Annual report 2009 · 2015. 5. 14. · Preface Preface The Department of Biostatistics is part of...

Annual report 2009

Department of Biostatistics

University of Copenhagen

Preface

Preface

The Department of Biostatistics is part of the Institute of Public Health, Faculty ofHealth Sciences, University of Copenhagen. The present annual report documents theactivities of the scientific staff during 2009. Hopefully, the report may also serve asan introduction to the department. The report documents research projects, teachingand advisory work, as well as editorial and other organizational activities for thebiostatistical community. The reader will find lists of publications, talks and travels ofthe scientific staff, a list of visitors to the department and a list of talks in our seminarseries.

Annual reports have been published since the start of the department as a researchcouncil initiative in 1978. The present version follows the tradition in many ways, withtwo exceptions: the report is now only in English, and the production has been mod-ernized. The new production process is based on the Semantic Mediawiki Projectand has been implemented by Thomas A. Gerds with technical assistance by Tim F.Olsen and Klaus K. Holst and administrative assistance by Susanne Kragskov, StineSparre Kjær Urhøj, Jeanette Pollmann, Emilie Just-Østergaard and Kathe Jensen.Editorial details have been discussed with Esben Budtz-Jørgensen and Niels Keiding.The annual report is available on the website https://intra.ifsv.ku.dk/biostat_

annualreport/index.php5/Annual_reports which contains electronic search possibil-ities.

The Department of Biostatistics is the biostatistical resource for all parts of theFaculty of Health Sciences, which implies some special features in the daily work of thedepartment. In addition to research and teaching in the department’s core academiccompetence (biostatistics), the scientific staff has an extensive portfolio of collaborativemedical research, advisory and consulting activities at several levels, and an extensiveprogram of teaching of statistics to users within the faculty.

Copenhagen, November 2010

Niels Keiding

Department of Biostatistics, University of Copenhagen

Øster Farimagsgade 5, DK-1014 Copenhagen K, Denmark

Email: biostat @ biostat.ku.dk, Telephone: +45 35 32 79 01, Fax: +45 35 32 79 07

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Contents

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3Personnel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7External funding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

Research 91 Legend . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92 Statistical theory and methods . . . . . . . . . . . . . . . . . . . . . . 10

2.1 Biostatistics . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102.2 Demography . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172.3 Epidemiology . . . . . . . . . . . . . . . . . . . . . . . . . . . 172.4 Mathematical statistics . . . . . . . . . . . . . . . . . . . . . . 192.5 Statistical genetics . . . . . . . . . . . . . . . . . . . . . . . . 19

3 Applied statistical collaborations . . . . . . . . . . . . . . . . . . . . . 203.1 Clinical research . . . . . . . . . . . . . . . . . . . . . . . . . 203.2 Epidemiology . . . . . . . . . . . . . . . . . . . . . . . . . . . 323.3 Public health . . . . . . . . . . . . . . . . . . . . . . . . . . . 393.4 Statistical genetics . . . . . . . . . . . . . . . . . . . . . . . . 40

4 Statistical software development . . . . . . . . . . . . . . . . . . . . . 415 Core facility . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42

5.1 Core Facility: Projects . . . . . . . . . . . . . . . . . . . . . . . 425.2 Core Facility: Publications . . . . . . . . . . . . . . . . . . . . 45

Statistical community 471 Advisory and journal activities . . . . . . . . . . . . . . . . . . . . . . 472 International collaboration . . . . . . . . . . . . . . . . . . . . . . . . . 49

2.1 Visitors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 492.2 Seminar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51

3 External presentations of members of the department . . . . . . . . . 533.1 Talks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 533.2 Travels . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57

Teaching 611 Courses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61

1.1 Ph.D. courses . . . . . . . . . . . . . . . . . . . . . . . . . . . . 611.2 Master / Bachelor courses . . . . . . . . . . . . . . . . . . . . . 62

2 Supervision . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 623 Publications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65

3.1 Journal articles . . . . . . . . . . . . . . . . . . . . . . . . . . . 65

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CONTENTS

3.2 Research reports . . . . . . . . . . . . . . . . . . . . . . . . . . 73

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CONTENTS

Personnel

In 2009 the Department of Biostatistics (University of Copenhagen) employed thefollowing people:

Professor

Per Kragh AndersenNiels KeidingSvend KreinerThomas Scheike

Associate Professor

Esben Budtz-JørgensenKarl Bang ChristensenPeter DalgaardThomas Alexander GerdsJørgen Holm PetersenLene Theil Skovgaard

Assistant Professor

Julie Lyng FormanTheis Lange (since 14 April 2009)

Phd Student

Anders Albrechtsen (until 31 May 2009)

Mette Gerster (until 31 March 2009)

Randi Grøn (since 1 December 2009)

Klaus Kahler HolstBruno Paul MmbandoUlla Brasch MogensenLisbeth Nørgaard MøllerLars Hougaard Nielsen (until 28 February

2009)

Janne PetersenKyle Raymond (since 14 September 2009)

Susanne Rosthøj (until 28 February 2009)

Post Doc

Susanne Rosthøj (since 1 March 2009)

Research Assistant

Nina Breinegaard (since 1 July 2009)

Randi Grøn (1 March 2009 to 30 November

2009)

Marie-Louise Hansen (until 31 January 2009)

Maja Olsbjerg Larsen (since 1 August 2009)

Jeremy Silver (until 28 February 2009)

Louise Stage (until 31 January 2009)

Computing Assistant

Jacob Blindum (since 1 April 2009)

Sara BrebbiaNina Breinegaard (until 30 June 2009)

Therese GraversenRandi Grøn (until 28 February 2009)

Oluf Kristian Højbjerg HansenMartin Theil JensenKira Svendsen

Administrative Staff

Marianne Arnecke (until 31 January 2009)

Diana Bech (since 19 January 2009)

Kathe JensenEmilie Just-ØstergaardSusanne Kragskov LaupstadTim Frederik OlsenJeanette PollmannStine Sparre Kjær Urhøj

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External funding

External funding

In 2009, several people were partly financed by external sources. External funding wascoming from NIH (joint project with John Klein) the Graduate School in Biostatisticsfunded by the Danish Research Councils (Niels Keiding leader). Further external fund-ing was coming from several national and international fonds through collaborationwith the following people: Henrik Leffers (Department of Growth and Reproduction,Copenhagen University Hospital, Copenhagen, Denmark), Jesper Møller (Departmentof Mathematical Sciences, Aalborg University, Aalborg, Denmark) Philippe Grand-jean (Environmental Medicine, University of Southern Denmark, Odense, Denmark)Niels Erik Skakkebæk (Department of Growth and Reproduction, Copenhagen Uni-versity Hospital, Copenhagen, Denmark), Lars Vedel Kessing (Department of Psychi-atry, Copenhagen University Hospital, Copenhagen, Denmark), Bent Ottesen (TheJuliane Marie Center, Copenhagen University Hospital, Copenhagen, Denmark), Sig-urd Mikkelsen (Department of Occupational Medicine, Glostrup University Hospital,Glostrup, Denmark), Ulrik Gether (Molecular Neuropharmacology Group, Depart-ment of Pharmacology, University of Copenhagen, Copenhagen, Denmark)

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Research

The department conducts biostatistical research and software development, partici-pates in substantive research projects applying statistical methods, and offers bio-statistical advice to PhD students and staff in all disciplines of the Faculty of HealthSciences, including those engaged in experimental and clinical medicine, public health,and oral health. Furthermore, an important part of the research work is done in shortand long-term collaborations with researchers from outside the Faculty and from allover the world.

In this section the research activities from the year 2009 are listed in the subsec-tions methodological research, applied collaborations and development of statisticalsoftware. Research activity corresponding to the Core Facility of Biostatistics are col-lected in a separate subsection. Further structure is obtained from Keywords (Topics)that have been submitted by the responsible scientific staff for the single projects.

For some projects more information is available at the Internet site of this annualreport.

1 Legend

Throughout this chapter projects are listed in the following form:

Project titleStaff members of the Department of BiostatisticsExternal collaborators (Affiliations)

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Statistical theory and methods

2 Statistical theory and methods

2.1 Biostatistics

Diagnostic and predictive models

Methods for constructing age-specific 2-dimensional reference charts forreproductive hormonesJørgen Holm Petersen

Survival paths through the forestUlla Brasch Mogensen, Thomas Alexander GerdsJørgen Olsen (Department of Cellular and Molecular Medicine, University ofCopenhagen, Copenhagen, Denmark), Tom Skyhøj Olsen (Department of Neurore-habilitation, The Stroke Unit, Hvidovre University Hospital, Hvidovre, Denmark),Ole Winther (The Bioinformatics Centre, Department of Biology, University ofCopenhagen, Copenhagen, Denmark)

Guidelines for the use of ROC curves in the evaluation of diagnostic testsJørgen Hilden

Assessment of added diagnostic and prognostic powerJørgen Hilden, Thomas Alexander GerdsPer Winkel (Copenhagen Trial Unit (CTU), Centre for Clinical Intervention research,Copenhagen University Hospital, Copenhagen, Denmark)

Epidemiological methods

History of confounder control: weighting, modelling, standardizationNiels KeidingDavid Clayton (Department of Medical Genetics, Cambridge Institute for MedicalResearch, Cambridge University, Cambridge, England)

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Event history analysis

Extending the C-index for survival analysisThomas Alexander GerdsMichael Kattan (Department of Quantitative Health Sciences, Cleveland Clinic,Cleveland, USA), Martin Schumacher (Institute of Medical Biometry, University ofFreiburg, Freiburg, Germany)

Graphical goodness of fit methods for survival data based on pseudo-observations and Pseudo-observations in survival analysisPer Kragh AndersenMaja Pohar Perme (Institute of Biomedical Informatics, University of Ljubljana,Ljubljana, Slovenia)

Relative survival based on the proportional excess hazards model and theadditive hazards modelThomas ScheikeGiuliana Cortese (Department of Statistical Science, University of Padova, Padova,Italy)

Theoretical properties of the pseudo value approach to regression mod-elling in the presence of right censoring and competing risksThomas Alexander GerdsFrederik Graw (Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland),Martin Schumacher (Institute of Medical Biometry, University of Freiburg, Freiburg,Germany)

Model selection for survival data, including the lasso and Dantzig selector.Thomas ScheikeTorben Martinussen (Department of Biostatistics, University of Southern Denmark,Odense, Denmark)

Longitudinal risk evaluation tool for sickness absence, unemployment,return to work and disability pensionKarl Bang ChristensenJacob Pedersen (Danish National Research Centre for the Working Environment,Copenhagen, Denmark)

Describing association for competing risks dataThomas ScheikeYanqing Sun (Department of Mathematics and Statistics, The University of NorthCarolina at Charlotte, Charlotte, USA)

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Frailty models in case-cohort studiesPer Kragh AndersenLiselotte Petersen, Thorkild Sørensen (Institute of Preventive Medicine, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Random effects models for competing risks dataThomas ScheikeMei-Jie Zhang (Division of Biostatistics, Medical College of Wisconsin, Milwaukee,USA), Yanqing Sun (Department of Mathematics and Statistics, The University ofNorth Carolina at Charlotte, Charlotte, USA), Tina Kold Jensen (Department ofEnvironmental Medicine, Institute of Public Health, University of Southern Denmark,Odense, Denmark)

High-dimensional covariates for survival data and their use for the case-cohort designThomas ScheikeAnders Gorst Rasmussen (Department of Mathematical Sciences, Aalborg University,Aalborg, Denmark)

Frailty models for the additive risk modelThomas ScheikeTorben Martinussen (Department of Biostatistics, University of Southern Denmark,Odense, Denmark), David Zucker (Department of Statistics, Hebrew University,Mount Scopus, Jerusalem, Israel)

Haplotype effects in the additive hazards modelThomas ScheikeTorben Martinussen (Department of Biostatistics, University of Southern Denmark,Odense, Denmark), Mei-Jie Zhang (Division of Biostatistics, Medical College ofWisconsin, Milwaukee, USA)

Haplotype effects on the cumulative incidence function for competing risksdata: An application to BMT data.Thomas ScheikeMei-Jie Zhang (Division of Biostatistics, Medical College of Wisconsin, Milwaukee,USA)

Competing risks in epidemiologyPer Kragh AndersenHein Putter (Leiden University Medical Centre, Leiden, Holland), Ronald Geskus(Department of Clinical Epidemiology, Biostatistics and Bioinformatics, AcademicMedical Center, Amsterdam, The Netherlands)

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Flexible regression modelling for survival dataThomas ScheikeTorben Martinussen (Department of Biostatistics, University of Southern Denmark,Odense, Denmark), Giuliana Cortese (Department of Statistical Science, Universityof Padova, Padova, Italy)

Flexible competing risks regression using RThomas ScheikeMei-Jie Zhang (Division of Biostatistics, Medical College of Wisconsin, Milwaukee,USA)

Competing risks models with time-dependent covariatesPer Kragh AndersenGiuliana Cortese (Department of Statistical Science, University of Padova, Padova,Italy)

Case cohort designThomas ScheikeYanqing Sun (Department of Mathematics and Statistics, The University of NorthCarolina at Charlotte, Charlotte, USA)

Heritability for survival dataKlaus Kahler Holst, Jørgen Holm Petersen, Thomas Scheike

Competing risks problems for BMT patientsThomas ScheikeMei-Jie Zhang (Division of Biostatistics, Medical College of Wisconsin, Milwaukee,USA)

Approximation of Event History ModelsRandi Grøn, Thomas Alexander Gerds, Per Kragh AndersenSøren Feodor Nielsen (Copenhagen Business School, Copenhagen, Denmark)

Explained variation in a fully specified model for data-grouped survivaldata with application to flowering of sugar beet plantsThomas ScheikeChristian Ritz (Department of Basic Sciences and Environment, Faculty of LifeSciences, University of Copenhagen, Copenhagen, Denmark), Christian Pipper(Department of Basic Sciences and Environment, Faculty of Life Sciences, Universityof Copenhagen, Copenhagen, Denmark)

Estimation of haplotype effects for survival dataThomas Scheike, Jeremy SilverTorben Martinussen (Department of Biostatistics, University of Southern Denmark,Odense, Denmark)

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Methods for analysing repeated events in affective disordersTine Kajsa Kvist, Per Kragh AndersenLars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital,Copenhagen, Denmark)

Multi-state models in bone marrow transplantation studiesPer Kragh AndersenMaja Pohar Perme (Institute of Biomedical Informatics, University of Ljubljana,Ljubljana, Slovenia)

