7/30/2019 AHF Infographic

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34%

Acute heart failure (AHF) is a lifethreatening condition where

the heart cannot pump enoughblood around the body

Patients rushed tothe emergency room

for urgent treatment45

Most common cause ofhospitalization in patients

over 65 years1,6,7WHAT IS AHF?

ACUTE HEART FAILURE IS ASSOCIATED WITH HIGH

MORTALITY AND IRREPARABLE DAMAGE TO MAJOR ORGANS

SIGNS & SYMPTOMS23

DOWNWARD SPIRAL

The condition is often FATALwhen patients have one

or repeated acuteheart failure episodes1

of patientsdo not survive the

initial episode8

Every episode results inworsening health and damage

to vital organs, such as theheart and kidneys, whichdecreases the chance of

the patient survivinganother episode1,4,7

It felt like I was drowning

2030%of patients die within

1 year after experiencingan AHF episode2,913

REFERENCES1. Zannad F. et al, Heart failure burden and therapy, Europace 2009, 11; v1-v9. 2. Mosterd A, Hoes, A, Clinical epidemiology of heart failure, Heart2007;93:1137-1146.3. Irish Heart Foundation. Living well with heart failure patient booklet. http://www.irishheart.ie/media/pub/patient_-booklets/living_with_heart_failure.pdf. Accessed August 2013. 4. Gheorghiade M, Pang P, Acute heart failure syndromes, Journal of the American College of Cardiology2009; 53 (7):557-73. 5. Felker et al. Clinical trial of pharmacological therapies in acute heart failure syndromes, CircHeart Fail. 2010;3:314-325. 6. Healthcare Cost and Utilization P roject 2009 (http://www.hcup-us.ahrq.gov/reports/factsandfigures/2009/pdfs/FF_2009_exhibit2_4.pdf). 7. Gheorghiade M et al, Rehospitalization for heart failure: problems and perspectives, Journal of the American Collegeof Cardiology2013, 61(4):391-403. 8. Weintraub et al. Acute heart failure syndromes: emergency department presentation, treatment, and disposition: current approaches and future aims: a scientific statement from the American Heart Association. Circulation. 2010; 122:1975-1996.9. Harrisons Principles of Internal Medicine, Seventeenth Edition pages 1442 1455. 10. Hunt S et al. Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of CardiologyFoundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation. Circulation. 2009;119:e391-e479. 11. Lloyd-Jones et al. Heart disease and stroke statistics--2010 update: a report fromthe American Heart Association. Circulation. 2010;121:e46-215. 12. National heart failure audit: April 2010 March 2011, NICOR and The British Society for Heart Failure, commissioned by the Healthcare Quality Improvement Partnership (HQIP). 13. OConnor M et al. Causes of death andrehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: Results from efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan (EVEREST) program, American Heart Journal2010;159(5): 842-849.14. Novartis data on file, approximately 1.86 million diagnosed events in the US and 1.6 million in the top 5 EU markets.

Severe breathlessness1

Rapid weight gain2

Fluid build-up in the

lungs and aroundthe body

3

~3.5 millionAHF episodes happen each year

in the US and EU alone4,14