All Knowmedge internal medicine flashcard
Transcript of All Knowmedge internal medicine flashcard
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24 hour urine cortisol greater than what value suggests a Cushing problem?
Greater than 100 mg/dl
Along with homocysteine, what levels can be elevated with vitamin B12 deficiency?
Methylmalonic acid levels
Anaphlyaxis reaction is an example of which type of hypersensitivity reaction?
Type 1 hypersensitivity reaction
Anti-smooth muscle antibodies areassociated with which condition?
Autoimmune hepatitis
Ascitic fluid containing polymorphonuclearleukocytes (PMNs) greater than this numberindicates spontaneous bacterial peritonitis (SBP)?
Greater than 250/mm3
ATP7B mutation is associated with which condition?
Wilson's Disease
Back pain that improves with leaningforward is the the classic presentation of
what musculoskeletal condition?
Spinal stenosis
Before starting patient on TNF-alphainhibitors, what test should be performed?
Purified protein derivative(PPD) tuberculin skin test
Besides a traumatic tap, what condition isoften associated with red blood cells in thecerebrospinal fluid on lumbar puncture?
HSV encephalitis
Besides elevated MCV, what else can beelevated with folate deficiency?
Homocysteine levels
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Besides rhabdomyolysis, what three majorconditions will produce blood in the urine
without seeing RBCs in urine?
Contamination with povidine, vitamin Cexcess, Paroxsysmal nocturnal
hemoglobinuria (PNH)
Best next step after pt has tried NSAIDs /OCPs for primary dymenorrhea but
symptoms persist >3 months?
Ultrasound to rule out uterine
abnormalities like fibroidsBilateral lateral rectus palsy is often seen
with what vascular condition?Cavernous sinus thrombosis
Blister cells or bite cells on peripheralsmear are most often seen with what
condition?
Glucose 6 phosphatedehydrogenase deficiency (G6PD)
Blood pressure greater than or equal to what value is a contraindication for t-PA therapy in patients with ischemic stroke?
Systolic blood pressure greater than185mmHg or Diastolic blood pressure greater
than 110mmHg
Boceprevir and Telaprevir are new hepatitisC agents that can only be used against which
HCV genotype?
HCV genotype 1
Breast cancer along with sarcomas,leukemia, lymphoma, brain tumors andadrenal cancer defines which syndrome?
Li-Fraumeni Syndrome
Digestion of which toxin from reef fish cancause for peri-oral parasthesias to occur?
Ciguatera toxin
During exercise, what is the formula used todetermine the maximum heart rate an
individual should achieve?
(220 - age in years) X 85%
Excessive ingestion of licorice can lead to which electrolyte abnormality?
Hypokalemia
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Finasteride, used to assist patients with benign prostatichyperplasia , acts on which enzyme to inhibit conversionof testosterone to dihydrotestosterone?
5 alpha reductase
Foamy macrophages on PAS stain on a small bowel biopsy is seen in what condition?
Whipple's Disease
Greater than what value is the white bloodcell (WBC) count expected to be in cases of
septic arthritis?
More than 50,000/uL
How do residual lung volumes and DLCOchange with kyphosis compared to normal
lungs?
DLCO remains normal while residual lung volumes are increased compared to normal
How do you differentiate chronic hepatitis Binfection from the carrier state?
Check liver function tests. Increased inchronic state and normal in carrier state
How many days after aminoglycoside usecan acute tubular necrosis arise?
4-5 days
If a diabetic patient requires insulin therapy andhas normal renal function, how many units/kg isthe recommended daily insulin requirement?
0.5 units/kg
If patient with inflammatory bowel disease isfound to have dysplasia on colonoscopy, whatis the next step in management?
Proctocolectomy
If pts with osteoarthritis present withmorning stiffness, what length of time should
it not exceed?
30 minutes
In hemochromatosis, which condition, if developed, is irreversible?
Hypogonadism which can leadto infertility
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In males, a creatinine level of this orhigher is a contraindication to giving
metformin?
1.5 mg/dl or higher
In patient with antibodies to pre-synapticacetylcholine receptors, are reflexes
increased or decreased?
Decreased (condition is Eaton-
Lambert Syndrome)Individuals who have both Addison's Diseaseand Hashimoto thyroiditis are known to have
what syndrome?