Partial Least Squares for the additive hazards modelThomas ScheikeTorben Martinussen (Department of Biostatistics, University of Southern Denmark,Odense, Denmark)

Algorithms for analysing interval censored survival data in dental researchNiels Keiding, Thomas Alexander Gerds, Randi GrønHalina Frydman (Stern School of Business, New York University, New York, USA),Daniel Commenges (INSERM, Epidemiology and Biostatistics Research Center,Bordeaux, France), Pierre Joly (INSERM, Epidemiology and Biostatistics ResearchCenter, Bordeaux, France), Vibeke Qvist (Department of Cariology and Endodontics,Faculty of Health Sciences, School of Dentistry, University of Copenhagen, Copen-hagen, Denmark)

The prediction error of risk prediction models in survival analysisThomas Alexander GerdsMartin Schumacher (Institute of Medical Biometry, University of Freiburg, Freiburg,Germany)

Graphical models

Applying graphical models to the adoption study designJørgen Holm PetersenThorkild I.A. Sørensen (Institute of Preventive Medicine, Copenhagen UniversityHospitals, Copenhagen, Denmark)

Assessment of model search procedures in graphical models by MonteCarlo and Bootstrap methodsSvend KreinerVolkert Siersma (Section and Research Unit of General Practice, Institute of PublicHealth, University of Copenhagen, Copenhagen, Denmark)

Functional collapsibility in chain graph modelsSvend Kreiner

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Marginalization and conditioning in chain graph modelsSvend Kreiner, Jørgen Holm PetersenVolkert Siersma (Section and Research Unit of General Practice, Institute of PublicHealth, University of Copenhagen, Copenhagen, Denmark)

Item response models

Item analysis by stochastically ordered mixture Rasch modelsSvend Kreiner

Item analysis by graphical loglinear Rasch modelsKarl Bang Christensen, Svend Kreiner

IRT models with uniform local dependenceSvend Kreiner

Assessment of targeting of IRT modelsSvend Kreiner

Exact properties of person estimates in Rasch modelsSvend Kreiner

Latent class models

Definition of syndromes by latent variables: HIV-associated lipodystrophysyndromeJanne Petersen, Esben Budtz-JørgensenKlaus Larsen (Lundbeck A/S, Copenhagen, Denmark), Ove Andersen (Departmentof Infectious Diseases, Hvidovre University Hospital, Hvidovre, Denmark)

Latent variable models

Estimation of variance Components in the Rasch ModelJørgen Holm Petersen, Karl Bang Christensen, Jacob Blindum

Approximative likelihood inference in latent variable variable models withnonlinear structural effectsKlaus Kahler Holst, Esben Budtz-Jørgensen

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Ordered categorical data

Models for repeated ordinal measurementsSvend Kreiner

Standardized gamma coefficients for loglinear modelsSvend KreinerVolkert Siersma (Section and Research Unit of General Practice, Institute of PublicHealth, University of Copenhagen, Copenhagen, Denmark)

Analysis of rater agreement by item response modelsSvend Kreiner, Jørgen Holm PetersenKlaus Larsen (Lundbeck A/S, Copenhagen, Denmark)

Repeated measurements and functional data

Statistical analysis of gait data quantified by measurements of angularrotations of different joints using functional data analysisKlaus Kahler Holst, Thomas Scheike, Jørgen Holm Petersen

Structural equation models

Latent variable models in neuroimagingKlaus Kahler Holst, Esben Budtz-JørgensenGitte Moos Knudsen (Dept. Neurology and Neurobiology Research Unit, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Structural equation models in environmental risk assessmentEsben Budtz-Jørgensen, Niels KeidingPhilippe Grandjean (Institute of Public Health, University of Southern Denmark,Odense, Denmark)

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2.2 Demography

Abortion parity and birth parity specific abortion rates and birth ratesNiels Keiding, Ditte Mølgaard-Nielsen, Marie-Louise Hansen, Louise Stage

Application of age-period-cohort models for describing fertility variationsand variation in abortion frequencyNiels KeidingLisbeth B. Knudsen (Department 1 - Department of Sociology, Social Work andOrganisation, Aalborg University, Aalborg, Denmark), Katrine Strandberg-Larsen(Centre for Alcohol Research, National Institute of Public Health,University ofSouthern Denmark, Copenhagen, Denmark)

Methods for determining the causal effect of female education and labourmarket participation on fertilityMette Gerster, Niels KeidingLisbeth B. Knudsen (Department 1 - Department of Sociology, Social Work andOrganisation, Aalborg University, Aalborg, Denmark), Katrine Strandberg-Larsen(Centre for Alcohol Research, National Institute of Public Health,University of South-ern Denmark, Copenhagen, Denmark), Mette Erjnæs (Department of Economics,University of Copenhagen, Copenhagen, Denmark), Trude Lappegard (StatisticsNorway, Research department, Oslo, Norway)

2.3 Epidemiology

Causal inference

Mediation analysis in a survival contextTheis Lange

Dynamic treatment strategies

Dynamic statistical modelling of maintenance therapy of children withacute lymphoblastic leukaemiaSusanne Rosthøj, Niels KeidingKjeld Schmiegelow (Institute of Gynecology, Obstetrics, and Pediatrics, Departmentof Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark)

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Epidemiological methods

Assessing safety limits in environmental epidemiologyEsben Budtz-Jørgensen, Niels KeidingPhilippe Grandjean (Institute of Public Health, University of Southern Denmark,Odense, Denmark)

Methods of estimating time to pregnancyNiels Keiding, Oluf Kristian Højbjerg HansenRemy Slama (Institut national de la sante et de la recherche medicale, University JFourier Grenoble, Avenir Team Environmental Epidemiology Applied to Fecundityand Reproduction, Grenoble, France), Rene Eijkemans (Department of ReproductiveMedicine and Gynecology, University Medical Center Utrecht, Utrecht, The Nether-lands)

Model averaging in risk assessmentEsben Budtz-Jørgensen, Niels KeidingPhilippe Grandjean (Institute of Public Health, University of Southern Denmark,Odense, Denmark)

Methodological problems in vaccine studies in developing countriesPer Kragh AndersenHenrik Ravn (Bandim Health Project, Danish Epidemiology Science Centre, StatensSerum Institut, Copenhagen, Denmark), Paddy Farrington (Department of Mathe-matics and Statistics, The Open University, Milton Keynes, England)

The concept of biological interaction in epidemiologyPer Kragh AndersenAnders Skrondal (Division of Epidemiology, Norwegian Institute of Public Health,Oslo, Norway)

Pharmacoepidemiology

The problems of the use of prescription databases to assess the risk of sideeffects of hormone therapyLars Hougaard Nielsen, Niels KeidingAnne Helms Andreasen (Research Centre for Prevention and Health, Glostrup Uni-versity Hospital, Glostrup, Denmark), Yrsa Andersen Hundrup (National Instituteof Public Health, University of Southern Denmark, Copenhagen, Denmark), EllenLøkkegaard (Department of Gynecology and Obstetrics, Hillerød Hospital, Hillerød,Denmark)

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2.4 Mathematical statistics

Asymptotic statistical theory

Heavy tail asymptotics in explosive time series modelsTheis LangeSøren Johansen (Department of Economics, University of Copenhagen, Copenhagen,Denmark)

Diffusion models

Goodness of fit test for diffusion-type models based on estimating functionsJulie Lyng FormanHelle Sørensen (Department of Mathematical Sciences, University of Copenhagen,Copenhagen, Denmark), Bo Markussen (Department of Basic Sciences and Environ-ment, University of Copenhagen, Copenhagen, Denmark)

Statistical modeling of protein dynamicsJulie Lyng FormanMichael Sørensen (Department of Mathematical Sciences, University of Copenhagen,Copenhagen, Denmark), Jesper Lund Pedersen (Department of Mathematical Sci-ences, University of Copenhagen, Copenhagen, Denmark), Jesper Ferkinghoff-Borg(Department of Medicine and Technology, DTU-Elektro, Lyngby, Denmark), SandroBottero (Department of Medicine and Technology, DTU-Elektro, Lyngby, Denmark),Thomas Hamelryck (The Bioinformatics Centre, Department of Biology, Universityof Copenhagen, Copenhagen, Denmark)

Measurement error

Calculating the age of the universeJørgen Holm Petersen, Klaus Kahler Holst, Esben Budtz-Jørgensen, Jacob Blindum

2.5 Statistical genetics

Diagnostic and predictive models

Modelling microarray and metabolite data to improve the diagnosis ofinflammatory bowel disease patientsThomas Alexander Gerds, Ulla Brasch MogensenJørgen Olsen (Department of Cellular and Molecular Medicine, University ofCopenhagen, Copenhagen, Denmark), Morten Hansen (Department of Cardiology,Bispebjerg University Hospital, Bispebjerg, Denmark)

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Applied statistical collaborations

Statistical genetics

Recombinations effect on the site frequency spectrum and biased geneconversionsAnders AlbrechtsenInes Hellmann (Departments of Integrative Biology and Statistics, University ofCalifornia, Berkeley, USA), Rasmus Nielsen (Department of Biology, University ofCopenhagen, Copenhagen, Denmark)

Comparison of statistical methods for analysing metabolic dataThomas Alexander Gerds, Anders AlbrechtsenTune Pers (Center for Biological Sequence Analysis, Department of Systems Biology,The Technical University of Denmark, Lyngby, Denmark), Thorkild I.A. Sørensen(Institute of Preventive Medicine, Copenhagen University Hospitals, Copenhagen,Denmark), Claus Holst (Institute of Preventive Medicine, Copenhagen UniversityHospital, Copenhagen, Denmark)

A new method for detecting IBD regions in multiple individuals: makingdisease mapping based on very few individuals possibleAnders AlbrechtsenIda Moltke (The Bioinformatics Centre, Department of Biology, University of Copen-hagen, Copenhagen, Denmark), Rasmus Nielsen (Department of Biology, Universityof Copenhagen, Copenhagen, Denmark)

3 Applied statistical collaborations

3.1 Clinical research

Anaesthesiology

Various neuromuscular blocking agentsLene Theil SkovgaardJørgen Viby Mogensen (Department of Anaesthesia and Intensive Care, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Long-term Consequences of Postoperative Cognitive DysfunctionKarl Bang ChristensenJacob Steinmetz (Department of Anesthesia, Center of Head and Orthopedics, Copen-hagen University Hospital, Copenhagen, Denmark), Lars Rasmussen (Departmentof Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital,Copenhagen, Denmark)

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Predictive risk factors for postherniotomy painJulie Lyng FormanEske Aasvang (Section of Surgical Pathophysiology, Copenhagen University Hospital,Copenhagen, Denmark), Henrik Kehlet (Section of Surgical Pathophysiology, Copen-hagen University Hospital, Copenhagen, Denmark)

Effect of acute and delayed hyperbaric oxygen therapy on cyanide wholeblood levels during acute cyanide intoxication.Esben Budtz-JørgensenPia Lawson-Smith (Department of Anaesthesia, Centre of Head and Orthopaedics,Copenhagen University Hospital, Copenhagen, Denmark)

Mast cell tryptase in patients with suspected allergic reactions duringanesthesiaLene Theil SkovgaardLene Heise (Gentofte University Hospital, Gentofte, Denmark)

Variation in stroke volume under fluid therapyLene Theil SkovgaardMorten Bundgaard-Nielsen (Department of Anaesthesia, Copenhagen UniversityHospital, Copenhagen, Denmark)

Biomedical optics

Precision of continuous estimation of cerebral autoregulation by near-infrared spectroscopy in preterm infantsKarl Bang ChristensenGitte Holst Hahn (Department of Neonatology, Copenhagen University Hospital,Copenhagen, Denmark), Gorm Greisen (Department of Neonatology, CopenhagenUniversity Hospital, Copenhagen, Denmark)

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Cancer incidence and cancer prognosis

Social inequality in cancerTheis LangeUlla Hvidtfeldt (Department of Social Medicine, Institute of Public Health, Universityof Copenhagen, Copenhagen, Denmark), Naja Hulvej Rod (Department of SocialMedicine, Institute of Public Health, University of Copenhagen, Copenhagen, Den-mark), Finn Diderichsen (Section of Social Medicine, Department of Public Health,University of Copenhagen, Copenhagen, Denmark), Ingelise Andersen (Department ofSocial Medicine, Institute of Public Health, University of Copenhagen, Copenhagen,Denmark)

Colorectal polyps and their role in the development of colorectal cancerLene Theil SkovgaardMahin Mohammadi (Department of Pathology, Copenhagen University Hospital,Copenhagen, Denmark)

Hormonal treatment and risk of ovarian cancerLene Theil SkovgaardLina Mørch (Institute of Public Health, University of Southern Denmark, Copen-hagen, Denmark)

Cardiology

DANTRIP: collaboration on pharmacoepidemiological approach to car-diovascular epidemiologyNiels KeidingChristian Torp-Petersen (Department of Cardiology, Gentofte University Hospital,Gentofte, Denmark)

Quantifying the predictive power of new markers for predicting events inthe presence of competing risks.Thomas Alexander GerdsThomas Sehestedt (Cardiovascular Research Unit, Glostrup University Hospital,Copenhagen, Denmark)

Morphological appearances of the stent/vessel wall complexLene Theil SkovgaardMaria Radu (Cardiologic Laboratory, Copenhagen University Hospital, Copenhagen,Denmark)

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Home-based cardiac rehabilitation among elderly with coronary heartdiseaseLene Theil SkovgaardBodil Ørkild (Department of Cardiology, Bispebjerg University Hospital, Copenhagen,Denmark)

Depression in patients with coronary artery disease trial (DECARD)Susanne RosthøjJamal A Hanash (Psychiatric Centre, Bispebjerg University Hospital, Copenhagen,Denmark)

Diabetes

Effect of rehabilitation of patients with type 2 diabetes, in comparison toadvisory lifestyle interventionLene Theil SkovgaardEva Soelberg Vadstrup (Bispebjerg University Hospital, Copenhagen, Denmark)

Fertility

Risk charts predicting ovarian responseThomas Alexander Gerds, Julie Lyng Forman, Jeremy SilverNina La Cour Freiesleben (The Fertility Clinic, The Juliane Marie Center, Copen-hagen University Hospital, Copenhagen, Denmark), Anders Nyboe Andersen (FertilityClinic, Copenhagen University Hospital, Copenhagen, Denmark)

