ALE and BrainMapEducational Course on Neuroimaging Meta-Analysis

2016 OHBM Annual Meeting - 26 June 2016

Angie LairdAssociate Professor

Departments of Physics, Psychology, and Neuroscience

Coordinate-Based Results in Neuroimaging StudiesSummary results of functional neuroimaging studies as represented by statistical parametric images

Reported in the literature in the form of stereotactic coordinates

(x,y,z) (x,y,z)(x,y,z)

(x,y,z)

(x,y,z)

(x,y,z)

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

BrainMap Database: Archives Peak Coordinates and Metadata

“Quick Author Search”

2,636 papers 12,643 contrasts100,890 locations

Scribe: submit papers to BrainMap

Sleuth: search papers in BrainMap

GingerALE: perform meta-analyses

“What brain regions are typically activated in a memory task in schizophrenia patients?

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

BrainMap Scribe

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

BrainMap Scribe - Screencast

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

BrainMap Scribe - Behavioral Domain and Paradigm Class

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

BrainMap Sleuth

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

BrainMap Sleuth - Screencast

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BrainMap Sleuth - Exported Foci

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

Literature Search: Face Discrimination Studies

BrainMap Database>2K Publications

>12K Experiments

BrainMap Search Criteria: “Face Monitor/

Discrimination” AND “Normal Mapping”

Example Search Result: 2 Experiments Returned from 1 Publication, 8 and 6 Foci Total

Paller et al., “Neural correlates of person recognition”, Learning & Memory, 2003

BrainMap search yielded 396 experiments of healthy

controls that participated in a face discrimination task

Whole brain sets of coordinates (foci) from all 396 Face Discrimination experiments visualized in

the BrainMap Sleuth application

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

Coordinate-Based Meta-Analysis: Activation Likelihood Estimation

BrainMap Database>2K Publications

>12K Experiments

BrainMap Search Criteria: “Face Discrimination”

Search results = 396 sets of coordinates

Meta-Analysis: Where do the foci converge?Reported coordinates are not treated as points

but as centers of probability distributionsEach foci is modeled by a 3D Gaussian distribution

x

y

Activation Likelihood EstimationALE originally developed by Turkeltaub et al. (2002); has been adopted by BrainMap and revised and expanded several times (Laird et

al., 2005; Eickhoff et al., 2009; 2012; Turkeltaub et al., 2012)

ALE Meta-Analysis: Face DiscriminationCompute ALE scores

Determine statistical significance Threshold final ALE images P<0.05, correctedL R

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

BrainMap GingerALE

Talairach or MNI

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BrainMap GingerALE - Screencast

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Mango - Viewing ALE Results

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

ALE Applications: Paradigm-Based Meta-AnalysesSingle word reading and speech productionObject naming of animals and toolsn-back working memorySaccades and gaze perceptionPain, painful stimulation, and pain empathyTask switchingAnticipatory effect of choiceRisk, reward, and decision-makingFinger tappingGo/No-Go and response inhibitionMovement perception, dance, and emotionText, speech, and metaphor comprehensionAesthetic appraisalEmotional processingMorality, theory of mind, and empathyRegulation of negative affectEpisodic encoding and retrievalSwallowing, eating, and drinkingDefault mode processingExecutive function and cognitive controlStressor-evoked blood pressure reactivityTime perception and timingTaste and craving, food and drug cuesPhonological processing of Chinese characters and alphabetic wordsReflexive reorienting, motor inhibition, and action updatingSublexical speech, speech effectors, phonation and articulation

Numeracy, number processing, and calculationSpatial organization of sound processingEmbodiment in language Pain, hyperalgesia, and allodyniaEmotional processing and recognitionMulti-sensory imageryMotor learningNoun and verb processingAcupuncture needle stimulationCentral processing of autonomic function Semantic processing and semantic memoryAction imitation and observationRectal distension

Stuttering, dyslexia, schizophrenia, OCD, depression, ADHD, Alzheimer’s disease, mild cognitive impairment, autism spectrum disorders, bipolar disorder, aphasia, psychosis, addiction, anorexia nervosa, PTSD, tinnitus, TBI, stroke, chronic pain, borderline personality disorder, Huntington’s disease, social anxiety disorder, obesity

Diseases and Disorders

brainmap.org/pubs

“ALEandBrainMap”~Educa2onalCourseonNeuroimagingMeta-Analysis~2016OHBMAnnualMee2ng

Thank You!

BrainMap is supported by the National Institute of Mental Health (R01 HM074457)