Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites,...

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Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena, Philip J.S. Stork, Alexandr P. Kornev, Susan S. Taylor, Andrey S. Shaw Cell Volume 154, Issue 5, Pages 1036-1046 (August 2013) DOI: 10.1016/j.cell.2013.07.046 Copyright © 2013 Elsevier Inc. Terms and Conditions

Transcript of Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites,...

Page 1: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers 

Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena, Philip J.S. Stork, Alexandr P. Kornev, Susan S. Taylor, Andrey S. Shaw 

Cell Volume 154, Issue 5, Pages 1036-1046 (August 2013)

DOI: 10.1016/j.cell.2013.07.046

Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 2: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure 1

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 3: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure 2

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 4: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure 3

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 5: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure 4

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 6: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure 5

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 7: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure 6

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 8: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure S1

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 9: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure S2

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 10: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure S3

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 11: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure S4

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 12: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure S5

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 13: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Figure S6

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 14: Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers Jiancheng Hu, Edward C. Stites, Haiyang Yu, Elizabeth A. Germino, Hiruy S. Meharena,

Cell 2013 154, 1036-1046DOI: (10.1016/j.cell.2013.07.046) Copyright © 2013 Elsevier Inc. Terms and Conditions