Functional anatomy: dynamic states in basal ganglia circuits
Anatomy of basal ganglia
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Transcript of Anatomy of basal ganglia
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BASAL GANGLIA
Dr. Israa M. SulaimanDepartment of Anatomy
IMS/MSU
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• Define basal ganglia and describe the parts
• Describe the main connections and functions
• Describe the function and the disorders of basal ganglia such as Parkinsonism and tremors
OBJECTIVES
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Basal gangliaThe basal ganglia is a
collection of gray matter in the cerebrum including the corpus striatum, amygdala
and claustrum.Has important
connections with other regions of the brain, particularly: thalamus, subthalamic nuclei, red nucleus and substantia nigra
Important in coordinating movement.
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Traditional Concepts of Basal GangliaTraditional Concepts of Basal Ganglia
Corpus StriatumCorpus Striatum
Caudate NucleusCaudate Nucleus
Lenticular Nucleus PutamenLenticular Nucleus Putamen
Globus Pallidus Paleostriatum PallidumGlobus Pallidus Paleostriatum Pallidum
Corpus Amygdaloideum ArchistriatumCorpus Amygdaloideum Archistriatum
Neostriatum StriatumNeostriatum Striatum
Basal GangliaBasal Ganglia Basal GangliaBasal Ganglia
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1. Putamen1. Putamen2. Tail of caudate 2. Tail of caudate
nucleusnucleus3. 3.
CaudatolenticCaudatolenticular gray ular gray bridgebridge
4. Amygdaloid body4. Amygdaloid body5. thalamus5. thalamus
Lateral surface Lateral surface of basal gangliaof basal ganglia
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1. head of 1. head of caudate nuceluscaudate nucelus
2. body of 2. body of caudate nuceluscaudate nucelus
3. caudatolenticular 3. caudatolenticular gray bridgegray bridge
4. putamen4. putamen
5. tail of 5. tail of caudate nucleus caudate nucleus
6. external segment of 6. external segment of globus pallidus globus pallidus
7. internal segment of 7. internal segment of globus pallidusglobus pallidus
8. amygdaloid body8. amygdaloid body
9. nucleus accumbens 9. nucleus accumbens septisepti
Medial surface of basal gangliaMedial surface of basal ganglia
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Components of Basal GangliaComponents of Basal Ganglia
Corpus StriatumCorpus Striatum
Striatum ----- Caudate Nucleus & PutamenStriatum ----- Caudate Nucleus & Putamen
Pallidum ----- Globus Pallidus (GP)Pallidum ----- Globus Pallidus (GP)
Substantia NigraSubstantia Nigra
Pars Compacta (SNc)Pars Compacta (SNc)
Pars Reticulata (SNr)Pars Reticulata (SNr)
Subthalamic Nucleus (STN)Subthalamic Nucleus (STN)
Ventral Striatum and Ventral PallidumVentral Striatum and Ventral Pallidum
Nucleus Accumbens SeptiNucleus Accumbens Septi
Non cholinergic portion of Substantia InnominataNon cholinergic portion of Substantia Innominata
Basal Ganglia Components Basal Ganglia Components Basal Ganglia Components Basal Ganglia Components
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STRIATUMSTRIATUM
Caudate NucleusCaudate Nucleus Head, (Corpus), TailHead, (Corpus), Tail
caudatolenticular gray bridgecaudatolenticular gray bridge
PutamenPutamen
Ventral StriatumVentral Striatum: : Nucleus Accumbens (Septi)Nucleus Accumbens (Septi)
Basal Ganglia Components Basal Ganglia Components Basal Ganglia Components Basal Ganglia Components
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BASAL GANGLIA
BASAL GANGLIA
CORPUS STRIATUM AMYGDALA
NEOSTRIATUM
CAUDATE NUCLEUS
PALEOSTRIATUM
PUTAMEN GLOBUS PALLIDUS
LENTIFORM NUCLEUS
CLAUSTRUM
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TERMINOLOGIESNeurological structure
Basal nuclei
Corpus striatum Caudate nucleus + lentiform nucleus
Amygdala Amygdaloid nucleus
Claustrum Claustrum
Neostriatum Caudate nucleus + putamen
Paleostriatum Globus pallidus
Caudate nucleus Caudate nucleus
Lentiform nucleus Globus pallidus + putamen
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Anterior horn
Inferior horn
Posterior horn
Amygdaloid nucleus
Basal ganglia
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Basal Ganglia Components Basal Ganglia Components Basal Ganglia Components Basal Ganglia Components
Striosome and Striosome and Matrix compartmentMatrix compartment
AchE
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PutamenPutamenGlobus pallidusGlobus pallidus external segmentexternal segment internal segmentinternal segmentSubthalamic NucleusSubthalamic NucleusSubstantia nigraSubstantia nigra