Power calculations for effect of YKL on pregnancy problem outcomesThomas ScheikeDorte Brask (Neurobiology Research Unit, Copenhagen University Hospital, Copen-hagen, Denmark)

Reference curves for AMHThomas ScheikeTrine Holm Johannsen (Department of Clinical Biochemistry, Herlev University Hos-pital, Herlev, Denmark), Lennart Friis-Hansen (Department of Clinical Biochemistry,Copenhagen University Hospital, Copenhagen, Denmark)

Timing of menopause based on the twin registryThomas ScheikeTina Kold Jensen (Department of Environmental Medicine, Institute of PublicHealth, University of Southern Denmark, Odense, Denmark), Annette TønnesPedersen (Clinic of Gynaecology, Copenhagen University Hospital, Copenhagen,Denmark)

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Morbidity in children born after assisted reproductive technology - AScandinavian studyJulie Lyng FormanAnna-Karina Aaris (The Fertility Clinic, Copenhagen University Hospital, Copen-hagen, Denmark), Anja Pinborg (Fertility Clinic, Copenhagen University Hospital,Copenhagen, Denmark), Anders Nyboe Andersen (Fertility Clinic, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Overstimulation at fertility treatmentThomas ScheikeMette Toftager (National Institute of Public Health, University of Southern Denmark,Copenhagen, Denmark)

Relationship between body mass index and outcome of fertility treatmentPer Kragh AndersenLone Schmidt (Department of Social Medicine, Institute of Public Health, Universityof Copenhagen, Copenhagen, Denmark)

Gastroenterology

A meta-analysis of nitroglycerine treatment in pancreatitisPer Kragh AndersenCamilla Nøjgaard (Department of Gastroenterology, Hvidovre University Hospital,Hvidovre, Denmark)

Multistate models in prognostic studies in liver cirrhosisPer Kragh AndersenPeter Jepsen (Department of Clinical Epidemiology, Aarhus University Hospital,Aarhus, Denmark)

Prognostic studies in liver cirrhosisPer Kragh AndersenPeter Jepsen (Department of Clinical Epidemiology, Aarhus University Hospital,Aarhus, Denmark)

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Growth and reproduction

Maternal use of nicotine replacement therapy during pregnancy, and itsrelation to offspringLene Theil SkovgaardTina Harmer Lassen (Department of Growth and Reproduction, Copenhagen Univer-sity Hospital, Copenhagen, Denmark)

Vitamin D metabolism in human spermatozoaJørgen Holm PetersenMartin Blomberg Jensen (Department of Growth and Reproduction, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Gynaecology

Register-based analysis on venous thrombosis among pregnant women inDenmark 1995-2005Ulla Brasch Mogensen, Anne Louise SvendsenØjvind Lidegaard (Gynecologic Clinic, Copenhagen University Hospital, Copenhagen,Denmark)

Heart diseases

Childhood growth and heart diseases in adulthoodPer Kragh AndersenMichael Gamborg (Institute of Preventive Medicine, Copenhagen University Hospi-tal, Copenhagen, Denmark), Thorkild Sørensen (Institute of Preventive Medicine,Copenhagen University Hospitals, Copenhagen, Denmark)

The prognostic effect of heart-rate rhythm on different outcomes.Thomas ScheikeUffe Gang (Department of Cardiology, Gentofte University Hospital, Gentofte,Denmark)

Metformin treatment is associated with reduced mortality in diabetespatients with heart failureTheis LangeCharlotte Andersson (Department of Cardiology, Gentofte University Hospital,Gentofte, Denmark), Christian Torp-Petersen (Department of Cardiology, GentofteUniversity Hospital, Gentofte, Denmark)

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CLARICOR project: Antibiotics and ischaemic heart diseaseJørgen HildenChristian Gluud (Copenhagen Trial Unit, Center for Clinical Intervention Research,Copenhagen University Hospital, Copenhagen, Denmark)

Lung medicine

Development of lung function for patients with Primary Ciliary DyskinesiaLene Theil SkovgaardJune Kehlet Marthin (Pediatric Pulmonary Service and Cystic Fibrosis Centre,Copenhagen University Hospital, Copenhagen, Denmark)

Malaria research

Weight loss for mice with malariaLene Theil SkovgaardJørgen Kurtzhals (Department of Clinical Microbiology, Copenhagen UnicersityHospital, Copenhagen, Denmark)

Neurology

Socioeconomic risk factors for Tourette’s syndromeNiels Keiding, Kira SvendsenNanette Mol Debes (Pediatric Department, Glostrup University Hospital, Glostrup,Denmark)

Immunoglobulin treatment of patients with Inclusion body myositis (IBM)Lene Theil SkovgaardNanna Witting (Department of Neurology, Copenhagen University Hospital, Copen-hagen, Denmark)

Fat metabolism in patients with neuromuscular disordersLene Theil SkovgaardMette Cathrine Ørngreen (Neuromuscular Research Unit, Copenhagen UniversityHospital, Copenhagen, Denmark)

Diagnosis of Lyme borreliosisJørgen HildenRam Dessau (Department of Clinical Microbiology, Næstved Hospital, Næstved,Denmark), Tove Ejlertsen (Department of Clinical Microbiology, Aalborg Hospital,Aalborg, Denmark)

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DAISY: Psycho-social intervention project for dementia patientsNiels KeidingGunhild Waldemar (Memory Disorders Research Unit, Department of Neurology,Copenhagen University Hospital, Copenhagen, Denmark), Frans Waldorff (ResearchUnit and Department of General Practice, Institute of Public Health, University ofCopenhagen, Copenhagen, Denmark)

Oncology

Maintenance therapy of adolescents with B-lineage intermediate risk acutelymphoblastic leukemiaSusanne RosthøjKjeld Schmiegelow (Institute of Gynecology, Obstetrics, and Pediatrics, Departmentof Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark)

Postmenopausal hormone therapy and cancer risk based on prescriptionregistryNiels Keiding, Lars Hougaard NielsenEllen Løkkegaard (Department of Gynecology and Obstetrics, Hillerød Hospital,Hillerød, Denmark), Yrsa Andersen Hundrup (National Institute of Public Health,University of Southern Denmark, Copenhagen, Denmark), Anne Helms Andreasen(Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup,Denmark)

DNA-incorporation of 6-thioguanine nucleotides during maintenancetherapy of childhood acute lymphoblastic leukemia and non-HodgkinlymphomaSusanne RosthøjKjeld Schmiegelow (Institute of Gynecology, Obstetrics, and Pediatrics, Departmentof Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark), RikkeHedeland (Section for Pediatric Hematology and Oncology, Pediatric Clinic II, TheJuliane Marie Center, Copenhagen University Hospital, Copenhagen, Denmark)

Inclusion of white blood count in risk stratification of treatment protocolsfor childhood acute lymphoblastic leukaemia.Susanne RosthøjKjeld Schmiegelow (Institute of Gynecology, Obstetrics, and Pediatrics, Departmentof Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark), GodaVaitkeviciene

Survival of patients developing cardiotoxicity after epirubicin treatmentfor breast cancerPer Kragh Andersen, Martin Theil JensenMarianne Ryberg (Department of Oncology, Herlev University Hospital, Herlev,Denmark)

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F18-cholin-PET imaging in the staging of cancer prostataeJørgen HildenJørn Theil Nielsen (Department of Clinical Physiology and Nuclear Medicine, AarhusUniversitt Hospital, Skejby, Aarhus, Denmark), Bodil Engelmann (Department ofGastrointestinal Surgery D, University Hospital of Glostrup, Copenhagen, Denmark),Liselotte Højgaard (Department of Clinical Physiology and Nuclear Medicine andPET, Copenhagen University Hospital, Copenhagen, Denmark)

MTHFR polymorphisms in treatment of colo-rectal cancerPer Kragh AndersenShoaib Afzal (Institute of Forensic Medicine, University of Aarhus, Aarhus, Denmark)

Monitoring of chemotherapy of children with acute lymphoblasticleukaemiaSusanne Rosthøj, Niels KeidingKjeld Schmiegelow (Institute of Gynecology, Obstetrics, and Pediatrics, Departmentof Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark)

Ophthalmology

Optical coherence tomography is related to intracranial pressure andvisual field sensitivity in idiopathic intracranial hypertensionThomas Alexander GerdsMaren Skau (Danish Headache Center, Glostrup University Hospital, Glostrup,Denmark)

Risk factors of retinopathy of prematurityJulie Lyng FormanCarina Slidsborg (Department of Ophthalmology, Copenhagen University Hospital,Copenhagen, Denmark), Gorm Greisen (Department of Neonatology, CopenhagenUniversity Hospital, Copenhagen, Denmark), Morten la Cour (Department ofOphthalmology, Copenhagen University Hospital, Glostrup Hospital, Copenhagen,Denmark)

A register based study of normal tension glaucoma and risk of dementiaUlla Brasch Mogensen, Julie Lyng Forman, Per Kragh AndersenDaniella Bach Pedersen (Gluacoma Clinic, Eye Clinic, Rigshospitalet, Copenhagen,Denmark), Svend Vedel Kessing (Gluacoma Clinic, Eye Clinic, Rigshospitalet,Copenhagen, Denmark), Lars Vedel Kessing (Department of Psychiatry, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Retinal function in diabetic patientsLene Theil SkovgaardStig Holfort (Dept. of Ophtalmology, Glostrup Hospital, Glostrup, Denmark)

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Oral health research

Qualitative interview and questionnaires are investigated as tools foranamnesis in oral rehabilitationLene Theil SkovgaardEsben Ozhayat (Department of Odontology, University of Copenhagen, Copenhagen,Denmark)

A radiographic study of bone grafts after maxillary sinus floor augmenta-tionJulie Lyng FormanThomas Jensen (Department of Oral Surgery, Aarhus University Hospital, AalborgHospital, Aalborg, Denmark)

Treatment of deformational plagiocephalyLene Theil SkovgaardTron Darvann (3D Craniofacial Image Research Laboratory,Copenhagen UniversityHospital, Copenhagen, Denmark)

Pulp fiction: Developing an online risk calculator for traumatology indentistryThomas Alexander GerdsJens Andreasen (Department of Oral and Maxillofacial Surgery, Copenhagen Univer-sity Hospital, Copenhagen, Denmark), Eva Lauridsen (Resource Center for Rare OralDiseases, University Hospital of Copenhagen, Copenhagen, Denmark), Søren Steno(Department of Oral and Maxillofacial Surgery, Copenhagen University Hospital,,Copenhagen, Denmark)

Analysis of the development stage of wisdom teethThomas Alexander GerdsSøren Rødsgaard (Department of Oral and Maxillofacial Surgery, CopenhagenUniversity Hospital, Copenhagen, Denmark)

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Pediatry

Mortality of children born premature: A Scandinavian studyJulie Lyng FormanRene Mathiasen (Department of Neonatology, Copenhagen University Hospital,Copenhagen, Denmark), Bo Mølholm Hansen (Department of Neonatology, Copen-hagen University Hospital, Copenhagen, Denmark), Gorm Greisen (Department ofNeonatology, Copenhagen University Hospital, Copenhagen, Denmark)

Disease course differences between children and adults in inflammatorybowel diseaseRandi Grøn, Thomas Alexander GerdsAnders Pærregaard (Pediatric Department, Hvidovre University Hospital, Hvidovre,Denmark), Christian Jacobsen (Pediatric Department, Hvidovre University Hospital,Hvidovre, Denmark), Jiri Bartek (Hvidovre Hospital, Hvidovre, Denmark)

Cognitive performance of children with Tourette syndromeTheis LangeNanette Mol Debes (Pediatric Department, Glostrup University Hospital, Glostrup,Denmark), Liselotte Skov (Pediatric Department, Glostrup University Hospital,Glostrup, Denmark)

Pesticide

Pesticide use and symptoms of poisoningJørgen Holm PetersenHanne Klith Jensen (Department of Veterinary Disease Biology/Section for Microbi-ology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark)

Psychiatry

A register-based study of anti-psychotic treatment and risk of diabetesPer Kragh Andersen, Ulla Brasch MogensenLars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital,Copenhagen, Denmark), Anders Frøkjær Thomsen (Department of Psychiatry,Copenhagen University Hospital, Copenhagen, Denmark)

A register-based study on the effect of antidepressants and mood stabiliz-ing medicine on the onset of dementiaJulie Lyng Forman, Per Kragh AndersenLars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital,Copenhagen, Denmark), Lars Søndergaard (Department of Cardiology, The HeartCentre, Copenhagen University Hospital, Copenhagen, Denmark)

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Psycho-social health of children born premature in Denmark 1974-1996Julie Lyng FormanRene Mathiasen (Department of Neonatology, Copenhagen University Hospital,Copenhagen, Denmark), Bo Mølholm Hansen (Department of Neonatology, Copen-hagen University Hospital, Copenhagen, Denmark), Gorm Greisen (Department ofNeonatology, Copenhagen University Hospital, Copenhagen, Denmark), Lars VedelKessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen,Denmark)

Effect of antidepressant medicine and depression during pregnancyRandi Grøn, Per Kragh AndersenLars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital,Copenhagen, Denmark), Øjvind Lidegaard (Gynecologic Clinic, Copenhagen Uni-versity Hospital, Copenhagen, Denmark), Lars Henning Pedersen (School of PublicHealth, Aarhus University, Aarhus, Denmark), Ellen Margrethe Christensen (Depart-ment of Psychiatry, Copenhagen University Hospital, Copenhagen, Denmark), HansMørch Jensen (Psykiatrisk Center Bispebjerg, Copenhagen, Denmark)

Assortative matingMaja Olsbjerg Larsen, Per Kragh AndersenLars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital,Copenhagen, Denmark), Anders Frøkjær Thomsen (Department of Psychiatry,Copenhagen University Hospital, Copenhagen, Denmark)

Prescription of anti-psychotics with or without prior psychiatric contactsPer Kragh Andersen, Gunnar HellmundLars Vedel Kessing (Department of Psychiatry, Copenhagen University Hospital,Copenhagen, Denmark)

Bio-characterization of depressive patients and their relativesJørgen HildenUlla Knorr (Center of Psychiatry, Copenhagen University Hospital, Copenhagen,Denmark), Lars Vedel Kessing (Department of Psychiatry, Copenhagen UniversityHospital, Copenhagen, Denmark)

Respiratory diseases

Two compartment model for flow rate data of COPD patientsThomas Alexander Gerds, Esben Budtz-JørgensenNassim Bazeghi Roberts (GlaxoSmithKline, Copenhagen, Denmark), Jørgen Vestbo(University of Manchester, North West Lung Research Centre, University Hospital ofSouth Manchester Foundation Trust, Manchester, England)

