. aureus, 268P. aeruginosa, 789synergy

3-lactams, 789tobramycin, 789

FR 17027in vitro activity, 174P-lactamase stability, 174

Furazolidonetraveler's diarrhea, 160

Fusidic acidmethicillin-resistant S. aureus, 268

Gentamicinaminoglycoside-resistant P. aeruginosa,

275combinations

cefotaxime, 260penicillin G, 260vancomycin, 260

comparative activityamifloxacin, 275

group G streptococci, 260resistant bacteria

amifloxacin, 781uptake by S. aureus, 563

Glutaric acidmechanism of action, 924

SUBJECT INDEX vii

rhinovirus inactivation, 928virucidal activity, 924, 928

Gonorrheasulbactam, 683

Gram-negative bacteriaenoxacin, 97meningitis, 850moxalactam, 850

Granulocytopeniacancer patients, 870

Haemophilus influenzaeampicillin resistance, 235rifampin interactions

ampicillin, 91chloramphenicol, 91

Heavy-metal saltsM. fortuitum biovariants, 594

Herbicolin AAcholeplasma spp., 112Mycoplasma spp., 112Spiroplasma spp., 112Ureaplasma spp., 112

Herpes simplex virusacyclovir, 557, 887arabinosyladenine, 382arabinosyl hypoxanthine, 557atropine, 702azone, 819(E)-5-(2-bromovinyl)-2'-deoxyuridine,

155, 762, 778deoxycoformycin, 3829-(1,3-dihydroxy-2-propoxymethyl)-

guanine, 283, 9372'-fluoro- 1-4-D-arabinofuranosylpyri-

midine, 778genital infections

fluoropyrimidines, 354infection in mice, 155interferon, 557, 599, 937lymphocyte transformation response,

887macromolecule synthesis, 283phosphonoacetate, 65polyriboinosinic acid-polyribocytidylic

acid complex, 557propylene glycol, 819thymidylate kinase, 778trifluorothymidine penetration, 819vidarabine, 557

High-pressure liquid chromatographyaminoglycoside-acetylating enzymes, 10amphotericin B, 314cephalosporins, 652cilastatin, 78flucytosine, 303imipenem, 78mezlocillin quantitation, 775phenoxymethylpenicillin, 300

HR 810in vitro activity, 277

Hydroxylamine techniquepenicillin inactivation of tobramycin,

643

Imipenemantagonism of piperacillin activity, 272bacterial infections, 673B. pertussis, 604combinations

cilastatin, 715

disposition in humans, 707endocarditis, 909enterococci, 909high-pressure liquid chromatography,

78P. aeruginosa, 673, 678pharmacokinetics, 715postantibiotic effect, 678radiolabeling studies, 707synergy

aminoglycosides, 909Immunofluorescence

indirectC. trachomatis, 13ofloxacin, 13tetracycline, 13

Influenza virusribavirin aerosol, 200rimantidine hydrochloride, 101

Interferoncombinations

acyclovir, 557arabinosyl hypoxanthine, 5579-(1,3-dihydroxy-2-propoxymethyl)-

guanine, 441, 937polyriboinosinic acid-polyribocytidy-

lic acid complex, 557vidarabine, 557

cytomegalovirus, 441, 599herpes simplex virus, 557, 599, 937rhinovirus, 31vesicular stomatitis virus, 450

Itraconazoleaspergillosis, 527candidal vaginitis, 266in vitro studies, 5P. orbiculare, 773

K-4619antibacterial activities, 187

KetoconazoleC. albicans

bioluminescent assay, 22intracellular ATP levels, 22membrane damage, 22

candidal vaginitis, 266P. orbiculare, 773

3-Ketodihydrosphingosine synthetasesL-cycloserine, 211inhibition, 211

Klebsiella pneumoniaeamikacin, 224aztreonam, 224cefoperazone, 224

,-LactamasesB. bivius, 694inhibitors, 358,B-lactam resistance, 485S. saprophyticus, 670

