Ajai Khanna, M.D., Ph.D. Curriculum Vitae - 0Ajai Khanna, M.D., Ph.D. Curriculum Vitae - 2 1982-1983...

Ajai Khanna, M.D., Ph.D. Curriculum Vitae - 0

CURRICULUM VITAE

Ajai Khanna MD., Ph.D., FACS., FRCS (Eng. & Glasg.)

University of California San Diego


Curriculum Vitae and Bibliography

AJAI KHANNA M.D., Ph.D.

PART I. GENERAL INFORMATION

Date Prepared: August 6, 2012

ADDRESS: Department of Surgery

200 West Arbor Drive

San Diego, California 92103-8401

[email protected]

CURRENT POSITION: Professor of Surgery

University of California, San Diego

WEBSITE: http://drkhanna.ucsd.edu

CITIZENSHIP: Permanent Resident of US

CONTACT: Phone: 619 543 5870

EDUCATION:

1977 SSLC Honors Senior Cambridge Certification, St Joseph’s High School, Allahabad,

India

1983 MD (First in Class) University of Allahabad Medical School, India

1986 MS General Surgery University of Allahabad Medical School, India

2000 Ph.D. (Immunology) University of Manchester, UK

2006 MBA (Healthcare Finance) Rady School of Management, University of California San Diego

PROFESSIONAL EXPERIENCE AND POSTDOCTORAL TRAINING

mailto:[email protected]

http://drkhanna.ucsd.edu/


1982-1983 Internship, University of Allahabad, India

1983-1987 MS Residency in General Surgery, University of Allahabad, India

1987-1988 Clinical Instructor in Surgical Oncology, Cancer Institute, University

Madras Hospital; Chennai, India

1989-1993 General Surgery Residency, University Hospitals of Aberdeen and

London, UK

1994-1995 Fellow/ Instructor Multi-organ Transplant Surgery, University of

Pittsburgh, School of Medicine, Thomas E. Starzl Transplantation

Institute, Pittsburgh PA

1996-1998 Fellow/Instructor in Intestinal, Multi-visceral, Pediatric Abdominal

Transplantation, Univ. of Pittsburgh, School of Medicine, Thomas

E. Starzl Transplantation Institute and Children’s Hospital of

Pittsburgh, Post-Doctoral Fellow in Transplant Immunology,

University of Pittsburgh School of Medicine, Pittsburgh PA

PROFESSIONAL LICENSES

1998 Medical Board of California (#A71256)

1994 Commonwealth of Pennsylvania (Inactive)

1992/1998 The General Medical Council UK Specialist Register

CERTIFICATION 2010 Certification in Robotic Surgery

2009 European Board of Transplant Surgery

2009 FEBS Fellow European Board of Surgery

2005 FACS Fellow, American College of Surgeons

1998 Certification American Society for Transplant Surgeons

1997 Certification in General Surgery Royal Colleges of

Surgeons of England, United Kingdom

1990 FRCS (Eng.) Fellow, The Royal College of Surgeons of

England

1990 FRCS (Glasg.) Fellow,The Royal College of Physicians and

Surgeons of Glasgow

ACADEMIC APPOINTMENTS

1986-1988 Instructor in Surgery, University of Allahabad and Madras, India

1993-1994 Instructor/ Senior Registrar in General Surgery, St. George’s

Hospital and Medical School, University of London, UK

1994-1998 Instructor in Transplantation Surgery, University of Pittsburgh

School of Medicine,

Thomas E. Starzl Transplantation Institute; Pittsburgh, PA

1998-2002 Assistant Professor of Surgery, School of Medicine; University of

California, San Diego


2002-2008 Associate Professor of Surgery, School of Medicine; University of


2009-present Professor of Surgery, Department of Surgery, University of

California, San Diego School of Medicine

HOSPITAL OR AFFILIATED INSTITUTION APPOINTMENTS

1994-1998 Fellow and Instructor in Transplant Surgery, University of Pittsburgh

Medical Center and Children’s Hospital of Pittsburgh

1998- 2011 Director, Pediatric Abdominal Transplant Programs; University of

California, San Diego and Rady Childrens Hospital, San Diego

Director Kidney and Kidney Pancreas Transplant Programs,

University of California, San Diego

1998- present Active Medical Staff: University of California, San Diego

2001- present Active Medical Staff, Rady Children’s Hospital of San Diego

2006-2009 Interim Director, Abdominal Transplant Programs and Abdominal

Transplant Service Line; University of California, San Diego

SCOPE OF PRACTICE Adult and Pediatric Liver, Kidney, Pancreas and Multivisceral

Transplantation

Live-Donor Liver and Kidney Transplantation

Hepatobiliary Surgery

Minimally Invasive and Robotic Surgery

Laparoscopic and Robotic live donor nephrectomy

Laparoscopic liver resection

MAJOR ADMINISTRATIVE RESPONSIBILITIES AT UCSD

2006 – 2009 Interim Director of Abdominal Transplant Programs and Abdominal

Transplant Service Line, University of California, San Diego

1999-2011 Director Abdominal Transplant Programs, Rady Children’s Hospital

of San Diego

2010- Primary Surgeon Live Donor Liver Transplant Program UCSD

2004- Director Kidney and Kidney-Pancreas Program, University of


1998- 2011 Chair, Liver and Kidney Transplant Selection Committee, UCSD

Medical Center and Rady Children’s Hospital of San Diego

1998- 2011 Chair, Liver and Kidney Transplant QA Committee, UCSD Medical

Center and Rady Children’s Hospital

2000-2004 Credentials Committee UCSD Medical Center

2004- Member, Rebecca and John Moores Cancer Center, University of


2006- 2009 Chair, Liver and Kidney Transplant Selection Committee, UCSD

Medical Center

2006- 2009 Chair, QA Committee, Abdominal Transplant Programs, UCSD

Medical Center


2006- Member, University of California, San Diego, Clinical Investigation

Institute

2009 Search Committee, Chief of Abdominal Transplantation, UCSD

Medical Center

2009 Search Committee, Chief of Transplant Nephrology, UCSD Medical

Center

UCSD SCHOOL OF MEDICINE

2004- Director Transplant 431 Course for 4th

year medical students

2004-2009 Director Transplant Fellowship Course in Abdominal

Transplantation

NATIONAL SERVICE

1998- 2006 Member of Medical Advisory Committee, Lifesharing* of San Diego

2000- present Member Scientific Advisory Board of Lifesharing of San Diego for

Organ Procurement

2000-present UNOS Region 5, Liver Regional Review Board Member and

Representative

2005-present Educational Committee, Studies in Pediatric Liver Transplantation

2007- 2009 Chair, Medical Advisory Committee, Lifesharing of San Diego

*

Organ Procurement Organization for San Diego

COMMUNITY SERVICE RELATED TO PROFESSIONAL WORK

2010- Course in Leadership Development and Advisory Panel on Business

of Healthcare, University of San Diego

http://www.sandiego.edu/business/about/business_of_healthcare/advisory_panel.php

2011 Advisory Board Member Global Bio Therapeutics: In-vivo delivery

of biotherapeutics for inborn errors of metabolism/ Gene

therapeutics, February 15, 2011

2010 Errors in Organ Transplantation: Invited lecture at University of San

Diego School of Business, November 8, 2010

Visiting faculty School of Business University of San Diego

2010 Panelist Springboard Graduation Panel, CortiCare-provides EEG

(cEEG) brain monitoring service to enhance neurological assessment

of ICU patients, August 11, 2010

2011 Visiting Professor: University of San Diego School of Business

1. 4/4/2011 "Complexity and Error in Medicine." Harvard Business School

Note 699-024. Errors in Organ Transplantation: Invited lecture at

University of San Diego School of Business, San Diego.

2. 11/8/2010 Dana Farber Cancer Institute, Errors in Organ

Transplantation: Invited lecture at University of San Diego School of

Business.

http://www.sandiego.edu/business/about/business_of_healthcare/advisory_panel.php


2008- Mentoring minority undergraduate students at UCSD

Wint Lwin BS 2010

Rachel Orlino BS 2008

INTERNATIONAL

2009- Chair, Committtee on Organ Transplantation, American Association of

Physicians of Indian Origin (AAPI)

Chair Development of Deceased Donation in India taskforce of AAPI

OTHER PROFESSIONAL POSITIONS AND VISITING PROFESSOR APPOINTMENTS

January 2011 Department of Transplant Surgery, Medanta Institute of Medical

Sciences New Delhi, AS Soin MD : Director

August 2009 Department of Surgery, Hepatobiliary and Transplantation Surgery,

Hospital Mondor, Cedex, France August 2009: Jacques Belgheti

MD, Professor of Surgery

August 2009 Department of Hepato-Pancreato-Biliary and Liver Transplantation,

Hospital Beaujon, Clichy, France, August 2009: Daniel Cherqui MD,

Professor of Surgery

October 2007, February 2008 Department of Surgery, University of Tripoli, Libya: Live Donor

Liver Transplantation Ehtush Ehtush MD, Chairman of Surgery

January 2006 Mayo Clinic Scottsdale AZ-2006 to present Live Donor Liver

Transplantation David Mulligan MD., Professor of Surgery

December 2004 University of Allahabad; Allahabad, India – Dec. 2004

Atul Mathur MD; Professor of Medicine

December 2004 Sir Ganga Ram Hospital, University of New Delhi; New Delhi, India

Avi Soin MD; Professor of Surgery

February 2004 University of California, San Francisco Nancy Ascher MD., Ph.D;


December 2002 University of Allahabad; Allahabad, India S.P. Mishra MD;

Professor of Medicine

December 2002 G.B. Pant Hospital; New Delhi, India Samiran Nundy MD; Professor

of Surgery

February 2002 Kyoto University, Dept. of Transplantation and Immunology; Kyoto,

Koichi Tanaka MD., Ph.D; Chairman of Surgery

May 2001 Stanford University Medical Center; Palo Alto, CA

Oscar Salvatierra MD; Professor of Surgery

February 2001 University of Southern California Medical Center; Los Angeles, CA

Robert Selby MD; Professor of Surgery

July 2000 University of North Carolina; Chapel Hill, NC. David Gerber MD;



AWARDS AND HONORS

1986 Rotary International Award for Professionalism

1996 Young Investigator Award American Society for Transplant

Surgeons

2000 Outstanding Intellectuals of the 21st Century

2008 Nominated for Kaiser Medical Student Excellence in Teaching

Award

US PATENT REFERENCES

Characterization of liver-derived dendritic cells: Original work on dendritic cells published in Journal

of Immunology cited in 2 U.S. patents:

Khanna A, Morelli AE, Zhong C, Takayama T, Lu L, Thomson AW. J Immunol Feb 1, 2000;

164(3):1346-54. "Effects of liver-derived dendritic cell progenitors on Th1-and Th2-like

cytokine responses in vitro and in vivo".

(1) United States Patent 6,660,523. Blom et al, December 9, 2003. Blom; Bianca (Uithoorn, NL), Liu; Yong-Jun (Palo Alto, CA)

Assignee: Schering Corporation (Kenilworth, NJ)

(2) United States Patent 6,913,924. Blom et al, July 5, 2005

Blom; Bianca (Uithoorn, NL), Liu; Yong-Jun (Palo Alto, CA)

Assignee: Schering Corporation (Kenilworth, NJ)

First report of accelerated allograft rejection caused by the cytokine Flt3:

Antonysamy MA, Steptoe RJ, Khanna A, Rudert WA, Subbotin VM, Thomson AW. Flt-3 ligand

increases microchimerism but can prevent the therapeutic effect of donor bone marrow in

transiently immunosuppressed cardiac allograft recipients. J Immunol. 1998 Apr 15;

160(8):4106-13.

MEMBERSHIP PROFESSIONAL SOCIETIES

Society of University Surgeons

Association for Academic Surgery

American College of Surgeons

American Society of Histocompatibility and Immunogenetics

American Society of Transplant Surgeons

American Association for Study of Liver Diseases

American Association for the Advancement of Science

Society of American Gastrointestinal Endoscopic Surgeons

American Association of Physicians of India

Pacific Coast Surgical Association

Society of Biological Engineering

Royal College of Surgeons of England

Royal College of Physicians and Surgeons of Glasgow

http://www.ncbi.nlm.nih.gov/pubmed/9558122?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum


International Liver Transplant Society

International Pediatric Transplant Association

Indian Medical Association

The Transplantation Society

European Society for Organ Transplantation

Asian Pacific Association for Study of Liver

Association of Surgeons of India

EDITORIAL BOARD AND JOURNAL REVIEWS

Editorial Board Clinical Transplantation 2010-present

Reviewer for

Transplantation, 1996-present

Transplantation Proceedings 2000-present

Journal of Pediatric Transplantation 2000-present

Transplantation International, 2005-present

Journal of Laparoendoscopic & Advanced Surgical Techniques 2005-present

American Journal of Transplantation 2008-present

Clinical Transplantation 2009-present

Hepatology International 2009-present

Journal of American College of Surgeons 2010-present

PART II. RESEARCH, TEACHING AND CLINICAL CONTRIBUTIONS

RESEARCH

Basic Science Research

A. RNA Interference (RNA i) to knock down hub genes in Jurkat and HeLa cells invitro to

develop transplant tolerance

In the Transplant Laboratory at UCSD I evaluated the role of systems biology and RNA interference to

anergize T cells invitro. The project was titled ‘Systems biology approach to transplant tolerance:

proof of concept experiments using RNA interference (RNAi) to knock down hub genes in Jurkat and

HeLa cells in vitro’

DESCRIPTION OF PROJECT

Systems biology is gaining importance in studying complex systems such as the functional

interconnections of human genes. To investigate the molecular interactions involved in T cell immune

responses, we used databases of physical gene-gene interactions to constructed molecular interaction

networks (interconnections) with R language algorithms. This helped to identify highly interconnected

"hub" genes AT(1)P5C1, IL6ST, PRKCZ, MYC, FOS, JUN, and MAPK1. We hypothesized that

suppression of these hub genes in the gene network would result in significant phenotypic effects on T


cells and examined this in vitro. The molecular interaction networks were then analyzed and visualized

with Cytoscape.

Jurkat and HeLa cells were transfected with siRNA for the selected hub genes. Cell proliferation was

measured using ATP luminescence and BrdU labeling, which were measured 36, 72, and 96 h after

activation.

Following T cell stimulation, we found a significant decrease in ATP production (P < 0.05) when the

hub genes ATP5C1 and PRKCZ were knocked down using siRNA transfection, whereas no difference

in ATP production was observed in siRNA transfected HeLa cells. However, HeLa cells showed a

significant (P < 0.05) decrease in cell proliferation when the genes MAPK1, IL6ST, ATP5C1, JUN,

and FOS were knocked down.

