behavioral and biochemical effects of cannabis sativa and their modulation by antidepressant drugs
Antidepressant Drugs
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Transcript of Antidepressant Drugs
ANTIDEPRESSANT DRUGS
TRULY SITORUSDepart.Of Pharmacology & Therapy
Faculty Of Medicine – Padjadjaran University
ANTIDEPRESSANT DRUGSDEPRESSANTIs due to a deficiency of monoamine such as:
NOR EPINEPHRINESEROTONINEDOPAMINE
THE SYMPTOM OF DEPRESSANT:– Intense feelings of sadness– Hopelessness– Despair– Inability ti experience pleasure in usual activities
MANIACaused by an overproduction of MONOAMINE NEUROTRANSMITTERS
CLASIFICATIONI. TRICYCLIC/ POLYCYCLIC ANTIDEPRESSANT
1ST generation: AMITRIPTYLINE 2ND generation: AMOXAPINE
II. SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI) Fluoxetine
III. MONOAMINE OXIDASE INHIBITORS (MAO INHIBITORS)
Isocarboxazid
Drugs used to treat mania: LITHIUM SALTS
TCAIncrease the function of monoamine synapses by inhibiting reuptake of the neurotransmitter substances.
Pharmacokinetics
Relative receptor specificity of antidepressant drugs
Drug
UPTAKE INHIBITION RECEPTOR AFINITIESNorepinephrine Serotonin Muscarinic Histaminergic Adrenergic
Tricyclic antidepressant imipramide
++ +++ ++ - +
Selective serotonin reuptake inhibitor Fluoxetine
0 ++++ 0 0 0
INDICATION1. SEVERE MAJOR DEPRESSION2. PANIC DISORDERS3. CONTROL BED-WETTING IN CHILDREN (older
than 6 years)
ADVERSE EFFECTS• Antimuscarinic effects• Cardiovascular effects• Orthostatic hypotension• Sedation
DRUGS INTERACTIONPotentiate effects of biogenic amines drugs by preventing
Their removal from synaptic cleft
Direct actingAdrenergic
drugs
Tricyclicantidepressants
Indirect-actingAdrenergic
drugs
Block effects of Indirect-acting sympathomimetic drugs byPreventing the drugs from reaching their intraceluller sites of action
EthanolOther CNS depressants
Toxicsedation
MAOInhibitors
Mutual enhancement:Hypertension,hyperpyrexia,
convulsions, and coma
SSRISelectively inhibit serotonin reuptake by nerveEndings
– Antimuscarinic effects– Cardiotoxicity
DRUGS INTERACTION
INDICATION1. Depression2. Bulimia nervosa3. Obsessive – compulsive4. Anorexia nervosa5. Panic disorder6. PAIN associated with DIABETIC
NEUROPATHY7. Premenstrual syndrome
MAO INHIBITOR
Inactive the enzyme monoamine neurotransmitter
ISOCARBOXAZID
INDICATION1. Depressed patient – Unresponsive to TCA2. Allergic to TCA3. Strong anxiety4. Atypical depression CONTRAINDICATION1. Food: aged cheeses, chicken liver, beer, and
red wines (contain TYRAMINE)2. SRRI