ANATOMY & CELL BIOLOGY · Good introduction to what graduate school and research ... Department of...
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10 th ANNUAL ANATOMY & CELL BIOLOGY UNDERGRADUATE RESEARCH & LAB RECRUITMENT DAY Thursday, November 28, 2019
Transcript of ANATOMY & CELL BIOLOGY · Good introduction to what graduate school and research ... Department of...
10th ANNUALANATOMY & CELL BIOLOGY
UNDERGRADUATE RESEARCH &LAB RECRUITMENT DAY
Thursday, November 28, 2019
Benefits of Doing Research as an Undergraduate
• Good introduction to what graduate school and research is like
• A fun and rewarding way to earn credits (and sometimes income)
• Great opportunity to acquire an academic reference by working with an individual professor
• Professional Skills Development:o Problem-solving and time management skills
o Presentation and communication skills
o Teamwork and independent work skills
Undergraduate Research Opportunities
Work or Volunteer Experience:
• Volunteer part-time in a lab during the academic year
• Paid or volunteer work during the summer
• Work Study positions: mcgill.ca/studentaid/work-study
Undergraduate Research Fellowships:
• NSERC USRA: mcgill.ca/medresearch/biomedical/nserc
• Pan-McGill SURA: mcgill.ca/science/research/undergraduate-research/sura
• John Bergeron Summer Research Scholarship: macssmcgill.com/scholarships
Credit options:
• ANAT 432
• 396 Research Projects
ANAT 396 Undergraduate Research Project
• Course Coordinator: Dr. Craig Mandato
• 3 credits, one semester
• Approximately 10 hours per week, for 13 weeks
• Offered in Fall, Winter, Summer semesters (depending on supervisor availability)
• All 396 courses count as electives and ACB students can do a 396 in other departments (HGEN 396, PHGY 396, etc.)
• mcgill.ca/science/research/undergraduate-research/science-research-courses
ANAT 396 Undergraduate Research Project
How it works:• Contact potential supervisors affiliated with the Department who
are doing research you find interesting• ANAT 396 supervisor can be any faculty member listed at:
mcgill.ca/anatomy/directory• If they agree to supervise a project, you’ll develop a proposal with
them, fill out a 396 project form and submit it for approval (to Joelle in M/28)
Evaluation:• To be determined with your supervisor• Minimum 50% of grade for final report
ANAT 432 Honours Research Project
• Course Coordinator: Dr. Huy Bui• 9 credits • Summer semester: Full-time, 5 full days per week, minimum
of 16 weeks• Fall/Winter: Part-time, 2 full days per week, in both Fall &
Winter semesters• Required course for ACB Honours students• Prerequisite BIOL 301 (or prior research experience) • Open to ACB Major students with a minimum CGPA 3.2, when
space permits (counts for 3 credits of BOC + 6 credits of electives)
ANAT 432 Honours Research Project
How it works:• Find a supervisor who’s affiliated with the Department
• With supervisor, develop a suitable research project and determine expectations for the year/semester
• Gain a comprehensive understanding of the research question and research field
Evaluation:• 10% Midterm
o 5% oral presentation (chalk talk format)
o 5% abstract
• 35% Supervisor evaluation
• 30% Final report, written as a scientific paper
• 25% Oral presentation and defense
The life of a researcher…
Insights and experiences from students and faculty
Katya Peri
U3 BSc student
(Dr. Bui’s lab)
Sarah Gagnon
MSc student
(Dr. Rocheleau’s lab)
David Zhou
PhD 3 student
(Dr. Mandato’s lab)
Kimberley Gauthier
PhD 7 student
(Dr. Rocheleau’s lab)
Dr. Jean-François Cloutier Professor
Department of Neurology & Neurosurgery (MNI) and
Department of Anatomy & Cell Biology
cloutierlab.mcgill.ca
Jean-François Cloutier, Montreal Neurological Institute
Becoming a Researcher: Hang on for a crazy ride!
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Becoming a PI; Choice or Chance?
Ph.D. Post-Doc
My Lab
Highlights and lowlights
What’s it like being a researcher?
Highlights:
Lowlights:
Work with colleagues with very different backgrounds.
Work independently yet you are part of a bigger team.
Make friends for life.
Whether you get it right or wrong, you’re actually doing science!
Mentoring junior colleagues and trainees.
Get to have fun!
Learning to deal with grant application rejections.
Learning to deal with manuscript rejections.
Learning to deal with rejections from your experiments!
Advice on choosing an advisor
So you’re thinking about becoming a researcher…
Commonly asked questions:
2. How do I get a PI to be interested in my application to do research in their lab?
3. What are the most important criteria when choosing a lab for a research project?
1. Do I need a high GPA to become a good scientist?
Thank you!
Dr. Dieter P. ReinhardtProfessor
Department of Anatomy & Cell Biology and
Faculty of Dentistry
reinhardt-lab.mcgill.ca
Dieter P. Reinhardt, Ph.D.Faculty of Medicine
Department of Anatomy and Cell Biologyand
Faculty of DentistryDivision of Biomedical Sciences
Extracellular fiber systems in health and disease
Cells
Extracellularmatrixfibers
Structuralcomponents
Physiol. activecomponents
Microfibrils in tissues - elastic fibers
Elastin core
Microfibrils
Microfibrils in tissues – ciliary zonules
Ciliary zonules
Lens
Genetic disorders caused by mutations in Fibrillins
Fibrillin-1: Marfan syndrome stiff skin syndromedominant Weill-Marchesani syndrome acromicric dysplasiageleophysic dysplasiaprogeroid Marfan syndromefamilial aortic aneurysmMASS syndromefamilial ectopia lentis
Fibrillin-2: congenital contractural arachnodactyly (Beal’s syndrome)
Fibrillin-3: polycystic ovary syndrome?
55 mm
Marfan syndrome - clinical features
Skeletal SystemLong bone overgrowth
CardiovascularSystem
Aneurysm
OcularSystem
Ectopia lentis
Ciliary zonules
Dominant Weill-Marchesani syndrome
Source: Hum Genet (2002) 110 :366–370, J Fr. Ophtalmol., 2001; 24, 9, 944-948
Progeroid–lipodystrophy syndrome
• Pathological pathways and treatment of the disorders
• Role of extracellular fiber systems in growth factor regulation
• Formation and degradation
• Molecular functions and cell matrix dynamics
• Regulation by microRNAs
Research Interests in the Reinhardt Lab
Dr. Susanne Bechstedt
Assistant Professor
Department of Anatomy & Cell Biology
bechstedt.lab.mcgill.ca
Microtubules and Associated Proteins (MAPs)
Susanne Bechstedt
MicrotubulesAxonsDendrites
Cell shapeTransport by motors
Torsten Wittmann
MitosisMeiosis
Lilian Kabeche
Cilia
Gwen V. Childs
Protofilament
α
βTubulin (GTP)
+
CKAP2 increases spontaneous microtubule nucleation
CKAP2 Knockouts show severe spindle defects as well as ‘donut’ nuclei and multinucleated cells
HT1080 cells CKAP2 homozygous KO
MicrotubulesDNA
Multipolar spindles & chromosome alignment ‘Donut’ nucleiAzriel Lopez
Dr. Joaquin Ortega Professor
Department of Anatomy & Cell Biology
joaquinortega9.wixsite.com/ortegalabmcgill
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