AHS13 Victoria Prince Fatty Liver -- Is It the Fat's Fault?

download AHS13 Victoria Prince Fatty Liver -- Is It the Fat's Fault?

If you can't read please download the document

Embed Size (px)

Transcript of AHS13 Victoria Prince Fatty Liver -- Is It the Fat's Fault?

  • 1. Fatty Liver: Is it the (dietary) fats fault?Victoria Prince PhD, MSIV

2. Fatty Liver Disease 2 hit theory 3. Fatty Liver disease ControlAlcohol-fed 4. How does the fat get there? Major Factors Alcohol Sugars Fats Synthesis Nutrient Deficiency Export Vitamin D (?) Metabolism Microbiota InflammationCohen et al 2011 5. Models of Fatty Liver Disease Earliest research focused on alcoholic fatty liverDiets require large amounts of dietary fat to produce effects.Lieberet al 2007 Lieber et al 2007 6. But what about humans? 1986- French and Nanji Cirrhosis positively correlated with dietarypolyunsaturated fats Cirrhosis negatively associated with dietary saturated fats and cholesterol 1989- Beef Fat Prevents Alcoholic Liver Diseasein the Rat The correlation between the degree of histological abnormality and the linoleic acid content of the diet strongly implicates linoleic acid as an essential factor in the development of ALD. Nanjiet al 1989 7. Non-Alcoholic Fatty Liver Disease Diets high in corn oil cause fatty liver. Replacing corn oil with medium chain fats reverses thecondition.Roniset al 2013 8. Whats going on Fats for fuel vs. fats for function Essential Fatty AcidsEssential good fuel 9. Whats the problem: fuel vs. function Problems with PUFA Increased Reactive Oxygen Species Production High peroxidation potential Liver-saving Saturated Fats Easy in easy out- no first hit Increased Metabolism Better Gut Integrity Lower inflammation 10. Fish oil- a case study in fuel vs. function Deficiency in long chain 3s associated with FattyLiver Disease. Supplementation with fish oil reversed fatty liver in some patients. BUT experimental models using large proportions of fish oil led to increased histopathology ROS production PeroxidizabilityCell-signaling Insulin sensitizing effects 11. Pulling it all together Is it the fats fault? What might we do with this information? 12. Thank youPrincipleIntoPractice.com