Schimdt's Syndrome (autoimmunepolyglandular type II)
Long term use of NSAIDS increases,decreases, or has no effect on the risk of
developing colon cancer?
Decreases
Long-term use of which potent antibioticrequires performing regular eye exams?
Linezolid
Loss of passive flexion of the foot when thecalf is squeezed with achilles tendon tears is
known as what test?
Positive Thompson test
Muddy brown casts in a urinalysis is aclue towards which renal process?
Acute tubular necrosis (ATN)
Name four commonly prescribedmedications that can cause aseptic
meningitis.
TMP-SMX (Trimethoprim-Sulfamethoxazole), IVIG (Immunoglobulin),
NSAIDS, Carbamazepine
Name the four main causes of microcytic anemia.
Thalassemia, Iron deficiency, Anemia of chronic disease, Sideroblastic anemia
(mnemonic TICS)
Name the supplement: Sleep aid also usedfor stress/anxiety relief. If combined with
EtOH, can oversedate.
Kava
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Name the supplement: Used againstdementia. Can increase the risk of bleeding.
Ginkgo Biloba
Name the supplement: Used against thecommon cold. Can cause nausea, rash and
itchiness.
Echinacea
Name the supplement: Used as an anti-depressant. Can potentially inducescytochrome P450 drug metabolism.
St. John's Wort
Name the supplement: Used for benignprostatic hyperplasia. Can cause headaches
and/or abdominal pain/nausea.
Saw Palmetto
Name three conditions that are very oftenassociated with hypogammaglobulinemia
CLL, nephrotic syndrome, bronchiectasis
NSAIDS are known to cause allergic interstitial nephritis without eosinophils. What other class of medication isknown to cause allergic interstitial nephritis withouteosinophils about 33% of the time?
Proton pump inhibitors (PPI)
An obese individual with headaches is found to have ahigh opening pressure during lumbar pressure. Whatis the best medication for this pt's l ikely condition?
Acetazolamide (Carbonicanhydrase inhibitor)
Of the MCP, PIP, and DIP joint, which of thefollowing is least likely to be involved with
rhematoid arthritis?
DIP joint
Of the three major forms of hepatitis, which does not currently have a vaccine
against it?
Hepatitis C
On a DEXA scan, what T score will indicate osteoporosis?
T score of less than -2.5
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On fundoscopic examination, whichcondition is associated with cherry red spots
of the macula?
Retinal artery occlusion
On the morning of surgery, what changeshould be made to long standing insulin in
diabetic patients?
Give half the dose of long
acting insulin
Optic chiasm compression willlead to what eye abnormality?
Bitemporal hemianopsia
Patient develops a pneumonia soon afterrecovering from the flu. What organism is
most often associated in this scenario?
Staphylococcus aureus
Patient is found to have a Pelger-Huetanomaly and hyposegmented neutrophils. What condition does this patient likely have?
Myelodysplastic syndrome
Patient is found to have left homonymousquadrantanopia. Where is the lesion?
Right optic radiation
Patient is found to have positive antibodiesto soluble liver antigen (SLA). Whatcondition does this patient likely have?
Autoimmune hepatitis (which alsohas anti-smooth muscle antibodies)
Patient who uses cocaine and has a weak handshake. What is the likely diagnosis?
Inclusion body myositis
Patient with polymyositis is on high dosesteroids. CPK levels are improving but
weakness worsening. What to do?
Taper down on the steroids
Patient with rheumatoid arthritis on leflunomidedecides she wants to get pregnant. What is the bestnext step in management?
Give cholestyramine for 9-11days
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Peripheral blood showing smudge cells ismost specifically associated with what
condition?
Chronic LymphocyticLeukemia (CLL)
Post renal transplant lymphoma is mostoften associated with which organism?
Epstein Barr Virus (EBV)
Post-gallbladder removal, patient has rightupper abdominal pain and still has elevated
LFTs. Next step in management?
Check manometery studies to ruleout sphincter of oddi function
Proxmimal bicarbonate reabsorption isseen in which renal tubular acidosis type?
Renal tubular acidosis type 2
Strong family history of premature heartdisease + patient has a low HDL. What level
is likely to be elevated?
Lipoprotein a or Lp(a)
Sweet's Syndrome can be associated with what type of malignancy?
Acute myelogenous leukemia
Trastuzumab is used for what positivemarker in patients with breast cancer?
