Ande, Satyanarayana, PhD Dr. Ande’s lab investigates the … · 2019-02-26 · Manicassamy,...
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Ande, Satyanarayana, PhD Cancer Biology, CN3150 Associate Professor of Biochemistry and Molecular Biology [email protected] Dr. Ande’s lab investigates the regulation and function of specific transcription factors and tumor suppressors in liver tumorigenesis and liver tumor angiogenesis. His lab also studies adipose tissue metabolism and obesity and the molecular links between obesity and liver cancer by utilizing knockout and transgenic mouse models. Arbab, Ali, PhD, MBBS Cancer Biology, CN 3141 Professor, Biochemistry and Molecular Biology Phone: (706) 721-8909 [email protected] Our laboratory creates different orthotropic animal models for human glioma. We use in vivo MRI, SPECT and optical imaging to determine the tumor growth, tumor vascular parameters, migration and accumulation of endogenous or exogenously administered stem/progenitor cells in the tumor neovascularization, and accumul-ation of laminin avid nanoparticle based contrast agents. Browning, Darren, PhD Director, Graduate Program in Biochemistry and Cancer Biology Biochemistry, CN 1164 Professor, Biochemistry and Molecular Biology Phone: (706) 721-9526 [email protected] Our focus is cGMP signaling through protein kinases (PKG) in the gastrointestinal tract. My lab has characterized anti-tumor properties of PKG in colon cancer, including: blockade of proliferation, angiogenesis, and hypoxic adaptation. Using knockout mice, we showed that PKG2 regulates colon homeostasis and strengthens the mucosal barrier. The lab is currently testing PDE5 inhibitors for the treatment and prevention of colitis and colon cancer in preclinical models. Celis, Esteban, MD, PhD Cancer Biology, CN 4121 Professor of Biochemistry and Molecular Biology Phone: (706) 721- 5668 [email protected] A major challenge for developing effective cancer vaccines against is overcoming tolerance. This is where CD8 T lymphocytes that should recognize and kill tumor cells are not induced by conventional vaccines. We have designed a novel vaccination approach that uses synthetic peptides representing CD8 T cell epitopes, Toll- like receptor agonists that function as a potent immunological adjuvants and immune costimulatory monoclonal antibodies.
Transcript of Ande, Satyanarayana, PhD Dr. Ande’s lab investigates the … · 2019-02-26 · Manicassamy,...
Ande,Satyanarayana,PhDCancerBiology,CN3150AssociateProfessorofBiochemistryandMolecularBiologySANDE@augusta.edu
Dr. Ande’s lab investigates the regulation andfunction of specific transcription factors andtumor suppressors in liver tumorigenesis andliver tumor angiogenesis. His lab also studiesadipose tissuemetabolismandobesityand themolecularlinksbetweenobesityandlivercancerby utilizing knockout and transgenic mousemodels.
Arbab,Ali,PhD,MBBSCancerBiology,CN3141Professor,BiochemistryandMolecularBiologyPhone:(706)721-8909
Our laboratory creates different orthotropicanimal models for human glioma. We use invivo MRI, SPECT and optical imaging todetermine the tumor growth, tumor vascularparameters, migration and accumulation ofendogenous or exogenously administeredstem/progenitor cells in the tumorneovascularization,andaccumul-ationoflamininavidnanoparticlebasedcontrastagents.
Browning,Darren,PhDDirector,GraduatePrograminBiochemistryandCancerBiologyBiochemistry,CN1164Professor,BiochemistryandMolecularBiologyPhone:(706)[email protected]
Our focus is cGMP signaling through proteinkinases(PKG)inthegastrointestinaltract.Mylabhas characterizedanti-tumorpropertiesofPKGin colon cancer, including: blockade ofproliferation, angiogenesis, and hypoxicadaptation. Using knockout mice, we showedthat PKG2 regulates colon homeostasis andstrengthens the mucosal barrier. The lab iscurrently testing PDE5 inhibitors for thetreatment and prevention of colitis and coloncancerinpreclinicalmodels.
