Allergy Antibody Assessments IgG & IgE Specific … · Allergy Antibody Assessments IgG & IgE...
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O NE -P AGE T EST D ESCRIPTION I MMUNOLOGY A SSESSMENTS BLOOD sample type: Allergy Antibody Assessments IgG & IgE Specific Antibodies The incidence of food sensitivities has increased dramatically over the years. It is estimated that up to 20% of the population have adverse reactions to foods. Genova’s Food Allergy Antibody Assessments help identify those with true IgE-mediated allergies as well as IgG-mediated food intolerances. The tests measure IgG antibody levels to 87 foods or quantitative IgE antibody levels to the most common types of dietary allergens, and total IgE. Additional tests are also available for common inhalants, moulds and spices. The Consequences of Food Allergies Increased total antigenic load related to food and environmental sensitivities has been associated with a wide range of medical conditions affecting virtually every part of the body. Mood and behaviour, including hyperactivity disorders in children, are profoundly influenced by food allergies. Symptoms can range from mildly uncomfortable to severe. They may include any of the following: • Asthma • Eczema • Arthritis • Sinusitis • Migraine • Urticaria • Ear Infections • Colitis IgE vs. IgG Mediated Reactions Classical skin testing for allergies such as skin-scratch testing only measures IgE- Mediated reactions. Assessment of relative IgG antibody levels to a multitude of foods using sensitive Enzyme-Linked Immunosorbent Assay (ELISA) technology identifies those foods against which the patient is producing antibodies. Measuring both relative IgE & IgG antibody levels provides an invaluable starting point for dietary intervention. The key differences between IgE & IgG mediated allergies/sensitivities are summarised below: IgE-Mediated Allergies IgG-Mediated Allergies • Immediate onset (within minutes) • Delayed onset (4-72 hours) • Circulating half-life of 1-2 days • Circulating half-life of 21 days • Permanent allergies (life-long) • Temporary allergies • Stimulates histamine release • Stimulates histamine release • Includes foods, inhalants & moulds and activates complement • Includes foods, herbs & spices Testing Options for Clinicians • IgG Food Antibodies - IgG antibody levels to 87 foods and Total IgE • IgE Foods – Quantitative IgE antibody levels to 37 common foods • IgE Inhalants -Quantitative IgE to 27 common environmental inhalants specific to western Europe geographic regions. • IgE Individual Allergens – Quantitative IgE antibody levels to specific requests • IgG Spices – IgG antibodies to 24 commonly used herbs and spices, and Total IgE Several controls are routinely included with each test to check for auto reactivity and to ensure optimal accuracy. • Testing Options: IgE Individual Allergens (by Request) IgE Inhalants IgE Foods IgG Food Antibodies • Specimen Requirements: 7 ml serum in SST • Before Taking this Test: - Immuno-suppressive medications may result in reduced antibody levels - Chemotherapy may interfere with test results - See instructions inside test kit for details
Transcript of Allergy Antibody Assessments IgG & IgE Specific … · Allergy Antibody Assessments IgG & IgE...
O N E - P A G E T E S TD E S C R I P T I O N
I M M U N O L O G Y A S S E S S M E N T S
BLOODsample type:
Allergy Antibody Assessments IgG & IgE Specific Antibodies
The incidence of food sensitivities has increased dramatically over the years. It is estimated that up to 20% of the population have adverse reactions to foods. Genova’s Food Allergy Antibody Assessments help identify those with true IgE-mediated allergies as well as IgG-mediated food intolerances. The tests measure IgG antibody levels to 87 foods or quantitative IgE antibody levels to the most common types of dietary allergens, and total IgE. Additional tests are also available for common inhalants, moulds and spices.