In both Jurkat and HeLa cells, targeted gene knockdown using siRNA showed decreased cell

proliferation and ATP production in both Jurkat and HeLa cells. However, Jurkat T cells and HELA

cells use different hub genes to regulate activation responses. This experiment provides proof of

principle of applying siRNA knockdown of T cell hub genes to evaluate their proliferative capacity

and ATP production. This novel concept outlines a systems biology approach to identify hub genes for

targeted therapeutics.

This work was recently published http://www.ncbi.nlm.nih.gov/pubmed/22342379

B. Generation of inducible pluripotent stem cells (iPSC) from skin fibroblasts of deceased

donors with genetic diseases: Hemophilia, Alport’s syndrome and Cystic Fibrosis with the

objective of developing ‘Disease in a dish’

This work is being done in collaboration with the laboratory of Inder Verma Ph.D., Irvin and Joan

Jacobs Professor and Chair in LifeSciences at The Salk Institute, La Jolla.

Cystic Fibrosis

Current animal models of CF poorly simulate clinical lung disease and a lack of primary lung tissues

has limited the rate of research progress. With this in mind we are using patient derived iPSC to

generate a reproducible in vitro model of CF with potential for a matched positive control using

homologous recombination techniques to correct the identified mutation.

The results we have so far demonstrate the potential to differentiate patient specific iPSC through

steps mimicking embryonic development to lung epithelial cells. The precise identity and the purity of

the airway epithelial cells present still remains to be fully determined and functional tests are underway

to study chloride channel regulation in the wild type and CF mutant lines.

It is hoped that pure populations of ciliated, alveolar and mucus secreting cells can be repeatedly and

robustly generated to form a reproducible model for drug screening on human cells.

This work was presented at the 10th

Annual Meeting of International Society for Stem Cell Research

June 13-16, 2012, Pacifico Yokohama, Yokohama, Japan.

http://www.ncbi.nlm.nih.gov/pubmed/22342379


‘Generation of an In Vitro model of cystic fibrosis: Amy L Firth, Susan J Qualls, Oded Singer, Tushar

Menon, Ajai Khanna, Inder M Verma: The Salk Institute, La Jolla, USA and University of California

San Diego’

Alport’s Syndrome

Generation of in vitro model of Alport’s syndrome from skin fibroblast derived iPSC from patient with

Alport's Syndrome.

Currently we have generated pro-virus free iPSC and identified a novel mutation in COL4A5 from an

X-linked Alport’s Syndrome organ donor. We are continuing to resolve the effect of this particular

mutation on collagen IV formation. We will optimize the renal differentiation protocol to use it as a

tool for research. In addition iPSC derived mesenchymal stem cells and renal epithelial cells will be

utilized to study cellular and molecular mechanisms affected in Alport’s disease with the hope of

identifying potential therapeutic targets whilst understanding more about the cellular effects of the

disease.

With the vast amount of causative mutations already known for Alport’s disease having the ability to

generate patient specific models of the disease has the potential for the development of novel and

patient specific therapeutic approaches.

This work was presented at the Presented at 10th

Annual Meeting of International Society for Stem Cell

Research June 13-16, 2012, Pacifico Yokohama, Yokohama, Japan

‘Patient derived iPSC to study Alport's Disease: Amy L Firth, Oded Singer, Susan J Qualls, Ajai

Khanna, Inder M Verma: The Salk Institute, La Jolla, USA and University of California San Diego’

C. Large animal laboratory: Robotic Kidney Transplantation

I am currently working on the use of robots in kidney transplantation and have developed a training

model of robotic kidney transplantation using pig kidneys.


Robotic kidney transplantation is now being performed in select group of obese patients. This avoids

large flank incision in obese patients. In the large animal laboratory based at the Center for Future of

Surgery we are currently performing robotic kidney transplantation in pigs.

Clinical Research

A. Role of Domino Liver Transplantation in Metabolic Liver Diseases

Maple Syrup Urine Disease

UCSD has world renowned faculty in the Division of Biochemical Genetics. We were the first to show

that domino liver transplantation can be successfully performed using liver from patients with Maple

Syrup Urine Disease without the domino recipient developing MSUD. We established that the enzyme



branched chain keto acid dehydrogenase is produced in extrahepatic sites, hence domino liver

transplant can be performed from MSUD patients.

http://www.nejm.org/doi/full/10.1056/NEJM200512013532220


Since our first reports, several centers have performed domino liver transplant in this condition

including children without the anxiety that the domino recipient will develop MSUD.

Methyl Malonic Acidemia

We were the first to show that domino liver transplantation can be successfully performed using liver

from patients with Methyl Malonic Acidemia without the domino recipient developing the disease.

This manuscript has been submitted to Hepatology: review pending

B. Successful Kidney Transplantation in highly sensitized patients with hepatitis B using the

proteasome inhibitor bortezumib for post transplant desensitization

Solid organ transplant patients who have been exposed to hepatitis B or are antigen positive are known

to get hepatitis B recurrence under immunosuppression. This can result in acute liver failure or chronic

hepatitis B. Therapy following transplantation can be further complicated if patients require potent

immunosuppression due to high levels of donor specific antibody (DSA) and are associated with

positive T or B cell cross match.

We are currently exploring the use of IVIg, plasmapheresis, thymoglobulin induction followed by use

of proteasome inhibitor bortezumib for post transplant desensitization. Persistently elevated DSA and

biopsy proven antibody mediated rejection is treated with 4 doses of bortezomib. Allograft function is

monitored and antiviral therapy with entecavir and tenofovir and is started. Patients had excellent

allograft function post therapy upto 8 months following transplantation. This study was presented at

the American transplant Congress Boston, June 2-6, 2012.

http://www.abstracts2view.com/atc/view.php?nu=ATC12L_1299&terms=

C. Single incision and Robotic donor nephrectomy for transplantation

I developed single incision laparoscopic donor nephrectomy program at UCSD.

http://online.liebertpub.com/doi/full/10.1089/vor.2011.0051

Since last year I have been involved in developing robotic donor nephrectomy program at UCSD with

the help of Minimally Invasive Team. We have performed 30 robotic donor nephrectomies with

excellent outcomes.

D. Applying telemedicine for donor management, recovery and allocation

With the help of UCSD Center for telemedicine and seed grant from Lifesharing (Organ Procurement

Organization in San Diego) I am developing a network to help remote monitoring and management of

deceased donors at hospitals served by Lifesharing. This will allow monitoring of donor management

http://www.nejm.org/doi/full/10.1056/NEJM200512013532220


http://www.abstracts2view.com/atc/view.php?nu=ATC12L_1299&terms



by onsite coordinators, recovery of organs and give real time information to the home surgeon

regarding the quality of procured organ, gross and histopathological appearances transmitted over the

web in real time. This will help the recipient surgeon and team to make an informed decision to accept

or turn down an organ, increase organ utilization and improve transplant program quality.

ADMINISTRATIVE/ LEADERSHIP ACHIEVEMENTS AT UCSD

Organization of Transplant Service Line

As Interim Director of Abdominal Transplant Program Service Line, I was responsible for

restructuring of the Liver and Kidney Transplant enterprise at UCSD. UNOS and CMS audits led to

several corrective measures during my tenure as Interim Director with improved SRTR outcomes that

have been consistent through several SRTR cycles.

With resources and commitment from the hospital leadership, I was able to reorganize the Abdominal

Transplant Programs by improving work flow, establishing UNOS and CMS mandated policies and

procedures, recruiting new providers and physicians, developing training and teaching modules for

various programs, as well as streamlining the QA, audit processes and wait list management modules.

Several policies were developed for managing patients on the wait list: follow up of inactive patients,

screening of expanded criteria donors, reducing cold ischemia time, as well as the management of

immunosuppression, post-transplant infections and diabetes. Several innovative techniques to improve

patient workflow process were introduced during this period, which led to improved outcomes. All

policies were aligned with CMS conditions of participation leading to successful CMS audit. I

implemented a state of the art Transplant Database at UCSD leading to computerized management of

new referrals and waitlisted patients.

Transplant QA process: Development of quality tools to evaluate and monitor transplant program

These measures led to improved transplant outcomes, patient and staff satisfaction and morale, and

increased referrals to UCSD Abdominal Transplant Programs. These restructuring measures and

successful outcomes have been presented at multiple meetings across the country, and UCSD QAPI

dashboards have been adopted by several transplant programs.

Please see UCSD QAPI process that we developed, acknowledged in the following document

https://www.cms.gov/Outreach-and-

Education/Outreach/OpenDoorForums/downloads/QAPIResourceGuide090810.pdf

UCSD Abdominal Transplant Programs are now UNOS and CMS compliant. The transplant programs

attained fiscal independence and were profitable during this period following optimization of CMS

cost reporting

MERGER OF UCSD AND RADY CHILDRENS HOSPITAL ABDOMINAL TRANSPLANT

PROGRAMS

As Director of Pediatric Abdominal Transplant Service Line, I helped develop the Pediatric Liver and

Kidney Transplant Programs initially at UCSD, and later at Rady Childrens Hospital of San Diego

https://www.cms.gov/Outreach-and-Education/Outreach/OpenDoorForums/downloads/QAPIResourceGuide090810.pdf

https://www.cms.gov/Outreach-and-Education/Outreach/OpenDoorForums/downloads/QAPIResourceGuide090810.pdf


following M & A of the two systems. As Director of Transplant Programs, I played a key role during

transitioning of Pediatric abdominal programs from UCSD to Rady Childrens Hospital when the two

systems merged. I helped Rady Children Hospital establish a free standing UNOS certified Transplant

Program.

TRANSPLANT FINANCING AND COST REPORTING

During my tenure as interim director of Abdominal Transplant Service Line at UCSD, I was involved

in restructuring transplant cost reporting. We changed ‘one size fits all’ and ‘we’ve always done it this

way’ approach of transplant billing and reporting to a new system of organized, well documented and

itemized billing and cost reporting. A transplant finance team was created to include transplant

administrator, system reimbursement director, patient financial services director, Medicare and

commercial billing manager, patient registration and access manager, transplant financial coordinator,

IT director for patient financial services and the CFO of the hospital. This team was responsible for

creation and implementation of new transplant billing processes.

An effective system geared to work for all points of patient access was created. This allowed the

Medical Group to bill related charges appropriately and allowed transplant finance services to obtain

clear and meaningful information for allocation to the Medicare cost report. Allowable pre-transplant

and donor expenses, commercial collectibles, and organ acquisition charges improved under this new

system. This system also led to proper application of Medicare ratio and improved reimbursement for

all phases of transplant.

The redesigned system of charge capture includes a transplant flag and patient medical record number.

This allows each patient contact event to be transferred to the transplant database using FTP (File

Transfer Protocol) resulting in automatic documentation and billing. These measures resulted in

consistently increased Medicare Pre-transplant and Incremental Medicare reimbursement over the last

2 years with transplant programs in positive margin after indirect costs were applied.

TEACHING

My responsibilities include teaching medical students, residents, fellows in classroom, on the wards, in

the operating room and transplant laboratories. I have developed a curriculum for students and fellows

that outlines an organized approach to transplant immunology, pharmacology, workup of transplant

patients and donor and recipient surgery. It also outlines post transplant management,

immunosuppression monitoring and management of complications.

CURRENT TEACHING ACTIVITIES

Director UCSD Surgery 401 and 431 Transplant course for medical students

Co-Director of Transplant Fellowship training at UCSD

Teaching and training fellows in transplant surgery, general surgery,hepatology, nephrology,

critical care, pediatrics, pediatric critical care, pediatric gastroenterology, and pediatric nephrology

Mentor and supervisor, transplantation research for postdoctoral fellows

Mentor, UCSD graduate and undergraduate students


FUNDING

CURRENT LABORATORY AND COLLABORATIVE RESEARCH

Grants Recently Submitted as Co-PI

1. California Institute of Regenerative Medicine (CIRM) GRANT: Generation of genetically

corrected hepatocytes from autologous induced pluripotent stem cells (iPSC) from Hemophilia

B patients.

2. Department of Health and Human Services: Clinical Interventions in the Management of

Neonatal and Pediatric Donors

3. Roche Organ Transplant Foundation Grant: Donor Specific Antibody monitoring in

immunosuppresed high risk pediatric kidney recipients

Development and Characterization of Hepatocellular Tumor Proteome: Co-Investigator: Jan Schnitzer

MD: Prism Institute, San Diego

Natural Orifice Translumenal Endoscopic Surgery (NOTES) and Laparoscopic Assisted NOTE

Hepatobiliary Procedures: To Assess the Safety and Efficacy of a Novel Approach to Access the Liver.

Co-Investigator: Santiago Horgan MD, Professor and Director Minimally Invasive Surgery Division,


GRANTS

Open, Prospective, Historic-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of

Infusion of Liver Cell Suspension (HHLivC) in Children With Urea Cycle Disorders. Co-Principal

Investigator

Sponsor: Cytonet GmbH & Co. KG; Albert-Ludwig-Grimm-Str. 20; D-69469 Weinheim

Phase 2, Randomized, Open-Label, Parallel Group, Multi-Center Study to Assess the Safety and

Efficacy of Alefacept in de Novo Kidney Transplant Recipients: Co-Principal Investigator

Sponsor: Astellas Pharmaceuticals

A Phase 3, Double-Blind, Double-Dummy, Multi-Center, Prospective, Randomized Study of the

Efficacy and Safety of LCP-Tacro™ Tablets, Once Daily, Compared to Prograf® Capsules, Twice

Daily, in Combination with Mycophenolate Mofetil for the Prevention of Acute Allograft Rejection in

De Novo Adult Kidney Transplant Recipients: Co-Investigator

Sponsor: LifeCycle Pharma A/S, IND No. 75,250, EudraCT 2008-003241-89

Controlled, Randomized, Prospective, Double-Blind, Multicenter, Phase I/II, Dose-Escalation Study of

the Safety, PK, and Clinical Activity of I5NP for Prophylaxis of Delayed Graft Function in Patients

Undergoing Deceased Donor Kidney Transplantation: Co-Investigator


Sponsor: Quark Pharmaceuticals QRK.006

Clinical Study Protocol CRAD001AUS92: A 12 Month, Multi-Center, Randomized, Open-Label

Noninferiority Study Comparing the Safety and Efficacy of Concentration-Controlled Everolimus with

Low Dose Tacrolimus to CellCept® (Mycophenolate Mofetil) with Standard Dose Tacrolimus in de

novo Renal Transplant Recipients: Co-Investigator

Sponsor Novartis

Ex-Vivo Imaging of the Liver to Evaluate Accuracy of MRI as a Diagnostic Tool in Liver Tumors:

Co-Investigator

Sponsor Bayer Pharmaceuticals

FORMER GRANTS

UCSD Academic Senate Grant: Laparoscopic Liver Resection and Liver Regeneration in a

Canine Model. Principal Investigator

Hoffman-LaRoche: Protocol No. ML-17225/01265 – Open-Label, Prospective, Randomized,

Controlled, Multi-Center Study Assessing Fixed Dose vs. Concentration-Controlled Cellcept

