Anal Health in Rectal Microbicide Studies Ross D. Cranston MD FRCP Assistant Professor University of...
-
Upload
arthur-lane -
Category
Documents
-
view
216 -
download
3
Transcript of Anal Health in Rectal Microbicide Studies Ross D. Cranston MD FRCP Assistant Professor University of...
![Page 1: Anal Health in Rectal Microbicide Studies Ross D. Cranston MD FRCP Assistant Professor University of Pittsburgh.](https://reader036.fdocuments.in/reader036/viewer/2022070410/56649eaa5503460f94bafbbb/html5/thumbnails/1.jpg)
Anal Health in Rectal Microbicide Studies
Ross D. Cranston MD FRCP
Assistant Professor
University of Pittsburgh
![Page 2: Anal Health in Rectal Microbicide Studies Ross D. Cranston MD FRCP Assistant Professor University of Pittsburgh.](https://reader036.fdocuments.in/reader036/viewer/2022070410/56649eaa5503460f94bafbbb/html5/thumbnails/2.jpg)
Plan
Anatomy and physiology Adverse events in microbicide studies Anal diagnoses RAI and the anal canal Anal care for populations who have RAI
![Page 4: Anal Health in Rectal Microbicide Studies Ross D. Cranston MD FRCP Assistant Professor University of Pittsburgh.](https://reader036.fdocuments.in/reader036/viewer/2022070410/56649eaa5503460f94bafbbb/html5/thumbnails/4.jpg)
Anal Sphincter
Resting 70 mmHg (ref. vagina 0 mmHg)
Squeeze 180 mmHg
![Page 5: Anal Health in Rectal Microbicide Studies Ross D. Cranston MD FRCP Assistant Professor University of Pittsburgh.](https://reader036.fdocuments.in/reader036/viewer/2022070410/56649eaa5503460f94bafbbb/html5/thumbnails/5.jpg)
Perception (Anus vs. Rectum)
Anus Rectum
Sensation HotColdWet DryLight touchPin prickDistensionPleasurePain
DistensionPleasurePain
![Page 6: Anal Health in Rectal Microbicide Studies Ross D. Cranston MD FRCP Assistant Professor University of Pittsburgh.](https://reader036.fdocuments.in/reader036/viewer/2022070410/56649eaa5503460f94bafbbb/html5/thumbnails/6.jpg)
Rectal Microbicide AE Reporting
AE severity will be graded per the Division of AIDS Table for Grading Adult and Pediatric Adverse Events, Version 1.0, December 2004 (Clarification dated August 2009) and the Rectal Grading Table for Use in Microbicide Studies, Addendum 3 in the Division of AIDS Table for Grading Severity of Adult and Pediatric Adverse Events, Version 1.0, December 2004 (Clarification dated August 2009)
Adverse Events
Anal Rectal
Symptoms and signs 11 13
MTN 007 protocol
![Page 8: Anal Health in Rectal Microbicide Studies Ross D. Cranston MD FRCP Assistant Professor University of Pittsburgh.](https://reader036.fdocuments.in/reader036/viewer/2022070410/56649eaa5503460f94bafbbb/html5/thumbnails/8.jpg)
RAI and the Anal Canal
Increase in anal: Fissure Fistula Abscess Ulceration Herpes simplex Human papillomavirus/dysplasia/cancer
![Page 9: Anal Health in Rectal Microbicide Studies Ross D. Cranston MD FRCP Assistant Professor University of Pittsburgh.](https://reader036.fdocuments.in/reader036/viewer/2022070410/56649eaa5503460f94bafbbb/html5/thumbnails/9.jpg)
Anal Care in Populations who have RAI
Increasing anal awareness What can go wrong?
It is NOT always a hemorrhoid
When to seek help?
Pitt 2007
![Page 12: Anal Health in Rectal Microbicide Studies Ross D. Cranston MD FRCP Assistant Professor University of Pittsburgh.](https://reader036.fdocuments.in/reader036/viewer/2022070410/56649eaa5503460f94bafbbb/html5/thumbnails/12.jpg)
Summary
The anal canal is distinct from the rectum with a unique set of diagnoses
Anal sensation informs the perception of rectal products including candidate rectal microbicides
Study clinicians must be aware of anal conditions and examine ppts appropriately
There is a need to increase anal awareness in populations who have RAI