ANTIBIOTIC SENSETIVITYANTIBIOTIC SENSETIVITY

**Antibiotics: Are chemicals produced by Antibiotics: Are chemicals produced by microorganisms that inhibit the growth of other microorganisms that inhibit the growth of other microorganisms.microorganisms.

**Chemotherapeutic agent: (Synthetic **Chemotherapeutic agent: (Synthetic versions )versions )..

ANTIBIOTIC TYPESANTIBIOTIC TYPES::11--BOARD SPECTRUM ANTIBIOTICSBOARD SPECTRUM ANTIBIOTICS-:-:

This against wide range of both G+ve This against wide range of both G+ve and G-ve bacteriaand G-ve bacteria. .

22--Narrow spectrum antibiotics : This Narrow spectrum antibiotics : This against selective groups of organismsagainst selective groups of organisms

MODE OF ACTIONS OF MODE OF ACTIONS OF ANTIBIOTICSANTIBIOTICS::

11--Distruptions of cell wall synthesisDistruptions of cell wall synthesis. .

22--Distruptions of cell membrane functionDistruptions of cell membrane function

33--Inhibition of protein synthesisInhibition of protein synthesis

44 - -Inhibition of nucleic acid synthesisInhibition of nucleic acid synthesis

55--Competitive Inhibition of metabolic pathwaysCompetitive Inhibition of metabolic pathways . .

** **Drug resistanceDrug resistance?? ??

Procedure for antibiotic sensitivity testProcedure for antibiotic sensitivity test: :

11--Diffusion method (Kirby Baur disk diffusion)Diffusion method (Kirby Baur disk diffusion)

22--Pour plate MethodPour plate Method..

The Kirby procedure used to determine the effect The Kirby procedure used to determine the effect of the drug on the bacterial growthof the drug on the bacterial growth..

R: RESISTANCER: RESISTANCE S:SENSETIVE S:SENSETIVE

I:INTERMEDIATE I:INTERMEDIATE

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