Regimes for Patients Following a Single-Organ Renal Transplantation in Combination with Full-

Dose and Reduced-Dose Calcineurin Inhibitors: Co- investigator

NIH: Studies of Pediatric Liver Transplantation (SPLIT): Co-investigator

Novartis: COLO400A2419 – A Six-Month Open-Label, Multi-Center, Randomized Study to

Compare the Incidence of New Onset Diabetes Mellitus and Glucose Metabolism in Patients

Receiving Neoral® with C-2 Monitoring versus Tacrolimus after de novo Kidney Transplantation:

Co-investigator

Astellas: A Phase III, Randomized, Open-Label, Comparative, Multi-Center Study to Assess the

Safety and Efficacy of Prograf (Tacrolimus) MMF, Modified Release (MR) Tacrolimus/MMF and

Neoral® (cyclosporine)/MMF in de novo Kidney Transplant Recipients. Co-investigator

Roche: PA16290/B – A Pilot Study of the Pharmacokinetics, Safety and Efficacy of

Mycophenolate Mofetil (CellCept®) and Sirolimus (Rapamune®) in Renal Transplantation when

used in Conjunction with Daclizumab (Zenepax®) and Corticosteroids. Co-investigator

UCSD: IRB #02-0983 – Pilot Study to Evaluate the Efficacy of Low-Dose Recombinant Factor

VII (rFV11a) in Liver Transplantation: Co-investigator

Faculty Sponsor Award for the Chancellor’s Undergraduate Research Scholarship

REPORT OF CURRENT RESEARCH

Project


Bench Research

A. RNA Interference (RNA i) to knock down hub genes in Jurkat and HeLa cells invitro to

develop transplant tolerance: PI

B. Generation of inducible pluripotent stem cells (iPSC) from skin fibroblasts of deceased donors

with genetic diseases: Hemophilia, Alport’s syndrome and Cystic Fibrosis with the objective of

developing ‘Disease in a dish’ Co-PI

C. Robotic kidney transplantation in large animal model PI

Clinical Research

D. Role of Domino Liver Transplantation in Metabolic Liver Diseases PI

E. Applying telemedicine for donor management, recovery and allocation PI

F. Domino Liver Transplantation in Metabolic Liver Diseases PI

G. Use of Bortezumib in highly sensitized kidney recipients infected with hepatitis PI

REPORT OF TEACHING

Medical School

University of Allahabad School of Medicine, India

1982-1986 Core Clerkship in Surgery

Teaching role: Resident and Fellow

Type of students: Average 80 University of Allahabad 3rd

and 4th

year Medical Students

per year

Preparation and contact time: Average 10-12 hrs per week

University of Madras Hospital, India

1987-1988 Core Clerkship in Surgical Oncology

Teaching Role: Fellow

Type of students: Average of 50 medical students per year

Preparation and contact time: Average of 8-10 hrs per week

University of Aberdeen School of Medicine, Scotland, UK

1989-1991 Core Clerkship in General Surgery

Teaching Role: Resident and Fellow

Type of Students: Average of 20-25 University of Aberdeen Medical

School Students per year

Preparation and Contact time: Average 8-10 hrs per week

University of Manchester, England, UK

1991-1993


Core Clerkship in General Surgery


Type of Students: Average of 20-25 University of Manchester

Medical Students per year


University of London, St. George’s Medical School, London, UK

1993 Core Clerkship in General Surgery


Type of Students: Average of 20-25 St. George’s Medical School

Medical Students per year


University of California San Diego, CA, USA

1998-present Core Clerkship in General Surgery

Teaching Role: Transplant Attending

Type of Students: Average of 20-25 University of California San

Diego Medical Students per year


Graduate Medical Courses

University of Allahabad School of Medicine, India

1982-1986 Surgical teaching to surgical interns and residents on the surgical

service

Chairman Nandlal Tahiliani MD, MS., FRCS

Teaching role: Resident and Fellow

Average 30 University of Allahabad Medical School Surgical

Residents per year


University of Madras Hospital, India

1987-1988 Surgical teaching to Surgical Residents and Fellows on the surgical

service

Chairman S. Krishnamurthy MD.

Teaching role: Fellow

Average 10 University of Madras Medical School Surgical Residents

per year


University of Aberdeen School of Medicine, Scotland, UK


1989-1991 General Surgery

Chairman: Norman Matheson MD., FRCS


Type of Residents: Average of 10-12 University of Aberdeen

Medical School Surgical residents per year


University of Manchester, England, UK

1991-1993

General Surgery

Chairman: Philip Schofield MD., FRCS


Type of Residents: Average of 10-12 University of Manchester

Medical School Surgical residents per year


University of London, St. George’s Medical School, London, UK

1993 General Surgery

Chairman: George Herman-Taylor MD., FRCS


Type of Residents: Average of 8-10 St. Georges Medical School

School Surgical residents per year


University of Pittsburgh School of Medicine, Pittsburgh, PA., USA

1994-1998 Transplant Surgery and Hepatobiliary Surgery

Chairman: Thomas E. Starzl MD., Ph.D.

Teaching Role: Fellow and Instructor American Society of

Transplant Surgeons (ASTS) approved Transplant Fellowship

Type of Fellows Average of 4-6 Transplant Fellows and 10 Surgical

UPMC Surgical Residents per year

Instructor for pre- and post-operative care and operative technique to

transplant fellows



1998-present Residency Program in General Surgery

A.R. Moossa MD., FRCS., FACS Chairman of Surgery

Mark A. Talamini MD., FACS Chairman of Surgery

Transplant Surgery and Hepatobiliary Surgery

Teaching Role: Attending surgeon and Professor

36 UCSD Surgical Residents per year


Instructor for pre- and post-operative care and operative technique in

Hepatobiliary Surgery and Abdominal Transplantation to Surgical

Residents



1998-present Abdominal Transplant Fellowship

Transplant Fellowship Director

A.R. Moossa MD., FRCS., FACS Chairman of Surgery

Mark A. Talamini MD., FACS Chairman of Surgery

Transplant Surgery and Hepatobiliary Surgery

Teaching Role: Attending surgeon and Professor

One Transplant Fellow per year

Instructor for pre- and post-operative care and operative technique in

Hepatobiliary Surgery and Abdominal Transplantation to Transplant

Surgery Fellows


Local Invited teaching presentations

1984-86 University of Allahabad School of Medicine

Instructor and Fellow “Hepatobiliary malignancies” 3rd

and 4th

year medical students on

surgical service. Lectures given every month to 30-40 students each rotation as part of

their core surgical curriculum. Preparation and contact time: Approximately 5 hours

1988-1991 University of Aberdeen, Scotland, UK

Lecturer 1988-1991 “General Surgical procedures in cirrhotic patients” Lecture given to

20 3rd

and 4th

year medical students every month as part of their core surgical

curriculum. Preparation and contact time: Approximately 5 hours

Didactic teaching topics included

Cirrhosis and portal hypertension

Primary Liver tumors

Hepatobiliary malignancies

Cholelithiasis

1991-1993 University of Manchester Medical School Christie’s Hospital, Manchester, UK

Lecturer 1991-1993 “Hepatobiliary malignancies” Lecture given to 20 3rd

and 4th

year

medical students every month as part of their core surgical curriculum. Preparation and

contact time: Approximately 5 hours

1993 St George’s Medical School, London, UK

Lecturer 1993


“General Surgical procedures in cirrhotic patients” and “Cholelithiasis” Lecture given

to 20 3rd

and 4th

year medical students as part of their core surgical curriculum.

Preparation and contact time: Approximately 5 hours

1994-1998 University of Pittsburgh School of Medicine, PA, USA

Lecturer and Instructor

“Organ Transplantation” Transplant Fellows

“Transplant Immunology” Transplant Fellows

1998-present University of California San Diego

Lecturer

Quarterly lectures to General Surgery Residents

Weekly didactic lectures to 3rd

and 4th

year Medical Students and Residents on Transplant rotation.

Following lectures are given to the Students, Residents and Transplant Fellows through the academic

year:

Transplant Immunology

General Surgical Procedures in cirrhotic patients

Donation after cardiac death

Deceased organ donation: history and operative steps

Kidney transplantation

Kidney-pancreas transplantation

Pediatric enbloc kidney transplantation

Benign liver tumors

Hepatobiliary malignancies

Live donor liver transplantation

Pediatric liver transplantation

Pediatric kidney transplantation

Transplant immunosuppression

Muliorgan and Multivisceral Transplantation

Hepatocellular carcinoma

Liver transplantation for metastatic carcinoid tumor

Bile duct and liver injuries following laparoscopic cholecystecytomy

Some of the lectures given locally are listed below.

1. “Pediatric Liver and Kidney Post-Transplant Immunosuppression Protocols.” UCSD—

Clinical Series; San Diego, CA, Sept. 9, 2004

2. “Multi-Organ and Multivisceral Transplantation.” Grand Rounds, UCSD Medical Center;

San Diego, CA, Feb. 15, 2003

3. “Liver Transplantation.” Basic Transplant Workshop, UCSD Medical Center, Sept. 25, 2002

4. “Donor Follow-Up Care.” Living Kidney Donation Workshop, UCSD Center for

Transplantation; San Diego, CA, April 20, 2002

5. “Liver Transplantation.” Basic Transplant Workshop, UCSD Medical Center, March 21, 2002

6. “Pediatric Liver Transplantation in San Diego.” Pediatric Grand Rounds, Scripps Mercy

Hospital; San Diego, CA, Feb. 21, 2002


7. “Pediatric Liver Transplantation in San Diego.” Pediatric Grand Rounds, Children’s Hospital

and Health Center; San Diego, CA, Oct. 5, 2001

8. “Liver Transplantation.” Nursing Resident and Education Department, UCSD, Medical

Center, Sept. 17, 2001

9. Presentation on ‘Organ Transplantation’ to Howard Hughes Program. Biology and Chemistry

undergraduates, UCSD, Aug. 1, 2001

10. Liver Transplantation.” Transplant Workshop, UCSD Medical Center, Oct. 27, 2000

11. “Donor Management and Organ Donation.” UCSD Grand Rounds

12. “Pediatric en bloc Kidney Transplantation.” Transplant Patients’ Support Group, UCSD

Medical Center, April 18, 2000

13. “Fulminant Liver Failure in Children.” Grand Rounds, Children’s Hospital and Health

Center; San Diego, CA; Sept. 17, 1999

14. Pediatric/Liver Transplant Program at UCSD; San Diego, CA; July 27, 1999

15. “Split Liver Transplantation.” UCSD Liver Center Grand Rounds, UCSD Med. Ctr., Mar 23,

1999

16. “Pediatric Liver Transplantation: Splitting Livers to Expand the Donor Pool.” Grand

Rounds, UCSD Medical Center; Feb. 27, 1999

17. “Split Livers—Can We Increase Our Available Donor Livers?” Liver Support Group, UCSD

Medical Center; Feb. 9, 1999

18. “Kidney and Pancreas Transplantation.” Kidney and Kidney/Pancreas Transplant Support

Group, UCSD Medical Center; Jan. 19, 1999

CME COURSES

1. Hepatitis C-HIV coinfection and HCC: NIH symposium Institute of Liver Disease and Biliary

Science New Delhi, March 6-7, 2010

2. “Pediatric liver disease and transplantation”, American Liver Foundation San Diego Chapter

Update in liver diseases September 2009

3. “Immune Mediated Coagulopathy”: Mayo Clinic Jacksonville, May 2009

4. “Liver Transplantation: Patient Selection and Evaluation”, “Hospitalization to Discharge Care

Issues”, University of California San Diego Medical Center, The 10th Optum Annual:

Management of Transplantation and Other Complex Medical Conditions. San Diego,

California, March 3, 2009

5. Preemptive Kidney Transplantation: The Right Thing to Do? A Summary of the National

Kidney Foundation Consensus Conference: University of California San Diego Medical

Center, The 10th Optum Annual: Management of Transplantation and Other Complex Medical

Conditions San Diego, California, March 3, 2009

6. “Update on Pediatric Kidney and Liver Transplantation”, Moderator, Dana Point, CA , April

26, 2008

7. “Liver Transplantation”, Menifee Valley Medical Center, 19th

Annual Update in Medicine.

October 6, 2007

8. “Portal Hypertension: To shunt or not to in the era of liver transplantation”. Lecture at Post

Graduate Assembly in Surgery February 2007, University of California San Diego

9. “Benign Liver Tumors”. Lecture at Post Graduate Assembly in Surgery February 2007,



10. “Domino Liver Transplantation in Maple Syrup Urine Disease.” Symposium on MSUD,

Children’s Hospital of Pittsburgh, May 19, 2006

11. Live Donor Liver Transplantation: An Update.” Organ Donation and Transplantation,

June 27, 2005

12. “Liver Transplantation: An Update.” University of California, Irvine, May 10, 2005

13. “Organ Donation and Retrieval—Cadaver and Living Related.” San Diego Postgraduate

Assembly in Surgery, UCSD Medical Center; San Diego, CA, March 14, 2005

14. “Live Donor Kidney Transplantation.” University of California, Irvine, March 12, 2005

15. “Liver Trauma.” Gastro Club of Allahabad, University of Allahabad (India), Dec. 19, 2004

16. “Living-Related Liver Transplantation.” Sir Ganga Ram Hospital, University of Delhi; Delhi,

India, Dec. 14, 2004

17. Postoperative complications after liver transplantation, Asian Pacific Association for the Study

of the Liver, Dec. 12, 2004

18. “Management of Liver Trauma.” Asian Pacific Association for the Study of the Liver; Delhi,

India, Dec. 10-12, 2004

19. “Domino Liver Transplantation.” Asian Pacific Association for the Study of the Liver; Delhi,

India, Dec. 10-12, 2004

20. “Advances in Radiological Techniques for Evaluation of Liver Anatomy.” Asian Pacific

Association for the Study of the Liver; Delhi, India, Dec. 10-12, 2004

21. “Multi-Organ and Multivisceral Transplantation.” Grand Rounds, Kern Medical Center;

Bakersfield, CA, Dec. 4, 2004

22. “Benign Tumors of the Liver.” San Diego Postgraduate Assembly in Surgery; San Diego,

CA, Feb. 16-20, 2004

23. “Adult-to-Adult Liver Transplantation.” Grand Rounds, Kern Medical Center; Bakersfield,

CA, April 16, 2003

24. “Pediatric Liver Transplantation.” Pediatric Grand Rounds, Sunrise Hospital; Las Vegas, NV,

March 27, 2003

25. “Artificial Livers, Factor VII and Transplantation.” North American Transplant Coordinators

Organization; San Diego, CA, March 15, 2003

26. “Adult Live Donor-Pediatric Recipient.” San Diego Ultrasound Society; San Diego, CA,

Feb. 25, 2003

27. “Pediatric Liver Transplantation.” University of Allahabad Alumni Meeting; Allahabad,

India, Dec. 2002

28. “Immunobiology of Transplantation.” Dept. of Gastroenterology, G.B. Pant Hospital;

New Delhi, India, Dec. 2002

29. “Immunosuppression Post-Liver Transplantation in Patients with Recurrent HCV.”