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Sports medicine

Effect of a training program on hamstring injuries in footballEsben Budtz-JørgensenJesper Petersen (Microarray Technology Group, Department of Micro and Nanotech-nology, Technical University of Denmark, Lyngby, Denmark), Kristian Thorborg(Department of Orthopaedic Surgery, Amager Hospital., Copenhagen, Denmark),Michael Bachmann Nielsen (Department of Radiology, Section of Ultrasound, Diag-nostic Centre, Rigshospitalet., Copenhagen, Denmark), Per Holmich (Department ofOrthopaedic Surgery, Amager Hospital., Copenhagen, Denmark)

Tomography

Features of strut apposition after coronary stent implantationLene Theil Skovgaard, Sara BrebbiaMaria Radu (Cardiologic Laboratory, Copenhagen University Hospital, Copenhagen,Denmark)

3.2 Epidemiology

Diabetes

Insulin-resistance and chronic low-grade inflammationKarl Bang Christensen, Kira Dynnes SvendsenSofie Andreasen (The Centre of Inflammation and Metabolism, Copenhagen Univer-sity Hospital, Copenhagen, Denmark)

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Environmental epidemiology

Air pollution, Methods for assessing the effects of air pollution on urgenthospital admissionThomas Alexander Gerds, Sara Brebbia, Jens FlachsJanine Wichmann (School of Health Systems and Public Health, Health SciencesFaculty, University of Pretoria, Pretoria, South Africa), Zorana Jovanovic Andersen(Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark),Steffen Loft (Section of Environmental Health, Department of Public Health, Univer-sity of Copenhagen, Copenhagen, Denmark)

An international pooled analysis for obtaining a Benchmark dose forexposure to leadEsben Budtz-JørgensenBruce Lanphear (Cincinnati Children’s Environmental Health Center, Departmentof Pediatrics and of Environmental Health, Cincinnati, USA), David Bellinger(Department of Neurology, Children’s Hospital Boston and Harvard Medical School,Boston, USA), Philippe Grandjean (Institute of Public Health, University of SouthernDenmark, Odense, Denmark)

Environmental epidemiologyEsben Budtz-JørgensenPhilippe Grandjean (Institute of Public Health, University of Southern Denmark,Odense, Denmark)

Epidemiology and social medicine

Social Differences in Specialized careJørgen Holm PetersenPernille Due (National Institute of Public Health, University of Southern Denmark,Copenhagen, Denmark)

Bereavement and risk of ischaemic heart diseasePer Kragh AndersenMargit Kriegbaum (Department of Social Medicine, Institute of Public Health,University of Copenhagen, Copenhagen, Denmark)

Social inequalities in headache among adolescentsPer Kragh AndersenChristina Schnohr (Department of Social Medicine, Institute of Public Health,University of Copenhagen, Copenhagen, Denmark)

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Preventive child health care at general practitioner and social differencesin the use of specialized careJørgen Holm PetersenSolvej Martensson (Research Centre for Prevention and Health, Glostrup UniversityHospital, Glostrup, Denmark), Pernille Due (National Institute of Public Health,University of Southern Denmark, Copenhagen, Denmark)

Familial aggregation of deep venous thrombosisLars Jorge Diaz, Per Kragh AndersenHenrik Toft Sørensen (Clinical Epidemiology, Aarhus University, Aarhus, Denmark)

Physical exercise as a risk factor for fetal deathPer Kragh AndersenMette Juhl (National Institute of Public Health, University of Southern Denmark,Copenhagen, Denmark)

Socio-economic position and risk of preterm birthPer Kragh AndersenCamilla Morgen (National Institute of Public Health, University of Southern Den-mark, Copenhagen, Denmark)

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Genetic epidemiology

LuCamp: Lundbeck Foundation Centre for Applied Medical Genomics inPersonalised Disease Prediction, Prevention and Care.Anders AlbrechtsenOluf Pedersen (Steno Diabetes Center, Gentofte, Denmark), Torben Hansen (Techni-cal University of Denmark, Lyngby, Denmark), Jun Wang (Division of DevelopmentalGenetics, Institute of Molecular Embryology and Genetics, Kumamoto University,Kumamoto, Japan), Knut Borch Johnsen (Steno Diabetes Center, Gentofte, Den-mark), Gitte Andersen (Steno Diabetes Center, Gentofte, Denmark), Lars Bolund(Department of Human Genetics, University of Aarhus, Aarhus, Denmark), OleSchmitz (Department of Diabetes, University Hospital of Aarhus, Aarhus, Denmark),Torsten Lauritzen (Department of General Practice, Institute of Public Health, Uni-versity of Aarhus, Aarhus, Denmark), Karsten Kristiansen (Department of Biology,University of Copenhagen, Copenhagen, Denmark), Torben Jørgensen (ResearchCentre for Prevention and Health, Glostrup University Hospital, Copenhagen,Denmark), Arne Astrup (Department of Human Nutrition, Faculty of Life Sciences,University of Copenhagen, Copenhagen, Denmark), Thue Schwartz (Laboratory forMolecular Pharmacology, Institute of Neuroscience and Pharmacology, Universityof Copenhagen, Copenhagen, Denmark), Rasmus Nielsen (Department of Biology,University of Copenhagen, Copenhagen, Denmark)

Pubertal Onset in Boys and the Growth Hormone Receptor Exon 3 GeneDeletionJørgen Holm PetersenKaspar Sørensen (Department of Growth and Reproduction, Copenhagen UniversityHospital, Copenhagen, Denmark)

Twin study about heritability of heart functionEsben Budtz-JørgensenChristian Haarmark Nielsen (Laboratory of Experimental Cardiology, University ofCopenhagen, Copenhagen, Denmark), Jørgen K. Kanters (Laboratory of Experimen-tal Cardiology, University of Copenhagen, Copenhagen, Denmark), Kirsten O. Kyvik(The Danish Twin Registry, University of Southern Denmark, Odense, Denmark)

Education and morbidity/mortality in twinsPer Kragh AndersenMia Madsen (Department of Environmental Medicine, Institute of Public Health,University of Southern Denmark, Odense, Denmark)

Genetic prevalence of mutant genes related to malariaLene Theil SkovgaardHelle Holm Hansson (Department of International Health, Immunology and Microbi-ology, University of Copenhagen, Copenhagen, Denmark)

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Reference levels for AMHJørgen Holm PetersenAnders Juul (Department of Growth and Reproduction, Copenhagen UniversityHospital, Copenhagen, Denmark)

Survey in France of time to pregnancyNiels Keiding, Oluf Kristian Højbjerg HansenRemy Slama (Institut national de la sante et de la recherche medicale, University JFourier Grenoble, Avenir Team Environmental Epidemiology Applied to Fecundityand Reproduction, Grenoble, France), Jean Bouyer (Inserm, National Institute ofHealth and Medical Research, U569, Paris, France)

Timing of menarche and estimation of heritability based on the twin-registryThomas ScheikeAnders Juul (Department of Growth and Reproduction, Copenhagen UniversityHospital, Copenhagen, Denmark), Tina Kold Jensen (Department of EnvironmentalMedicine, Institute of Public Health, University of Southern Denmark, Odense,Denmark), Kaspar Sørensen (Department of Growth and Reproduction, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Time to pregnancyThomas ScheikeTina Kold Jensen (Department of Environmental Medicine, Institute of PublicHealth, University of Southern Denmark, Odense, Denmark)

Thyroid hormones during normal pregnanciesJulie Lyng Forman, Jørgen Holm PetersenMalene Boas (Department of Growth and Reproduction, Copenhagen UniversityHospital, Copenhagen, Denmark), Katharina Main (Department of Growth andReproduction, Copenhagen University Hospital, Copenhagen, Denmark)

Human nutrition

Determinants for vitamin D levelLene Theil SkovgaardRikke Andersen (Department of Nutrition, National Food Institute, TechnicalUniversity, Søborg, Denmark)

Evaluation of a nutritional program for children in EthiopiaLene Theil SkovgaardJutta Skau (Department of Public Health, Faculty of Health Sciences, University ofCopenhagen, Copenhagen, Denmark)

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Immunology

Chronic lymphocytic leukæmia and autoimmunityJørgen HildenViggo Jønsson (Division of Hematology, Aker University Hospital, University of Oslo,Oslo, Norway)

Malaria research

Risk Factors and Spatial Variation in Malaria in Area of Different Trans-mission Intensities in Northeastern TanzaniaBruno Paul Mmbando, Thomas ScheikeThor Theander (Department of International Health, Immunology and Microbiology,University of Copenhagen, Copenhagen, Denmark)

Consequences of pregnancy-associated malaria on fetal growthThomas ScheikeThor Theander (Department of International Health, Immunology and Microbiology,University of Copenhagen, Copenhagen, Denmark), Christentze Schmiegelow

Mediation analysis

Poor sleep quality and mortality: Is the relation mediated by diabetes,weight changes, and/or hypertension?Theis LangeNaja Hulvej Rod (Department of Social Medicine, Institute of Public Health,University of Copenhagen, Copenhagen, Denmark)

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Neuroimaging

Examination of seasonal variation in plasma membrane serotonin trans-porter measured by PET-scansEsben Budtz-Jørgensen, Klaus Kahler HolstGitte Moos Knudsen (Dept. Neurology and Neurobiology Research Unit, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Association between response to pain and 5-HT2A receptor binding in thehuman brainEsben Budtz-JørgensenRon Kupers (Department of Clinical Physiology and Nuclear Medicine and PET,Copenhagen University Hospital, Copenhagen, Denmark), Gitte Moos Knudsen(Dept. Neurology and Neurobiology Research Unit, Copenhagen University Hospital,Copenhagen, Denmark), Vibe Frøkjær (Neurobiology Research Unit and Center forIntegrated Molecular Brain Imaging, Copenhagen University Hospital, Copenhagen,Denmark)

Genetic predictors of brain serotonin 2A receptor bindingEsben Budtz-Jørgensen, Klaus Kahler HolstGitte Moos Knudsen (Dept. Neurology and Neurobiology Research Unit, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Using structural equation models to describe the variation in PET-dataEsben Budtz-Jørgensen, Klaus Kahler HolstGitte Moos Knudsen (Dept. Neurology and Neurobiology Research Unit, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Obesity

Overweight among children in GreenlandJørgen Holm PetersenChristina Schnohr (Department of Social Medicine, Institute of Public Health,University of Copenhagen, Copenhagen, Denmark)

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Occupational epidemiology

Occupational exposure to the sun and risk of skin and lip cancer amongmale wage earnersEsben Budtz-JørgensenLine Kenborg (Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen,Denmark), Ane Dahl Jørgensen (Institute of Cancer Epidemiology, Danish Cancer So-ciety, Copenhagen, Denmark), Lisbeth E Knudsen (Department of Occupational andEnvironmental Health, University of Copenhagen, Copenhagen, Denmark), JohnniHansen (Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen,Denmark)

Occupational medicine

Factors of importance for sickness absenceSigne Jensen, Svend Kreiner, Nina BreinegaardSigurd Mikkelsen (Department of Occupational Medicine, Glostrup UniversityHospital, Glostrup, Denmark)

Work environment

Risk factors for disability pensionKarl Bang ChristensenHelene Feveile (The National Research Centre for the Working Environment, Copen-hagen, Denmark)

Noise exposure as a risk factor for long-term sickness absenceKarl Bang ChristensenThomas Clausen (National Research Centre for the Working Environment, Copen-hagen, Denmark)

3.3 Public health

Health Economics

Quality of life adjusted survival after myocardial infarctionPer Kragh Andersen, Kira Dynnes SvendsenAnne Hvenegaard (Danish Institute for Health Services Research, Copenhagen,Denmark), Jes Søgaard (Danish Institute for Health Services Research, Copenhagen,Denmark)

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Health services research

Effect of ethnic background on Danish health care utilisation patternsNiels Keiding, Ana Garcia LopezMarie Nørredam (Section for Health Services Research, Department of Public Health,University of Copenhagen, Copenhagen, Denmark), Allan Krasnik (Section for HealthServices Research, University of Copenhagen, Copenhagen, Denmark)

3.4 Statistical genetics


Genetic factors behind male infertilityJeremy Silver, Thomas Alexander GerdsHenrik Leffers (Department of Growth and Reproduction, Copenhagen UniversityHospital, Copenhagen, Denmark), Ramneek Gupta (Center for Biological SequenceAnalysis, Department of Systems Biology, Technical University of Denmark, Lyngby,Denmark)

Statistical genetics

Association studies for major depressive disorder using SNP chip dataAnders Albrechtsen, Peter DalgaardThomas Hansen (Department of Chemistry, Centre for Catalysis and SustainableChemistry, Technical University of Denmark, Lyngby, Denmark), Ulrik Gether(Molecular Neuropharmacology Group, Department of Pharmacology, Universityof Copenhagen, Copenhagen, Denmark), Thomas Werge (Research Institute ofBiological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen UniversityHospital, Roskilde, Denmark)

Relatedness and linkage analysis using 500k Affymetrix dataAnders AlbrechtsenFinn Cilius Nielsen (Bioinformatics Centre, University of Copenhagen, Copenhagen,Denmark), Thomas van Overeem Hansen (Department of Chemistry, Centre forCatalysis and Sustainable Chemistry, Technical University of Denmark, Lyngby,Denmark)

Darwinian and demographic forces affecting human protein coding genesAnders AlbrechtsenRasmus Nielsen (Department of Biology, University of Copenhagen, Copenhagen,Denmark), Ines Hellmann (Departments of Integrative Biology and Statistics,University of California, Berkeley, USA)

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Statistical software development

Genetic variant near IRS1 is associated with type 2 diabetes, insulinresistance and hyperinsulinemiaAnders Albrechtsen

Genetic and environmental effects in infectious diseasesPer Kragh AndersenLiselotte Petersen (Institute of Preventive Medicine, Copenhagen University Hospital,Copenhagen, Denmark)

Prevention of von Hippel-Lindaus diseaseEsben Budtz-JørgensenMarie-Louise Bisgaard (Department of Cellular and Molecular Medicine, University ofCopenhagen, Copenhagen, Denmark), Marie Louise Poulsen (Department of Cellularand Molecular Medicine, University of Copenhagen, Copenhagen, Denmark)

4 Statistical software development

Digram: a program for analysis of ordinal categorical dataSvend Kreiner

Timereg R package : Extensive R package of programs for estimation ofadvanced modern survival modelsThomas Scheike

MultiComp : R package for modelling of dependence for multivariatecompeting risks data.Thomas ScheikeYanqing Sun (Department of Mathematics and Statistics, The University of NorthCarolina at Charlotte, Charlotte, USA)

Prediction error curves: R package to compare survival prediction mod-elling strategies.Thomas Alexander Gerds

HaploSurvival : R-package for haplotype effects in survival and competingrisks dataThomas Scheike, Jeremy Silver

R-package for the product-limit method in event history modelsThomas Alexander Gerds

Development of residual-based goodness-of-fit tests in RKlaus Kahler Holst

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Core facility

Development of Latent Variable Modelling framework in RKlaus Kahler Holst

Implementation of IRT models in SASKarl Bang Christensen, Maja Olsbjerg Larsen

AssoF, AssoG: R package generator for association studies.Anders AlbrechtsenTorben Hansen (Technical University of Denmark, Lyngby, Denmark), Niels Grarup(Steno Diabetes Center, Gentofte, Denmark), Thomas Sparsø(Steno Diabetes Center,Gentofte, Denmark), Oluf Pedersen (Steno Diabetes Center, Gentofte, Denmark),Camilla Andersen (Department of Veterinary Pathobiology, The Royal Veterinaryand Agricultural University, Copenhagen, Denmark)

5 Core facility

The Faculty of Health Sciences has created a Core Facility in Biostatistics led by NielsKeiding. The Core Facility started in 2007 and will run until 2011. The purpose ofthe Core Facility is to conduct independent biostatistical research as well as assistingthe Cluster of Fetal Environmental and Postnatal Disease (lead by Professor AndersJuul, Department of Growth and Reproduction, Rigshospitalet) and the Post-GenomicPublic Health Cluster - GENPUB (lead by Professor Steffen Loft, Department ofEnvironmental Health, Institute of Public Health) with biostatistical tasks.