1-LactamsD-amino acids, 414Bacteroides spp., 410B. bivius susceptibility, 694combinations

aminoglycosides, 535comparative activity

penicillin G, 410cross-resistance

aminoglycosides, 797quinolones, 797

growth inhibition, 414inoculum effect, 42,-lactamase-resistant

P. aeruginosa, 485lysis, 414multiple resistance, 797P. aeruginosa, 42, 789synergy

aminoglycosides, 535fosfomycin, 789tobramycin, 789

Lactobacillus acidophilusbacteriocin lactacin B, 328

L cellsamphotericin B

permeabilization, 892stimulation, 892toxicity, 892

Leishmania majorcutaneous leishmaniasis

topical treatment, 745Leishmaniasis

L. major, 745topical treatment, 745

Leukocytesoxygen consumption

tetracyclines, 489UV light, 489

Lipidspotentiation of aminoglycoside activity,

306Lipopolysaccharides

P. aeruginosa resistance, 250Lymphocytes

acyclovii, 887cefodizime, 752cefotaxime, 752ceftizoxime, 752herpes simplex virus

transformation response, 887stimulation, 752

MacrodilutionS. aureus MBCs, 815

Macrolidescanine gut, 863gastrointestinal motor stimulation, 863

MBC determinationS. aureus, 214

Meningitisgram-negative bacilli, 850moxalactam, 850pefloxacin, 289pneumococcal

apalcillin, 578cefpiramide, 578

MethicillinS. aureus, 829S. saprophyticus, 670

N-Methylisatin-P-4,4-diethylthiosemicar-bazone

Moloney leukemia virusprotein synthesis, 913

Metronidazolereduction

C. pasteurianum, 665ferredoxin, 665

T. gondii, 26Mezlocillin

combinationsamikacin, 256cefoxitin, 256

VOL. 26, 1984

ANTIMICROB. AGENTS CHEMOTHER.

ceftizoxime, 256moxalactam, 256

high-dose therapy, 686high-pressure liquid chromatography,

775quantitation in serum, 775saturable clearance, 686

Moloney leukemia virusN-methylisatin-P-4,4-diethylsemicarba-

zone, 913protein synthesis, 913

Moxalactambacterial infections, 310combinations

amikacin, 378azlocillin, 256mezlocillin, 256

comparative activityBMY-28142, 585cefbuperazone, 585cefpiramide, 585MT-141, 722timentin, 310

Enterobacteriaceae resistance, 378gram-negative bacilli, 850meningitis, 850penetration

cardiac vegetations, 228heart valve, 228myocardium, 228

pharmacokinetics, 388physiological distribution spaces, 228protein binding, 228

MT- 141comparative activity

cefmetazole, 722cefoperazone, 722cefotaxime, 722cefoxitin, 722moxalactam, 722

Mycobacteriaciprofloxacin, 94fatty acids, 164norfloxacin, 94

Mycobacterium avium-intracellulare com-

plexaminoglycosides, 841

Mycobacterium fortuitumbiovariantsfortuitum, 594heavy-metal salts, 594

Mycobacterium spp.Crohn's disease, 930susceptibility, 930

Mycocereinactivity, 939characterization, 939

Mycoplasma spp.herbicolin A, 112

Nafcillincomparative activity

teicoplanin, 61endocarditis, 61S. aureus, 61

Nalidixic acidpneumococci, 933

Neisseria gonorrhoeaeciprofloxacin, 608inoculum effect, 192norfloxacin, 608ofloxacin, 608