Hepatitis C, Epidemiology, Diagnosis and Treatment Symposium; Las Vegas NV June 17,

2000

30. “Type I Diabetes. What’s New in Management?” San Diego Postgraduate Assembly in

Surgery; San Diego, CA, Feb. 21-25, 2000

31. Moderator. Fifth Annual Symposium on Management of Common Gastrointestinal and Liver

Diseases; San Diego, CA; Nov. 13, 1999

32. “Liver Transplantation.” Pediatric Department Morning Conference, Naval Medical Center;

San Diego, CA; June 25, 1999

33. “Split Liver Transplantation.” Grand Rounds, Kern Medical Center; Bakersfield, CA; Mar 31,

1999


34. “Split Livers.” American Liver Foundation; March 16, 1999

35. Natural Orifice Translumenal Endoscopic Surgery (NOTES): 4th UCSD Hands-On NOTES

and Single Site Surgery Symposium November 11-13, 2010

36. Natural Orifice Translumenal Endoscopic Surgery (NOTES): 3rd UCSD Hands-On NOTES

and Single Site Surgery Symposium November 19-21, 2009

Advisory and supervisory responsibilities in clinical and laboratory setting

1998-2011

Director Kidney and Kidney Pancreas Transplant Programs


Director Liver and Kidney Transplant Programs

Rady Childrens Hospital


Director Transplant Fellowship

Department of Surgery

Section of Transplantation


San Diego CA

Advise and supervise 24-30 interns/residents on transplant rotation each year along with

the Transplant Fellow

Preparation and contact time 8 hours per week

2009-2010 PI Transplant Immunology Laboratory


Advised and supervised graduate student Wint Lwin and Transplant Fellows on Basic

Science project

Teaching and Leadership role in Department of Surgery and UCSD School of Medicine

2000-2009 Co-Director ASTS Approved Transplant Surgery Fellowship

Responsible for recruitment, training, and certification of transplant surgery fellows

Names of Advisees or Trainees

TRANSPLANT SURGERY FELLOWS MENTORED AND CURRENT POSITION


1998-1999: James Cashman, M.D.; Director, Abdominal Transplant Program, Good

Samaritan Hospital; Phoenix, AZ

1999-2000: Mark Garfinkel, M.D.; Director, Kidney and Kidney Pancreas Transplant

Program, University of Southern Illinois, Springfield, IL


2000-2001: Bobby Nibhanupudhy, M.D.; Director, Kidney Transplant Program;

Jacksonville, FL

2001-2002: Andrew F. Precht, M.D.; Director, Liver Transplant Program; Swedish Hospital;

Seattle, WA

2002-2003: Jeffrey Brink, M.D.; Multi-Organ Transplant Surgeon, Good Samaritan

Hospital; Phoenix, AZ

2003-2004: Alger Aquino, M.D., Multiorgan Transplant Surgeon, Tijuana Hospitals, Mexico

2004-2005: Samuel Obiekwe, M.D., Multiorgan Transplant Surgeon Hospital Bordeaux,

France

2006-2007: Srinivas Chava M.D., Transplant Surgeon Kings College Hospital, London, UK

2011- Phyllis Napoles MD, Transplant Fellow, Department of Surgery, University of

California, San Diego, CA

TRANSPLANT SURGERY FACULTY MENTORED AND CURRENT POSITION

2004- Karen Kling MD: Pediatric Transplant Surgeon UCSD and Rady Childrens

Hospital, San Diego, CA

2006-2008: Christopher T Barry MD., Ph.D. Multiorgan Transplant Surgeon, University of

Rochester, NY

2009- 2012 Angeles Baquirezo MD, Multiorgan Transplant Surgeon, University of

California San Diego, CA: Private Practice

OTHER FACULTY RECENTLY MENTORED

Transplant Hepatology University of California San Diego

Alex Kuo MD (2009), Rohit Loomba MD (2010), Heather Patton MD (2011)

Transplant Nephrology University of California San Diego

Shagun Chopra MD (2008), Jerry Meng MD (2009), Rodolfo Batarse MD (2010)

Pediatric Transplant Hepatology University of California San Diego

Mamta Sivagnam MD (2008), Xenia Hom MD (2008), Jeannie Huang MD (2009), Lilian Choi MD

(2009), Sherry Huang MD (2010)

Pediatric Transplant Nephrology University of California San Diego

Liz Ingulli MD (2007), Kritida Mistry MD (2009)

POSTDOC RESEARCH STUDENTS AND FACULTY

2010- present Amy L. Firth Ph.D.: Laboratory of Genetics, Salk Institute of Biological Studies: La

Jolla, CA, USA

1. Generation of an In Vitro model of cystic fibrosis from patient derived iPSC: Disease in a dish


2. Patient derived iPSC to study Alport's Disease

2010-present Suvashini Ramasamy Ph.D: Laboratory of Genetics, Salk Institute of Biological Studies:

La Jolla, CA, USA

Isolation and expansion of Stem cells from Hemophiliacs

SURGICAL RESIDENTS RECENTLY MENTORED WITH CURRENT POSITIONS

2011 Jennifer Berumen MD Multiorgan Transplant Fellow Stanford Hospital and

Clinics, Stanford University, Stanford CA, Worked on

Donation after Cardiac Death protocols and gave UCSD

Department of Surgery Grand Rounds

2009 Jonathan Greenberg MD Vascular Surgery Private Practice

2005 Matthew Katz MD Attending Surgeon Surgical Oncology University of

Texas MD Anderson Cancer Center

2004 Waddah Al Rafaie MD Attending Surgeon University of Minnesota, Minneapolis

2001 Bobby Nibhanapuddy MD Attending Transplant Surgeon Florida Hospital, Orlando

FL

2000 Mark Garfinkel MD Director, Kidney and Kidney-Pancreas Transplant

Program, University of Southern Illinois, Springfield, IL

RECENT UNDERGRADUATE UCSD STUDENTS MENTORED

2011-present Kelly Blakely BS Student at UCSD

Desensitization Protocols in Kidney Transplantation

2008-2010: Wint Lwin BS Bioengineering student at UCSD

T cell responses to hub gene knockout in in-vitro propagated Jurkat Cells: Application to Systems

Biology

2007-2008: Oanh Nguyen BS student at UCSD

Metabolic liver diseases

Regional, National or International Contributions

2005- present Member and UCSD representative to United Network for Organ Sharing (UNOS)

Region 5 Regional Review Board

2010-present Chair Organ Transplant Committee on development of Organ Sharing Network in India

11/9/2011 Fourth Meeting of the WHO Global Initiative for Emergency and Essential Surgical Care

(GIEESC) organised in co-sponsorship with The University of California, San Diego, California, USA, 9 November 2011 ‘Deceased Donor Organ Transplantation in India’

Invited Speaking Commitments at Future International Meetings


10/25/12 Invited speaker at Indian Society for Organ Transplantation Mumbai, India

‘Regulatory aspects of Live Donor Liver Transplantation’

11/28/12 Invited speaker Indian Society of Gastroenterology, 53rd

Annual Meeting Jaipur, India

‘Liver Transplantation for Metabolic Liver Diseases’

12/5/12 Invited speaker at the 22nd

World Congress of The International Association of

Surgeons, Gastroenterologists and Oncologists, Bangkok, Thailand

‘Recent Advances in Liver Transplantation’

‘Iatrogenic Bile Duct Injuries’

REPORT OF CLINICAL ACTIVITIES

Description of Clinical Activities

My clinical practice includes deceased and live donor liver and kidney transplants, multiorgan

transplant, nontransplant hepatobiliary surgery including surgical shunts, pancreas transplants,

deceased donor and non heart beating donor recoveries.

Patient Load and complexitity of cases

The patient population consists of local and distant referrals with complex benign and malignant

hepatobiliary problems, patients with endstage liver and kidney disease as well as deceased and

healthy adult donors. I perform laparoscopic liver resections and am involved in establishing the

robotic donor nephrectomy program at UCSD. I am actively learning this procedure having performed

laparoscopic donor nephrectomy for over 8 years. I perform over 200 complex surgical procedures

annually with excellent outcomes.

Significant Clinical Contributions at UCSD and beyond

CLINICAL/ ACADEMIC ACHIEVEMENTS AT UNIVERSITY OF CALIFORNIA, SAN

DIEGO AND RADY CHILDRENS HOSPITAL SAN DIEGO

Development of Laparoscopic, Single incision and Robotic Donor Nephrectomy Programs

Development of Adult and Pediatric Living-Related Liver Transplantation Programs

Development of Hepatobiliary Service

Development of Pediatric Liver and Kidney Programs

Introduction of novel techniques in liver and pancreas transplantation at UCSD

First to do solitary pancreas transplant at UCSD

Development of UCSD Transplant Laboratory

Development of curriculum and fellowship training programs in multi-organ transplant surgery at

UCSD Medical Center

First to perform live donor liver transplantation in San Diego


First world report of domino liver transplantation from a patient with maple syrup urine disease

First to perform multi-organ transplantation (en bloc liver , kidney and pancreas) in San Diego

Development of adult and pediatric non-heart beating donation programs

First to perform paired exchange kidney donor transplant at UCSD and Rady Childrens Hospital,

San Diego

First ever report of Domino Liver Transplantation for Methyl Malonic Acidemia

First in San Diego to do dual kidney transplant from borderline adult donor kidneys

PART III: BIBLIOGRAPHY

Thesis

Ph.D. University of Manchester United Kingdom 2000

Project Title: Microchimerism, allograft tolerance and the role of cytokine Flt-3

Outline of work done for Ph.D. in Immunology

A. Impact of Flt-3 ligand on donor-derived antigen presenting cells and alloimmune

reactivity in heart graft recipients given adjuvant donor bone marrow

Khanna A, Antonysamy MA, Subbotin VM, Steptoe RJ, Li W, Rudert WA, Thomson AW.:

Transpl Immunol. 1998 Dec;6(4):225-34

The influence of the haematopoietic growth factor Flt-3 ligand (FL) on the incidence and function of

donor major histocompatibility complex (MHC) class II+ cells in the lymphoid tissues of

noncytoablated recipients of heart allografts and donor bone marrow (BM) cells was investigated. C3H

(H2k) mice received a nonvascularized B10 (H2b) heart allograft in the dorsal ear pinna, followed by

an i.v. infusion of 50 x 10(6) donor BM cells. They were given FL (10 microg/day i.p., x7 days),

tacrolimus (2mg/kg/day i.p., x13 days) or both agents immediately following heart transplantation

(HTx) and were killed 10 or 21 days later. Their BM cells were propagated in vitro in granulocyte

macrophage colony stimulating factor (GM-CSF) and IL-4 for 5 days to promote the growth of

dendritic cells (DC). Donor DC were identified by immunocytochemical staining. Spleens were

harvested, and donor (IAb+) cells enumerated by immunohistochemical analysis. Donor MHC class II

DNA was detected in spleens and cultured BM-derived cells by reverse transcriptase-polymerase chain

reaction (RT-PCR). A striking increase in donor MHC class II+ cells was noted in both the spleen and

BM of the BM + tacrolimus-treated group compared to either the BM alone, or BM + FL-treated

groups. Addition of FL treatment to BM + tacrolimus led to a further increase in donor cells in spleen

(three-fold at 10 days, and two-fold at 21 days). The increase in donor cells at 10 days was almost 140-

fold compared to that with donor BM alone. PCR analysis at this time revealed enhanced donor DNA

http://www.ncbi.nlm.nih.gov/pubmed?term=Khanna%20A%5BAuthor%5D&cauthor=true&cauthor_uid=10342736

http://www.ncbi.nlm.nih.gov/pubmed?term=Antonysamy%20MA%5BAuthor%5D&cauthor=true&cauthor_uid=10342736

http://www.ncbi.nlm.nih.gov/pubmed?term=Subbotin%20VM%5BAuthor%5D&cauthor=true&cauthor_uid=10342736

http://www.ncbi.nlm.nih.gov/pubmed?term=Steptoe%20RJ%5BAuthor%5D&cauthor=true&cauthor_uid=10342736

http://www.ncbi.nlm.nih.gov/pubmed?term=Li%20W%5BAuthor%5D&cauthor=true&cauthor_uid=10342736

http://www.ncbi.nlm.nih.gov/pubmed?term=Rudert%20WA%5BAuthor%5D&cauthor=true&cauthor_uid=10342736

http://www.ncbi.nlm.nih.gov/pubmed?term=Thomson%20AW%5BAuthor%5D&cauthor=true&cauthor_uid=10342736



in the BM + FL + tacrolimus group compared to that in the BM + tacrolimus group. FL treatment

augmented mixed leucocyte reactions (MLR) and cytotoxic T lymphocyte (CTL) activity of host

spleen cells against donor alloantigens. These effects were reversed by tacrolimus administration.

Histopathology of heart grafts from tacrolimus-treated animals at 10 and 21 days showed absence or

substantial reduction in cellular infiltration, and the preservation of viable myocardium. By contrast, in

untreated mice, or animals given BM or BM + FL alone, there was marked cellular infiltration, and

features of accelerated rejection. Donor-derived DC could be propagated in vitro from the BM of heart

transplant recipients given donor BM, especially from mice that also received tacrolimus +/- FL. At

day 21, donor-derived cells could only be propagated from the BM + FL + tacrolimus-treated group.

These findings show that numbers of donor antigen presenting cells (APC) or their progenitors can be

markedly increased in conventionally immunosuppressed organ allograft recipients given donor BM +

a potent haematopoietic and DC-growth promoting cytokine. Although withdrawal of systemic

immunosuppression appears to allow exhibition of the potential allostimulatory activity of these donor

APC leading to rejection, the model provides a useful basis for further evaluation of the persistence

and manipulation of donor haematopoietic cells and in particular, donor-derived APC, on the outcome

of organ transplantation.

B. Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses

in vitro and in vivo.

Khanna A, Morelli AE, Zhong C, Takayama T, Lu L, Thomson AW J Immunol. 2000 Feb

1;164(3):1346-54

There is evidence that donor-derived dendritic cells (DC), particularly those at a precursor/immature

stage, may play a role in the immune privilege of liver allografts. Underlying mechanisms are poorly

understood. We have examined the influence of in vitro generated mouse liver-derived DC progenitors

(DCp) on proliferative, cytotoxic, and Th1/Th2 cytokine responses induced in allogeneic T cells. Liver

DCp, propagated in GM-CSF from C57B10 mice (H2b), induced only minimal proliferation, and weak

cytotoxic responses in allogeneic (C3H; H2k) T cells compared with mature bone marrow (BM)-

derived DC. Flow-cytometric analysis of intracellular cytokine staining revealed that mature BM DC,

but not liver DCp, elicited CD4+ T cell production of IFN-gamma. Intracellular expression of IL-10

was very low in both BM DC- and liver DCp-stimulated CD4+ T cells. Only stimulation by liver DCp

was associated with IL-10 secretion in primary MLR. Notably, these liver DCp cocultured with

allogeneic T cells stained strongly for IL-10. Following local (s.c. ) injection in allogeneic recipients,

both BM DC and liver DCp homed to T cell areas of draining lymph nodes and spleen, where they

were readily detected by immunohistochemistry up to 2 wk postinjection. Liver DCp induced clusters

of IL-10- and IL-4-secreting mononuclear cells, whereas Th2 cytokine-secreting cells were not

detected in mice injected with mature BM DC. By contrast, comparatively high numbers of IFN-

gamma+ cells were induced by BM DC. Modulation of Th2 cytokine production by donor-derived

DCp may contribute to the comparative immune privilege of hepatic allografts.