Celis,Esteban,MD,PhDCancerBiology,CN4121ProfessorofBiochemistryandMolecularBiologyPhone:(706)[email protected]
A major challenge for developing effectivecancervaccinesagainstisovercomingtolerance.This is where CD8 T lymphocytes that shouldrecognizeandkilltumorcellsarenotinducedbyconventionalvaccines.Wehavedesignedanovelvaccination approach that uses syntheticpeptides representingCD8Tcellepitopes,Toll-like receptoragonists that functionasapotentimmunological adjuvants and immunecostimulatorymonoclonalantibodies.
Chadli,Ahmed,MS,PhDCancerBiology,CN3151MolecularChaperoneBiologyAssociateProfessorofMedicinePhone:(706)[email protected]
Research in Dr. Chadli’s laboratory focuses onunderstanding theHsp90 chaperoningmachineand co-chaperones in the initiation andprogressionofbreastandprostatecancersusinginvitroandmouseconditionalknockoutmodels.WebelievethattargetingtheHsp90machinewillhave a powerful impact on dysfunctionalcircuitries that underlie cancer, and we aredeveloping a high-throughput technology toidentifycompoundstoinactivateHsp90.
Cowell,John,PhDInterimDirector,GeorgiaCancerCenterCancerBiology,CN4121ProfessorofPathologyPhone:(706)[email protected]
Dr.JohnCowellstudiesthemoleculargeneticsofcancer using a variety of genomics, cell, andmolecularapproaches.Hecurrently studies therole of the WASF3 gene in the promotion ofcancermetastasis using in vivomodels inmiceand zebrafish.Healso studiesof themolecularetiology of Stem Cell Leukemia/Lymphoma(SCLL) syndrome which is characterized bychromosome8p11translocationsactivatingtheFGFR1kinase.
Ding,Han-Fei,PhDCancerBiology,CN4132ProfessorofPathologyPhone:(706)[email protected]
TheresearchprogramoftheDinglaboratoryistodefinethemolecularandcellularbasisofcancerdevelopment in selectmodel systems.Ongoingprojects include developmental biology ofneuroblastoma and NF-kB2 signaling in thepathogenesisoflymphoma.
He,Yukai,MD,PhDCancerBiology,CN4150ProfessorofMedicinePhone:(706)[email protected]
Dr. He studies the basic mechanisms of howvaccines activate the immune system and theinnovative design of cancer vaccines. Hisresearchfocusisoncreationofcancervaccinesformelanoma and hepatocellular carcinoma inmice and on translation of animal studies intoclinicalapplications.
Horuzsko,Anatolij,MD,PhDCancerBiology,CN3154ProfessorofMedicinePhone:(706)[email protected]
Dr. Horuzsko's studies focus on organtransplantationandtheroleofHumanLeukocyteAntigen-G(HLA-G).Hisaimistoimproveallograftsurvival in patients and address allergy,autoimmune diseases and graft-versus-hostdisease.Hisworkintransplantationisrelevanttocancer, but he also studies the inflammatorymechanismsofhostdefenseandcarcinogenesis.
Koni,Pandelakis,PhDCancerBiology,CN4154AssociateProfessorofMedicineBasicScienceFacultyPhone:(706)[email protected]
Dr. Pandelakis Koni, runs a mouse modelresearch lab, and focuses on which genespromotecancerandthemechanismsthatallowit to happen. By turning genes off or silencingtheir expression in engineered mice, hecompares themtonormalmiceand findscluesabout which genes promote cancer in people.Research interests include immune regulation,inflammation, interface between antigen-presentingandTcells.
Korkaya,Hasan,DVM,PhDCancerBiology,CN2136AssistantProfessorofBiochemistryandMolecularBiologyPhone:(706)[email protected]
Dr.Korkayadevelopsmousexenograftmodelsofhumanmalignancies and uses thesemodels toinvestigate the mechanisms of metastasis andtherapeutic resistance. He aims to identifydrivers of epithelial tomesenchymal transitionand self-renewal in cancer stem cells. His labshowed that high levels of IL6 in tumors,promotes the metastatic phenotype andblocking this pathway is therapeutic in mousepreclinicalmodels.