In 2009, the following people were fully or partly financed by the Core Facility:Thomas Scheike, Thomas Alexander Gerds, Jørgen Holm Petersen, Julie Lyng Forman,and Sara Brebbia. In 2009, part of the work of these people was directly connected tothe Core Facility in Biostatistics.

5.1 Core Facility: Projects

In 2009, the following projects were directly associated to the Core Facility of Bio-statistics1:

Reference levels for AMHJørgen Holm PetersenAnders Juul (Department of Growth and Reproduction, Copenhagen UniversityHospital, Copenhagen, Denmark)

Overweight among children in GreenlandJørgen Holm PetersenChristina Schnohr (Department of Social Medicine, Institute of Public Health,University of Copenhagen, Copenhagen, Denmark)

1Note, that the same projects are also listed in the previous subsections

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Core facility

Risk charts predicting ovarian responseThomas Alexander Gerds, Julie Lyng Forman, Jeremy SilverNina La Cour Freiesleben (The Fertility Clinic, The Juliane Marie Center, Copen-hagen University Hospital, Copenhagen, Denmark), Anders Nyboe Andersen (FertilityClinic, Copenhagen University Hospital, Copenhagen, Denmark)

Methods for constructing age-specific 2-dimensional reference charts forreproductive hormonesJørgen Holm Petersen

Modelling microarray and metabolite data to improve the diagnosis ofinflammatory bowel disease patientsThomas Alexander Gerds, Ulla Brasch MogensenJørgen Olsen (Department of Cellular and Molecular Medicine, University ofCopenhagen, Copenhagen, Denmark), Morten Hansen (Department of Cardiology,Bispebjerg University Hospital, Bispebjerg, Denmark)

Timing of menarche and estimation of heritability based on the twin-registryThomas ScheikeAnders Juul (Department of Growth and Reproduction, Copenhagen UniversityHospital, Copenhagen, Denmark), Tina Kold Jensen (Department of EnvironmentalMedicine, Institute of Public Health, University of Southern Denmark, Odense,Denmark), Kaspar Sørensen (Department of Growth and Reproduction, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Comparison of statistical methods for analysing metabolic dataThomas Alexander Gerds, Anders AlbrechtsenTune Pers (Center for Biological Sequence Analysis, Department of Systems Biology,The Technical University of Denmark, Lyngby, Denmark), Thorkild I.A. Sørensen(Institute of Preventive Medicine, Copenhagen University Hospitals, Copenhagen,Denmark), Claus Holst (Institute of Preventive Medicine, Copenhagen UniversityHospital, Copenhagen, Denmark)

Describing association for competing risks dataThomas ScheikeYanqing Sun (Department of Mathematics and Statistics, The University of NorthCarolina at Charlotte, Charlotte, USA)

Random effects models for competing risks dataThomas ScheikeMei-Jie Zhang (Division of Biostatistics, Medical College of Wisconsin, Milwaukee,USA), Yanqing Sun (Department of Mathematics and Statistics, The University ofNorth Carolina at Charlotte, Charlotte, USA), Tina Kold Jensen (Department ofEnvironmental Medicine, Institute of Public Health, University of Southern Denmark,Odense, Denmark)

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Core facility

MultiComp : R package for modelling of dependence for multivariatecompeting risks data.Thomas ScheikeYanqing Sun (Department of Mathematics and Statistics, The University of NorthCarolina at Charlotte, Charlotte, USA)

Timing of menopause based on the twin registryThomas ScheikeTina Kold Jensen (Department of Environmental Medicine, Institute of PublicHealth, University of Southern Denmark, Odense, Denmark), Annette TønnesPedersen (Clinic of Gynaecology, Copenhagen University Hospital, Copenhagen,Denmark)

Psycho-social health of children born premature in Denmark 1974-1996Julie Lyng FormanRene Mathiasen (Department of Neonatology, Copenhagen University Hospital,Copenhagen, Denmark), Bo Mølholm Hansen (Department of Neonatology, Copen-hagen University Hospital, Copenhagen, Denmark), Gorm Greisen (Department ofNeonatology, Copenhagen University Hospital, Copenhagen, Denmark), Lars VedelKessing (Department of Psychiatry, Copenhagen University Hospital, Copenhagen,Denmark)

Risk factors of retinopathy of prematurityJulie Lyng FormanCarina Slidsborg (Department of Ophthalmology, Copenhagen University Hospital,Copenhagen, Denmark), Gorm Greisen (Department of Neonatology, CopenhagenUniversity Hospital, Copenhagen, Denmark), Morten la Cour (Department ofOphthalmology, Copenhagen University Hospital, Glostrup Hospital, Copenhagen,Denmark)

Morbidity in children born after assisted reproductive technology - AScandinavian studyJulie Lyng FormanAnna-Karina Aaris (The Fertility Clinic, Copenhagen University Hospital, Copen-hagen, Denmark), Anja Pinborg (Fertility Clinic, Copenhagen University Hospital,Copenhagen, Denmark), Anders Nyboe Andersen (Fertility Clinic, CopenhagenUniversity Hospital, Copenhagen, Denmark)

Pubertal Onset in Boys and the Growth Hormone Receptor Exon 3 GeneDeletionJørgen Holm PetersenKaspar Sørensen (Department of Growth and Reproduction, Copenhagen UniversityHospital, Copenhagen, Denmark)

Heritability for survival dataKlaus Kahler Holst, Jørgen Holm Petersen, Thomas Scheike

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Core facility

Mortality of children born premature: A Scandinavian studyJulie Lyng FormanRene Mathiasen (Department of Neonatology, Copenhagen University Hospital,Copenhagen, Denmark), Bo Mølholm Hansen (Department of Neonatology, Copen-hagen University Hospital, Copenhagen, Denmark), Gorm Greisen (Department ofNeonatology, Copenhagen University Hospital, Copenhagen, Denmark)

Time to pregnancyThomas ScheikeTina Kold Jensen (Department of Environmental Medicine, Institute of PublicHealth, University of Southern Denmark, Odense, Denmark)

Thyroid hormones during normal pregnanciesJulie Lyng Forman, Jørgen Holm PetersenMalene Boas (Department of Growth and Reproduction, Copenhagen UniversityHospital, Copenhagen, Denmark), Katharina Main (Department of Growth andReproduction, Copenhagen University Hospital, Copenhagen, Denmark)

5.2 Core Facility: Publications

In 2009, the following publications were associated to the Core Facility in Biostatis-tics2:

Boas M, Forman JL, Juul A, Feldt-Rasmussen U, Skakkebæk NE, Chellakooty M,

Larsen T, Falck Larsen J, Petersen JH & Main KM (2009) Narrow intra-individual

variation of maternal thyroid function in pregnancy based on a longitudinal study of 132

women European Journal of Endocrinology 161 903-910.

Petersen JH (2009) A non-parametric conditional bivariate reference region with an appli-

cation to height/weight measurements on normal girls Biometrical Journal 51 (4) 697-709.

Olsen J, Gerds TA, Seidelin JB, Csillag C, Bjerrum JT, Troelsen JT & Nielsen OH

(2009) Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling

of genome-wide gene expression data Inflammatory Bowel Diseases 15 (7) 1032-1038.

Joffe M, Key J, Best N, Jensen TK & Keiding N (2009) The role of biological fertility

in predicting family size Human Reproduction 24 (8) 1999-2006.

Key J, Best N, Joffe M, Jensen TK & Keiding N (2009) Methodological issues in

analyzing time trends in biologic fertility: Protection bias American Journal of Epidemiology

169 (3) 285-293.

Pers TH, Albrechtsen A, Holst C, Sørensen TIA & Gerds TA (2009) The validation

and assessment of machine learning: A game of prediction from high-dimensional data PLoS

ONE 4 (8) e6287.

Teilmann G, Petersen JH, Gormsen M, Damgaard K, Skakkebæk NE & Jensen

TK (2009) Early puberty in internationally adopted girls: hormonal and clinical markers of

puberty in 276 girls examined biannually over two years Hormone Research 72 (4) 236-246.

2The same publications are also listed later on in chapter Publications

45

Core facility

Bang AK, Petersen JH, Petersen PM, Andersson A, Daugaard G & Jørgensen

N (2009) Testosterone production is better preserved after 16 than 20 Gray irradiation treat-

ment against testicular carcinoma in situ cells International Journal of Radiation: Oncology

- Biology - Physics 75 (3) 672-676.

Sørensen K, Aksglaede L, Munch-Andersen T, Aachmann-Andersen NJ, Petersen

JH, Hilsted L, Helge JW & Juul A (2009) Sex hormone-binding globulin levels predict

insulin sensitivity, disposition index, and cardiovascular risk during puberty Diabetes Care 32

(5) 909-914.

Aksglaede L, Sørensen K, Petersen JH, Skakkebæk NE & Juul A (2009) Recent

decline in age at breast development: The Copenhagen Puberty Study Pediatrics Electronic

Pages 123 (5) 932-939.

46

Statistical community

1 Advisory and journal activities

Members of the staff are actively engaged in editorial work and various activities thatare beneficial for statistical society.

Esben Budtz-Jørgensen

• Statistical Advisor - Environmental Health

• Member of ISI- Committee on Risk Analysis

• PhD committee Mette Gerster (Department of Biostatistics)

Jørgen Holm Petersen

• Associate Editor (Biometrical Journal)

Niels Keiding

• Advisory board (Biostatistics)

• Editorial Board (Chapman & Halls Monographs in Statistics)

• Editorial Board (Chapman & Hall Interdisciplinary Statistics Series)

• Member of advisory board, Linnaeus project ’Ageing and living conditions’ (Uni-versity of Umea)

• Member of steering committee, Evaluation of mammography screening (Norwe-gian Research Council)

47

Advisory and journal activities

Per Kragh Andersen

• Associate Editor (Statistical Methods in Medical Research)

• Associate Editor (Biometrics)

• Associate Editor (Lifetime Data Analysis)

Peter Dalgaard

• Member (The R Foundation for Statistical Software)

Thomas Alexander Gerds

• Associate Editor (Biometrical Journal)

Thomas Scheike

• Associate Editor (Journal of the Royal Statistical Society Series B)

• Associate editor (Lifetime Data Analysis)

• Member of the Research Section (The Royal Statistical Society)

48

International collaboration

2 International collaboration

The department has many international contacts, both through international visitorshere and through our own study leaves abroad and participation in international con-ferences. This section lists guests and seminars, as well as talks and travels of thescientific staff.

2.1 Visitors

March

Michael Kattan (Quantitative Health Sciences, Cleveland Clinic, Ohio, USA)

Thomas Lumley (Department of Biostatistics, University of Washington, Seattle, USA)

May

Kyle Raymond (University of Waterloo, Ontario, Canada)

Giuliana Cortese (Department of Statistical Science, University of Padova, Padova, Italy)

Jessica Kasza (University of Adelaide, Adelaide, Australia)

June

Anthony J. McMichael (National Centre for Epidemiology and Population Health, The

Australian National University, Canberra, Australia)

Halina Frydman (Stern School of Business, New York University, New York, USA)

Bastian Mengelle (Ecole Nationale de la Statistique et de lAnalyse de lInformation, Rennes,

France)

Yacine el Bouhairi (Ecole Nationale de la Statistique et de lAnalyse de lInformation,

Rennes, France)

Stijn Vansteelandt (Department of Applied Mathematics and Computer Science, University

of Ghent, Belgium)

Yanqing Sun (Department of Mathematics and Statistics, University of North Carolina at

Charlotte)

49


Victor Panaretos (Institute of Mathematics, Ecole Polytechnique Federale de Lausanne)

July

Yacine el Bouhairi (Ecole Nationale de la Statistique et de lAnalyse de lInformation,

Rennes, France)

Bastian Mengelle (Ecole Nationale de la Statistique et de lAnalyse de lInformation, Rennes,

France)

Martin Machler (Swiss Federal Institute of Technology Zurich, Switzerland)

John Chambers (Stanford University, California, USA)

Deepayan Sarkar (Fred Hutchinson Cancer Research Center, Seattle, USA)

Simon Urbanek (AT+T Labs, New Jersey, USA)

Luke Tierney (University of Iowa, Iowa City, USA)

Jonas Abrahamsson (Department of Pediatrics, Queen Silvia Children’s Hospital, Goteborg,

Sweden)

Uwe Ligges (University of Dortmund, Germany)

Doug Bates (University of Wisconsin, Madison, Wisconsin, USA)

August

Knut Liestøl (University of Oslo, Norway)

Roger Bivand (Norwegian School of Economics and Business Administration, Bergen,

Norway)

Ørnulf Borgan (University of Oslo, Norway)

Martyn Plummer (International Agency for Research on Cancer, Lyon, France)

50


September

Vladimir Canudas-Romo (Johns Hopkins University, Baltimore, USA)

Giuliana Cortese (Department of Statistical Science, University of Padova, Padova, Italy)

Øystein Kravdal (Department of Economics, University of Oslo, Oslo, Norway)

Aurelien Latouche (Universite Versailles St. Quentin, Versailles, France)

October

James Carpenter (London School of Hygiene and Tropical Medicine, London, England)

November

Vanessa Didelez (University of Bristol, Bristol, England)

Mounir Mesbah (Universite Pierre et Marie Curie, Paris, France)

Bianca de Stavola (London School of Hygiene and Tropical Medicine, London, England)

2.2 Seminar

The following researchers presented at the department:

26 January 2009Umberto Picchini Department of Mathematical Sciences, University of CopenhagenRandom parameters in stochastic differential equation models with applications

16 March 2009Michael Kattan Quantitative Health Sciences, Cleveland ClinicEncouraging the Use of Statistical Prediction Models

31 March 2009Thomas Lumley Department of Biostatistics, University of Washington, SeattleCase-crossover and other case-distribution designs

51


20 April 2009Karl Bang Christensen Department of Biostatistics, University of CopenhagenMonte Carlo tests of the Rasch model based on scalability coefficients. Joint work withSvend Kreiner

18 May 2009Ole Winther Intelligent Signal Processing, Informatics and Mathematical Modelling,Technical University of DenmarkBayesian networks and graphical models with machine learning applications

8 June 2009Yanqing Sun Department of Mathematics and Statistics, University of NorthCarolina at CharlotteEmpirical likelihood inference for the Cox model with time-dependent coefficients vialocal partial likelihood

15 June 2009Victor Panaretos Institute of Mathematics, Ecole Polytechnique Federale deLausanneSecond-Order Functional Comparison of DNA Minicircles.