Basic Research: Original Articles

1. Lwin WW, Park K, Wauson M, Gao Q, Finn PW, Perkins D, Khanna A. Systems

Biology Approach to Transplant Tolerance: Proof of Concept Experiments Using RNA

Interference (RNAi) to Knock Down Hub Genes in Jurkat and HeLa Cells In Vitro.

http://www.ncbi.nlm.nih.gov/pubmed?term=Khanna%20A%5BAuthor%5D&cauthor=true&cauthor_uid=10640749

http://www.ncbi.nlm.nih.gov/pubmed?term=Morelli%20AE%5BAuthor%5D&cauthor=true&cauthor_uid=10640749

http://www.ncbi.nlm.nih.gov/pubmed?term=Zhong%20C%5BAuthor%5D&cauthor=true&cauthor_uid=10640749

http://www.ncbi.nlm.nih.gov/pubmed?term=Takayama%20T%5BAuthor%5D&cauthor=true&cauthor_uid=10640749

http://www.ncbi.nlm.nih.gov/pubmed?term=Lu%20L%5BAuthor%5D&cauthor=true&cauthor_uid=10640749

http://www.ncbi.nlm.nih.gov/pubmed?term=Thomson%20AW%5BAuthor%5D&cauthor=true&cauthor_uid=10640749



J Surg Res. 2012 Jul;176(1):e41-6

http://www.sciencedirect.com/science/article/pii/S0022480411020087

2. Khanna A, Horgan S. A laboratory training and evaluation technique for robot assisted ex vivo

kidney transplantation. Int. J Med Robot. 2011 Mar; 7(1):118-22.

http://onlinelibrary.wiley.com/doi/10.1002/rcs.379/abstract

3. Barshop B.A., Nyhan W.L., Gwynne J., Paynard-Davis J., Khanna A. Liver transplantation in

maple syrup urine disease, including domino transplantation. Mol Genet Metab 2005; 3:213-

214.

4. Hong I.C., Mullen P.M., Precht A.F., Khanna A., Li M., Behling, C., Lopez V., Chiou H., Moss

R., Hart M. Non-viral human IL-10 gene expression reduces acute rejection in heterotopic

auxiliary liver transplantation in rats. Microsurgery 2003; 23:432-436.

http://www.ncbi.nlm.nih.gov/pubmed?term=hong%20IC%2C%20KHANNA%20A

5. Morelli A.E., O’Connell P.J., Khanna A., Logar A.J., Lu L., Thomson A.W. Preferential

induction of TH1 responses by functionally mature hepatic (CD8α –

and CD8α+)

dendritic cells.

Transplantation 2000; 69(12):2647-57. http://www.ncbi.nlm.nih.gov/pubmed/10910289

6. Khanna A., Morelli A.E., Zhong C., Takayama T., Lu L., Thomson A.W. Effects of liver-

derived dendritic cell progenitors on Th1- and Th2-like cytokine response in vitro and in vivo. J

Immunol 2000; 164(3):1346-54. http://www.jimmunol.org/content/164/3/1346.full.pdf+html

7. Chapman W.C., Clavien P.A., Fung J., Khanna A., Bonham A. Effective control of hepatic

bleeding with a novel collagen-based composite combined with autologous plasma. Arch Surg

2000; 135:1200-04. http://archsurg.jamanetwork.com/article.aspx?articleid=390729

8. Patzer J., Mazariegos G., Lopez R., Molmenti E., Gerber D., Riddervold F., Khanna A., Yao Yin

W., Chen Y., Scott V., Aggarwal S., Kramer D., Wagner R., Zhu Y., Fulmer M., Block G.,

Amiot B. Novel bio-artificial liver support system: preclinical evaluation. Ann NY Acad Sci

1999; 875:340-352. http://www.ncbi.nlm.nih.gov/pubmed/10415580

9. Patzer J.F. II, Block G.D., Khanna A., Yin W.Y., Molmenti E., Gerber D., Kramer D.J., Scott

V.L., Aggarwal S., Wagner R.A., Fulmer M.L., Amiot B.P., Mazariegos G.V. D-galactosamine

based canine acute liver failure model. Hepatobiliary Pancreat Dis Int 2002; 1(3):354-367.


10. Khanna A., Anatonysamy M.A., Subbotin V.M., Steptoe R.J., Li W., Rudert W.A., Thomson

A.W.. Impact of Flt-3 ligand on donor-derived antigen presenting cells and alloimmune

reactivity in heart graft recipients given adjuvant donor bone marrow. Transpl Immunol 1998;

6:225-234. http://www.ncbi.nlm.nih.gov/pubmed/10342736

11. Khanna A., Steptoe R.J., Li W., Morris R.E., Thomson A.W. Donor bone marrow potentates the

effect of Tacrolimus on non-vascularized heart allograft survival. Transplantation 1998; 65:479-

485. http://www.ncbi.nlm.nih.gov/pubmed/9500620

http://www.sciencedirect.com/science/article/pii/S0022480411020087

http://onlinelibrary.wiley.com/doi/10.1002/rcs.379/abstract

http://www.ncbi.nlm.nih.gov/pubmed?term=hong%20IC%2C%20KHANNA%20A


http://www.jimmunol.org/content/164/3/1346.full.pdf+html

http://archsurg.jamanetwork.com/article.aspx?articleid=390729






12. Antonysamy M.A., Steptoe R.J., Khanna A., Subbotin V.A., Rudert W.A., Thomson A.W.. Flt-

3 promotes microchimerism but can augment anti-donor immunity. J. Immunol 1998; 160:4106-


13. Iyengar A.R., Bonham C.A., Antonysamy M.A., Subbotin V.A., Khanna A., Murase N., Rao

A.S., Starzl T.E., Thomson A.W. Striking augmentation of hematopoietic cell chimerism in non-

cytoablated allogeneic bone marrow recipients by Flt3 ligand and Tacrolimus. Transplantation-

Rapid Communication 1997; 63(9).

http://journals.lww.com/transplantjournal/pages/articleviewer.aspx?year=1997&issue=05150&art

icle=00001&type=abstract

Clinical:

14. Domino Liver Transplantation for methylmalonic academia: First ever report: Submitted

Hepatology July 2012: A Khanna, A Hemming, K Mekeel, SC Winter, A Kuo, WL Nyhan, R

Gish, BA Barshop.

15. Are Natural Orifice Transluminal Endoscopic Surgery (NOTES) and Single Incision Surgery

(SIS) viable techniques for cholecystectomy? Khanna A.; Invited Commentary to Journal of

Laparoendoscopic & Advanced Surgical Techniques 2011.

http://online.liebertpub.com/doi/pdfplus/10.1089/lap.2012.9999

16. Minimally invasive supra-pubic laparoscopic donor nephrectomy. Journal of Laparoendoscopic

& Advanced Surgical Techniques & Part B: Videoscopy. Khanna A., Hagen M., Horgan S.

2011


17. Hemming A.W., Mekeel K., Khanna A., Baquerizo A., Kim R.D. Portal vein resection in

management of hilar cholangiocarcinoma. J Am Coll Surg. 2011 Apr;212(4):604-13


18. Outcomes of 5-year survivors of pediatric liver transplantation: report on 461 children from a

North American multicenter registry. Pediatrics. 2008 Dec;122(6):e1128-35. Ng VL, Fecteau

A., Shepherd R., Magee J., Bucuvalas J., Alonso E., McDiarmid S., Cohen G., Anand R.;

Studies of Pediatric Liver Transplantation Research Group.

19. Bodor R., Greenberg J.I., Abrams R.A., Obiekwe S., Hart M., Lavine J.E., Khanna A.

Microvascular hepatic artery reconstruction in pediatric abdominal transplantation: pearls and

pitfalls. Pediatric Transplant. 2007 Aug;11(5):471-6

http://www.ncbi.nlm.nih.gov/pubmed?term=khanna%20a%2C%20bodor%20r

20. Khanna A., Hart M., Nyhan W.L., Hassanein T., Panyard-Davis J., Barshop B.A. Domino liver

transplantation in maple syrup urine disease. Liver Transplant 2006; 12(5):876-82.



http://journals.lww.com/transplantjournal/pages/articleviewer.aspx?year=1997&issue=05150&article=00001&type=abstract

http://journals.lww.com/transplantjournal/pages/articleviewer.aspx?year=1997&issue=05150&article=00001&type=abstract

http://online.liebertpub.com/doi/pdfplus/10.1089/lap.2012.9999



http://www.ncbi.nlm.nih.gov/pubmed?term=khanna%20a%2C%20bodor%20r



21. Barshop B.A., Khanna A. Domino hepatic transplantation in maple syrup urine disease. N Engl J

Med 2005; 353(22):2410-11.

http://www.nejm.org/doi/full/10.1056/NEJM200512013532220#t=citedby

22. Laving A., Khanna A., Rubin L., Ing F., Dohil R., Lavine J.E. Successful liver transplantation in

a child with severe portopulmonary hypertension treated with epoprostenol . J Pediatrics

Gastroenterol Nutr 2005; 41(4):466-468.

http://www.ncbi.nlm.nih.gov/pubmed?term=khanna%20a%2C%20laving%20a

23. Grover I., Conley L., Alzate G., Lavine J., Van Hoesen K., Khanna A. Hyperbaric oxygen

therapy for hepatic artery thrombosis following liver transplantation: current concepts. Pediatr

Transpl 2006; 10(2):234-239.

http://www.ncbi.nlm.nih.gov/pubmed?term=khanna%20a%2C%20grover%20i

24. Rose S.C., Hassanein T.I., Bouvet M., Hart M.E., Khanna A. Delivery of radiofrequency ablation

probes to the targeted liver malignancy: using all the players on the field. J Vasc Interv Radiol

2002; 13(10):1060-61.


25. Nyhan W., Khanna A., Barshop B., Naviaux R., Precht A.F., Lavine J.E., Hart M., Hainline B.E.,

Wappner R.S., Nichols S., Haas M. Pyruvate carboxylase deficiency—insights from liver

transplantation. Mol Genet Metab 2002; 77:143-149.


26. Haque T., Taylor C., Wilkie G.M., Murad P., Amot P.L., Beath S., McKiernan P.H., Crawford

D.H. Complete regression of post-transplant lymphoproliferative disease using partially HLA-

matched Epstein-Barr virus-specific cytotoxic T cells. Transplantation 2001; 72:1352-53. Invited

Commentary. Khanna A.

27. Jain A., Kashyap R., Marsh W., Rohal S., Khanna A., Fung J.J. Reasons for long-term use of

steroid in primary adult liver transplantation using Tacrolimus. Transplantation 2001; 71(8):1102-


28. Jain A., Mazariegos G., Kashyap R., Marsh W., Khanna A., Iurlano K., Fung J.J. Reasons why

some children receiving Tacrolimus therapy require steroids more than five years post liver

transplantation. Transplantation 2001; 5(2):93-98.


29. Rose S.C., Andre M.P., Roberts A.C., Kinney T.B., Valji K., Ronaghi A.H., Hassanein T.I., Lavine

J.E., Hart M.E., Khanna A. Integral role of interventional radiology in the development of a

pediatric liver transplantation program. Pediatric Transplantation 2001; 5:331-338.


30. Song Z., Khanna A., Patel N.H., Dindal R.M. Is specific immunosuppression necessary for

pancreas transplantation? Curr Opin Organ Transpl 2001; 6:188-193.

http://www.nejm.org/doi/full/10.1056/NEJM200512013532220#t=citedby

http://www.ncbi.nlm.nih.gov/pubmed?term=khanna%20a%2C%20laving%20a

http://www.ncbi.nlm.nih.gov/pubmed?term=khanna%20a%2C%20grover%20i







31. Patel N.H., Revanur V.K., Khanna A., Hodges C., Jindal R.M. Vascular access for hemodialysis:

an in-depth review. J Nephrol 2001; 14(3):146-156.



32. Jordan M.L., Shapiro R., Gritsch H.A., Egidi F., Khanna A., Vivas C.A., Scahtlebury V.P., Fung

J.J., Starzl T.E., Corry R.J. Long-term results of pancreas transplantation under Tacrolimus.

Transplantation 1999; 67(2):266-272.

http://www.ncbi.nlm.nih.gov/pubmed?term=jordan%20m%2C%20khanna%20a

33. Molmenti E., Mazariegos G., Bueno J., Cacciarelli T., Alasio T., Khanna A., Kosmach B., Jain A.,

Fung J., Reyes J. Noncompliance after pediatric liver transplantation. Transplant Proc 1999;

31(1-2):408.


34. Khanna A., Newman B., Reyes J., Todo S., Fung J.J., Starzl T.E. Internal hernia and volvulus of

small bowel following liver transplantation. (original article) Transpl Intl 1997; 10(2):133-136.

http://www.ncbi.nlm.nih.gov/pubmed?term=khanna%20a%2C%20newman%20b

35. Khanna A., Jain A., Ziady G., Demetris A.J., Fung J.J., Kramer D., Starzl T.E. Cardiac changes at

autopsy on adult liver transplant recipients under Tacrolimus. Transplant Proc 1997; 29:532-533.


36. Egidi M.F., Shapiro R., Khanna A., Fung J.J., Corry R.J. Fine-needle aspiration biopsy in

pancreatic transplantation. Transplant Proc 1995; 27(6):3055-66.


37. Khanna A., Gandhi A., Sykes P.A. Blunt abdominal injury associated with colonic rupture into

abdominal muscles—a case report. Injury 1995; 26(5):337-338.

http://www.ncbi.nlm.nih.gov/pubmed?term=khanna%20a%2C%20sykes%20p

Invited Reviews and Chapters:

38. Fulminant Liver Failure: When to Transplant? Khanna A.; Hemming A.W.: Surgical Clinics of

North America, June 2010 Surg Clin North Am. 2010 Aug; 90(4):877-89. Epub 2010 Jun 9.


39. Khanna A., Patel N.H., Song Z., Jindal R.M. Pancreas transplantation. In: Ultrasound of

Abdominal Transplantation. Eds: Pal S. Sidhu, Grant M. Baxter; Thieme & Stuttgart, New York,

2002, pp. 125-130.