penicillinase, 192, 770rosoxacin, 608U-63366, 608

Nephrotoxicitynetilmicin, 766tobramycin, 766

Netilmicinnephrotoxicity, 766toxicity

auditory, 766Nitrothiazole

C. coli, 498C. jejuni, 498

Norfloxacinfecal recovery, 110microflora

fecal, 481periurethral, 481

mycobacteria, 94N. gonorrhoeae, 608urinary tract infections, 481

Novobiocinpneumococci, 933

Ocular antisepsischlorhexidine gluconate, 793

Ofloxacincomparative activity

tetracycline, 13C. trachomatis, 13immunofluorescence, 13N. gonorrhoeae, 608

Open-heart surgerycefazolin, 347cefonicid, 347

Ornithyl amphotericin methyl estercandidiasis, 108

Oxyhelium gasbacterial response to antimicrobial

agents, 833

Pefloxacincerebrospinal fluid penetration, 289meningitis patients, 289

Penicillincombinations

gentamicin, 260E. corrodens, 947group G streptococci, 260pneumococcal infections

efficacy, 903exchange transfusion, 903

S. aureus hypersensitivity, 149S. saprophyticus, 6706a-substitutedBRL 36650, 734

tobramycin activationhydroxylamine technique, 643

ureidoazlocillin, 256mezlocillin, 256

PenicillinaseN. gonorrhoeae, 770

Penicillin-binding proteinsE. coli K-12

temocillin, 335Penicillin GBacteroides spp., 410comparative activity

P-lactams, 410Penicillin G benzathine

comparative activitySch 29482, 401

syphilis, 401Pharmacokinetics

amphotericin B, 446apalcillin, 578aztreonam

cancer patients, 455children, 196

cefmenoximehealthy volunteers, 845hemodialysis, 845renal insufficiency, 322

cefotiamhealthy adults, 513hemodialysis patients, 647renal impairment, 368, 647

cefpimizoleintravenous infusion, 802normal humans, 802

cefpiramide, 578cefsulodin

renal impairment, 368ceftazidime

animals, 204newborn infants, 583normal volunteers, 388

ceftriaxoneanimals, 204

cilastatinmultiple-dose, 715

ciprofloxacinchanges over 7-day course, 757intravenous, 208normal volunteers, 741

enoxacin, 17imipenem

multiple-dose, 715moxalactamnormal volunteers, 388

pipemidic acid, 69Ro 17-2301humans, 898

rosaramicin, 522Sch 28191, 446sulbactam

gonorrhea, 683sulfamethoxazolenormal meninges, 811

teicoplaninhuman, 881

trimethoprimnormal meninges, 811

YM-13115animals, 204

Phenoxymethylpenicillinhigh-pressure liquid chromatography,

300I-N-PhenylnaphthylamineP. aeruginosa outer membrane, 546

Phospholipidstetracycline

bilayer diffusion, 263binding, 263

Phosphonoacetateherpes simplex virus, 65

Pipemidic acidpharmacokinetics, 69

Piperacillinbacterial infections, 310combinations

amikacin, 378aztreonam, 519

viii SUBJECT INDEX

VOL. 26, 1984

vancomycin, 295comparative activity

apalcillin, 660timentin, 310

Enterobacteriaceae resistance, 378febrile cancer patients, 295gram-negative bacilli, 660P. aeruginosa, 519imipenem antagonism, 272

Pityrosporum orbiculareitraconazole, 773ketoconazole, 773

Plaque aggregatesfluoride gels, 807S. mutans, 807

Plasmodium cynomolgicycloguanil pamoate, 6114,4'-diacetyldiaminodiphenylsulfone,

611Plasmodium falciparum

pyrimethamine-resistant, 656Pneumococci

multiply resistantcoumermycin, 933nalidixic acid, 933novobiocin, 933

penicillinefficacy, 903exchange transfusion, 903

Pneumocystis carinlidiaminophenylsulfone, 436pneumonitis, 436

PneumoniaP. aeruginosa, I

Pneumonitisdiaminophenylsulfone, 436P. carinii, 436

Polymeric biocidesantibacterial activity, 139synthesis, 139

Polymorphonuclear leukocytesS. aureus, 149

Polymyxin BP. aeruginosa resistance, 539

Polypeptide antibioticschandramycin, 394S. lydicus, 394

Polypeptidesbovine granulocytopenic

antibiotic activity, 405Polyriboinosinic acid-polyribocytidylic

acid complexcombinations

acyclovir, 557arabinosyl hypoxanthine, 557interferon, 557vidarabine, 557

herpes simplex virus, 557Postantibiotic effectsimipenem, 678P. aeruginosa, 678

Probenecidenhancement of bone penetration

azlocillin, 292cefonicid, 292

Propylene glycolherpes simplex virus, 819trifluorothymidine penetration, 819

Proteus pennerisusceptibility, 419

Pseudomonas aeruginosaamifloxacin, 275amikacin, 224

aminoglycoside resistance, 250, 275ampicillin, 275antipseudomonal agents, 417apalcillin, 408azlocillin, 519aztreonam, 224, 275, 519carboxypenicillin-aminoglycoside, 575cefoperazone, 224cefotaxime, 275cephalexin, 275cinoxacin, 275ciprofloxacin, 1enoxacin, 417fosfomycin, 789gentamicin, 275imipenem, 673, 678infections, 6733-lactam-resistant, 181, 4853-lactams, 42, 789

lipopolysaccharidechanges, 250structure, 181

outer membraneaminoglycosides, 546permeability, 48I-N-phenylnaphthylamine, 546

permeability resistance, 181piperacillincombined with aztreonam, 519imipenem antagonism, 272

pneumonia, 1polymyxin B-resistant, 539postantibiotic effect, 678resistant mechanisms, 539rifampin, 575ticarcillin, 1tobramycin, 1, 789

