Annotated Bibliographies:

-Carmona L, Cross M, Williams B, Lassere M, March Lyn. 2010. Rheumatoid arthritis. Best Practice & Research Clinical Rheumatology [Internet]; [cited 2014 Oct 3]. 24(6)733-745. doi: 10.1016/j.berh.2010.10.00

The purpose of this article is to provide a panoramic view at the risks, and instruction

management of Rheumatoid Arthritis (RA). It starts off by giving a description of the disease’s

epidemiology. This disease has no proven cause. Next, its prevalence is estimated between 0.2%

and 1.2% and the morbidity gives you an idea on what is linked and not linked to the appearance

of RA. Risk factors associated to this disease are cancer, infections, depression, and mortality.

What really makes this article special is the geographical variation in which RA is widespread

all over many regions and countries around the world. Later, deducing by facts that females are

the most likely to suffer from this disease. This article concludes that the interactions of genetics

with environmental factors have possibilities of causing this disease. Meanwhile, these important

facts backs up on what I want to develop for possible risk factors of RA, evidently for my paper.

-Cipriani P, Ruscitti P, Carrubi F , Liakouli V, Giacomelli R. 2014. Methotrexate in Rheumatoid Arthritis: Optimizing Therapy Among Different Formulations. Current and Emerging Paradigms. Clinical Therapeutics [Internet]; [cited 2014 Sep 25]. 36(3):427-435.doi:10.1016/j.clinthera.2014.01.014

The purpose of this study was to account for a remedy in relation to Methotrexate (MTX) and how it is useful for Rheumatoid Arthritis (RA) patients.  By the usage of MeSH terms and references from the retrieved studies, they could find many research articles from the MEDLINE and Cochrane Library. They resulted with the importance of MTX and the routes of administration (orally, subcutaneously, and intramuscularly). Secondly, the dosage and quantity of MTX is a factor in terms of the direct effect of the drug. The importance of the oral MTX route is highlighted throughout the study. One of the goals is to reduce the sensitive and continual toxicity. However, the main reason parenteral administration of this drug is implied is because of the patient’s poor fulfillment toward the oral form. This article provided good and helpful information on whether to consider the oral administration of MTX, or parenteral administration, having in mind that both are beneficial in the quality of life of the patient with RA.

-Gaujoux-Vialaa C, Gossecb L, Cantagrelc A, Dougadosd M, Fautrelb B, Mariettee X, Nataff H, Sarauxg A, Tropei S, Combej B. 2014. Recommendations of the French Society for Rheumatology for managing rheumatoid arthritis. Joint Bone Spine [Internet]; [cited 2014 Oct 3]. 81(4)287-297.doi: 10.1016/j.jbspin.2014.05.002

The purpose of this article was to state the most recent recommendations made by the

French Society for Rheumatology (SFR), in relation to rheumatoid arthritis (RA). Thanks to the

testimonies of the hospital and community-based rheumatologists, EULAR issued

recommendations and a literature evaluation. This article summarizes treatment decisions for

patients. Strategies from a recent-onset RA, inadequate response to methrotrexate, and to

biologic therapy, all separated in phases from 1 to 3. The recommendations cover self-

management abilities, remission or minimal disease activity as the treatment objective, and the

requirements for initiating disease-modifying drugs as fast as possible as well as for the useful

treatment of this autoimmune disease. Other specific options are methotrexate monotherapy,

glucocorticoid therapy, and synthetic DMARD therapy. The article emphasized valuable

treatments that are already approved and highly recommended. The final goal is to ensure a

better life style for patients suffering from rheumatoid arthritis. This beneficiates and diversifies

my review paper thanks to the different treatments and therapy’s that this article recommends.