What Amino's database reveals about

chronic gastrointestinal conditions

Full report available at amino.com/blog

March 2016

America’s Gut Check

Celiac disease

Crohn's disease

Colon cancer

Irritable bowel syndrome

Ulcerative colitis

Gallstones

Acid reflux

0 1 M 2 M

© 2016 AMINO INC.

ACID REFLUX R ANKS HIGHEST ON OUR LIST OF GUT CONDITIONSPatients diagnosed with select gut conditions in 2014 & 2015

BASED ON 4,719,900 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE

2.56 M

1.05 M

501 k

344 k

326 k

267 k

53 k

© 2016 AMINO INC.

MORE WOMEN ARE DIAGNOSED WITH GUT CONDITIONS THAN MENPatients diagnosed with select gut conditions in 2014 & 2015

Celiac disease

Crohn's disease

Colon cancer

Irritable bowel syndrome

Ulcerative colitis

Gallstones

Acid reflux

0.0 500.0 k 1.0 M 1.5 M

MaleFemale

BASED ON 4,719,900 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE

© 2016 AMINO INC.

ACID REFLUX MOST COMMONLY AFFECTS INFANTS & PEOPLE OVER 50 Distribution of 2,564,700 patients diagnosed with acid re!ux, by age

Patient age

BASED ON 2,564,700 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH ACID REFLUX BETWEEN 2014 & 2015

0.0%

0.5%

1.0%

1.5%

0 10 20 30 40 50 60 70 80

MaleFemale

0.0%

0.5%

1.0%

1.5%

0 10 20 30 40 50 60 70 80

© 2016 AMINO INC.

WOMEN GET DIAGNOSED WITH IBS NE ARLY 3X MORE THAN MEN Distribution of 344,300 patients diagnosed with irritable bowel syndrome (IBS), by age

MaleFemale

Patient age

BASED ON 344,300 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH IBS BETWEEN 2014 & 2015

© 2016 AMINO INC.

FOR E VERY ONE MAN, 2.9 WOMEN ARE DIAGNOSED WITH IBSRelative comparison of patients diagnosed with select gut conditions in 2014 & 2015

Men

BASED ON 4,188,200 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE

Women

Irritable bowel syndrome

Celiac disease

Gallstones

Acid re!ux

Crohn’s disease

2.9x

2.3x

2.1x

1.5x

1.2x

0.0%

0.5%

1.0%

1.5%

0 10 20 30 40 50 60 70 80

© 2016 AMINO INC.

ULCER ATIVE COLITIS DIAGNOSES DOUBLE FROM AGE 14 TO 20Distribution of 501,100 patients diagnosed with ulcerative colitis, by age

MaleFemale

Patient age

BASED ON 501,100 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH ULCERATIVE COLITIS BETWEEN 2014 & 2015

0.0%

0.5%

1.0%

1.5%

0 10 20 30 40 50 60 70 80

© 2016 AMINO INC.

GALLSTONES DIAGNOSES INCRE ASE 4X FOR WOMEN FROM AGE 17 TO 30Distribution of 1,050,800 patients diagnosed with gallstones, by age

MaleFemale

Patient age

BASED ON 1,050,800 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH GALLSTONES BETWEEN 2014 & 2015

0.0%

0.5%

1.0%

1.5%

0 10 20 30 40 50 60 70 80

© 2016 AMINO INC.

CROHN’S DISE ASE DIAGNOSES DOUBLE FROM AGE 14 TO 20Distribution of 266,900 patients diagnosed with Crohn’s disease, by age

MaleFemale

Patient age

BASED ON 266,900 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH CROHN’S DISEASE BETWEEN 2014 & 2015

0.0%

0.5%

1.0%

1.5%

0 10 20 30 40 50 60 70 80

© 2016 AMINO INC.

MEN GET DIAGNOSED WITH COLON CANCER MORE THAN WOMENDistribution of 326,000 patients diagnosed with colon cancer, by age

MaleFemale

Patient age

BASED ON 326,000 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH COLON CANCER BETWEEN 2014 & 2015

0.0%

0.5%

1.0%

1.5%

0 10 20 30 40 50 60 70 80

© 2016 AMINO INC.

WOMEN GET DIAGNOSED WITH CELIAC DISE ASE 2X MORE THAN MEN

MaleFemale

Patient age

Distribution of 52,900 patients diagnosed with celiac disease, by age

BASED ON 52,900 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH CELIAC DISEASE BETWEEN 2014 & 2015

0%

1%

2%

3%

0 10 20 30 40 50 60 70 80

© 2016 AMINO INC.

GOOD NE WS! AMERICANS FOLLOW COLONOSCOPY GUIDELINESDistribution of 5,964,800 patients who received a colonoscopy, by age

Patient age

BASED ON 5,964,800 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE WHO RECEIVED A COLONOSCOPY BETWEEN 2014 & 2015

MaleFemale

2.8 M

3.2 MFemale

Male

0 1 M 2 M 3 M

© 2016 AMINO INC.

WOMEN GET COLONOSCOPIES MORE THAN MENPatients receiving a colonoscopy between 2014 & 2015

BASED ON 5,964,800 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE WHO RECEIVED A COLONOSCOPY BETWEEN 2014 & 2015

Female

Male

0% 25% 50% 75% 100%

© 2016 AMINO INC.

BIOPSIES & REMOVAL OF POLYPS ARE COMMON DURING COLONOSCOPIESPercent of patients receiving a colonoscopy by type

BASED ON 5,964,800 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE WHO RECEIVED A COLONOSCOPY BETWEEN 2014 & 2015

Screening Screening with biopsy and/or removal Other

60.3%36.1%

43.5% 53.5%

Full report + an interactive chart that shows you how

gut conditions are related to other health issues

available at amino.com/blog