40. Khanna A., Jindal R.M. Small bowel and multi-visceral transplantation. In: Ultrasound of

Abdominal Transplantation. Pal S. Sidhu, Grant M. Baxter (eds.); Thieme & Stuttgart, New York,

2002, pp. 131-135.



http://www.ncbi.nlm.nih.gov/pubmed?term=jordan%20m%2C%20khanna%20a


http://www.ncbi.nlm.nih.gov/pubmed?term=khanna%20a%2C%20newman%20b



http://www.ncbi.nlm.nih.gov/pubmed?term=khanna%20a%2C%20sykes%20p



41. Hart M.E., Khanna A., Dunn J.F. Organ transplantation. In: Essential Surgical Practice/Higher

Surgical Training, 4th edition, chap. 64. A. Cuschieri, R.J.C Steele, A.R. Moossa (eds.). Arnold,

London, UK; 2002, pp. 1343-56.

42. Khanna A., Fung J.J. Liver transplantation. In: Blue Books of Practical Neurology, “Neurologic

Complications in Organ Transplantation.” Eelco (ed.). F.M. Wijdick, Mayo Clinic, Rochester

MN; 1999, 21, pp. 19-31.

43. Khanna A., Thomson A.W. Hematopoietic Growth Factors in Transplantation: Biology and

clinical applications (review article). Transplant Rev 1998; 12:121-139..

44. Khanna A., Rosenbloom A., Bonham C.A., Fung J.J. In: Textbook of Critical Care, 4th

edition,

chap. 178. S.M. Ayers, A. Grenvik, P.R. Holbrook, W.C. Shoemaker (eds.). W.B. Saunders Co.,

Philadelphia; 1999, pp. 1925-38.

45. Khanna A., Jain A., Eghtesad B., Rakela J. Liver Transplantation for Metabolic Liver Diseases.

Surg Clin North Am 1999; 79:153-162.


46. Jain A., Khanna A., Molmenti E.P., Rishi N., Fung J.J. Immunosuppressive Therapy: New

Concepts. Surg Clin North Am 1999; 79:59-76.


PUBLISHED ABSTRACTS

Basic Research:

1. Generation of an In Vitro model of cystic fibrosis: Amy L Firth, Susan J Qualls, Oded Singer,

Tushar Menon, Ajai Khanna, Inder M Verma: The Salk Institute, La Jolla, USA and University of

California San Diego. Presented at 10th Annual Meeting of International Society for Stem Cell

Research June 13-16, 2012, Pacifico Yokohama, Yokohama, Japan.

2. Patient derived iPSC to study Alport's Disease: Amy L Firth, Oded Singer, Susan J Qualls, Ajai

Khanna, Inder M Verma: The Salk Institute, La Jolla, USA and University of California San

Diego. Presented at 10th Annual Meeting of International Society for Stem Cell Research June 13-

16, 2012, Pacifico Yokohama, Yokohama, Japan.

3. Applying systems biology to develop T cell tolerance: Jurkat cell responses to knockdown hub

genes using siRNA in-vitro transfection Wint Lwin, Ajai Khanna: XII TTS Basic Science

Symposium and II ESOT Basic Science Meeting, Cape Cod June 11-14, 2011

4. Return of lymphocyte immunoreactivity after discontinuation of a brief course of Prograf,

Cyclosporine, or Sirolimus in normal subjects: Wint Lwin, Robert Steiner, Ajai Khanna, David

Perkins: XII TTS Basic Science Symposium and II ESOT Basic Science Meeting, Cape Cod June

11-14, 2011




5. Role of systems biology to develop T cell tolerance: Jurkat cell responses to knockdown hub genes

using siRNA in-vitro transfection: Wint Lwin, David Perkins, Ajai Khanna: Immunology 2011

98th Annual Meeting American Association of Immunologists, May 13-17th

, 2011, San Francisco

CA

6. Lymphocyte immunoreactivity after administration of Prograf, Cyclosporine, or Sirolimus in

normal subjects. Wint Lwin, Robert Steiner, Ajai Khanna, David Perkins. Immunology 2011 98th

Annual Meeting American Association of Immunologists, May 13-17th

,2011, San Francisco CA

7. Proteasome inhibitor, Bortezomib for the treatment of elevated DSA in highly sensitized hepatitis

B core antibody positive renal transplantation: Abstract accepted at the American Transplant

Congress, June 2-6, 2012 Boston., USA, Napoles P., Eckles D., Kuo A., Mekeel K., Ward D.,

Khanna A.

8. The 96th Annual Meeting, The American Association of Immunologists, May 8-12, 2009, Seattle: T

cell responses to hub gene knockout in in-vitro propagated Jurkat Cells: Application to Systems

Biology: A. Khanna The Journal of Immunology, 2009, 182, 141.50

9. American Transplant Congress 2009, May 30-June 3, Boston: A. Khanna T cell responses to hub

gene knockout in in-vitro propagated Jurkat Cells: Application to Systems Biology

10. Bruce A. Barshop, William L. Nyhan, Jennifer Gwynne, Janice Panyard-Davis, A. Khanna. Liver

transplantation in maple syrup urine disease, including domino transplantation: SIMD abstracts,

Molecular Genetics and Metabolism 84 (2005) 193-242.

11. Barshop B.A., Nyhan W.L., Khanna A., Hepatic and domino hepatic transplantation in maple

syrup urine disease: J. Inherit. Metab. Dis. 28 (2005) Suppl.1

12. Barshop B.A., Nyhan W.L., Gwynne J., Panyard-Davis J., Khanna A. Liver transplantation in

maple syrup urine disease, including domino liver transplantation. Annual Meeting for Society for

Inherited Metabolic Disorders; March 2005, Pacific Grove CA.

13. Khanna A. Transplant genomics: applying human genome to improve transplant outcomes. 10th

Congress of the International Liver Transplantation Society Meeting; June 2004, Kyoto, Japan.

14. Khanna A., Morelli A., Zhong C., Thomson A.W., Lu L. Allogeneic liver-derived dendritic cell

progenitors selectively induce Th2 cytokine responses in vitro and in vivo. 18th Annual meeting of

the American Society of Transplantation; May 1999, Chicago IL. Transplantation 1999; 67:S22.

15. Morelli A.E., Khanna A., Qian S., Lu L., Thomson A.W. Dendritic cells from livers that are

acutely rejected or accepted differentially affect allogeneic Th1 cytokine production in vivo. 18th

Annual Meeting of the American Society of Transplantation; May 1999, Chicago IL.

Transplantation 1999; 67:S242.


16. Khanna A., Antonysamy M.A., Subbotin V., Steptoe R.J., Rudert W., Thomson A.W. Impact of

Flt-3 ligand on donor derived dendritic cells and alloimmune reactivity in heart graft recipients

given adjuvant donor bone marrow. 5th International Symposium on Dendritic Cells in

Fundamental and Clinical Immunology; Sept. 1998, Pittsburgh PA. J Leukocyte Biol 1998;

(suppl.), p. 54.

17. Khanna A., Thomson A.W., Zhong C., Banas R., Logar A., Lu L. Liver-derived dendritic cell

progenitors induce allogeneic Th2 cell responses. 5th International Symposium on Dendritic Cells

in Fundamental and Clinical Immunology; Sept. 1998, Pittsburgh PA. J Leukocyte Biol 1998;

(suppl.), p. 53.

18. Khanna A., Banas R., Logar A., Thomson A.W., Lu L Allogeneic liver-derived dendritic cell

progenitors induce only low intracellular secreted Th1 cytokine production and minimal CTL

generation: association with ‘spontaneous’ allograft acceptance. American Society of Transplant

Physicians; May 1998, Chicago IL.

19. Thomson A.W., Antonysamy M.A., Steptoe R.J., Khanna A., Li W., Lu L. Flt-3 ligand increases

microchimerism but can prevent the therapeutic effect of donor bone marrow in transiently

immunosuppressed cardiac allograft recipients. Presented at the 17th Annual Meeting of the

American Society of Transplant Physicians; May 1998, Chicago IL.

20. Khanna A., Logar A., Banas R., Thomson A.W., Lu L. Influence of allogeneic liver-derived

dendritic cell progenitors on CD4+ T-cell differentiation: relevance to allograft survival. XVII

World Congress of the Transplantation Society; 1998, Montreal, Canada.

21. Khanna A., Banas R., Logar A., Thomson A.W., Lu L. Allogeneic liver-derived dendritic cell

progenitors induce only low intracellular secreted Th1 cytokine production and minimal CTL

generation: association with ‘spontaneous’ allograft acceptance. Keystone Symposia on Cellular

and Molecular Biology of Dendritic Cells; March 1998, Santa Fe NM.

22. Thomson A.W., Antonysamy M.A., Steptoe R.J., Khanna A., Li W., Lu L. Flt-3 ligand increases

microchimerism but can prevent the therapeutic effect of donor bone marrow in transiently

immunosuppressed cardiac allograft recipients. Keystone Symposia on Cellular and Molecular

Biology of Dendritic Cells; March 1998, Santa Fe NM.

23. Khanna A., Subbotin V., Rudert W., Li W., Antonysamy M.A., Steptoe R.J., Lu L., Thomson

A.W. Chimerism, growth of donor-derived cells and heart allograft survival in transiently

immunosuppressed recipients treated with Flt-3 ligand. Presented at the 24th Annual Meeting of the

American Society of Transplant Surgeons; 1998, Chicago IL.

24. Khanna A., Mazariegos G., Lopez R., Molmenti E., Gerber D., Riddervold F., Chen Y., Lin W.Y.,

Scott V.L., Aggarwal S., Kramer D.J., Block G.D., Wagner R.A., Fulmer M., Amiot B.P., Patzer

J.F. II. Presented at the 24th Annual Meeting of the American Society of Transplant Surgeons;

1998, Chicago IL.


25. Mazariegos G.V., Lopez R., Ridderwaal F., Molmenti E., Gerber D., Khanna A., Zhu Y., Block

G.D., Scott V.L., Aggarwal S., Kramer D.J., Lin W.Y., Wagner R.A., Fulmer M.L., Amiot B.P.,

Patzer J.F. II. Preclinical evaluation of a bioartificial liver assist device. Presented at the 44th

Annual Conference of the American Society for Artificial Internal Organs/CVST; 1998, New York

NY.

26. Khanna A., Antonysamy M.A., Steptoe R.J., Li W., Lu L., Thomson A.W. The hematopoietic

growth factor Flt-3 ligand reverses the therapeutic effect of donor bone marrow in transiently

immunosuppressed cardiac allograft recipients. Presented at the 23rd Annual Meeting of the

American Society for Histocompatibility and Immunogenetics; Oct 1997, Atlanta GA.

27. Khanna A., Antonysamy M.A., Steptoe R.J., Rudert W.A., Subbotin V.M., Thomson A.W. A

short course of Flt-3 ligand prevents the therapeutic effect of donor bone marrow in transiently

immunosuppressed cardiac allograft recipients. Presented at the 25th Anniversary Meeting, The

British Transplantation Society; Oct. 1997, London UK.

28. Khanna A., Antonysamy M.A., Steptoe R.J., Li W., Lu L., Thomson A.W. A short course of Flt-3

ligand reverses the therapeutic effect of donor bone marrow in transiently immunosuppressed

cardiac allograft recipients. Presented at the 23rd Annual Meeting of the American Society for

Histocompatibility and Immunogenetics; Oct. 1997, Atlanta GA.

29. Khanna A., Antonysamy M.A., Steptoe R.J., Li W., Lu L., Thomson A.W. A short course of Flt-3

ligand reverses the therapeutic effect of donor bone marrow in transiently immunosuppressed

cardiac allograft recipients. Presented at the 5th Basic Science Symposium of the Transplantation

Society; Sept. 1997, Chautauqua NY.

30. Khanna A., Steptoe R.J., Li W., Morris R.E., Thomson A.W.. Donor bone marrow potentiates the

effect of Tacrolimus on nonvascularized heart allograft survival. Presented at the American Society

of Transplant Surgeons, 23rd Annual Scientific Meeting; May 1997, Chicago IL.

31. Thomson A.W., Iyengar A.R., Antonysamy M.A., Khanna A., Subbotin V.M., Bonham C.A.,

Murase N., Rao A.S., Starzl T.E. Striking augmentation of hematopoietic cell chimerism in

noncytoablated allogeneic bone marrow recipients by Flt-3 ligand and Tacrolimus. Presented at

the American Society of Transplant Physicians, 15th Annual Scientific Meeting; May 1997, Chicago

IL.

32. Khanna A., Steptoe R.J., Li W., Morris R.E., Thomson A.W. Donor bone marrow potentiates the

effect of Tacrolimus on nonvascularized heart allograft survival. Invited speaker, 10th Transplant

Fellows Workshop; April 30-May 2, 1997, New Orleans LA.

33. Mazariegos G., Khanna A., Block G., Chen Y., Lin W.Y., Scott V.L., Aggarwal S., Kramer D.J.,

Wagner W.A., Molmenti E., Gerber D., Amiot B.P., Patzer J.F. II. Canine evaluation of a novel

bioartificial liver. Presented at the 4th Congress of the International Liver Transplantation Society;

Oct. 1997, Seattle WA.


34. Block G., Mazariegos G., Khanna A., Chen Y., Scott V.L., Aggarwal S., Lin W.Y., Kramer D.J.,

Wagner W.A., Amiot B.P., Patzer J.F. II. Intracranial (ICP) and cerebral perfusion pressure

stabilization with a bioartificial liver assist device in a canine liver failure model. Presented at the

Xth World Congress of the International Society of Artificial Organs; June 29-July 1, 1997,

Providence RI.

35. Block G., Mazariegos G., Khanna A., Chen Y., Lin W.Y., Scott V.L., Aggarwal S., Kramer D.J.,

Wagner W.A., Molmenti E., Gerber D., Amiot B.P., Patzer J.F. II. D-Galactosamine canine liver

failure model. Presented at the 43rd Annual Conference of the American Society for Artificial

Internal Organs; May 1997, Atlanta GA.

36. Block G.D., Mazariegos G., Aggarwal S., Chen Y., Khanna A., Amiot B.P., Wagner R., Patzer

J.F. D-galactosamine-induced liver injury in large dogs: Is it really fulminant liver failure?

Presented at 47th Annual Meeting of the American Association for the Study of Liver Diseases;

Nov. 1996, Chicago IL.

Clinical:

37. Bruce Barshop, William L. Nyhan, Ajai Khanna: Domino Liver Transplantation in

Methylmalonic academia: Society for the Study of Inborn Errors of Metabolism: Annual

Symposium 2012, September 4-7, 2012, Birmingham, UK

38. Ajai Khanna, M.D., Ph.D., Lysa Woodall, RN, Alexander Aussi, BSN., MBA, Andrea Snyder,

R.N., MBA, Angeles Baquerizo, M.D., Kristin Mekeel, M.D. and Alan W. Hemming, M.D., MSc.

