2002 Aminocarboxylic acids (hydrazinocarboxylic acids) and esters

Aminocarboxylic acids (hydrazinocarboxylic acids) and estersP 0270 anti-Selective SMP-Catalyzed Direct Asymmetric Mannich-Type Reactions:

Synthesis of Functionalized Amino Acid Derivatives. — Unmodified aldehydes (I) and the imine (II) undergo a direct Mannich type reaction in the presence of (S)-2-methoxymethylpyrrolidine as the catalyst. β-Formyl functionalized amino acid derivatives (III) are prepared in moderate stereoselectivity. — (CORDOVA, A.; BARBAS* III, C. F.; Tetrahedron Lett. 43 (2002) 43, 7749-7752; Skaggs Inst. Chem. Biol., Scripps Res. Inst., San Diego, La Jolla, CA 92037, USA; Eng.) — Mais

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