25 June 2009Stijn Vansteelandt Department of Applied Mathematics and Computer ScienceGhent UniversityAdjusting for time-varying confounding in survival analysis with competing risks

17 August 2009Martyn Plummer Infection and Cancer Epidemiology (ICE) group, InternationalAgency for Research on Cancer, LyonBayesian hierarchical modelling with JAGS

28 September 2009Aurelien Latouche Universite Versailles St-Quentin, FranceA Regression Model for the Conditional Cumulative Incidence Function

2 November 2009Bendix Carstensen Steno Diabetes Center, Gentofte & Department of Biostatistics,University of CopenhagenPractical aspects of multistate modelling: Representation, timescales and prediction

19 November 2009Bianca De Stavola London School of Hygiene and Tropical MedicineFamilial and socio-economic influences on foetal growth across three generations: TheUppsala Birth Cohort Multigenerational study, Sweden, 1915-2002

52

External presentations of members of the department

3 External presentations of members of the de-partment

3.1 Talks

Anders Albrechtsen

Bayesian association studies, allowing for higher order interaction in association studiesENAR, Spring Meeting with IMS and Sections of ASASan Antonio, Texas, USA

Per Kragh Andersen

Applications of counting processes in epidemiologyUniversite Bordeaux 2

Biological interaction from a statistical point of view2nd Channel Network Conference of the IBSGent, Belgien

Multi-state models and models for competing risksErasmus MCRotterdam, Holland

Follow-up studiesEuropean Educational Programme in EpidemiologyFirenze, Italy

Event dependent sampling of recurrent eventsISCBISCB, Prague, Czech Republic

The influence of Cox’s article about regression models and life-tablesInternational Conference of the Royal Statistical SocietyEdinburgh, Scotland

Competing risks and time-dependent covariatesDSTS todagesmøde, SDUOdense

Recurrent events in psychiatric epidemiology9th Galician congress on statistics and operations researchOurence, Spanien

Biological interaction from a statistical point of viewWorkshop on mediation and interactionSchæffergarden, Gentofte, Denmark


Joint analysis data from two cohort studies on the health effects of prenatal exposuresto mercury and PCBThorshavn

53


Different approaches to model averaging in environmental risk assessmentInternational Conference of the Royal Statistical SocietyEdinburgh, Scotland

Approaches to handling uncertainty when setting environmental exposure standardsUniversity of Southern Denmark

An international pooled analysis for obtaining a benchmark dose for environmentallead exposure in childrenpptoxII (conference)Miami, USA.

Peter Dalgaard

Ideas about likelihood-based data analysis in RStatistisk stjerneforskernetværkJørlunde

Everything you ever wanted to know about R (almost)DTU Informatics, Sect. f. Scientific Computing

Strengths and weaknesses of the R language for statistical computingInvited paper sessionIMST 2009, Plzen, Czech Republic

Ideas about likelihood-based data analysis in RDirections in Statistical Computing (DSC)Copenhagen, Denmark

Ideas about likelihood-based data analysis in R2nd Nordic-Baltic Biometric ConferenceTartu, Estland

What we wish people knew more about when working with RuseR, Invited LectureRennes, France

Julie Lyng Forman

The Pearson diffusions: Statistically tractable diffusionsJoint Statistical Meeting 2009Washington DC


The statistical evaluation of risk prediction modelsINSERM, Epidemiology and Biostatistics Research Center, Bordeaux, France

Random survival forests in actionStatistisches KolloquiumHeinrich-Heine University, Dusseldorf, Germany

54


Gunnar Hellmund

Statistical analysis of FLIM dataWorkshopDepartment of Mathematical Science, University of Aarhus

Jørgen Hilden

Borrelia diagnostics - statistical aspectsNordiske BorreliadageOrenas Slott, Skane, Sweden

Klaus Kahler Holst

An R package for structural equation modelingStatistisk stjerneforskernetværkJørlunde

Non-linear structural equation models with applications in NeuroimagingJoint Statistical Meeting 2009Washington DC

Niels Keiding

Estimation of time-to-pregnancy from current duration dataStatistisk stjerneforskernetværkJørlunde

Har peer review stadig en chance?Arsmøde i Nationalkomiteen for VidenskabsfilosofiNiels Bohr Instituttet

Design and analysis of time-to-pregnancy studiesDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden

Talk with panel discussionCausal inference: State-of-the-ArtUniversity of Cambridge

Kan man forudsige den enkelte patients restlevetid?InstitutkonferenceKollekolle

Event history analysis and the cross-sectionDepartment of Statistics, University of Chicago

Greenberg Lecture Series, part I: A Event history analysis and the cross section. BDesign and analysis of time-to-pregnancy - Classical approaches.Greenberg Lecture SeriesDepartment of Biostatistics, University of North Carolina at Chapel Hill, North Car-olina

55


Greenberg Lecture Series, part II: A Design and analysis of time-to-pregnancy -Current duration data. B Pharmacoepidemiology: prescription registries and cross-sectional surveysGreenberg Lecture SeriesDepartment of Biostatistics, University of North Carolina at Chapel Hill, North Car-olina

Rates of births and induced abortions in Denmark according to age, previous births,and previous abortions57th Session of the ISIDurban, South Africa (via e-link)

Biostatisticians - the Danish model: the challenge of using both cerebral hemispheresLeiden University

The role of study design in the evaluation of health effects of postmenopausal hormonetherapyWorkshop on Causal ModellingOslo

Estimation of time-to-pregnancy from current duration dataMRC Biostatistics UnitCambridge

Analysis of time-to-pregnancyMRC Centre for Causal Analyses in Translational EpidemiologyDepartment of Social Medicine, University of Bristol, England

Theis Lange

Mediation in Survival AnalysisDSTS todagesmøde, University of Southern DenmarkOdense

Ulla Brasch Mogensen

Survival paths through the forestStatistisk stjerneforskernetværkJørlunde

Application of random survival forests based on pseudo-valuesISCBISCB, Prague, Czech Republic

Lisbeth Nørgaard Møller

Determinants for GP visits in a primary intervention settingForskningens DagGlostrup Hospital

56


Janne Petersen

Latent Class Predictions for Subsequent AnalysisJoint statistical meetingWashington

Jørgen Holm Petersen

Løgn og StatistikHvidovre Hospital

Thomas Scheike

Time-to-pregnancy as measure of biological fecundity: design problems and relationto semen qualityPostgraduate CourseCopenhagen University Hospital

Competing risks with missing covariates: Effect on haplotype match on BMT patientsJoint Statistical Meeting 2009Washington DC, USA

Estimation of haplotype effects for survival dataDSTS todagesmøde, University of Southern DenmarkOdense, Denmark

3.2 Travels

Per Kragh Andersen

JanuaryUniversite Bordeaux 2, Marseille, France

JulyFirenze, Italy (European Educational Programme in Epidemiology)

SeptemberEdinburgh, Scotland

SeptemberPrague, Czech Republic (ISCB)

NovemberUniversida de Vigo, Spain

Nina Breinegaard

AugustPrague, Czech Republic (ISCB conference)

57


SeptemberUniversite Catholique de Louvain, Louvain-la-Neuve, Belgium (Course)


AprilAmsterdam, The Netherlands (EFSA, Expert Committee on the BMD approach)

SeptemberThorshavn, The Faroe Islands

SeptemberEdinburgh, Scotland (International Conference of the Royal Statistical Society)

DecemberMiami, USA. (pptoxII (conference))

Karl Bang Christensen

AugustBled, Slovenia (Invited International Rasch Measurement Workshop)

Peter Dalgaard

JuneTartu, Estland (2nd Nordic-Baltic Biometric Conference)

JulyRennes, France (useR! The R User Conference)

Julie Lyng Forman

SeptemberWashington DC, USA (JSM)

Randi Grøn

JuneErasmus MC, Rotterdam, The Netherlands (Course on multistate models andcompeting risks)

SeptemberPrague, Czech Republic (ISCB)

Klaus Kahler Holst

SeptemberWashington DC, USA (JSM)

58


Niels Keiding

FebruaryAgeing and living conditions, University of Umea

FebruaryDepartment of Epidemiology and Biostatistics, Karolinska Institutet, Stockholm

MarchStatistical Laboratory, Centre for Mathematical Science, Cambridge, England (Causalinference: State-of-the-Art)

AprilDepartment of Statistics, University of Chicago

AprilNorges Forskningsrad, Norway

April – MayPopulation Association of America, Detroit, USA

MayObservatoire Epidemiologique de la fertilite en France, St. Francois de Sales, France

MayDepartment of Biostatistics, University of North Carolina

AugustLeiden University, The Netherlands (Vision on Statistical Science)

SeptemberWorkshop on Causal Modelling, Oslo

September – NovemberMRC Biostatistics Unit, Cambridge

NovemberMRC Centre for Causal Analyses in Translational Epidemiology (Department ofSocial Medicine, University of Bristol, England)

Svend Kreiner

JuneBled, Slovenia (Invited International Rasch Measurement Workshop)

Ulla Brasch Mogensen

SeptemberISCB, Prague, Czech Republic (ISCB)

59


Lisbeth Nørgaard Møller

MarchStatistical Laboratory, Centre for Mathematical Science, Cambridge, England (Causalinference: State-of-the-Art)

Susanne Rosthøj

AugustPrague, Czech Republic (ISCB)

September – NovemberOslo, Norway (Workshop on Causal Modelling)

Thomas Scheike

MarchGoteborg, Sverige (Annual meeting of the European group for blood and marrowtransplantation)

AugustWashington DC, USA (Joint Statistical Meeting 2009)

Lene Theil Skovgaard

SeptemberISCB, Prague (ISCB)

60

Teaching

1 Courses

The department offers basic statistic courses to students in health science and special-ized courses to Ph.D. students. In 2009, the department offered the following courses.

1.1 Ph.D. coursesIntroduction to SPSS (Spring)Organized by Svend Kreiner

The R statistical environment (Spring)Organized by Peter Dalgaard

Statistical analysis of survival data (Spring)Organized by Thomas Scheike

Statistical evaluation of diagnostic and predictive models (Spring)Organized by Thomas Alexander Gerds

Basic statistics for health researchers (Spring)Organized by Lene Theil Skovgaard

Validation of Scales (Spring)Organized by Svend Kreiner

Epidemiology (Spring)Organized by Per Kragh Andersen

Analysis of variance and regression for health researchers (Spring)Organized by Peter Dalgaard

Use of SAS statistical software (Spring)Organized by Esben Budtz-Jørgensen

Structural equation modeling (Fall)Organized by Esben Budtz-Jørgensen

Basic statistics for health researchers (Fall)Organized by Lene Theil Skovgaard

61

Supervision

Basic statistics for health researchers from foreign countries (Fall)Organized by Thomas Alexander Gerds

Use of SAS statistical software (Fall)Organized by Esben Budtz-Jørgensen

Advanced statistical analysis of epidemiological studies (Fall)Organized by Per Kragh Andersen

Introduction to SPSS (Fall)Organized by Svend Kreiner

Analysis of variance and regression for health researchers (Fall)Organized by Lene Theil Skovgaard

1.2 Master / Bachelor courses

Demography (Public Health) (Spring)Organized by Niels Keiding

Statistical methods (IT and Health) (Fall)Organized by Peter Dalgaard

Statistics 1.sem. (Master of Health Science) (Fall)Organized by Karl Bang Christensen

Statistics and data analysis for human biologists (Fall)Organized by Thomas Alexander Gerds

Demography (Public Health) (Fall)Organized by Esben Budtz-Jørgensen

Statistics (Medicine) (Fall)Organized by Thomas Scheike

Compulsory module 1 Statistics and epidemiology (Master of Public Health) (Fall)Organized by Per Kragh Andersen

Statistics (Odontology) (Fall)Organized by Thomas Scheike

Statistics (Public Health) (Fall)Organized by Jørgen Holm Petersen

2 Supervision

This section lists Ph.D. projects in biostatistics and Ph.D. students in other maindisciplines (co-supervision).

62

Supervision


Janne PetersenDefinition of syndromes by latent variables: HIV-associated lipodystrophy syndrome

Klaus Kahler HolstDevelopment of statistical methods for estimation of genetic effects on brain function-ing measured through PET and FMRI images.

Karl Bang Christensen

Kirstine Magtengaard RobinsonDiagnostic delay among gynecological cancer patients

Niels Keiding

Lars Hougaard NielsenPharmacoepidemiological methodology for prescription registries

Mette GersterUddannelse og fertilitet

Susanne RosthøjFeedback mechanisms in dosing strategies in child oncology

Ulla HvidtfeldtMediation of socio-economic gradients

Svend Kreiner

Christina Warrer SchnohrMeasuring and understanding social inequalities in adolescent smoking

Lisbeth Nørgaard MøllerMethods for estimating direct effects of repeated interventions


Randi GrønAccurate confidence limits for misspecified models with applications to longitudinaldata.

