An Introduction to the Institute of Translational Health Sciences (ITHS)
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Transcript of An Introduction to the Institute of Translational Health Sciences (ITHS)
An Introduction to the Institute of Translational Health Sciences (ITHS)
Cathryn Booth-LaForce, Ph.D.ITHS Director of Membership
ITHS Director of Center for Scientific Review
Improve the way biomedical research is conducted across the country
Reduce the time it takes for laboratory discoveries to become treatments for patients
Engage communities in clinical research efforts
Train a new generation of clinical and translational researchers
Led by the National Center for Research Resources,the CTSA program supports a national consortium of medical research institutions that work together and share a common vision to:
A Common Vision
CollaborationBreaking Down Institutional Barriers
Team Science
Connectivity Partnerships
CTSA Philosophy
Guiding Principles of the CTSA Program
MT
WY
ID
WA
OR
NV
UT
CA
AZ
ND
SD
NE
CO
NM
TX
OK
KS
AR
LA
MO
IA
MN
WI
ILIN
KY
TN
MS AL GA
FL
SC
VAWV
MINY
PA
MD
DE
NJCT
RIMA
ME
VT
NH
AK
HI
Building a National CTSA Consortium60 CTSA Sites in 30 States and the District of Columbia ($500
million annually)
NC
OH
PR
= CTSA States= 2006–2010 CTSA Sites= 2011 CTSA Sites
Some ITHS Services
• Study Design and Data Management-161 investigators assisted in 2010– Biomedical statistics– EMR data export for research (Amalga)– Cross site data sharing: LC Data QUEST– High throughput data: SNP genotyping data – REDCap: Devise surveys to build own database
• Regulatory and Bioethics-238 investigators assisted in 2010 – Research Coordinator Core– Regulatory compliance auditing – Cross institutional IRB advisory board– Bioethical issues in research
Education and Training—A Few ExamplesLifelong Learning Programs
www.iths.org/training/online
• Interdisciplinary Grand Rounds”Using Genomics to Individualize Drug Therapy: Technical, Clinical and Ethical Challenges”3/14/11 HSB D209 12-1 and webcast
• Clinical Research Education Series“Resolving Ethical Dilemmas in Clinical Research Studies” 5/5/11 T-739 11:45-1:15 and webcast
• Career Development Series“Behind Closed Doors: Secrets of a Study Section” 5/5/11 SLU 4-5 and webcast
ITHS Services• Pre-Clinical Research Development Network-
273 investigators assisted in 2010– Development of innovative products: software, drug delivery systems, drug
formulation, medical devices, etc.– Academic researchers, startups, entrepreneurs
• Community Outreach and Research Translation- 308 investigators assisted in 2010– Community/Practice/Tribe-based research in the WWAMI region– GHRI: Outcomes research, public policy issues– Online training to use plain language in studies: PRISM
Community Outreach & Research Translation Core(www.iths.org/CORT)
• Goals: – To facilitate community-academic research partnerships
that are true collaborations– To increase community involvement in every stage of
research– To promote research that will address priorities and health
outcomes in the communities and practices we work with– To support these communities in becoming more engaged
and savvy about research.
CORT works with…
• Community stakeholders (clinicians, advocates, tribal partners, policymakers)
• Academic researchers who want to integrate community partnerships into their work
CORT offers…..
• Consultation service for tribal research– Provides a resource for tribes and tribal organizations who
have questions about ongoing or proposed research in their communities.
• Research ethics• Institutional Review Board questions• Legal issues• Medical issues• Tribal regulation of research
– With the CORT Tribal Liaison (Abigail Echo-Hawk), CORT attempts to find a scientist specialized in the particular area to answer questions sent by tribal officials or potential research subjects.
CORT offers…..
• Grant-writing assistance (limited basis)– Literature reviews– Grant-writing– Facilitating relationships between tribes and academic
research partners – Identifying potential grants that align with individual
community needs.
CORT offers…..
Developing ProposalsFinding Funding Finding Collaborators Working With Practices and Communities Developing Multi-site Proposals Developing Multi-site Budgets
Starting Up a StudyHandling IRB, Regulatory, and Ethical Issues Setting Up Contracts and Agreements Establishing Multi-site Study Procedures Creating Consent Forms and Study Materials Training Study Staff
Conducting and Managing ProjectsCollecting and Sharing DataObtaining Consent Recruiting Participants Maximizing Participant Retention Overseeing Study Activities Maintaining Collaboration
• Tools and templates for conducting research– PRIMER (Partnership-driven Resources to IMprove and
Enhance Research)—A toolkit for health research in partnership with practices and communities. For example:
CORT offers…..
– LC Data Quest (Locally Controlled Data QUery Extraction Standardization and Translation), which implements a technical infrastructure for sharing electronic medical record data for research while communities retain local control and management of their own data
Contact CORT
• Go to www.iths.org/CORT• Click on “Contact ITHS CORT”
Contact ITHS CORT
ITHS Pilot Fundingwww.iths.org/funding
ITHS offered $1.3 million in funding opportunities in 2010
• Small Pilot Project Grants– Designed to provide preliminary data for larger grant applications
• Ignition Awards-preclinical research– Drug and device development
• Community/Practice/Tribe-based Research Award– Help WWAMI groups develop participatory research capability
Examples of Funded Tribe-based Research Awards
• Roundstone, David Northern Cheyenne (Tsitsistas)Ways of Knowing Gathering: Northern Cheyenne Board of Health
• Smoker, Kenneth Building Translational Research Capacity within the Fort Peck Tribes--Engaging Tribal Youth: Fort Peck Tribes Health Promotion Disease Prevention Program
• Milton, Ann Protecting our Future: Quinault Indian Nation Diabetes & Wellness Program
• Mittelstaedt, Gillian Chronic Respiratory Diseases and Woodstove Use in Tribal Households: A Survey to Understand Awareness, Concerns and Actions Taken: Tulalip Tribes
• Peter, Evon Building Culturally-Responsive Suicide Prevention: Developing Training for Behavioral Health Providers: Maniilaq Association
• Donatuto, Jamie Swinomish Seafood Diet Interview Analyses: Swinomish Indian Tribal Community, La Conner, WA
Membership-Free!www.iths.org/membership
• Benefits to ITHS Members– Eligible for grant funding– Reduced rates for ITHS sponsored resources– Preferred registration for select ITHS events
• Join as Scholar (trainee) or full Member• Clinical, basic and translational researchers, and
tribal/community partners welcome!• All members of research team welcome
(scientists, research coordinators, program managers, administrators)
ITHS Navigator Consult
www.iths.org
Dr. Beth [email protected]
206-616-3875
• Personalized help with translational and clinical research projects • Answer general questions about ITHS services