Validation of a liver transplant quality assessment and performance improvement (QAPI) process

in an academic liver transplant program: Submitted American Transplant Congress, April 30-May

4th, 2011, Philadelphia.

39. Seth A. Cohen, M.D., Jeffrey Woldrich M.D., Hayley Osen, B.A., Vieng Bounkeu, B.S., Ph.D,

Flor Mounts, B.A., Sam Park, B.A., Jonathan Shiau, B.S., Pietro Ingrade, R.H.I.T, Kerrin Palazzi-

Churas, M.P.H., Angeles Baquerizo, M.D., Ajai Khanna, M.D., Chang, Ph.D, M.P.H, Ithaar H.

Derweesh M.D.: Estimating the actual incidence of allograft torsion in the U.S. kidney transplant

population over a 10 year period. San Diego. October 23-29, 2010, 86th Annual Meeting of

Western Section of the American Urologic Association Waikoloa Hawaii, USA

40. Ex vivo model for robotic kidney transplantation A. Khanna; University of California San Diego,

San Diego, CA. 6th Academic Surgical Congress, Society of University Surgeons, February 1-3,

2011, Huntington Beach, CA, USA

41. Alan W. Hemming M.D., MSc FACS, Kristin Mekeel M.D., Ajai Khanna M.D. FACS, Angeles

Baquerizo M.D., Robin D. Kim M.D. Portal vein resection in the management of Hilar

Cholangiocarcinoma: Presented at the 122ndAnnual Session of the Southern Surgical Association

Palm Beach, Florida, December 5-8th

, 2010

42. Minimally invasive supra-pubic laparoscopic donor nephrectomy: A. Khanna, M. Hagen, S.

Horgan: submitted to Surgical Endoscopy, 2010.


43. Ex vivo MR imaging technique to co-localize internal components of liver nodules on imaging and

pathology: K. Ganesan, Emil Achmad, J.H.K Nguyen, A. Khanna, C. Sirlin Radiological Society

of North America Annual Meeting Nov 29-Dec 4, Chicago Certificate of Merit Award.

44. Intraoperative strategies in the management of a liver transplant patient: A. Khanna, S. Chava,

R. Sanchez: Liver Intensive Care Group of Europe Meeting June 19-20, 2009 Vienna, Austria.

45. Creation and execution of a comprehensive and transparent transplant QAPI Program. Khanna A.

MD, Michelle Deligencia MSN, R.N., CNOR, Andrea Snyder MBA, R.N., Alexander Aussi

M.B.A., R.N., Angela Scioscia M.D., David Ward M.D. 16th Annual Transplant Management

Forum, April 21-23, 2008.

46. Domino liver transplantation in children and adults with maple syrup urine disease. Khanna A., G.

Mazariegos, K.M. Gibson, H. Morton, K. Strauss, D. Finegold, L. Cropcho, M. Virji, J. Vockley,

Z. Machaidze, K. Soltys, G. Bond, R. Squires, B. Shneider, R. Romero and R. Sindhi. Hillman

Center for Pediatric Transplantation, Children’s Hospital of Pittsburgh, Clinic for Special Children,

Strasburg, PA., Children’s Healthcare of Atlanta, Thomas E. Starzl Transplantation

Institute,University of Pittsburgh. USA, University of California San Diego, CA American

Transplant Congress 2008 meeting at the Metro Toronto Convention Centre, Toronto, Ontario,

Canada, May 31− June 4, 2008.

47. Noncompliance among teenagers is the leading cause of kidney allograft failure in the 21st century

Khanna A. M.D., Karen Kling, M.D., Hanna Neumeier, Dina MacDonald, R.N., and Elizabeth

Ingulli, M.D. University of California, San Diego and Rady Children’s Hospital, San Diego, CA

USA American Transplant Congress 2008 meeting at the Metro Toronto Convention Centre,

Toronto, Ontario, Canada, May 31− June 4, 2008.

48. Technical feasibility of laparoscopic liver resection for transplantation in a canine model; causes of

early graft loss following renal transplantation and its impact on performance of an academic

transplant program. Khanna A. Mini-oral presentation at the 3rd Annual Academic Surgical

Congress February 13-15, 2008 in Huntington Beach, CA.

49. Development and prospective evaluation of performance indicators, surgical outcome reporting

and quality improvement initiatives for an academic abdominal transplant program. Khanna A.

Mini oral presentation at the 3rd Annual Academic Surgical Congress February 13-15, 2008 in

Huntington Beach, CA.

50. Causes of early graft loss following renal transplantation and its impact on performance of an

academic transplant program: Khanna A. Mini oral presentation at the 3rd Annual Academic

Surgical Congress February 13 15, 2008 in Huntington Beach, CA

51. Technical feasibility of laparoscopic liver resection for transplantation in a canine model: A.

Khanna Southwestern Surgical Congress 59th Annual Meeting, Rancho Mirage, March 25th-28th,

2007


52. Pearls and pitfalls: Microvascular hepatic artery reconstruction in pediatric abdominal

transplantation. Richard Bodor, M.D., Joshua I. Greenberg, M.D., Reid A. Abrams, M.D., Marquis

Hart, M.D. and Ajai Khanna, M.D., PhD, American Journal of Transplantation (2005) 986.

Presentations at the 91st Clinical Congress of the American College of Surgeons; Oct. 2005, San

Francisco CA. Am J Transplant 2006, 6(Suppl2) and Transplantation 2006, 82 (issue 1)(Suppl 3).

53. Khanna A., Hart M.E., Nyhan W.L., Hassanein T., Barshop B.A. Domino piggy-back liver

transplantation without veno-venous bypass for maple syrup urine disease. UCSD presentation

2005.

54. Quick A., Bosia J., Aquino A.A., Zimmerer S.E., Khanna A., Hart M.E. Single center experience

with expanded criteria donors in kidney transplantation. UCSD QA presentation 2004

55. Khanna A., Hart M.E., Nyhan W.L., Hassanein T., Barshop B.A. Domino piggy-back liver

transplantation without veno-venous bypass for maple syrup urine disease. 91st Clinical Congress

of the American College of Surgeons; Oct. 2005, San Francisco CA.

56. Quick A., Bosia J., Aquino A.A., Zimmerer S.E., Khanna A., Hart M.E. Single center experience

with expanded criteria donors in kidney transplantation. 91st Clinical Congress of the American

College of Surgeons; Oct. 2005, San Francisco, CA.

57. Zimmerer S.E., Lee V., Brink J.A., Bosia J., Chen C., Khanna A., Hart M.E. Activated

recombinant factor VII: a prospective randomized clinical trial in liver transplantation. American

Transplant Congress; 2005, Seattle, WA.

58. Khanna A., Hart M.E. Redefining liver transplant program profitability in a managed care setting.

10th Congress of the International Liver Transplantation Society meeting; June 2004; Kyoto,

Japan.

59. Khanna A., Hart M.E., Lavine J.E., Ingebo K., Pederson B., Grover I., Bailey B. Hepatic artery

thrombosis following pediatric liver transplantation: role of hyperbaric therapy. 10th Congress of

the International Liver Transplantation Society meeting; June 2004; Kyoto, Japan.

60. Khanna A., Hassanein T., Ward D.M., Hart M.E. En block liver/pancreas/kidney transplantation:

current status of multi-organ and multi-visceral transplantation. 10th Congress of the International

Liver Transplantation Society meeting; June 2004; Kyoto, Japan.

61. Khanna A., Dunn J., Lemire J., Hart M.E. Technical problems in pediatric renal transplantation:

lessons learned. American College of Surgeons Clinical Congress; Oct. 2003, Chicago IL.

62. Khanna A., Hart M.E., Hassanein T., Lavine J., Hall K., Moossa A.R. Living-related liver

transplantation in a managed care setting: lessons learned. American College of Surgeons Clinical

Congress; Oct. 2003, Chicago IL.


63. Khanna A., Precht A.F., Lavine J., Hall .K, Brink J.A., Hassanein T., Hart M.E. Living-related

pediatric liver transplant: early experiences. International Liver Transplant Society Meeting; June

2003; Barcelona, Spain.

64. Khanna A., Hart M.E., Precht A.F., Brink J.A., Lavine J., Hall K., Hassanein, Nyhan W. Lateral

segment liver transplantation from adult donors: a practical alternative to ameliorate metabolic

diseases in pediatric patients. International Liver Transplant Society Meeting; June 2003;

Barcelona, Spain.

65. Khanna A., Precht A.F., Lavine J., Hall K., Brink J.A., Hassanein T., Hart M.E. Living-related

pediatric liver transplant: early experiences. 2nd Congress of the International Pediatric

Transplant Association; April 2003; Rio de Janeiro, Brazil.

66. Khanna A, Hart M.E., Precht A.F., Brink J.A., Lavine J., Hall K., Hassanein T., Nyhan W.

Lateral segment liver transplantation from adult donors: a practical alternative to ameliorate

metabolic diseases in pediatric patients. 2nd Congress of the International Pediatric Transplant

Association; April 2003; Rio de Janeiro, Brazil.

67. Precht A.F., Brink J.A., Lavine J., Hall K., Hart M.E., Nyhan W., Khanna A. First living-related

liver transplant for pyruvate carboxylase deficiency—lessons learned. 2nd Congress of the

International Pediatric Transplant Association; April 2003; Rio de Janeiro, Brazil.

68. Hassanein T.I., Selim K., Oliver D.L., Mittal R, Khanna A., Hart M., Mehta R. Safety and

tolerability of the molecular absorbent recirculating system (MARS) using albumin in patients with

decompensated end-stage liver disease. Annual Meeting of the American Association for the Study

of Liver Diseases; Nov. 2002, Boston MA.

69. Costanza C., Oliver D., Barber E., Gutierrez L., Selim K., Khanna A., Hart M., Hassanein T.

Rising serum bilirubin impacts the predictive value of the meld score. Annual Meeting of the

American Association for the Study of Liver Diseases; Nov. 2002, Boston MA.

70. Zimmerer S.E., Precht A..F, Khanna A., Hart M.E. Activated recombinant factor VIIa: a novel

approach to conserve blood loss in liver transplantation. XIX International Congress of the

Transplantation Society; Aug. 2002, Miami FL.

71. Khanna A., Hall K., Perry W., Selim K., Hassanein T., Hart M. An analysis of causes of donor

withdrawal in adult living-related liver transplant. XIX International Congress of the

Transplantation Society; Aug. 2002, Miami FL.

72. Khanna A., Lavine J., Behling C., Dohil R., Shapiro W., Taylor S., Nyhan W., Malliki D., Hart M.

Graft steatosis: an emerging cause for elevated liver enzymes following pediatric liver

transplantation. XIX International Congress of the Transplantation Society; Aug. 2002, Miami FL.

73. Khanna A., Lavine J., Precht A., Hassanein T., Hall K., Frankville D., Wahlstrom E., Hart M.

Living-related pediatric liver transplant: early experiences. Abdominal Organ Transplantation

from Living Donors: State of the Art; June 2002; Gubbio, Italy.


74. Khanna A., Lavine J., Precht A., Hall K., Barshpo B., Naviaux R., Haas R., Hart M., Nyhan W.

Lateral segment LDLTX in pediatric recipients with metabolic disease. Abdominal Organ

Transplantation from Living Donors: State of the Art; June 2002; Gubbio, Italy.

75. Khanna A., Hall K., Perry W., Selim K., Precht A., Hart M. Causes of donor withdrawal in adult

living-related liver transplant. Abdominal Organ Transplantation from Living Donors: State of the

Art; June 2002; Gubbio, Italy.

76. Khanna A., Lavine J., Hassanein T., Precht A., Hart M. Setting up a living-donor pediatric

transplant program. Abdominal Organ Transplantation from Living Donors: State of the Art; June

2002; Gubbio, Italy.

77. Hart M., Zimmerer S.E., Khanna A., Precht A.F. Factor VIIa reduces blood transfusions in liver

transplant. Abdominal Organ Transplantation from Living Donors: State of the Art; June 2002;

Gubbio, Italy.

78. Khanna A., Lavine J., Behling C., Dohil R., Shapiro W., Taylor S., Nyhan W., Malliki D., Hart M.

Graft steatosis: an emerging cause for elevated liver enzymes following pediatric liver

transplantation. Annual Meeting of the International Liver Transplantation Society; June 2002,

Chicago IL.

79. Khanna A., Lavine J., Hassanein T., Hart M. Setting up pediatric abdominal transplantation

program in a managed care environment: preliminary experiences. Annual Meeting of the

International Liver Transplantation Society; June 2002, Chicago IL.

80. Khanna A., Lavine J., Precht A., Hassanein T., Hall K., Frankville D., Wahlstrom E., Hart M.

Living-related pediatric liver transplant: early experiences. Annual Meeting of the International

Liver Transplantation Society; June 2002, Chicago IL.

81. Khanna A., Hall K., Perry W., Selim K., Precht A., Hart M. An analysis of causes of donor

withdrawal in adult living-related liver transplant. Annual Meeting of the International Liver

Transplantation Society; June 2002, Chicago IL.

82. Zimmerer S., Precht A.F., Khanna A., Hart M. Activated recombinant factor VIIa: a novel

approach to conserve blood loss in liver transplantation. Annual Meeting of the International

Liver Transplantation Society; June 2002, Chicago IL.

83. Precht A.F., Naiaux R.K., Barshop B., Hart M.E., Shen G., Khanna A. First report of living-

related liver transplant for pyruvate carboxylase deficiency. Presented at the Annual Meeting of

the International Liver Transplantation Society; June 2002, Chicago IL.

84. Precht A.F., Hong I.C., Mullen P.M., Khanna A., Zimmerer S.E., Lopez V., Moss R.B., Chiou

H.C., Behling C., Li M., Hart M.E. Non-viral human IL-10 gene expression reduces acute

rejection in heterotopic auxiliary liver transplantation in rats. Presented at the Annual Meeting of

the International Liver Transplantation Society; June 2002, Chicago IL.


85. Khanna A., Hall K., Perry W., Selim K., Hassanein T., Hart M. An analysis of causes of donor

withdrawal in an adult-to-adult living-related liver transplant program. Presented at the 3rd

Joint Transplant Meeting, American Society of Transplant Surgeons; April/May

2002,Washington DC

86. Zimmerer S., Precht A.F., Khanna A., Hart M. Activated recombinant factor VIIa: a novel

approach to conserve blood loss in liver transplantation. Presented at the 3rd Joint Transplant

Meeting, American Society of Transplant Surgeons; April/May 2002, Washington DC.

87. Hassanein T.I., Abdeen O., El-Tahawy M., Hart M., Khanna A., Mehta R. Octreotide,

midodrine, and albumin, triple therapy is effective in reversing hepatorenal syndrome. Presented

at the Annual Meeting of the American Association for the Study of Liver Diseases; Nov. 2001,

Dallas TX.

