Antibiotics have saved millions of lives Antibiotics are losing their effect.
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Antibiotics have saved millions of
lives
Antibiotics are losing their effect
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Global mortality in infectious diseases (WHO estimates for 2002, from World Health Report
2004)
0
1
2
3
4
5
Acuterespiratoryinfections
HIV/AIDS Diarrhoealdiseases
Tuberculosis Malaria
Milli
ons
of d
eath
s
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The Rise of Antibacterial Resistance and the Decline in Innovation
The proportion (%) of MRSA among The proportion (%) of MRSA among positive blood cultures of Staphylococcus positive blood cultures of Staphylococcus aureus in aureus in England &Wales1989-2002
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5
10
15
20
1983-1987 1988-1992 1993-1997 1998-2002
No.
of F
DA
appr
oved
ant
ibac
teria
l NM
Es
Antibacterial new molecular entities approved for use in the United States 1983-2002
From Kaplan, Laing et al., Priority medicines for Europe and the world, 2004
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Increased knowledge on an increasing problem
number of hits in Pub-MED for (antibiotic or antimicrobial) + resistance by 5 year’s periods
02,0004,0006,0008,000
10,00012,00014,00016,00018,000
1965-70
1971-75
1976-80
1981-85
1986-90
1991-95
1996-2000
2001-05
ReviewsOriginal publ.
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Seminar on the Global Threat of Antibiotic Resistance
Exploring Roads towards Concerted Action
Uppsala 5-7 May, 2004
www.reactgroup.orgwww.reactgroup.org
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Since May 2004….• The clusters
– Communicating the message– Ensuring appropriate use– Ensuring supply of new antibiotics
• Some outcomes– Website (www.reactgroup.org)– WHA resolution– Priority medicines– Innovation study– Network broadened
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Current and future generations of people around the globe
should have access to effective
treatment of bacterial infections.
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Will we respond to antibiotic Will we respond to antibiotic resistance in time?resistance in time?
A seminar on the growing threat of antibiotic resistance September 14-17, 2005, Uppsala
STRAMA IHCAR
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The way forward?
1 + 1 >2
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Will we React in time?