Amino acid Metabolism 2
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Transcript of Amino acid Metabolism 2
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Amino acid Metabolism 2
C483 Spring 2013
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1. Arginine is biosynthesized from this precursor:A) PyruvateB) OxaloacetateC) a-ketoglutarateD) 3-phosphoglycerate
2. A Roundup Ready plant is one that has been genetically modified so that an enzyme (EPSP synthase) can no longer bind to the active ingredient (glyphosphate) which is a competitive inhibitor ofA) shikimate (in the aromatic amino acid pathway).B) tryptophan.C) lysine.D) phosphoenolpyruvate (PEP).
3. The conversion of tetrahydrofolate to methylene tetrahydrofolate is coupled to which amino acid conversion?A) serine → glycineB) glutamate → gglycineC) serine → threonineD) glycine → alanine
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4. If an amino acid is glucogenic, it will not be degraded to ________. A) pyruvate B) glutamate C) fumarate D) acetoacetate
5. T/F It is possible for an amino acid to be both ketogenic and glucogenic.
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Overview of Biosynthesis• Common intermediates
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Recognizing Carbon Chains
• Name these AA precursor molecules, and match them to the AA that is produced: alanine, serine, glutamate, asparagine
O
O
O
O
O
O
O
O
O
O
O
O
O
OO
O
OH
PO
O
O
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Essential Amino Acids
• Definition of “essential”
• Ambiguity with cysteine and tyrosine
• Arginine is essential in some mammals and in some development stages
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Aromatic AA Biosynthesis
NH
O
O
PO
O
O
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Catabolism of carbon chain
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Overview of Catabolism
• Ketogenic vs Glucogenic amino acids• Utilization of branched AA in muscle• Know particular cases– Deamination: Ala, Asp, Asn, Glu, Gln– Glucogenic: Arg– Ketogenic: Leu– Both: Ile– Cofactor synthesis: serine
• Importance of PLP in amino acid processing
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Ketogenic and Glucogenic
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Answers
1. C2. D3. A4. D5. T