Internal capsuleInternal capsule
Components ofComponents ofBasal GangliaBasal Ganglia
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habenularhabenularnucleusnucleus
habenularhabenularnucleusnucleus
tectumtectum(superior colliculus)(superior colliculus)
tectumtectum(superior colliculus)(superior colliculus)
PPNPPN(pedunculopontine nucleus)(pedunculopontine nucleus)
PPNPPN(pedunculopontine nucleus)(pedunculopontine nucleus)
amygdaloid bodyamygdaloid bodyamygdaloid bodyamygdaloid body
rapherapherapheraphe
CerebralCerebralCortexCortex
CerebralCerebralCortexCortex
STNSTNSTNSTN
PallidumPallidum
SNrSNr
PallidumPallidum
SNrSNr
STRIATUMSTRIATUMSTRIATUMSTRIATUM
Connections of the Basal GangliaConnections of the Basal GangliaConnections of the Basal GangliaConnections of the Basal Ganglia
SNcSNcSNcSNcThalamusThalamusThalamusThalamus
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Basal Ganglia (Prefronatal Complex Loop) Basal Ganglia (Prefronatal Complex Loop) Connections Connections
Basal Ganglia (Prefronatal Complex Loop) Basal Ganglia (Prefronatal Complex Loop) Connections Connections
PrefrontalPrefrontalAssociationAssociation
CortexCortex
PrimaryPrimaryMotor AreaMotor Area
(M I)(M I)
THALAMUSTHALAMUS(VLm, VAmc, MD)(VLm, VAmc, MD)
STRIATUMSTRIATUM(Caudate (Caudate Nucleus)Nucleus)
SNrSNr(Substantia Nigra,(Substantia Nigra,
pars reticulata)pars reticulata)
pyramidalpyramidal tracttract
LMNLMN
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Basal Ganglia (Limbic Loop) Basal Ganglia (Limbic Loop) ConnectionsConnections
Basal Ganglia (Limbic Loop) Basal Ganglia (Limbic Loop) ConnectionsConnections
Orbitofrontal CortexOrbitofrontal CortexAnterior Cingulate GyrusAnterior Cingulate GyrusHippocampal FormationHippocampal Formation
THALAMUSTHALAMUS(VAmc, MD)(VAmc, MD)
Ventral StriatumVentral StriatumCaudate NucleusCaudate Nucleus
Ventral PallidumVentral PallidumGPi, SNrGPi, SNr
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Basal Ganglia (Oculomotor Loop) Basal Ganglia (Oculomotor Loop) Connections Connections
Basal Ganglia (Oculomotor Loop) Basal Ganglia (Oculomotor Loop) Connections Connections
FrontalFrontalEye FieldEye Field(area 8)(area 8)
PrimaryPrimaryMotor AreaMotor Area
(M I)(M I)
THALAMUSTHALAMUS(VLm, VAmc, MD)(VLm, VAmc, MD)
STRIATUMSTRIATUM(Caudate (Caudate Nucleus)Nucleus)
SNrSNr(Substantia Nigra,(Substantia Nigra,
pars reticulata)pars reticulata)
pyramidalpyramidal tracttract
LMNLMN TectumTectum
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Basal GangliaBasal Ganglia (SNc and CM-PF nuclear complex) (SNc and CM-PF nuclear complex) Connections Connections
Basal GangliaBasal Ganglia (SNc and CM-PF nuclear complex) (SNc and CM-PF nuclear complex) Connections Connections
PallidumPallidum
StriatumStriatum
THALAMUSTHALAMUS(CM-PF)(CM-PF)
PallidumPallidum
StriatumStriatum
SNcSNc
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Basal Ganglia (Brain Stem Efferents) Basal Ganglia (Brain Stem Efferents) Phylogeny Phylogeny
Basal Ganglia (Brain Stem Efferents) Basal Ganglia (Brain Stem Efferents) Phylogeny Phylogeny
GPiGPi
SNrSNr
TectumTectum(superior (superior colliculus)colliculus)
SpL SpL nDCPnDCP
DIP (thalamus)DIP (thalamus)NeostriatumNeostriatumIntermedialeIntermediale
(motor cortex)(motor cortex)
aves (birds)aves (birds)
GPiGPi
SNrSNrTectumTectum
(superior (superior colliculus)colliculus)
nPCnPC
VA-VL complexVA-VL complex(thalamus)(thalamus)
motormotorcortexcortex
mammalsmammals
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Basal Ganglia (STN) Basal Ganglia (STN)
ConnectionsConnections
Basal Ganglia (STN) Basal Ganglia (STN)
ConnectionsConnections
SNrSNrGPiGPi
STNSTN
GPeGPe
subthalamicsubthalamic fasciculusfasciculus
OutputOutputPortionPortionofofBasalBasalGangliaGanglia
Cerebral CoretxCerebral Coretx
Thalamus (CM-PF)Thalamus (CM-PF)
PPNPPN
SubthalamicSubthalamicNucleusNucleus
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Caudate nucleus
Putamen
Globus pallidus
Claustrum
Lentiform nucleus Insula
Basal ganglia HORIZONTAL SECTIONANTERIOR
POSTERIOR
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Thalamus
Amygdala
SUPERIOR
INFERIOR
CORONAL SECTIONBasal ganglia
Caudate nucleus
Claustrum Lentiformnucleus
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Thalamus
Substantianigra
Subthalamic nucleus
SUPERIOR
INFERIOR
CORONAL SECTIONBasal ganglia
Caudate nucleus
Tail of Caudate nucleus
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Thalamus
Substantianigra