88. Hong I., Precht A.P., Mullen P., Khanna A., Dunn J., Behling C., Choui H., Lopez V., Moss R.,

Hart M. Non-viral human IL-10 gene expression reduces reperfusion injury in heterotopic

auxiliary liver transplantation in rats. Presented at the 2nd Annual Winter Symposium, American

Society of Transplant Surgeons; Jan. 2001, Jacksonville FL.

89. Hart M., Hassanein T., Rose S., Roberts A., Kinney T., Garfinkel M., Wahlstrom E., Lavine J.,

Khanna A. Evaluation and outcome of living-related donors for liver transplantation. Presented

at Workshop on Living Donor Liver Transplantation; Dec 2000.

90. Khanna A., Lavine J., Hassanein T., Garfinkel M., Hall K., Frankville D., Wahlstrom E., Hart M.

First-year evaluation of a living-related liver transplantation program at a major teaching hospital.

Presented at the 1st Congress of the International Pediatric Transplant Association; Aug. 2000;

Rome, Italy. Pediatr Transplant 2000; 4:P86.

91. Rose S, Kinney T.B., Stella D.L., Hart M., Hassanein T., Pretorius D., Nelson T., Levin D.,

Khanna A. Three-dimensional ultrasound (3D US) for estimation of left lateral segment liver

volume for split liver donation. Presented at the 1st Congress of the International Pediatric

Transplant Association; Aug. 2000; Rome, Italy. Pediatr Transplant 2000; 4:P66.

92. Rose S., Roberts A.C., Kinney T.B., Valji K., Hassanein T., Lavine J., Hart M., Khanna A.

Integral role of interventional radiology in the development of a pediatric liver transplantation

program. Presented at the 1st Congress of the International Pediatric Transplant Association;

Aug. 2000; Rome, Italy. Pediatr Transplant 2000; 4:P322.

93. Khanna A., Gutmacher H., Garfinkel M., Cashman J., Hall K., Randall C., Greenburg M.,

Frankville D., Dohil R., Shapiro W., Taylor S., Wahlstrom E., Hassanein T., Nyhan W., Lavine

J., Hart M. Early enteral feeding obviates the need for parenteral nutrition in pediatric liver

transplant (OLTX) patients. Presented at the 1st Congress of the International Pediatric

Transplant Association; Aug. 2000; Rome, Italy. Pediatr Transplant 2000; 4:P93.


94. Khanna A., Hart M., Lavine J., Cashman J., Hall K., Randall C., Greenburg, Frankville D,

Barshop B., Hass R., Nyhan W. Lateral segment liver transplantation from adult donor: a

practical alternative to ameliorate methylmalonic academia in a child. Presented at the 1st

Congress of the International Pediatric Transplant Association; Aug. 2000; Rome, Italy.

95. Khanna A., Lavine J., Cashman J., Garfinkel M., Hall K., Frankville D., Randall C., Nyhan W.,

Wahlstrom E., Hassanein T., Hart M. First-year evaluation of new pediatric abdominal

transplantation program at a major teaching hospital. Presented at the 1st Congress of the

International Pediatric Transplant Association; Aug. 2000; Rome, Italy. Pediatric Transplant

2000; 4:P86.

96. Khanna A., Lavine J., Hassanein T., Hart M. Setting up a pediatric abdominal transplantation

program in a managed care environment: preliminary experiences. Presented at the 1st Congress

of the International Pediatric Transplant Association; Aug. 2000; Rome, Italy. Pediatric

Transplant 2000; 4:P294.

97. Stewart M., Rose S.C., Mattrey R.F., Hart M., Khanna A., Chatfield E., Oliver D.L., Hwang S.,

Seville M.W., Hassanein T. Descriptive analysis of patterns leading to the detection of

hepatocellular cancer (HCC). Hepatology 2000; 32(4,

Pt. 2):619A.

98. Hillsabeck R.C., Hickman S., Boland B., Oliver D.L., Hart M., Khanna A., Perry W., Hassanein

T. Degree of cognitive impairment in patients evaluated for liver transplant. Hepatology 2000;

32(4, Pt. 2):606A.

99. Molmenti E., Mazariegos G., Bueno J., Cacciarelli T., Alasio T., Khanna A., Kosmach B., Jain

A., Fung J., Reyes J. Noncompliance after pediatric liver transplantation. Presented at the 49th

Annual Meeting of the American Association for the Study of Liver Diseases; Nov. 1998, Chicago

IL.

100. Khanna A., Abu-Elmagd K., Virji M.A., Carr B.I.. Retrospective analysis of 20 hepatocellular

carcinoma patients with adrenal metastases: the influence of liver transplantation and

adrenalectomy. Presented at the 49th Annual Meeting of the American Association for the Study

of Liver Diseases; Nov. 1998, Chicago IL; Hepatology 1998; 28:246A, abstract #335.

101. Khanna A., Mazariegos G., Fung J.J., Starzl T.E., Reyes J.D. The hepatic artery-celiac axis non-

touch technique of pediatric liver retrieval: advantages and outcome. Presented at the 3rd

International Congress on Pediatric Transplantation; July 1998, Boston MA.

102. Reyes J.D., Khanna A., Zeevi A., Nalesnik M., Yunis E., Rao A., Kohler M., Kocoshish S.,

Newman B., Fung J.J., Starzl T.E. Lethal GVHD in a pediatric liver recipient with hyper-IgE

syndrome: influence of pre-existing immune deficiency on allograft outcome. Presented at the

3rd International Congress on Pediatric Transplantation; July 1998, Boston MA.

103. Venkataraman R., Molmenti E., Zuckerman S., Swaminathan A., McGee W., Khanna A., Bueno

J., Fung J.J., Reyes J. Pediatric transplant patients handle mycophenolate mofetil differently than


adult transplant patients. Presented at the 3rd International Congress on Pediatric

Transplantation; July 1998, Boston MA.

104. Khanna A., Mazariegos G., Bueno J., Fung J.J. Allograft rejection in pediatric liver recipients

without elevation of liver enzymes: diagnostic implications and outcome. Presented at the 3rd

International Congress on Pediatric Transplantation; July 1998, Boston MA.

105. Khanna A., Mazariegos G., Bueno J., Fung J.J. Allograft rejection in pediatric liver recipients

without elevation of liver enzymes: diagnostic implications and outcome. Presented at the 24th

Annual Scientific Meeting of the American Society of Transplant Surgeons; May 1998, Chicago

IL.

106. Reyes J.D., Khanna A., Zeevi A., Yunis E., Rao A., Kohler M., Kocoshish S., Newman B., Fung

J.J., Starzl T.E. Lethal GVHD in a pediatric liver recipient with hyper-IgE syndrome: influence

of pre-existing immune deficiency on allograft outcome. Presented at the 24th Annual Scientific

Meeting of the American Society of Transplant Surgeons; May 1998, Chicago IL.

107. Khanna A., Mazariegos G., Fung J.J., Starzl T.E., Reyes J.D. The hepatic artery-celiac axis non-

touch technique of pediatric liver retrieval: technical considerations, advantages and outcome.

Presented at the 24th Annual Scientific Meeting of the American Society of Transplant Surgeons;

May 1998, Chicago IL.

108. Jordan M., Khanna A., Shapiro R., Vivas C., Scantlebury V., Corry R.J. Long-term results of

pancreas transplantation under Tacarolimus immunosuppression. Presented at the 24th Annual

Scientific Meeting of the American Society of Transplant Surgeons; May 1998, Chicago IL.

109. Khanna A., Mazariegos G.V., Lopez R., Molmenti E., Gerber D., Riddervold F., Yin W.Y.,

Scott V.L., Aggarwal S., Kramer D.J., Block G.D., Wagner R.A., Fulmer M., Amiot B.P., Patzer

J.F. II. Novel bioartificial liver preclinical evaluation. Presented at the World Congress of the

Transplantation Society; 1998; Montreal, Canada.

110. Molmenti E., Kosmach B., Bueno J., Khanna A., Reyes J.. Noncompliance after pediatric liver

transplantation. Presented at the 1st International Symposium on Transplant Recipient

Compliance; April 1998, Arlington VA.


J., Fung J.J., Reyes J. Pharmacokinetics of mycophenolic acid after oral administration of

mycophenolate mofetil in pediatric liver/small bowel transplant patients. Presented at the 4th

Congress of the International Liver Transplant Society; Sept. 1997.

112. Khanna A., Doria C., Fung J.J., Starzl T.E., Reyes J. Chylous collections following intestinal

transplantation in children. Presented at the 5th International Symposium on Intestinal

Transplantation; July/Aug 1997, Cambridge UK.

113. Khanna A., Venkataraman R., Molmenti E., Swaminathan A., McGee W., Bueno J., Fung J.J.,

Todo S., Reyes J. Pharmacokinetics of mycophenolic acid in pediatric small bowel


transplantation. Presented at the 5th International Symposium on Intestinal Transplantation;

July/Aug.1997, Cambridge UK.

114. Bueno J., Green M., Molmenti E., Khanna A., Furukawa H., Reyes J. The different clinical

behavior in CMV donor-positive/recipient-negative serological status after intestinal

transplantation in children. Presented at the 5th International Symposium on Intestinal

Transplantation; July/Aug. 1997, Cambridge UK.

115. Venkataraman R., Khanna A., Swaminathan A., Todo S., Reyes J. Presented at the 5th

International Symposium on Intestinal Transplantation; July/Aug. 1997, Cambridge UK.

116. Khanna A., Bueno J., Fung J.J., Reyes J. Liver allograft rejection in pediatric liver transplant

recipients without significant elevation of liver enzymes. Presented at the 4th Congress of

International Liver Transplantation Society; Oct. 1997, Seattle WA.


J., Fung J.J., Reyes J. Pharmacokinetics of mycophenolic acid after oral administration of

mycophenolate mofetil in pediatric liver/small bowel transplant patients. Presented at the

American Society of Transplant Physicians 16th Annual Scientific Meeting; May 1997, Chicago

IL.

118. Khanna A., Mieles L., Reyes J. Liver allograft rejection in pediatric liver transplant recipients

without significant elevation of liver enzymes. Presented at the 47th Annual Meeting, American

Association for the Study of Liver Diseases; Nov. 1996, Chicago IL.

119. Silverman W.B., Mieles L., Khanna A., Reyes J. Influence of ERCP in the diagnosis and

treatment of pediatric transplant patients. Presented at the 61st Annual Scientific Meeting,

American College of Gastroenterology; Oct. 1996, Seattle WA.

120. Khanna A., Jain A., Ziady G., Demetris A.J., Fung J.J., Kramer D., Starzl T.E.. Cardiac changes

at autopsy on adult orthotopic liver transplant recipients treated with Tacrolimus as primary

immuno¬suppression. Presented at the XVI International Congress of the Transplantation

Society; Aug. 1996; Barcelona, Spain.

121. Khanna A., Jain A., Mieles L., Fung J.J., Todo S., Starzl T.E., Reyes J. Liver retransplantation

in children: the Pittsburgh experience. Presented at the 2nd International Congress on Pediatric

Transplantation; Aug. 1996; Paris, France.

122. Khanna A., Jain A., Ziady G., Fung J.J., Jaffe R., Mieles L., Starzl T.E., Reyes J. Cardiac

changes at autopsy in pediatric liver transplant recipients under Tacrolimus. Presented at the 2nd

International Congress on Pediatric Transplantation; Aug. 1996; Paris, France.

123. Jonnalagada S., Jain A.B., Balan V., Khanna A., Rakela J., Starzl T.E.. Invasive fungal

infection in adult orthotopic liver transplant recipients under Tacrolimus. Presented at the

American Society of Gastroenterology Meeting, 1996.


124. Khanna A., Newman B., Reyes J., Todo S., Fung J.J., Starzl T.E. Internal hernia and volvulus

of the small bowel following liver transplantation. Presented at the International Liver

Transplantation Society Congress; Sept. 1995, London UK.

125. Khanna A., Sykes P.A. To operate or not to… octogenarians: ethical dilemma. Presented at the

5th International Conference on Ethics in Medicine; Aug./Sept. 1993, London UK.

SELECT NEWS REPORTS

Liver Transplants

http://www.signonsandiego.com/news/2009/jan/28/1m28aceta235244-event-set-rady-warn-danger/

http://ucsdnews.ucsd.edu/newsrel/health/06_17_Domino.asp

http://healthspan.ucsd.edu/2009/09/Pages/mc-transplant.aspx

http://www.10news.com/health/4747973/detail.html

http://www.kpbs.org/news/2009/jul/06/hepatitis-c-epidemic-more-widespread-hiv/

The Arizona Republic: Girl Gets Gift of Liver from Mom

http://ucsdnews.ucsd.edu/newsrel/health/karladis2.htm

Kidney Transplants

San Diego Celebrates 40 Years of Organ Transplants - Channel 6 - YouTube

http://www.nctimes.com/news/local/fallbrook/article_3029e2f3-98b9-5cf0-b78a-5b3c42b269ba.html

http://www.signonsandiego.com/news/2009/aug/25/local-couples-team-kidney-

transplants/?health&zIndex=154841

http://www.cbs8.com/global/story.asp?s=12470597


http://www.universityofcalifornia.edu/news/article/18852

http://www.signonsandiego.com/news/2009/jan/28/1m28aceta235244-event-set-rady-warn-danger/

http://ucsdnews.ucsd.edu/newsrel/health/06_17_Domino.asp

http://healthspan.ucsd.edu/2009/09/Pages/mc-transplant.aspx


http://www.kpbs.org/news/2009/jul/06/hepatitis-c-epidemic-more-widespread-hiv/

http://drkhanna.ucsd.edu/LinkClick.aspx?link=http%3a%2f%2fwww.azcentral.com%2fcommunity%2fchandler%2farticles%2f0411cr-livermom0411Z6.html%3f%26wired&tabid=49&mid=397

http://ucsdnews.ucsd.edu/newsrel/health/karladis2.htm

http://drkhanna.ucsd.edu/LinkClick.aspx?link=http%3a%2f%2fwww.youtube.com%2fwatch%3fv%3ddXBfDle3CM4&tabid=72&mid=396

http://www.nctimes.com/news/local/fallbrook/article_3029e2f3-98b9-5cf0-b78a-5b3c42b269ba.html

http://www.signonsandiego.com/news/2009/aug/25/local-couples-team-kidney-transplants/?health&zIndex=154841

http://www.signonsandiego.com/news/2009/aug/25/local-couples-team-kidney-transplants/?health&zIndex=154841

http://www.cbs8.com/global/story.asp?s=12470597


http://www.universityofcalifornia.edu/news/article/18852

Ajai Khanna, M.D., Ph.D. Curriculum Vitae - 0Ajai Khanna, M.D., Ph.D. Curriculum Vitae - 2 1982-1983...

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Transcript of Ajai Khanna, M.D., Ph.D. Curriculum Vitae - 0Ajai Khanna, M.D., Ph.D. Curriculum Vitae - 2 1982-1983...