HER2/neu positive
Treatment of MALT requireseradication of what organism?
Heliobacter Pylori (H. pylori)
Two fasting blood sugars greater than what # will diagnose diabetes mellitus?
125 mg/dl
What antibody can be associated inindividuals who have Crohn's Disease?
Anti-Saccharomyces cerevisiaeantibodies (ASCA)
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What are the CD markers for a ReedSternberg cell in Hodgkin's lymphoma?
CD15 and CD30
What are the most common vitaminK dependent clotting factors?
Factors II, VII, IX, and X
What are the MRI T1 (increased/decreased)and T2 (increased/decreased) signal changesseen in patients with multiple sclerosis?
Decreased T1 and IncreasedT2
What are the organisms thatmay lead to struvite stones?
Urea-splitting bacteria (Proteus,Klebsiella, or Pseudomonas)
What are the possible agents for treatinghypertension in pregnant women?
Hydralazine, Labetalol, Alphamethyldopa
What are the reflexes you would expect in anindividual who has antibodies to post
synaptic acetylcholine receptors?
Normal
What are the triad of diseases in multipleendocrine neoplasia (MEN) type I?
Parathyroid, pituitary, and pancreatic--remember them as the 3P's of MEN I
What are the two most common HLA markersassociated with a condition that has positiveantibodies to tissue transglutaminase?
HLA DQ-2 and HLA DQ-8
What are the two most common nerveroot impingements in lower back pain?
L5 and S1
What area of the brain is affected with thediagnosis featuring bradykinesia, cogwheelrigidity, postural instability and resting tremor?
Substantia nigra (likely diagnosis isParkinson's disease)
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What blood test is the initial screeningtest for suspected systemic mastocytosis?
Serum tryptase level
What cardiac condition has a loud holosystolicmurmur w/ palpable thrill along left sternal
border over 3rd or 4th intercostal space?
Ventricular septal defect
(VSD) What class of anti-depressants can be used
for patients who are suffering from urgeincontinence?
TCAs (Tricyclic anti-depressants)
What class of medication is the first-linetreatment of renal crisis in scleroderma?
ACE inhibitors
What condition does a patient likely have if onphysical exam you hear a loud systolic ejectionmurmur at the right 2nd intercostal space?
Aortic stenosis
What condition is known as "spotlessRocky Mountain spotted fever"?
Ehrlichiosis
What condition is often associated withantibodies positive to glutamic acid
decarboxylase?
Type 1 Diabetes Mellitus
What condition is often associated withhypersegmented neutrophils?
Vitamin B12 deficiency
What condition is often associated with pigeon or bat droppings?
Histoplasmosis
What degree of stenosis is an indicationfor carotid endarterectomy in female
patients?
70-99% stenosis
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What degree of stenosis is an indication forcarotid endarterectomy in male patients whoare symptomatic? And asymptomatic?
50-99% in symptomatic. 60-99% in asymptomatic.
What enteropathic organism is most oftenassociated with Guillain-Barre Syndrome
Campylobacter jejuni
What environmental exposure can lead toacute vitamin B12 deficiency?
Nitrous oxide
What group of testicular cancer isnot sensitive to radiation therapy?
Non-seminomas (eg. teratoma, embryonalcarcinoma, choriocarcinoma, yolk sac tumor)
What hematologic condition is oftenassociated with restless leg syndrome?
Iron deficiency anemia
What hematological condition is caused by a membrane defect of spectrin deficiency?
Hereditary spherocytosis
What HLA marker can often beassociated with ankylosing spondylitis?
HLA-B27
What is a very common organism forUTIs in young, pregnant women?
Staphylococcus saprophyticus
What is Charcot's triad? Fever, Right upper quadrantabdominal pain, and Jaundice
What is the anti-depressant category of choice in patients with bulemia?
SSRIs
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What is the antibiotic of choice for mildClostridium difficile colitis? Severe?
PO or IV metronidazole for mild.PO vancomycin for severe.
What is the best management in anindividual who has overdosed on TCAs and
has widened QRS on EKG?
Bicarbonate
What is the best next step in a patient withaspirin allergy who will be undergoing
elective coronary angioplasty?
Aspirin desensitization. Pts undergoingelective angioplasty should be pre-treated
with aspirin and clopidogrel.
What is the best screening blood test for acromegaly?
