ans-receptors-overview

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Receptors and signal transduction in the ANSReceptors and signal transduction in the ANS

Cholinergic Receptors

Nicotinic Muscarinic

Ganglionic SkeletalMuscle

NeuronalCNS


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Receptors and signal transduction in the ANS:Receptors and signal transduction in the ANS:

Nicotinic ReceptorsNicotinic Receptors

ACH ACHNa+

E EF

K H


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Nicotinic ReceptorsNicotinic Receptors

ACH ACHNa+

E EF

K H

NH3

OOH

E E

F

K H


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Cholinergic Receptors

Nicotinic Muscarinic

M1 M5M3 M4M2


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Muscarinic receptors are 7 transmembrane domain, GMuscarinic receptors are 7 transmembrane domain, G--proteinproteincoupled receptorscoupled receptors


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Muscarinic receptorsMuscarinic receptors(M(M11, M, M , M, M55))

N

C

Gq

Phospho-

lipase C

( )

PIP2

IP Diacylglycerol

Increase Ca2 Activate ProteinKinase C

Response


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Muscarinic ReceptorsMuscarinic Receptors

(M2 and M4)N

C

( )

ATP cAMP

Reduce cAMP ependentProtein inase Acti ity

Response

Adenylate Cyclase

X( )


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Adrenergic Receptors

E1A

E1 FE2

E1B E1D E2A E2B E2C F1 F2 F


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EE11--AdrenergicAdrenergicReceptorsReceptors

N

C

q

Phospho-

lipase C

P P

P Diac lgl cerol

ncrease Ca Acti ate ProteinKinase C

Response


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EE22--AdrenergicAdrenergicReceptorsReceptors

-

ATP cAMP

Reduce cAMP- ependentProtein inase Acti ity

Response

Adenylate Cyclase

X

N

C


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FF--AdrenergicAdrenergicReceptorsReceptors

S

A P cAMP

ncrease cAMP-DependentProtein Kinase Acti it

Response

Aden late C clase

N

C


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Effector rganAdrenergicResponse Receptor

CholinergicResponse Receptor

eartRate of Contraction Increase F1 Decrease M2

Force of Contraction Increase Decrease M2

Functional Responses Mediated by the ANS

F1,


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Arteries (most) Vasoconstriction E1 ---------- --

Veins Vasoconstriction E2 ---------- --

Skeletal Muscle Vasodilation F2 ---------- --

Endothelium ---------- -- Release EDRF M


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Lung

Bronchiolar

smooth muscle

Bronchodilation Bronchoconstriction MF2


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Bladder wall Relaxation F2 Contraction M

Ureter Contraction E1 Relaxation M

Sphincter Contraction E1 Relaxation M

Uterus (pregnant) Relaxation F2 Variable

Penis/vas deferens Ejaculation

Genitourinary, smooth muscle

Contraction ME1E

1 MErection


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Salivary Glands Increase secretion E1 Increase secretion

Smooth Muscle:

Relaxation E2 ,F2 M

Sphincters Contraction E1 Relaxation M

Secretion ---------- -- Increase secretion M

Gastrointestinal ract

M

Walls Contraction


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air follicles,

Smooth muscle

Contraction,

Piloerection

E1 -------------- --

Sweat glandshermoregulation Increase secretion

Skin

----------------M

Increase secretion E1Apocrine (stress) ----------------


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Iris

Radial muscle Contraction

Eye

----------------E1

-------------Circular muscle MContraction--

Ciliary muscle [Relaxation MContractionF2]

Ciliary epithelium Increase secretion

of aqueous humor

----------------F2


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Physiology of the eyePhysiology of the eye

Lens

Iris

Radialmuscle (E1)

Circularmuscle (M )

Canal ofSchlemm

rabecular

meshwork

Ciliary

muscle (M )

Ciliary

epithelium (F2)


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Pupil

Circular muscle

(M Receptors)


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Pupil

Contraction of circular

muscle leads to

miosis


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Pupil

Contraction of circular

muscle leads to

miosis


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Pupil

Radial Muscle

( E1 Receptors)


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Pupil

Contraction of radial

muscle leads to

mydriasis


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Liver Glycogenolysis -------------- --

Fat cells Lipolysis -------------- --

Kidney Increase renin

secretion

F1 -------------- --

Pancreas Decrease insulinrelease

Metabolic functions

----------------

F1,F

E2

Gluconeogenesis

E1,F2

ans-receptors-overview

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