Pyrimethaminecombinations

sulfadiazine, 26sulfadoxine, 26

P. falciparum resistance, 656T. gondii, 26

Quinolinescoumermycin, 933nalidixic acid, 933novobiocin, 933

Quinolonescross-resistance

aminoglycosides, 797J-lactams, 797

derivativesciprofloxacin, 608norfloxacin, 608ofloxacin, 608rosoxacin, 608

multiple resistance, 797

R 51,211see itraconazole

Radioimmunoassayamikacin, 87

Renal insufficiencycefmenoxime pharmacokinetics, 322

Respiratory syncytial virusbis(5-amidino-2-benzimidazolyl)meth-

ane, 591Rhinovirus

glutaric acid, 928

interferon-a2, 31Ribavirin

aerosolinfluenza virus infection, 200

antiviral activity, 466arenavirus, 476bunyavirus, 476synergy

selenazofurin, 466, 476tiazofurin, 476

togavirus, 476Rifampin

ampicillin interaction, 91chloramphenicol interaction, 91combinations

carboxypenicillin-aminoglycoside,575

H. influenzae, 91P. aeruginosa, 575S. aureus, 220vancomycin interaction, 220

Rimantidine hydrochlorideinfluenza virus infections, 101

Ro 17-2301pharmacokinetics, 898

Rosaramicinmetabolism, 522pharmacokinetics, 522

RosoxacinN. gonorrhoeae, 608

Saccharomyces boulardiiclindamycin-induced mortality, 552

Sch 28191pharmacokinetics

animals, 446compared with amphotericin B, 446

Sch 29482comparative activity

penicillin G benzathine, 401syphilis, 401

Selenazofurinantiviral activity, 466arenavirus, 476bunyavirus, 476synergy

ribavirin, 466, 476togavirus, 476

Semisynthetic aminoglycosidesK-4619, 187

Serratia marcescensamikacin, 224aztreonam, 224cefoperazone, 224

SM-1213C. albicans, 74

Spectinomycinanalogs

U-63366, 608Spiroplasma spp.

herbicolin A, 112Staphylococcus aureus

endocarditisceftazidime, 231cephalothin, 231treatment, 61

enzymesaminoglycoside-modifying, 563plasmid-encoded, 563

gentamicin uptake, 563macrodilution, 214

SUBJECT INDEX ix

ANTIMICROB. AGENTS CHEMOTHER.

MBCsdetermination, 214reproducibility, 815

methicillin, 61, 829methicillin-resistantcheckerboard method, 220flucloxacillin, 268fosfomycin, 268fusidic acid, 268teichomycin, 268timed-kill method, 220vancomycin, 268vancomycin-rifampin interaction, 220

methicillin-susceptiblecheckerboard method, 220timed-kill method, 220vancomycin-rifampin interaction, 220

microdilution, 214nafcillin, 61penicillin-induced hypersensitivity, 149polymorphonuclear leukocytes, 149teicoplanin, 61tolerance, 829vancomycin, 61

Staphylococcus saprophyticuscephalothin, 670,-lactamase production, 670methicillin, 670penicillin, 670susceptibility testing, 670