Insulin growth factor 1 (IGF-1)
What is the best treatment for penicillin-allergic, pregnant female with UTI?
Nitrofurantoin
What is the best way to prevent foot ulcersfrom occuring in diabetic patients?
Perform monofilament testing
What is the earliest lab value to increaseafter repleting iron in patients with iron
deficiency anemia?
Reticulocyte count
What is the enzyme that convertstestosterone to estradiol?
Aromatase
What is the fundoscopic exam finding oftenseen with idiopathic intracranial
hypertension (Pseudotumor cerebri)?
Papilledema
What is the goal hemoglobin level inpatients with end stage renal disease?
11-12 g/dl (higher than this can increaserisk of embolism or strokes)
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What is the goal uric acid level to preventfurther attacks in patients with gout?
Less than 6mg/dl
What is the gold standard for diagnosingsmall intestinal bacterial overgrowth?
Endoscopy with jejunal
aspirate What is the gold standard imaging
modality for diagnosing kidney stones?Noncontrast spiral CT
What is the ideal LDL goal in CADpatients or CAD equvialent patients?
Less than 70 mg/dl
What is the inheritance pattern forHereditary Hemorrhagic Telangiectasia
(HHT)?
Autosomal dominant. HHT is also knownas Osler-Weber-Randau syndrome
What is the initial diagnostic test to check inan individual you suspect of having
polymyositis?
Creatine phosphokinase (CPK)or Creatinine kinase (CK)
What is the initial diagnostic test to check inan individual you suspect to have temporal
arteritis?
Erythrocyte sedimentationrate (ESR)
What is the laboratory screeningtest for chronic alcohol abuse?
Carbohydrate free transferrinlevel elevated
What is the leading cause of death inpatients with systemic lupus erythematosus?
Cardiovascular disease
What is the leading cause of suddencardiac death in young athletes?
Hypertrophic cardiomyopathy
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What is the main anti-depressant to beavoided in patients with seizure disorder?
Buproprion
What is the main pulmonary function testthat helps differentiate obstructive from
restrictive lung disease?
Total lung capacity (TLC)
What is the main vector of LymeDisease in North America?
Ixodes scapularis
What is the MOST commoncause of aseptic meningitis?
Enterovirus (more thanEchovirus)
What is the most common cause of pneumonia in HIV patients?
Streptococcus pneumoniae
What is the most common cause of septicarthritis in inviduals greater than 40 years of
age?
Staph aureus
What is the most common electrolyteabnormality associated with tamoxifen use?
Hypercalcemia
What is the most common extra-articularmanifestation of rheumatoid arthritis?
Rheumatoid nodules
What is the most common presentingsymptom of an individual with acute
altitude sickness?
Headaches
What is the most commonsubytpe of thyroid cancer?
Papillary thyroid cancer(papillary carcinoma)
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What is the most common symptom of Hereditary Hemorrhagic Telangiectasia
(HHT)?
Epistaxis (nose bleeding)
What is the most common type of glomerulonephritis throughout the world?
IgA Nephropathy
What is the most commonly used agent inthe treatment of Familial Mediterranean
Fever?
Colchicine
What is the most important prognosticfactor in a patient with breast cancer?
Lymph node positivity
What is the most likely diagnosis in a patienton hemodialysis with skin ulcerations and anelevated calcium-phosphate product?
Calciphylaxis
What is the most likely diagnosis in diabeticpt with diarrhea, weight loss, flatulence and vitamin A, D, B12 deficiencies?
Small intestinal bacterialovergrowth
What is the most likely organism thatcauses post partum endometritis?
Group B Streptococcus(Streptococcus agalactiae)
What is the most sensitive method of diagnosing avascular necrosis?
MRI
What is the most specific test fordiagnosing rheumatoid arthritis?
Anti-citrullinated protein(anti-CCP) antibody
What is the name of the sign in which RLQpain is elicited with LLQ palpation in apatient suspected of having appendicitis?
Positive Rovsing sign
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What is the number of dermatomes over which apatient with Herpes Zoster virus requires bothcontact and airborne precautions?
Two dermatomes
What is the rash that is commonly associated with celiac disease?
Dermatitis herpetiformis
What is the recommendation for initialcolonoscopy after inflammatory bowel diseasediagnosis and follow up colonoscopies?