Li,Honglin,PhDBiochemistry,CN2176AssociateProfessor,BiochemistryandMolecularBiologyPhone:(706)[email protected]
Dr.ListudiestherolesoftheUfm1conjugationsystem (a novel ubiquitin-like system) and itsassociated proteins in animal development,signal transduction, stress response andtumorigenesis.
Liu,Kebin,PhDBiochemistry,CN1173ProfessorofBiochemistryandMolecularBiologyPhone:(706)[email protected]
AgraduateoftheUniversityofOklahoma,Dr.Liustudies epigenetic and genetic regulation oftumor suppressor gene expression, molecularmechanisms of apoptosis resistance in tumorimmuneevasion andescape, anddevelopmentof molecular target-based chemotherapy toenhancetheefficacyofcancerimmunotherapy.
Lokeshwar,BalPhDDirector,GraduatePrograminBiochemistryandCancerBiologyCancerBiology,CN3130ProfessorofMedicinePhone:(706)[email protected]
Theresearchprogramisfocusedontwoaspectsof cancer: cancer prevention using naturalproducts and understanding themechanism ofcancer progression leading to metastasis.Currentprojectsinhislaboratoryinvestigatetherole of CXC chemokines and their receptors(CXCRs) that contribute to cancer progressionand metastasis. The laboratory is engaged intranslational research, where the group isinvestigating novel compounds isolated fromdietary spices that may prevent cancerdevelopmentandenhance response toexistingtherapyforprostateandbreastcancers.
Lokeshwar,Vinata,PhDBiochemistry,CN1161ProfessorandChairBiochemistryandMolecularBiologyPhone:(706)[email protected]
Themajorfocusofthelaboratoryistoexaminehow extracellular matrix-driven tumor cellsignaling promotes tumor growth, metastasisand angiogenesis. The emphasis is to discoverandvalidateaccuratediagnosticandprognosticbiomarkers for prostate, bladder and renal cellcarcinomas and to design biomarker-driventargeted treatments and chemodietarypreventionstrategiesformetastaticcancers.Thelaboratory provides training in translationalresearchandacollaborativeatmosphere.
Maihle,Nita,PhDAssociateCancerCenterDirectorofEducation.CancerBiology,CN3114Professor,[email protected]
Dr. Maihle studies fundamental aspects ofreceptor-extracellular matrix regulation bysEGFR/sHER’s,withanemphasisoncellsurvivalsignaling,aswellastheclinicaldevelopmentofthesenewlydiscoveredHERreceptorisoformsasbiotherapeutics, and also as prognostic,diagnostic, and theragnostic biomarkers(serum/tissue/tumor). More recent studiesincludethediscoveryofmechanismsunderlyingprimaryresistancetobiologically-targetedHER-directedtherapeutics.
Manicassamy,Kumar,PhDCancerBiology,CN4158AProfessor,[email protected]
Dr.Manicassamyisexaminingcriticalmechanismsthatregulateadoptiveimmuneresponsesatthemucosalsurfacesofthegastrointestinaltract.Hisresearchwillshedlightoninteractionsbetweencommensalmicroorganismsandhowtheseinteractionscanbecomedysfunctionaltocauseincreasedriskofinflammatoryboweldiseaseandcoloncancers.
Dr.Manicassamyisexaminingcriticalmechanisms that regulate adoptive immuneresponsesatthemucosalsurfacesofthegastrointestinal tract. His researchwill shedlightoninteractionsbetweencommensalmicroorganismsandhowtheseinteractionscanbecomedysfunctionaltocauseincreasedriskofinflammatoryboweldiseaseandcoloncancers.
Martin,Pamela,PhDBiochemistry,CN1160AssociateProfessor,Biochemistry&MolecularBiology,andOphthalmologyPhone:(706)[email protected]
Dr.Martin'sfocusisonthediscoveryandanalysisofnovelbiochemicaltransportersandreceptorsinretinawhichmaybeusefulinthedevelopmentofnew therapeutic targets in the treatment andpreventionofdiabeticretinopathy.
