Aiming to achieve HAT elimination - DNDi · Towards elimination of human African trypanosomiasis...

Towards elimination of human African trypanosomiasis (HAT) DNDi Symposium, ASTMH‘ New Orleans , November 5, 2014

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Aiming to achieve HAT elimination.


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Cases THA, 1940-2013


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Cases THA, 1940-2013


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SSNCP

http://www.gatesfoundation.org/Pages/home.aspx


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WHO HAT elimination strategy: Objectives

Goal of WHO NTD Roadmap: “To eliminate gambiense HAT as a public health problem” by 2020. This is an intermediate step, defined as <1 new case in 10,000 inhabitants in at least 90% of foci, with < 2,000 cases reported annually at continental level.


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Number of cases reported

Gambiense HAT elimination: Progression

10'388

9'685

6'978 6'637

7'106

6'228

6'000 5'500

5'000 4'500

4'000 3'500

3'000 2'500

2'000

0

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2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020

HA

T c

ases

Year

Reported cases

Expected cases


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Final goal of WHO and DEC and according to NTD STAG recommendations: "To interrupt transmission of gambiense HAT" by 2030 This is a sustainable final step, defined as reduction to zero of the incidence of infection caused by gambiense HAT in endemic countries Continued actions will be required to prevent re-establishment of the disease.


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Final goal of WHO and DEC and according to NTD STAG recommendations: "To interrupt transmission of gambiense HAT" by 2030 This is a SUSTAINABLE final step, defined as reduction to zero of the incidence of infection caused by gambiense HAT in endemic countries Continued actions will be required to prevent re-establishment of the disease.

Being a zoonosis, the elimination of rhodesiense HAT as the total interruption of transmission of rhodesiense HAT is not feasible at this time.


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Number of cases reported

Gambiense HAT elimination: Progression

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Geographical extent of the disease

Towards elimination of human African trypanosomiasis (HAT ( DNDi Symposium, ASTMH‘ New Orleans , November 5, 2014

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Population at risk

Total: 52.7 million

4.1

14.1

34.5

0

5

10

15

20

25

30

35

40

45

VH - H M L - VLno. p

erso

ns ×

106

2003 - 2007

1.6

10.9

42.5

0

5

10

15

20

25

30

35

40

45

VH - H M L - VL

no. p

erso

ns ×

106

2008 - 2012

Total: 55.0 million

Towards elimination of human African trypanosomiasis (HAT ( DNDi Symposium, ASTMH‘ New Orleans , November 5, 2014

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Gambiense HAT elimination strategy: Methods

There are four classical HAT control elements:

Active case-finding through mobile teams

Passive case-finding integrated in fixed health

facilities

Vector control to reduce tsetse populations

Management of detected cases


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Gambiense HAT elimination strategy: Methods

There are four classical HAT control elements: - Active case-finding through mobile teams, - Passive case-finding integrated in fixed health facilities, - Vector control to reduce tsetse populations, - Management of detected cases.

The strategy has to be flexible and dynamic enough to be adapted to: - the disease progress

- the changes affecting the local health services.

- The social changes in the population

- the new tools and the results of the researchers


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Country Progress Meeting

Gambiense network

Implementation Coordination Group

Development of new tools. Integration of new

tools into national and global policies.

Operational research

coordination

Ad-hoc country coordination

WHO Network for HAT elimination

Scientific Consultative Group

Rhodesiense network

Country Progress Meeting

Development of new tools and integration

into national policies.

Ad-hoc country coordination

Implementation Coordination Group

Aiming to achieve HAT elimination - DNDi · Towards elimination of human African trypanosomiasis...

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