8 years after diagnosis andthen every 1-2 years
What is the simplest test to differentiateanemia of chronic disease from iron
deficiency?
Total iron-binding capacity (TIBC)
What is the syndrome that contains thetriad of ptosis, miosis, and anhidrosis?
Horner's Syndrome
What is the treatment of choice for unstablept with wide complex tachycardia?
Immediate synchronizedcardio version
What is the treatment of choiceof dermatitis herpetiformis?
Dapsone
What is the treatment of M3form of AML?
All-Trans Retinoic Acid(ATRA)
What is the triad of symptoms you wouldexpect in a patient with normal pressure
hydrocephalus (NPH)?
Ataxia (wide based gait), dementia,and urinary incontinence
What is the valvular abnormality that canresult from dissection of the ascending
aorta?
Aortic regurgitation
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What is the valvular condition mostcommonly associated with pulsus tardus in
the carotids?
Aortic stenosis
What kidney stones are mostcommonly missed on plain xrays?
Uric acid stones
What mutation is often associated with polycythemia vera?
JAK2 mutation
What organism can cause febrile, hemolyticanemia esp in pts who visited Nantucket or
Long Island area?
Babesia microti
What organism is known as the"great mimicker" of appendicitis?
Yersinia enterocolitica
What organism is known tocause Q fever?
Coxiella burnetti
What reflexes (increased/decreased) would you expect with someone who is diagnosed
with West Nile Virus meningits?
Decreased
What rheumatological condition can often be associated with temporal arteritis?
Polymyalgia rheumatica(PMR)
What thyroid test level tends to beelevated in patients who have sick
euthyroid syndrome?
Reverse T3 (rT3)
What two antibiotics are most commonly used for the treatment of diverticulitis?
Ciprofloxacin andMetronidazole
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What two conditions are associated with bisferiens pulse in the carotids?
Aortic regurgitation andhypertrophic cardiomyopathy
What type of kidney stones areoften implicated in recurrent UTIs?
Struvite (Magnesium
ammonium phosphate) stones What type of reflexes would you expect in
a patient who has uncontrolledhypothyroidism?
Delayed
What vitamin deficiency can occur with use of Isoniazid (INH)?
Vitamin B6 (Pyridoxine)
What vitamin or mineral deficiency isassociated with rash and alopecia in patients
on TPN feeding?
Zinc deficiency
What will be the folate and vitamin B12levels in patients with Caribbean tropical
sprue?
Normal folate, decreased vitamin b12 levels
What would you expect pleural effusionglucose level to be in individuals with
rheumatoid arthritis?
Less than 30 mg/dl
What would you expect the C3 complement levelsto be (increased/decreased/same) in a patient withpost-infectious glomerulonephritis?
Decreased
Which agent used in the treatment of rheumatoid arthritis requires frequent eye
exams?
Hydroxychloroquine
Which antibody is associated with coldagglutinin hemolytic anemia?
IgM
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Which antibody is associated with CREST syndrome?
Anti-centromere
Which antibody is most specifically associated with type I diabetes?
Anti-glutamic acid
decarboxylase Which class of anti-depressants are
associated with widened QRS complex thatcan be treated with bicarbonate?
Tricyclic antidepressants(TCAs)
Which class of anti-diabetic agents should beavoided in patients who have underlying
congestive heart failure (CHF)?
Thiazolidinedione
Which class of antibiotics is most notoriously contraindicated in individuals with
myasthenia gravis?
Aminoglycosides
Which class of medication is used to prevent vasospasm in patients with subarachnoid
hemorrhage?
Calcium channel blockers (eg.nimodipine, nifedipine)
Which congestive heart failure medication isused for symptomatic relief but does not
decrease mortality?
Furosemide (Lasix)
Which disease is associated with decreaseduroporphyringoen decarboxylase activity?
Porphyria cutanea tarda
Which extra-intestinal manifestions canmirror inflammatory bowel disease?
Arthritis and ErythemaNodosum
Which form of lung cancer is most often associated with ectopic production of parathyroid hormone-related peptide (PTHrp)?
Squamous cell carcinoma of the lung
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Which form of nephrotic syndrome ismost associated with heroin use?
Focal segmentalglomerulosclerosis
Which form of nephrotic syndrome isoften associated with lithium use?