The Consequences of Food Allergies Increased total antigenic load related to food and environmental sensitivities has been associated with a wide range of medical conditions affecting virtually every part of the body. Mood and behaviour, including hyperactivity disorders in children, are profoundly influenced by food allergies. Symptoms can range from mildly uncomfortable to severe. They may include any of the following: • Asthma • Eczema • Arthritis • Sinusitis • Migraine • Urticaria • Ear Infections • Colitis
IgE vs. IgG Mediated Reactions Classical skin testing for allergies such as skin-scratch testing only measures IgE- Mediated reactions. Assessment of relative IgG antibody levels to a multitude of foods using sensitive Enzyme-Linked Immunosorbent Assay (ELISA) technology identifies those foods against which the patient is producing antibodies. Measuring both relative IgE & IgG antibody levels provides an invaluable starting point for dietary intervention.
The key differences between IgE & IgG mediated allergies/sensitivities are summarised below:
IgE-Mediated Allergies IgG-Mediated Allergies • Immediate onset (within minutes) • Delayed onset (4-72 hours) • Circulating half-life of 1-2 days • Circulating half-life of 21 days • Permanent allergies (life-long) • Temporary allergies • Stimulates histamine release • Stimulates histamine release • Includes foods, inhalants & moulds and activates complement
• Includes foods, herbs & spices
Testing Options for Clinicians • IgG Food Antibodies - IgG antibody levels to 87 foods and Total IgE • IgE Foods – Quantitative IgE antibody levels to 37 common foods • IgE Inhalants -Quantitative IgE to 27 common environmental inhalants specific to western Europe geographic regions. • IgE Individual Allergens – Quantitative IgE antibody levels to specific requests • IgG Spices – IgG antibodies to 24 commonly used herbs and spices, and Total IgE Several controls are routinely included with each test to check for auto reactivity and to ensure optimal accuracy.
• Testing Options: IgE Individual Allergens (by Request) IgE Inhalants IgE Foods IgG Food Antibodies
• Specimen Requirements:
7 ml serum in SST • Before Taking this Test:
- Immuno-suppressive medications may result in reduced antibody levels - Chemotherapy may interfere with test results - See instructions inside test kit for details
© 2009 Genova Diagnostics, Europei,td,FACT,032309
For test kits, clinical support, or more information contact:
Genova Diagnostics, EuropeParkgate House356 West Barnes LaneNew MaldenSurreyKT3 6NB+44 (0)20 8336 7750 • Fax: +44 (0)20 8336 7751
More detailed publications with references are also available: www.GDXuk.net
Order Number: D1234567
Genova Diagnostics Europe MRN: 00001234
Sex: FDOB: May 01, 1969
REPORTSAMPLE Patient:
© Genova Diagnostics · A. L. Peace-Brewer, PhD, D(ABMLI), Lab Director · CLIA Lic. #34D0655571 · Medicare Lic. #34-8475
Dairy Vegetables Fish/Shellfish Nuts and Grains2+VL01+0VL001+VL1+1+VL0VL001+VL
Miscellaneous00VLVL
Total IgEReference Range
<=87.0 IU/mL111.0
OutsideInside
VL0VLVL00000VL0VL
Poultry/MeatsVL2+VL1+001+
1+1+2+2+VLVL1+VL
0
VL001+00VLVLVL000000VLVL02+00
Fruits
000000000000000
GFREP RMS 28 Rev 5
This test reveals important clinical information about: • Immediate (IgE) and delayed (IgG) food reactions causing inflammation and altered intestinal permeability, thus playing a role in headache, fatigue, depression, anxiety, hyperactivity, mood shifts, dermatitis, arthritis, weight gain, irritable bowel syndrome, recurrent infection, and other chronic conditions • IgE-mediated immune reactions to specific environmental antigens and moulds associated with seasonal allergy symptoms such as runny nose, itchy eyes, asthma, or sinusitis • Total antigenic load that can place cumulative stress on the immune system, leading to chronic gastrointestinal disorders and autoimmune conditions • Patient-specific dietary instructions that outline foods to eliminate along with a detailed True Relief ® dietary rotation schedule of all tested foods
Nigel
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