Mivechi,Nahid,PhDCancerBiology,CN3153Professor,Radiology/RadiationOncology,MolecularChaperoneBiologyPhone:(706)[email protected]
Dr. Mivechi's laboratory focuses onunderstanding the molecular mechanisms ofstress response using genetically engineeredmouse models and zebrafish. The comparisonbetween conserved biochemical and molecularpathways in mice and zebrafish facilitatesunderstanding of how animals and therebyhumans respond and cope with theirenvironment.
Moskofidis,Dimitrios,MDCancerBiology,CN3143MolecularChaperoneBiologyProfessorofMedicinePhone:(706)[email protected]
Dr. Moskofidis explores basic processes in theimmune response against acute and persistentviralinfectionsinwell-establishedmousemodels,withlong-termgoalsofdevelopingorimprovingvaccination strategies for the prevention andtreatmentofviral infections inhumans.Healsostudies molecular chaperones in cancer andneurodegenerativediseases.
Munn,David,MDSeniorAdvisortoCancerCtrDirectorCancerBiology,CN4141ProfessorofPediatricsPhone:(706)[email protected]
Dr.Munn'slabstudiesmechanismsthatsuppresstheimmunesystem,makingthebodytolerantofa malignancy. He has identified the enzymeindoleamine2,3-dioxygenase(IDO)asa linchpinfor suppression and opened the way to novelstrategiestoblockitsactivity.Researchinterestsinclude macrophage and dendritic celldifferentiation;regulationofTcellactivation,IDOand trp metabolism; clinical trials of IDOinhibitorsincancer,HIV.
Nagendra,Singh,PhDBiochemistry,CN1176AssociateProfessorofBiochemistryandMolecularBiologyPhone:(706)[email protected]
Thereare10timesmorebacteriainourgutthanthetotalnumberofcellsinourbody.Withinthis“gutmicrobiota”arebadbacteriathatcaninduceinflammationandcancer,butalsogoodbacteriathat are protective. Research in Dr. Singh’slaboratory focuses on how metabolites fromgood bacteria interact with host genes such asGpr109a, Gpr43 to induce anti-inflammatorymechanisms such as tolerogenic dendritic cells,induction of T-regs, inhibition of inflammatorycytokines.
Pace,Betty,MDFrancisJ.Tedesco,MDDistinguishedChairinPediatricsActingChiefofPediatrics,SectionofPediatricHematology/Oncology,ProfessorofPediatricsandBiochemistry&MolecularBiologyPhone:(706)[email protected]
ThePacelaboratoryconductsresearchrelatedtothe developmental regulation of globin geneexpression using primary erythroid progenitors.Themajorefforthasbeentherolep38MAPKcellsignaling in drug-mediated fetal hemoglobininduction as a treatment for sickle cell disease.The laboratory also has conducted highthroughputdrugscreenstoidentifynovelgammaglobininducers.Genome-widestudiesarebeingconducted to identify geneticmodifiers of fetalhemoglobin.
Prasad,Puttur,PhDBiochemistry,CN1163ProfofObstetricsandGynecologyBiochemistry&MolecularBiologyPhone:(706)[email protected]
Dr. Prasad studies the nutrient and drugtransporters in the placenta as well as post-partumdepression.
Sakamuro,Daitoku,PhDBiochemistry,CN2177AssociateProfessorofBiochemistryandMolecularBiologyPhone:(706)[email protected]
The Sakamuro laboratory is interested in thesignalingmechanismsbywhichadvancedcancercells acquire resistance to DNA damage, p53-dependent apoptosis, and substratum dissoc-iation stress,and reverseEMT.One focus is thedual roles of the c-MYC transcription factor ingenomic instabilityandDNAdamage resistance.Anotheristhemechanismsofapoptosisinducedbythep53tumorsuppressor in thepresenceofchromatinremodelingfactors.