Streptococcigroup G

cefotaxime, 260gentamicin, 260penicillin G, 260vancomycin, 260

Streptococcus mutansacidulated fluoride gels, 807plaque aggregates, 807

Streptomyces lydicuspolypeptide antibioticschandramycin, 394

Streptomycinaccumulation in B. subtilis, 507cytochrome aa3 concentration, 507

Sulbactamcombinations

ampicillin, 580comparative activity

clavulanate, 580YTR 830, 580

pharmacokinetics, 678Sulfadiazinecombinations

pyrimethamine, 26T. gondii, 26

Sulfadoxinecombinations

pyrimethamine, 26T. gondii, 26

Sulfamethoxazolepharmacokinetics, 811

Susceptibility patternsC. coli, 351C. jejuni, 351

Susceptibility testinganaerobes, 601broth disk methods, 601

Synthetic immunomodulatorsSM-1213, 74

Syphilispenicillin G benzathine, 401Sch 29482, 401

Teichomycinmethicillin-resistant S. aureus, 268

Teicoplaninactivity, 881comparative activity

nafcillin, 61vancomycin, 61

endocarditis, 61mechanism of action, 917pharmacokinetics, 881S. aureus, 61

TemocillinE. coli penicillin-binding proteins, 335

Tetracyclineanalogs

amphotericin B enhancement, 837Aspergillus spp., 837

comparative activitytetracycline, 13

C. trachomatis, 13immunofluorescence, 13leukocyte oxygen consumption, 489phospholipids

bilayer diffusion, 263binding, 263

Thymidylate kinasesherpes simplex virus

(E)-5-(2-bromovinyl)-2'-deoxyuri-dine, 778

Vero cells2'-fluoro- l-J3-D-arabinofuranosylpyri-

midine, 778Tiazofurin

arenavirus, 476bunyavirus, 476synergy

ribavirin, 476togavirus, 476

Ticarcillincombinations

amikacin, 339comparative activity

ceftazidime, 339ciprofloxacin, 1tobramycin, 1

P. aeruginosa pneumonia, 1Timentin

bacterial infections, 310comparative activitymoxalactam, 310piperacillin, 310

TioconazoleC. albicans

bioluminescent assay, 22growth phase, 699intracellular ATP levels, 22membrane damage, 22

C. parapsilosis, 699fungicidal activity, 699

Tobramycincomparative activity

ciprofloxacin, 1ticarcillin, I

inactivationhydroxylamine technique, 643

nephrotoxicity, 766P. aeruginosa

pneumonia, 1synergy, 789

synergyfosfomycin, 789,3-lactams, 789

toxicity

auditory, 766Togavirus

ribavirin, 476selenazofurin, 476tiazofurin, 476

Toxicityauditory

netilmicin, 766tobramycin, 766

Toxoplasma gondiiclindamycin, 26cyclosporin A, 26metronidazole, 26micromethod, 26pyrimethamine, 26sulfadiazine, 26sulfadoxine, 26

Traveler's diarrheaampicillin, 160furazolidone, 160

Trifluorothymidineherpes simplex virus, 819penetration

azone, 819propylene glycol, 819

Trimethoprimpharmacokinetics, 811resistance, 82Tn7-specific probes, 82

Trimethoprim-sulfamethoxazolemicroflora

fecal, 481periurethral, 481

urinary tract infections, 481Typhoid fever

cefamandole, 426

U-63366N. gonorrhoeae, 608

UMP pyrophosphorylaseC. albicans, 5705-fluorocytosine resistance, 570

Ureaplasma spp.herbicolin A, 112

Urinary tract infectionsnorfloxacin, 481trimethoprim-sulfamethoxazole, 481

UV lightleukocyte oxygen consumption, 489

Vaginitiscandidal

itraconazole, 266ketoconazole, 266

Vancomycincombinations

gentamicin, 260piperacillin, 295

comparative activityteicoplanin, 61

endocarditis, 61febrile cancer patients, 295group G streptococci, 260methicillin-resistant S. aureus, 268rifampin interaction, 220S. aureus, 61, 220

Vero cellsthymidylate kinase(E)-5-(2-bromovinyl)-2 '-deoxyuri-

dine, 7782'-fluoro-l-1-D-arabinofuranosylpyri-

midine, 778

x SUBJECT INDEX

SUBJECT INDEX xi

Vesicular stomatitis virusinterferon, 450

Vidarabinecombinations

acyclovir, 557arabinosyl hypoxanthine, 557interferon, 557polyriboinosinic acid-polyribocytidy-

lic acid complex, 557herpes simplex virus, 557

WIN 49375antimicrobial spectrum, 104cancer patients, 421

YM-13115pharmacokinetics, 204

YTR 830combinations

amoxicillin, 580comparative activity

clavulanate, 580sulbactam, 580

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