Red nucleus
SUPERIOR
INFERIOR
CORONAL SECTIONBasal ganglia
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Caudate n
Thalamus
POST
ANT
Horizontal sectioncorpus striatum• Caudate nucleus• Putamen• Globus pallidus
lentiform nucleus• Putamen• Globus pallidus
neostriatum• Caudate nucleus• Putamen
paleostriatum• Globus pallidus
Globus pallidus
Putamen
Lateral ventricle-Ant horn
Third ventricle
Lateral ventricle-Post horn
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• Caudate nucleus• Putamen• Globus pallidus• Claustrum• Amygdala (part of
limbic system)
Basal ganglia
Caudate n
Thalamus
POST
ANT
Horizontal section
Globus pallidus
Putamen
Lateral ventricle-Ant horn
Third ventricle
Lateral ventricle-Post horn
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Lentiform
Caudate nucleus
thalamus
• C-shaped • Head, body,tail• Large head,tapering curved tail• Head-frontal lobe• Tail-occipital lobe• End of tail-temporal lobe
– -terminates in amygdaloid nucleus– (roof of inf horn of lateral ventricle)
Caudate
Amygdaloid
Caudate nucleus
Putamen Globus pallidus
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Caudate nucleus
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Lentiform nucleus
Lentiform
thalamusCaudate
Amygdaloid Putamen Globus pallidus
Putamen – lateral medullary lamina – Globus PallidusLat GP – medial medullary lamina – Med GP
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Lentiform nucleus
Putamen
Globus pallidus
Lateral medullary lamina
Medial medullary lamina
Lat GP Med GP
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Caudate n
Thalamus
POST
ANT
Horizontal section
Globuspallidus
Putamen
Lateral ventricle-Ant horn
Third ventricle
Lateral ventricle-Post horn
Lentiform nucleus
• Wedge-shaped
• Internal capsule
• External capsule
• Extreme capsule
• Claustrum
• Lateral and medial medullary lamina
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Amygdaloid nucleus
Lentiform
thalamusCaudate
Amygdaloid Putamen Globus pallidus
Temporal lobe - Roof of inf horn of lateral ventricle
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Caudate n
Thalamus
Globus pallidus
Putamen
Subthalamic nuclei
Substantia nigra
Substantia nigraSubthalamic nuclei
Coronal section
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Connections
• Caudate nucleus
• Putamen
• Globus pallidus – output leaves
receive input
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• Connections of striatum
– Caudate nucleus & putamen – input
– Receive afferent - cerebral cortex, intralaminar thalamic nuclei, subs nigra
– Efferent – globus pallidus, subs nigra
• Connections of globus pallidus
– 2 segments – med & lat– Med & subs nigra – output– Receive afferent – striatum,
subthalamic nucleus– Efferent
• Lat – subthalamic N
• Med – thalamus (VA,VL,CM) – motor areas
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Connections
CN/
i/laminar thal
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Connections of basal gangliaAfferent
• Corticostriate• Thalamostriate• Nigrostriate• Brainstem striatal fibres
• Striatopallidal• Subthalamic nucleus
• Mostly end in neostriatum except subthalamic N end in paleostriatum
Efferent• Striatopallidal• Striatonigral
• Pallidofugal fibres– Ansa lenticularis– Fasciculus lenticularis– Pallidotegmental– Pallidosubthalamic
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Corticostriate-Glutamate
thalamostriate
Nigrostriate-dopa
Striatopallidal-GABA
Brainstem striatal-serotonin
Striatopallidal-GABA
Striatonigral-GABA,Ach
Ansa lenticularis
Fasciculuslenticularis
pallidotegmental
pallidosubthalamic
Caudate n
Thalamus
Globus pallidus
Putamen
Subthalamic nuclei
Substantia nigra
Subthalamus-pallidal
Connections of basal ganglia Afferent fibres Efferent fibres
Pallidofugal fibres
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Connections of corpus striatumAfferent
• Cerebral cortex-Corticostriate
• Thalamic nuclei-Thalamostriate
• Substantia nigra-Nigrostriate
• Brainstem striatal fibres
Efferent
• Globus pallidus-Striatopallidal
• Substantia nigra-Striatonigral
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• Connections of striatum– Caudate nucleus & putamen – input– Receive afferent - cerebral cortex,
intralaminar thalamic nulcei, subs nigra– Efferent – globus pallidus, subs nigra
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premotor
1o sensory1
2
4Brainstem
supplementary motor
3
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Connections of globus pallidus Afferent
• Striatum-striatopallidal• Subthalamic nucleus• Subthalamonigral-