Minimal change disease
Which gene test should be checked beforeadministering azaithioprine to preventdangerous bone marrow suppression?
TPMT gene test (thiopurine S-methyltransferase)
Which hepatitis B markerindicates active replication?
HBeAg
Which hepatitis C treatment medicationmay exacerbate autoimmune hepatitis?
Interferon
Which hepatitis infection is the only type that is a DNA virus?
Hepatitis B
Which herpes virus is associated with Kaposi's sarcoma?
Human herpes virus 8
Which HIV medication is known to cause anasymptomatic elevation in MCV?
Zidovudine
Which HIV medication requires you to check HLA B-5701 to prevent hypersensitivity
reaction?
Abacavir
Which knee test can indicate that patient hasa lateral collateral ligament tear?
Positive varus test
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Which marker is oftenassociated with ovarian cancer?
CA 125
Which marker is often associated with pancreatic cancer?
CA 19-9
Which myeloproliferative disorder isassociated with BCR-ABL or t (9,22)
translocation?
Chronic MyelogenousLeukemia (CML)
Which organism can be associated withBurkitt's Lymphoma and nasopharyngeal
carcinoma?
Epstein-Barr Virus (EBV)
Which organism causesTrench Fever?
Bartonella quintana
Which organism commonly causesmeningitis in infants and the elderly,requiring treatment with ampicillin?
Listeria monocytogenes
Which organism is considered acontaminant in the blood if no central venous
catheter is present?
Staphylococcus epidermidis
Which organism is known tocause "desert rheumatism?"
Coccidioidomycosis
Which organism is notoriously known tocause hemolytic uremic syndrome (HUS)?
Escherichia coli O157:H7
Which organism is the most commoncause of diabetic foot ulcers?
Staphylococcus aureus
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Which pain medication should be avoidedin patients who are taking SSRIs for
depression?
Tramadol (concurrent use of SSRI withtramadol can cause serotonin syndrome)
Which renal disorder can present both asnephritic and nephrotic syndrome?
Membranoproliferative
glomerulonephritis (MPGN)
Which statin is the drug of choice in HIV patients?
Pravastatin
Which subtype of nephrotic syndrome ismost commonly associated with hepatitis B
infections?
Membranous nephropathy
Which two CD markers are often deficient inindividuals with paroxsysmal nocturnal
hemoglobinuria? (PNH)
CD55 and CD59
Which two hyperthyroid conditions willcause low radioactive iodine uptake?
Thyroiditis and exogenous use of thyroid medication
Which two murmurs decrease in intensity with leg raising and squatting?
Hypertrophic obstructive cardiomyopathy (HOCM) and Mitral valve prolapse (MVP)
Which two murmurs will decrease inintensity with squatting, sitting or leg
raising?
Hypertrophic obstructive cardiomyopathy and Mitral valve prolapse
Which type of anemia is a commoncomplication of chronic lymphocytic
leukemia?
Warm agglutinin autoimmunehemolytic anemia
Which type of beta blockers are okay togive to patients with hypertension and
asthma?
Cardioselective beta blockers (metoprolol,atenolol, bisoprolol, nebivolol)
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Which type of cancer is least likely tometastasize to the brain and usually
produces blastic bone lesions?
Prostate cancer
Which type of lung cancer can give aparaneoplastic syndrome of gynecomastia?
Large cell carcinoma
Which type of renal tubular acidosis isassociated with defect in proximal
bicarbonate absorption?
Renal tubular acidosis type II
Which vitamin is used toenhance iron absorption?
Vitamin C (Ascorbic acid)
Which vitamin toxicity may lead toidiopathic intracranial hypertension
(Pseudotumor cerebri)?
Vitamin A
With allergic bronchopulmonary aspergillosis (ABPA), what two labs will be
increased?
IgE and peripheral eosinophilsgreater than 10 percent
With osteoarthritis, what would you expectthe ESR and CRP levels to be?
Normal (versus elevated inrheumatoid arthritis)
With systemic lupus erythematosus exacerbation, what would you expect the complement (high/low), anti-dsDNA (pos/neg) and ESR (high/low) levels to be?
Low complement, pos anti-dsDNA, high ESR
With terminal complement deficiency, to which organism are patients most
susceptible?
Neisseria meningitis
Within what age range does USPSTFrecommend one-time screening for AAA in
men with a smoking history?
65 to 75 years