8/12/2019 Analysis of Neuroendocrine Differentiation and The

1/4

pringerLink - Journal Article

nalysis of neuroendocrine differentiation and the p53/BAXpathway in UICC

age III colorectal carcinoma identifies patients with good prognosis

urnal International Journal of Colorectal Disease

ublisher Springer Berlin / Heidelberg

SN 0179-1958 (Print) 1432-1262 (Online)

ubject Medicine

sue Volume 21, Number 3 / April, 2006

ategory Original Article

OI 10.1007/s00384-005-0779-5

ages 221-230

nline DateTuesday, June 14, 2005

Add to marked item

Add to shopping ca

Add to saved items

Recommend this

article

Disable Highlighting

Original Article

Analysis of

euroendocrine

ifferentiation and the p53/

AXpathway in UICC

tage III colorectal

arcinoma identifies

atients with good

rognosis

atricia Grabowski1,

srid Sturm2,

Katharina Schelwies2,

Kerstin Maaser1, Heinz-

ohannes Buhr3,

ernd Drken2,

Martin Zeitz1,

eter T. Daniel2andHans Scherbl1

ttp://www.springerlink.com/content/t4375016qq31l066/?p=fe68f9187b7e4f32a017fb4dea5065b7&pi=256 (1 of 4)26.11.2006 13:55:10

http://www.springerlink.com/content/1432-1262/http://www.springerlink.com/medicine/http://www.springerlink.com/content/q006302v3000/http://www.springerlink.com/content/t4375016qq31l066/?p=fe68f9187b7e4f32a017fb4dea5065b7&pi=256&mark=t4375016qq31l066http://www.springerlink.com/content/t4375016qq31l066/offerings/?p=53cf2c484075434aa5f64db1019eb3b5&pi=0http://www.springerlink.com/personalization/save-item.mpx?code=t4375016qq31l066http://www.springerlink.com/personalization/email-item.mpx?code=t4375016qq31l066http://www.springerlink.com/personalization/email-item.mpx?code=t4375016qq31l066http://www.springerlink.com/content/t4375016qq31l066/?p=fe68f9187b7e4f32a017fb4dea5065b7&pi=256&hl=uhttp://www.springerlink.com/content/t4375016qq31l066/?p=fe68f9187b7e4f32a017fb4dea5065b7&pi=256&hl=uhttp://www.springerlink.com/personalization/email-item.mpx?code=t4375016qq31l066http://www.springerlink.com/personalization/email-item.mpx?code=t4375016qq31l066http://www.springerlink.com/personalization/save-item.mpx?code=t4375016qq31l066http://www.springerlink.com/content/t4375016qq31l066/offerings/?p=53cf2c484075434aa5f64db1019eb3b5&pi=0http://www.springerlink.com/content/t4375016qq31l066/?p=fe68f9187b7e4f32a017fb4dea5065b7&pi=256&mark=t4375016qq31l066http://www.springerlink.com/content/q006302v3000/http://www.springerlink.com/medicine/http://www.springerlink.com/content/1432-1262/

8/12/2019 Analysis of Neuroendocrine Differentiation and The

2/4

pringerLink - Journal Article

1) Medizinische Klinik

I, Gastroenterologie/

Infektiologie/

Rheumatologie,

Charit-Campus

Benjamin Franklin,

Berlin, Germany

2) Abteilung fr

Hmatologie,

Onkologie und

Tumorimmunologie,

CharitCampus

Buch, Berlin,

Germany

3) Chirurgische Klinik,

CharitCampusBenjamin Franklin,

Berlin, Germany

Accepted:

5 April 2005 Published

nline: 14 June 2005

Abstract

ackground andims Neuroendocrine

ifferentiation is an

ndependent prognostic

actor in colorectal cancer.

Moreover, an altered p53/

AXpathway is associated

with a poor clinical

utcome in Union

nternationale Contre leancer (UICC) stage III

isease. Because these

markers are involved in

ifferent genetic events

isrupted in colorectal

ancer, we investigated

he prognostic power of a

multimarker analysis.

ttp://www.springerlink.com/content/t4375016qq31l066/?p=fe68f9187b7e4f32a017fb4dea5065b7&pi=256 (2 of 4)26.11.2006 13:55:10

8/12/2019 Analysis of Neuroendocrine Differentiation and The

3/4

pringerLink - Journal Article

atients and

methods Specimens were

nalyzed from 59 patients

with UICC stage III

isease who underwent

urgery for colorectal

denocarcinoma at our

nstitution and wereollowed up for 5 years or

ntil death. Tumors were

tudied for both p53

mutation and BAXprotein

xpression as well as for

he expression of

euroendocrine markers.

tatistical analysis of each

marker alone or inombination was

erformed.

esults p53status/BAX

xpression and

euroendocrine

ifferentiation are not

orrelated in stage III

olorectal cancers.

However, the combinationf both independent

vents identified a

ubgroup of patients with

n excellent prognosis:

atients whose tumors

were neuroendocrine

marker-negative and who

xhibited an intact p53/

AXpathway lived longermean survival, 93

months; range, 82104

months) than patients

whose tumors were either

euroendocrine marker-

ositive or whose tumors

ad a completely

isrupted apoptotic

ttp://www.springerlink.com/content/t4375016qq31l066/?p=fe68f9187b7e4f32a017fb4dea5065b7&pi=256 (3 of 4)26.11.2006 13:55:10

8/12/2019 Analysis of Neuroendocrine Differentiation and The

4/4

pringerLink - Journal Article

athway (41 months;

ange, 2657 months;