Efferent
• Thalamic nuclei-Ansa lenticularis
• Subthalamus-Fasciculus lenticularis
• Tegmental of midbrain-Pallidotegmental
• Subthalamic nuclei-Pallidosubthalamic
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• Connections of globus pallidus– 2 segments – med & lat– Med GP & subs nigra – output– Receive afferent – striatum, subthalamic
nucleus– Efferent
• Lat GP – subthalamic N• Med GP – thalamus (VA,VL,CM) – motor areas
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1
2
Ansa lenticularis
Fasc lenticularisPallidosubthalamic
Pallidotegmental
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Function • Cerebral cortex, basal ganglia, cerebellum
and thalamus– motor activity– muscle tone– organisation of movement
• What type ? -cerebral cortex• How to perform? -basal ganglia+cerebellum• Assist in regulation-thalamus
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• Part of extra-pyramidal motor system• Facilitate behaviour & movement – required and
appropriate• Inhibit unwanted & inappropriate
Function
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“Brake hypothesis”
• The deficits tend to fall into one of two categories: – the presence of extraneous unwanted
movements»OR
– an absence or difficulty with intended movements.
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• The balance between the cerebellum and the basal ganglia allows smooth, coordinated movement, and a disturbance in either system will show up as movement disorders.
Function
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• Destruction of primary motor –– Unable to perform fine
discrete movement– But still able to
perform crude movement
• Destruction of corpus striatum –– Total paralysis
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Cerebral cortex
Corticospinal CorticobulbarCorticostriatal
Direct Indirect
StriatonigralStriatopallidal
inhibitory
Disinhibit neurone thalamus
Facilitate movement
Subthalamic NMed pallidalinhibitory
inhibitoryLat pallidal
Activate neurone
Inhibit unwanted movement
excitatory
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Disease of basal ganglia
• Change in muscle tone• Abnormal involuntary movement
– Parkinsonism– Effect on the opposite side
• Degeneration of dopamine-producing cells in substantia nigra-depletion of dopamine in striatum
• Resting tremor• Rigidity – simultaneous contraction of flexors and extensors• Bradykinesia = Slowness of movement – brake cannot be
released• No paralysis, sensory loss, ataxia
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Cerebral cortex
Corticospinal CorticobulbarCorticostriatal
Direct Indirect
StriatonigralStriatopallidal
inhibitory
Disinhibit neurone thalamus
Facilitate movement
Subthalamic NMed pallidalinhibitory
inhibitoryLat pallidal
Activate neurone
Inhibit unwanted movement
excitatory
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Corticostriate-Glutamate
thalamostriate
Nigrostriate-dopa
Striatopallidal-GABA
Brainstem striatal-serotonin
Striatopallidal-GABA
Striatonigral-GABA,Ach
Ansa lenticularis
Fasciculuslenticularis
pallidotegmental
pallidotsubthalamic
Caudate n
Thalamus
Globus pallidus
Putamen
Subthalamic nuclei
Substantia nigra
Subthalamus-pallidal
Connections of basal ganglia Afferent fibres Efferent fibres
Pallidofugal fibres
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– Huntington’s disease – • hereditary disease of unwanted movements. It
results from degeneration of the caudate and putamen, and produces continuous dance-like movements of the face and limbs -choreoathetosis
– Hemiballism -• flailing movements of one arm and leg (one-sided),
which is caused by damage (i.e., stroke) of the subthalamic nucleus.
Disease of basal ganglia
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Caudate n
Thalamus
Globus pallidus
Putamen
Subthalamic nuclei
Substantia nigra
Afferent fibres Efferent fibres
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Caudate n
Thalamus
Globus pallidus
Putamen
Subthalamic nuclei
Substantia nigra
Afferent fibres Efferent fibres
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Connections of basal ganglia-afferent fibres
A-Brainstem striatal fibresB-thalamostriateC-corticostriateD-subthalamicE-nigrostriate
Match the connections -
EXCERCISE
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Connections of basal ganglia-efferent fibres
A-pallidosubthalamicB-striatopallidalC-ansa lenticularisD-striatonigral
Match the connections -
EXCERCISE
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