Aim
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This article and any supplementary material should be cited as follows: Ivey FM, Katzel LI, Sorkin JD, Macko RF, Shulman LM. The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function. J Rehabil Res Dev. 2012;49(8):1269–76. http://dx.doi.org/10.1682/JRRD.2011.06.0103 Slideshow Project DOI:10.1682/ JRRD.2011.06.0103JSP The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function Frederick M. Ivey, PhD; Leslie I. Katzel, MD, PhD; John D. Sorkin, MD, PhD; Richard F. Macko, MD; Lisa M. Shulman, MD
description
The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function. Frederick M. Ivey, PhD; Leslie I. Katzel, MD, PhD; John D. Sorkin, MD, PhD; Richard F. Macko, MD; Lisa M. Shulman, MD. Aim - PowerPoint PPT Presentation
Transcript of Aim
This article and any supplementary material should be cited as follows: Ivey FM, Katzel LI, Sorkin JD, Macko RF, Shulman LM. The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function. J Rehabil Res Dev. 2012;49(8):1269–76. http://dx.doi.org/10.1682/JRRD.2011.06.0103
Slideshow ProjectDOI:10.1682/JRRD.2011.06.0103JSP
The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory
functionFrederick M. Ivey, PhD; Leslie I. Katzel, MD, PhD; John D. Sorkin,
MD, PhD; Richard F. Macko, MD; Lisa M. Shulman, MD
This article and any supplementary material should be cited as follows: Ivey FM, Katzel LI, Sorkin JD, Macko RF, Shulman LM. The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function. J Rehabil Res Dev. 2012;49(8):1269–76. http://dx.doi.org/10.1682/JRRD.2011.06.0103
Slideshow ProjectDOI:10.1682/JRRD.2011.06.0103JSP
• Aim– Assess utility of Unified Parkinson’s Disease Rating Scale
(UPDRS) for predicting peak aerobic capacity (VO2 peak) and ambulatory function.
• Relevance– UPDRS is widely applied disease severity index but
doesn’t assess cardiovascular fitness and provides only limited information on functional performance.
– Therefore, there is value in determining predictive power of UPDRS for more time-consuming and resource-intensive measures such as VO2 peak and ambulatory function.
This article and any supplementary material should be cited as follows: Ivey FM, Katzel LI, Sorkin JD, Macko RF, Shulman LM. The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function. J Rehabil Res Dev. 2012;49(8):1269–76. http://dx.doi.org/10.1682/JRRD.2011.06.0103
Slideshow ProjectDOI:10.1682/JRRD.2011.06.0103JSP
Method
• 70 participants were evaluated: – UPDRS (Total and Motor ratings).– VO2 peak.– 6-minute walk distance (6MW).– 30-foot self-selected walking speed (SSWS).
• We determined how well Total and Motor UPDRS scores predicted each functional capacity measure.
• We also tested whether adding Hoehn & Yahr scale (H-Y) changed UPDRS’s predictive power.
This article and any supplementary material should be cited as follows: Ivey FM, Katzel LI, Sorkin JD, Macko RF, Shulman LM. The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function. J Rehabil Res Dev. 2012;49(8):1269–76. http://dx.doi.org/10.1682/JRRD.2011.06.0103
Slideshow ProjectDOI:10.1682/JRRD.2011.06.0103JSP
Results
• Adjusted for age and sex, both Total and Motor UPDRS subscales failed to predict VO2 peak.
• Total UPDRS weakly predicted 6MW and SSWS (p < 0.05)
• Motor UPDRS subscale didn’t predict these ambulatory function tests.
• After adding H-Y to model, Total UPDRS was no longer independent predictor of 6MW but remained predictor of SSWS.
This article and any supplementary material should be cited as follows: Ivey FM, Katzel LI, Sorkin JD, Macko RF, Shulman LM. The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function. J Rehabil Res Dev. 2012;49(8):1269–76. http://dx.doi.org/10.1682/JRRD.2011.06.0103
Slideshow ProjectDOI:10.1682/JRRD.2011.06.0103JSP
Relationship between total UPDRS and (a) 6MW or (b) SSWS.
Modest but significant relationship disappeared after adding Hoehn and Yahr to model for (a) but not (b).
This article and any supplementary material should be cited as follows: Ivey FM, Katzel LI, Sorkin JD, Macko RF, Shulman LM. The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function. J Rehabil Res Dev. 2012;49(8):1269–76. http://dx.doi.org/10.1682/JRRD.2011.06.0103
Slideshow ProjectDOI:10.1682/JRRD.2011.06.0103JSP
Conclusion
• Total and Motor UPDRS rating scales do not predict VO2 peak
• But weak relationship exists between Total UPDRS and measures of ambulatory function.