Ulla Brasch MogensenSurvival paths through the random forest

Thomas Scheike

Anders Gorst RasmussenModel selection and high-dimensional covariates for survival data

Bruno Paul MmbandoMalaria in Tanzania

63

Supervision

Jacob SimonsenSero epidemiology

Kyle RaymondHaplotype effects for competing risks data

Nina Gros PedersenGrowth based on ultra-sound measurements

64

Publications

3 Publications

The publications are listed in the following categories according to the research field:Statistics,Demography, Dentistry, Epidemiology, Genetics, Mathematics, Medicine, Natural sci-ence, Psychiatry, Public Health, Sociology. Books, articles in books and articles inproceedings, as well as PhD thesis are listed separately.

3.1 Journal articles

Statistics

Aalen OO, Andersen PK, Borgan Ø, Gill RD & Keiding N (2009) History of appli-

cations of martingales in survival analysis Journal Electronique d’Histoire des Probabililtes et

de la Statistique 5 Epub.

Dalgaard P (2009) Can we have better semantics for R’s attach mechanism? Computational

Statistics 24 263-269.

Graw F, Gerds TA & Schumacher M (2009) On pseudo-values for regression analysis in

competing risks models Lifetime Data Analysis 15 (2) 241-255.

Martinussen T & Scheike T (2009) The additive hazards model with high-dimensional

regressors Lifetime Data Analysis 15 (3) 330-42.

Martinussen T & Scheike T (2009) Covariate selection for the semiparametric additive

risk model Scandinavian Journal of Statistics 36 (4) 602-619.

Petersen JH (2009) A non-parametric conditional bivariate reference region with an appli-

cation to height/weight measurements on normal girls Biometrical Journal 51 (4) 697-709.

Sanchez BN, Budtz-Jørgensen E & Ryan LM (2009) An estimating equations approach

to fitting latent exposure models with longitudinal health outcomes Annals of Applied Statis-

tics 3 (2) 830-856.

Silver JD, Ritchie ME & Smyth GK (2009) Microarray background correction: maximum

likelihood estimation for the normal-exponential convolution Biostatistics 10 (2) 352-363.

Meira-Machado L, Una-Alvarez Jd, Cadarso-Suarez C & Andersen PK (2009)

Multi-state models for the analysis of time-to-event data Statistical Methods in Medical Re-

search 18 (2) 195-222.

Demography

Joffe M, Key J, Best N, Jensen TK & Keiding N (2009) The role of biological fertility

in predicting family size Human Reproduction 24 (8) 1999-2006.

Hansen MH, Mølgaard-Nielsen D, Knudsen LB & Keiding N (2009) Rates of induced

abortion in Denmark according to age, previous births, and previous abortions Demographic

Research 21 (22) 647-680.

65

Publications

Epidemiology

Andersen R, Brot C, Mejborn H, Mølgaard C, Skovgaard LT, Trolle E & Ovesen

L (2009) Vitamin D supplementation does not affect serum lipids and lipoproteins in Pakistani

immigrants European Journal of Clinical Nutrition 63 1150-1153.

Gamborg M, Andersen PK, Baker JL, Budtz-Jørgensen E, Jørgensen T, Jensen

G & Sørensen TIA (2009) Life course path analysis of birth weight, childhood growth, and

adult systolic blood pressure American Journal of Epidemiology 169 1167-1178.

Working group including Budtz-Jørgensen E (2009) Guidance of the Scientific Commit-

tee on the request from EFSA on the use of the benchmark dose approach in risk assessment

The EFSA Journal 1150 1-72.

Iversen MG, Hansen KS, Freil M & Kreiner S (2009) Do surgical patients differ in the

way they prioritise aspects of hospital care? Scandinavian Journal of Public Health 37 (3)

295-303.

Choi AL, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Salonen JT, Tuomainen T,

Murata K, Nielsen HP, Petersen MS, Askham J & Grandjean P (2009) Methylmer-

cury exposure and adverse cardiovascular effects in Faroese whaling men Environmental Health

Perspectives 117 (3) 367-72.

Lund T, Christensen KB, Vaez M, Labriola M, Josephson M, Villadsen E &

Voss M (2009) Differences in sickness absence in Sweden and Denmark: The cross national

HAKNAK study European Journal of Public Health 19 (3) 343-349.

SparsøT, Grarup N, Andreasen C, Albrechtsen A, Holmkvist J, Andersen G,

Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen

T & Pedersen O (2009) Combined analysis of 19 common validated type 2 diabetes sus-

ceptibility gene variants shows moderate discriminative value and no evidence of gene-gene

interaction Diabetologia 52 (7) 1308-1314.

Nabe-Nielsen K, Tuchsen F, Christensen KB, Garde AH & Diderichsen F (2009)

Differences between day and nonday workers in exposure to physical and psychosocial work

factors in the Danish eldercare sector Scandinavian Journal of Work, Environment & Health

35 (1) 48-55.

Labriola M, Feveile H, Christensen KB, Bultmann U & Lund T (2009) The impact

of job satisfaction on the risk of disability pension. A 15-year prospective study Scandinavian

Journal of Public Health 37 (7) 778-780.

Nielsen LH, Løkkegaard E, Andreasen AH, Hundrup YA & Keiding N (2009) Esti-

mating the effect of current, previous and never use of drugs in studies based on prescription

registries Pharmacoepidemiology and Drug Safety 18 (2) 147-153.

Rayce SLB, Holstein BE & Kreiner S (2009) Aspects of alienation and symptom load

among adolescents European Journal of Public Health 19 (1) 79-84.

Schnohr CW, Kreiner S, Rasmussen M, Due P & Diderichsen F (2009) Comparative

study on etiological mechanisms generating social inequalities in smoking: The role of chil-

dren’s school satisfaction and academic achievement Journal of Epidemiology & Community

Health 8 (17)

66

Publications

Key J, Best N, Joffe M, Jensen TK & Keiding N (2009) Methodological issues in

analyzing time trends in biologic fertility: Protection bias American Journal of Epidemiology

169 (3) 285-293.

Rose CS, Grarup N, Krarup NT, Poulsen P, Wegner L, Nielsen T, Banasik K,

Færch K, Andersen G, Albrechtsen A, Borch-Johnsen K, Clausen JO, Jørgensen

T, Vaag A, Pedersen O & Hansen T (2009) A variant in the G6PC2/ABCB11 locus is

associated with increased fasting plasma glucose, increased basal hepatic glucose production

and increased insulin release after oral and intravenous glucose loads Diabetologia 52 (10)

2122-2129.

Gylvin T, Ek J, Nolsøe R, Albrechtsen A, Andersen G, Bergholdt R, Brorsson

C, Bang-Berthelsen CH, Hansen T, Karlsen AE, Billestrup N, Borch-Johnsen

K, Jørgensen T, Pedersen O, Mandrup-Poulsen T, Nerup J & Pociot F (2009)

Functional SOCS1 polymorphisms are associated with variation in obesity in whites Diabetes,

Obesity and Metabolism 11 (3) 196-203.

Nørredam ML, Lopez AMG, Keiding N & Krasnik A (2009) Risk of mental disorders

in refugees and native Danes: A register-based retrospective cohort study Social Psychiatry

and Psychiatric Epidemiology 44 (12) 1023-1029.

Strandberg-Larsen K, Grønbæk M, Andersen AN, Andersen PK & Olsen J (2009)

Alcohol drinking pattern during pregnancy and risk of infant mortality Epidemiology 20 (6)

884-891.

Genetics

Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proena C,

Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand

E, Elliott P, Hadjadj S, Jarvelin M, Laitinen J, Lauritzen T, Marre M, Mazur

A, Meyre D, Montpetit A, Pisinger C, Posner B, Poulsen P, Pouta A, Prentki

M, Ribel-Madsen R, Ruokonen A, Sandbaek A, Serre D, Tichet J, Vaxillaire M,

Wojtaszewski J, Vaag A, Hansen T, Polychronakos C, Pedersen O, Froguel P

& Sladek R (2009) Genetic variant near IRS1 is associated with type 2 diabetes, insulin

resistance and hyperinsulinemia Nature Genetics 41 (10) 1110-1115.

Albrechtsen A, Korneliussen TS, Moltke I, Hansen TvO, Nielsen FC & Nielsen

R (2009) Relatedness mapping and tracts of relatedness for genome-wide data in the presence

of linkage disequilibrium Genetic Epidemiology 33 (3) 266-274.

Nørremølle A, Budtz-Jørgensen E, Fenger K, Nielsen JE, Sørensen SA & Hasholt

L (2009) 4p16.3 haplotype modifying age at onset of Huntington disease Clinical Genetics 75

(3) 244-250.

Nielsen R, Hubisz MJ, Torgerson D, Andres AM, Albrechtsen A, Gutenkunst R,

Adams M, Cargill M, Boyko A, Indap A, Bustamante C, Hellmann IG & Clark

AG (2009) Darwinian and demographic forces affecting human protein coding genes Genome

Research 19 (5) 838-849.

Larsen K, Petersen J, Bernstein I & Nilbert M (2009) A parametric model for ana-

lyzing anticipation in genetically predisposed families Statistical Applications in Genetics and

Molecular Biology 8 (26) Epub.

67

Publications

Mathematics

Harremoes P & Holst KK (2009) Convergence of markov chains in information divergence

Journal of Theoretical Probability 22 (1) 186-202.

Medicine

Mmbando BP, Lusingu JP, Vestergaard LS, Lemnge MM, Theander TG & Scheike

TH (2009) Parasite threshold associated with clinical malaria in areas of different transmission

intensities in north eastern Tanzania BMC Medical Research Methodology 9 75-86.

Mogensen M, Nurnberg BM, Forman JL, Thomsen JB, Thrane L & Jemec GBE

(2009) In vivo thickness measurement of basal cell carcinoma andactinic keratosis with optical

coherence tomography and 20-MHz ultrasound British Journal of Dermatology 160 1026-1033.

Jepsen JR, Laursen LH, Kreiner S & Larsen AI (2009) Diagnostic accuracy of the

neurological upper limb examination II: Relation to symptoms of patterns of findings Open

Neurology Journal 3 54-63.

Boas M, Forman JL, Juul A, Feldt-Rasmussen U, Skakkebæk NE, Chellakooty M,

Larsen T, Falck Larsen J, Petersen JH & Main KM (2009) Narrow intra-individual

variation of maternal thyroid function in pregnancy based on a longitudinal study of 132

women European Journal of Endocrinology 161 903-910.

Burton CM, Iversen M, Carlsen J, Mortensen J, Andersen CB, Steinbruchel D &

Scheike T (2009) Acute cellular rejection is a risk factor for bronchiolitis obliterans syndrome

independent of post-transplant baseline FEV1 Journal of Heart and Lung Transplantation 28

(9) 888-893.

Kastrup J, Johansen JS, Winkel P, Hansen JF, Hildebrandt P, Jensen GB, Jes-

persen CM, Kjøller E, Kolmos HJ, Lind I, Nielsen H, Gluud C & CLARICOR

Trial Group (2009) High serum YKL-40 concentration is associated with cardiovascular and

all-cause mortality in patients with stable coronary artery disease European Heart Journal 30

(9) 1066-1072.

Shaker SB, Dirksen A, Ulrik CS, Hestad M, Stavngaard T, Laursen LC, Maltbæk

N, Clementsen P, Skjærbæk N, Nielsen L, Stoel B, Skovgaard LT & Tonnesen

P (2009) The effect of inhaled corticosteroids on the development of emphysema in smokers

assessed by annual computed tomography. Journal of Chronic Obstructive Pulmonary Disease

6 (2) 104-111.

Jørgensen CC, Bundgaard-Nielsen M, Skovgaard LT, Secher NH & Kehlet H

(2009) Stroke volume averaging for individualized goal-directed fluid therapy with oesophageal

Doppler Acta Anaesthesiologica Scandinavica 53 (1) 34-38.

Sørensen JL, Løkkegaard E, Johansen M, Ringsted C, Kreiner S & McAleer S

(2009) The implementation and evaluation of a mandatory multi-professional obstetric skills

training program Acta Obstetricia et Gynecologica Scandinavica 88 (10) 1107-1117.

Haissman JM, Vestergaard LS, Sembuche S, Erikstrup C, Mmbando B, Mtullu

S, Lemnge MM, Gerstoft J & Ullum H (2009) Plasma cytokine levels in Tanzanian

HIV-1-infected adults and the effect of antiretroviral treatment Journal of Acquired Immune

Deficiency Syndromes 52 (4) 493-497.

68

Publications

Nøjgaard C, Hornum M, Elkjaer M, Hjalmarsson C, Heyries L, Hauge T,

Bakkevold K, Andersen PK & Matzen P (2009) Does glyceryl nitrate prevent post-

ERCP pancreatitis? A prospective, randomized, double-blind, placebo-controlled multicenter

trial Gastrointestinal Endoscopy 69 (6) 31-37.

Cham GKK, Turner L, Lusingu J, Vestergaard L, Mmbando BP, Kurtis JD,

Jensen ATR, Salanti A, Lavstsen T & Theander TG (2009) Sequential, ordered ac-

quisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains

Journal of Immunology 183 (5) 3356-3363.

Alifrangis M, Lusingu JP, Mmbando B, Dalgaard MB, Vestergaard LS, Ishengoma

D, Khalil IF, Theander TG, Lemnge MM & Bygbjerg IC (2009) Five-year surveil-

lance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe

District, Tanzania: Accumulation of the 581G mutation in the P. falciparum dihydropteroate

synthase gene American Journal of Tropical Medicine and Hygiene 80 (4) 523-527.

Jespersen CM, Kolmos HJ, Frydendall N, Hilden J, Gluud C, Hansen JF &

CLARICOR Trial Group (2009) Compliance with and short-term adverse events from

clarithromycin versus placebo in patients with stable coronary heart disease: the CLARICOR

trial Journal of Antimicrobial Chemotherapy 64 (2) 411-415.

Nielsen SS, Nørredam M, Christiansen KL, Obel C, Hilden J & Krasnik A (2009)

Betydning af opholdstid og antal flytninger paasylbørns psykiske helbred - sekundærpublika-

tion Ugeskrift for læger 171 (12) 981-984.

Gluud C & Hilden J (2009) Povl Heiberg’s 1897 methodological study on the statistical

method as an aid in therapeutic trials Preventive Medicine 48 (6) 600-603.