Shi,Huidong,PhDCancerBiology,CN2138ProfessorofBiochemistryandMolecularBiologyPhone:(706)[email protected]
Dr.Shistudiesepigenomics,anddevelopmentofhigh-throughput technologies for dissecting thecomplex epigenetic regulation in normal andtumor cells. Epigenetics is heritable chromatinorganization and gene expression not coded byDNA sequence. While epigenetics refers to thestudy of single genes or sets of genes,epigenomics is theglobalanalysesofepigeneticchangesacrossthegenome.
Thangaraju,Muthusamy,PhDBiochemistry,CN1161AssociateProfessorofBiochemistryandMolecularBiologyPhone:(706)[email protected]
Dr. “Raju” is interested in the role of plasmamembranetransportersintheuptakeofhistonedeacetylase (HDAC) inhibitors into tumor cells;Relevance of these transporters to tumorsuppression in mammary gland via HDACinhibition;Physiologic roleof these transportersin apoptosis during mammary gland involution;Epigenetic mechanisms for silencing of thesetransportersinbreastcancer.
Thompson,Stuart,PhDBiochemistry,CB2607AssociateProfessor,SectionforInfectiousDiseases,andBiochemistryandMolecularBiology,Phone:(706)[email protected]
MylabstudiesCampylobacterandHelicobacter,bacteria that cause gastroenteritis and gastriccancer, respectively. We use molecular andbiochemical techniques to elucidate themechanisms by which these pathogens causedisease. Specifically, we study gene regulationevents that link motility with formation ofbiofilms, bacterial communities that resistantibioticsandthehostimmunesystem.
Tuan-Lo,Dorothy,PhDBiochemistry,CN2173ProfessorofBiochemistryandMolecularBiologyPhone:(706)[email protected]
Dr. Tuan's research focuses on long-rangetranscriptional regulation of genes by the LocusControlRegion(LCR)andtheLTRretrotransposonof ERV-9 human endogenous retrovirus, inparticular, roles of long, noncoding RNAs(lncRNAs)transcribedbytheLCRandERV-9LTRinregulating red cell differentiation. An additionalresearch interest of her lab is molecularmechanismofgamma-globingenereactivationinsicklecelldiseaseandthalassemia.
VanRiggelen,Jan,PhDBiochemistry,CN2175AssistantProfessorofBiochemistryandMolecularBiologyPhone:(706)[email protected]
Dr.VanRiggelenusestheMyc/Miz1andSmad/TGFbsignalingpathwayinhematopoieticmalignanciesasamodelsystemtostudyhowdynamicsintheepigeneticlandscapedrive proliferation vs. cellular senescence.Our main focus is on DNA methyltransferases andgenome-wideDNAmethylationmediatedbyMycandSmad.Ourgoalistounderstandhowthesepathwayscontrol tumormaintenance, cellular senescence andtumorregression.
Yan,Chunhong,PhD CancerBiology,CN2134 [email protected]
Dr.Yan’slabutilizesbiochemicalapproachesandgenetically-engineered mouse models to studytumorsuppressornetworksandunderstandhowcancer is generated and progressed. Currentinterests include the p53 pathway and proteinmodifications (e.g., ubiquitination andacetylation)incellularresponsestoDNAdamageandmetabolic stresses.He is also interested indeveloping novel therapeutic strategiestargetingaberrantproteintranslationincancer.
Zhou,Gang,PhDCancerBiology,CN4140AssociateProfessorofMedicine,SectionofHematology/OncologyPhone:(706)[email protected]
Dr. Zhou's investigates the functions of theimmune system’s CD4+ T cells in cancer usingvarious animal models. CD4+ T cells can beprimedtohandlediverseassignmentseitherashelperorsuppressor(regulatory)cells.Ashelpercells,theycankillmalignantcellsdirectlyorhelpto activate other immune cells to attack thetumors.SuppressorCD4+Tcells,however,actasbrakes on the immune system, heading offautoimmunedisorders.