Steinmetz J, Christensen KB, Lund T, Lohse N, Rasmussen LS & ISPOCD Group

(2009) Long-term consequences of postoperative cognitive dysfunction Anesthesiology 110 (3)

548-555.

Hauge AW, Asghar MS, Schytz HW, Christensen K & Olesen J (2009) Effects of

tonabersat on migraine with aura: A randomised, double-blind, placebo-controlled crossover

study Lancet Neurology 8 (8) 718-723.

Bisgaard H, Loland L, Holst KK & Pipper CB (2009) Prenatal determinants of neonatal

lung function in high-risk newborns Journal of Allergy and Clinical Immunology 123 (3) 651-

657.

Aagaard L, Nielsen LH & Hansen EH (2009) Consumer reporting of adverse drug re-

actions: a retrospective analysis of the Danish adverse drug reaction database from 2004 to

2006 Drug Safety 32 (11) 1067-1074.

Claudius C, Viby-Mogensen J & Skovgaard LT (2009) Acceleromyography and

mechanomyography for establishing potency of neuromuscular blocking agents: A randomized-

controlled trial Acta Anaesthesiologica Scandinavica 53 (4) 449-54.

Nøjgaard C, Matzen P, Andersen PK & Bang UC (2009) Meta-analysis: Nitroglycerin

for prevention of post-ERCP pancreatitis Alimentary Pharmacology and Therapeutics 29 (10)

1078-1085.

Afzal S, Jensen SA, Vainer B, Vogel U, Matsen JP, Sørensen JB, Poulsen HE &

Andersen PK (2009) MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in

colorectal cancer Annals of Oncology 20 (10) 1660-1666.

69

Publications

Kørner A, Lopez AG, Lauritzen L, Andersen PK & Kessing LV (2009) Acute and

transient psychosis in old age and the subsequent risk of dementia: A nationwide register-

based study Geriatrics & Gerontology International 9 (1) 62-68.

Farrington CP, Firth MJ, Moulton LH, Ravn H, Evans S & Andersen PK (2009)

Epidemiological studies of the non-specific effects of vaccines: II–methodological issues in the

design and analysis of cohort studies Tropical Medicine & International Health 14 (9) 977-985.

Olsen J, Gerds TA, Seidelin JB, Csillag C, Bjerrum JT, Troelsen JT & Nielsen OH

(2009) Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling

of genome-wide gene expression data Inflammatory Bowel Diseases 15 (7) 1032-1038.

Hansen TV, Jønson L, Albrechtsen A, Andersen MK, Ejlertsen B & Nielsen FC

(2009) Large BRCA1 and BRCA2 genomic rearrangements in Danish high risk breast-ovarian

cancer families Breast Cancer Research and Treatment 115 (2) 315-323.

Sørensen M, Lopez AG, Andersen PK, Vogel U, Autrup H, Tjønneland A, Over-

vad K & Raaschou-Nielsen O (2009) Stratification for smoking in case-cohort studies of

genetic polymorphisms and lung cancer Lung Cancer 63 (3) 335-340.

Hansen TO, Ejlertsen B, Albrechtsen A, Bergsten E, Bjerregaard P, Hansen T,

Myrhøj T, Nielsen PB, Timmermans V, Andersen MK, Jønson L, Nielsen R &

Nielsen FC (2009) Common Inuit BRCA1 RING domain founder mutation Breast Cancer

Research and Treatment 115 (1) 69-76.

Møller LBK, Møller C, Thomsen SG, Andersen LF, Lundvall L, Lidegaard Ø, Kjer

JJ, Ingemanssen JL, Zobbe V, Floridon C, Petersen J & Ottesen B (2009) Success

and spontaneous pregnancy rates following systemic methotrexate versus laparoscopic surgery

for tubal pregnancies: A randomized trial Acta Obstetricia et Gynecologica Scandinavica 88

(12) 1331-1337.

Hansen BR , Petersen J, Haugaard SB, Madsbad S, Obel N, Suzuki Y & Andersen

O (2009) The prevalence of metabolic syndrome in Danish patients with HIV infection: The

effect of antiretroviral therapy HIV Medicine 10 (6) 378-387.

Jepsen P, Vilstrup H, Ott P, Keiding S, Andersen PK, Tygstrup N (2009) The

galactose elimination capacity and mortality in 781 Danish patients with newly-diagnosed

liver cirrhosis: A cohort study BMC Gastroenterology 9 (50) 1-6.

Jepsen P, Vilstrup H, Andersen PK, Sørensen HT (2009) Socioeconomic status and

survival of cirrhosis patients: A Danish nationwide cohort study BMC Gastroenterology 9

(35) 1-6.

Christophersen IE, Ravn LS, Budtz-Jørgensen E, Skytthe A, Haunsoe S, Svend-

sen JH & Christensen K (2009) Familial aggregation of atrial fibrillation: A study in

Danish twins Circulation, Arrhythmia and Electrophysiology 2 (4) 278-383.

Feveile H, Christensen KB & Flyvholm M (2009) Self-reported occupational skin con-

tact with cleaning agents and the risk of disability pension Contact Dermatitis 60 (3) 131-135.

Pers TH, Albrechtsen A, Holst C, Sørensen TIA & Gerds TA (2009) The validation

and assessment of machine learning: A game of prediction from high-dimensional data PLoS

ONE 4 (8) e6287.

70

Publications

Frøkjær VG, Vinberg M, Erritzoe D, Svarer C, Baare W, Budtz-Jørgensen E,

Madsen K, Madsen J, Kessing LV & Knudsen GM (2009) High familial risk for mood

disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding

NeuroImage 46 (2) 360-366.

Teilmann G, Petersen JH, Gormsen M, Damgaard K, Skakkebæk NE & Jensen

TK (2009) Early puberty in internationally adopted girls: hormonal and clinical markers of

puberty in 276 girls examined biannually over two years Hormone Research 72 (4) 236-246.

Bang AK, Petersen JH, Petersen PM, Andersson A, Daugaard G & Jørgensen

N (2009) Testosterone production is better preserved after 16 than 20 Gray irradiation treat-

ment against testicular carcinoma in situ cells International Journal of Radiation: Oncology

- Biology - Physics 75 (3) 672-676.

Sørensen K, Aksglaede L, Munch-Andersen T, Aachmann-Andersen NJ, Petersen

JH, Hilsted L, Helge JW & Juul A (2009) Sex hormone-binding globulin levels predict

insulin sensitivity, disposition index, and cardiovascular risk during puberty Diabetes Care 32

(5) 909-914.

Aksglaede L, Sørensen K, Petersen JH, Skakkebæk NE & Juul A (2009) Recent

decline in age at breast development: The Copenhagen Puberty Study Pediatrics Electronic

Pages 123 (5) 932-939.

Petersen JA, Christensen KB & Steinmetz J (2009) Penetrerende traumer behandlet

af akutlægebilen i København Ugeskrift for læger 171 (41) 2982-2985.

Robinson KM, Ottesen B, Christensen KB & Krasnik A (2009) Diagnostic delay

experienced among gynecological cancer patients: A nationwide survey in Denmark Acta

Obstetricia et Gynecologica Scandinavica 88 (6) 685-692.

Erritzoe D, Frokjaer VG, Haugbol S, Marner L, Svarer C, Baare WFC, Rasmussen

PM, Madsen J, Paulson OB, Knudsen GM & Holst KK (2009) Brain serotonin 2A

receptor binding: Relations to body mass index, tobacco and alcohol use NeuroImage 46 (1)

23-30.

Claudius C, Skovgaard LT & Viby-Mogensen J (2009) Is the performance of ac-

celeromyography improved with preload and normalization? A comparison with mechanomyo-

graphy Anesthesiology 110 (6) 1261-70.

Schmiegelow K, Heyman M, Kristinsson J, Mogensen UB, Rosthøj S, Vettenranta

K, Wesenberg F & Saarinen-Pihkala U (2009) Oral methotrexate/6-mercaptopurine may

be superior to a multidrug LSA2L2 maintenance therapy for higher risk childhood Acute Lym-

phoblastic Leukemia: Results from the NOPHO ALL-92 study Journal of Pediatric Hematol-

ogy / Oncology 31 (6) 385-392.

Psychiatry

Kessing LV, Søndergaard L, Forman JL & Andersen PK (2009) Antidepressants and

dementia Journal of Affective Disorders 117 24-29.

Smith EG, Søndergard L, Lopez AG, Andersen PK & Kessing LV (2009) Association

between consistent purchase of anticonvulsants or lithium and suicide risk: A longitudinal

cohort study from Denmark, 1995-2001 Journal of Affective Disorders 117 (3) 162-167.

71

Publications

Kørner A, Lopez AG, Lauritzen L, Andersen PK & Kessing LV (2009) Late and

very-late first-contact schizophrenia and the risk of dementia–a nationwide register based

study International Journal of Geriatric Psychiatry 24 (1) 61-67.

Public Health

Nielsen ABS, Siersma V, Kreiner S, Hiort LC, Drivsholm T, Eplov LF & Hollnagel

H (2009) The impact of changes in self-rated general health on 28-year mortality among

middle-aged Danes Scandinavian Journal of Primary Health Care 27 (3) 160-166.

Hansen M, Kreiner S & Hansen CR (2009) CHIPS for sig - læsning for sig Læsepæda-

gogen (6) 20-21.

Tuchsen F, Christensen KB, Feveile H & Dyreborg J (2009) Work injuries and dis-

ability Journal of Safety Research 40 (1) 21-24.

Clausen T, Christensen KB, Lund T & Kristiansen J (2009) Self-reported noise ex-

posure as a risk factor for long-term sickness absence Noise & Health 11 (43) 93-97.

Lund T, Labriola M, Feveile H & Christensen KB (2009) The fraction of disability

pensions attributable to smoking and obesity. Results from a 15-year follow-up study Journal

of Public Health 18 (3) 251-254.

Labriola M, Feveile H, Christensen KB, Strøyer J & Lund T (2009) The impact of

ergonomic work environment exposures on the risk of disability pension: Prospective results

from DWECS/DREAM Ergonomics 52 (11) 1419-22.

Sociology

Siersma V & Kreiner S (2009) A coefficient of association between categorical variables

with partial or tentative ordering of categories Sociological Methods & Research 38 (2) 265-

286.

Book

Kreiner S & Carstensen B (2009) Test i Folkeskolen Hans Reitzels Forlag.

Inbook

Budtz-Jørgensen E, Keiding N & Grandjean P (2009) Approaches to handlinguncertainty when setting environmental exposure standards Baveye P, Mysiak J &Laba M (eds.) Uncertainties in Environmental Modelling and Consequences for PolicyMaking. (267-280.) Springer Science+Business Media B.V.,

Carstensen B & Kreiner S (2009) Introduktion Carstensen B & Kreiner S (eds.)Test i Folkeskolen. (11-20.) Hans Reitzels Forlag,

72

Publications

Gerds TA, Qvist V, Strub JR, Pipper CB, Scheike T & Keiding N (2009)Failure time analysis Lesaffre E, Feine J, Leroux B & Declerck D (eds.) Statisticaland Methodological Aspects of Oral Health Research. (259-277.) John Wiley & Sons,

Hilden J (2009) Expected value of sample information, net benefit of samplingMichael W. Kattan (eds.) Encyclopedia of medical decision making. (481-486.) SagePublications,

Hilden J (2009) Bias in scientific studies Michael Kattan (eds.) Encyclopedia ofmedical decision making. (80-85.) Sage Publications,

Hilden J (2009) Boolean algebra and nodes Michael W. Kattan (eds.) Encyclopediaof medical decision making. (94-98.) Sage Publications,

Kreiner S (2009) Psykometriske brudstykker - om afprøvning af en matematiktestCarstensen B & Kreiner S (eds.) Test i Folkeskolen. (101-136.) Hans Reitzels Forlag,

Kreiner S (2009) Om udvikling og afprøvning af pædagogiske test Carstensen B &Kreiner S (eds.) Test i Folkeskolen. (43-82.) Hans Reitzels Forlag,

Lange T & Rahbek AC (2009) An Introduction to Regime Switching Time SeriesModels Andersen TG, Davis RA, Kreiss JP & Mikosch T (eds.) Handbook of FinancialTime Series. (871-888.) Springer Verlag,

Inproceedings

Dalgaard P (2009) Multivariate linear models and repeated measurements revisitedIvette Gomes, Pedro Luis do Nascimento Silva & Jose Alberto Silva (eds.), Bulletinof the International Statistical Institute (3649-3652) Lissabon

PhD thesis

Albrechtsen A (2009) New methods for modeling large scale human of genetic vari-ation data. University of Copenhagen.

Gerster M (2009) Socioeconomic determinants for fertility. University of Copen-hagen.

Rosthøj S (2009) Dynamic statistical modelling of maintenance therapy of childrenwith acute lymphoblastic leukemia. University of Copenhagen.

3.2 Research reports

1. Thomas Scheike, Jeremy SilverEstimating haplotype effects for survival data

73

Publications

2. Marie-Louise H. Hansen, Louise Stage, Lisbeth B. Knudsen, NielsKeidingDo Induced Abortions Affect the First Birth Probability? A National Register-Based Study of Danish Women

3. Richard D. Gill, Niels KeidingProduct-limit estimators of the gap time distribution of a renewal processunder different sampling patterns

4. Volkert SiersmaImportance Sampling Strategies for Off-Policy LSTD(1)

5. Tine Kajsa Kvist, Per Kragh Andersen, Jules Angst, Lars VedelKessingEvent dependent sampling of recurrent events

6. Thomas ScheikeA semiparametric random effects model for multivariate competing risks data

7. Lars Hougaard Nielsen, Niels KeidingDescribing episodes of drug treatment from joint observation of a prescriptionregistry and a cross-sectional survey

8. Lars Hougaard Nielsen, Ellen Løkkegaard, Niels KeidingImportance of effect measures in the evaluation of the effect of post menopausalhormone therapy on myocardial infarction

9. Giuliana Cortese, Per Kragh AndersenCompeting risks and time-dependent covariates

10. Svend Kreiner, Karl Bang ChristensenItem screening in graphical loglinear Rasch models

11. Per Kragh Andersen, Michael VæthSurvival Analysis

12. Mette Gerster, Mette Erjnæs, Niels KeidingThe effect of educational attainment on ultimate fertility - does feedback playa role?

13. Svend Kreiner, Jørgen Holm Petersen, Volkert SiersmaDeriving and testing hypotheses in chain graph models

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