Aging kidney-structural-and-functional-changes ayman seddik
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Transcript of Aging kidney-structural-and-functional-changes ayman seddik
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Dr Ayman Seddik , Msc , MD
Assistant Professor of Nephrology Ain Shams University , Consultant nephrologist
Dubai Hospital , Dubai Hospital Dubai Health Authority
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OUTLINE 1. Prevalence of CKD and other comorbidties with
aging
2. Our kidneys and aging structural and functional changes
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Hilary Cronin and Rose Anne Kenny
Part 2: The Aging Kidneys Morphological and Functional Changes
Gross granularity and pitting of the external surface
Loss of Mass & Loss of Function But with preserved homeostasis
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Diabetes prevalence in the aging
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Hypertension and the aging
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High cholesterol and statin use in the aging
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Prevalence of Chronic Kidney Disease (CKD) Stages by Age Group in NHANES 1988-1994 and 1999-2004
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Effects of CKD on mortality and cardiovascular disease in the elderly - mean 75yr
0
1
2
3
4
5
6
7
8
All cause
death
CV death Non-CV
death
Heart failure MI Stroke
Ev
en
ts/1
00
yrs
Normal kidney function
CKD 1-2
CKD 3-5
Shilpak at al Ann Int Med 2006;145:237
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Baseline eGFR threshold below which risk for ESRD exceeded risk for death for each age group
O’Hare 2007 JASN 18: 2758–2765
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.,
Sir William Osler, M.D 1849 -1919
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The Hallmarks of the Aging Kidney Intimal Thickening
of Interlobular Artery Hyaline Atherosclerosis Reduplication of
Internal Elastica Lamina
Glomerulosclerosis, Tubular Atrophy, Vascular Changes
Hypertrophic Glomerulus, Compensating for Obsolete Ones
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KI (2008) 74, 710–720
Global glomerulosclerosis
Moderate IF/TA
Arteriolar reveal hyalinosis
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• Age‐associated
decrease in GFR
is due to
reduction in RPF
and in Kf (UF
coef)
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Factors that mediate and moderate age-related
glomerulosclerosis and tubulointerstitial fibrosis.
Brenner and Rector's The Kidney, 9th ed.
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CONCLUSION
In conclusion, a large and growing number of elderly people meet criteria for CKD. However, many of these patients are less likely than their younger counterparts with similar levels of renal function to progress to ESRD.
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CONCLUSION HOWEVER a subset of older patients with CKD will
EVENTUALLY progress to ESRD and these individuals account for a growing proportion of the ESRD population.
Thus, a major challenge for nephrologists is to somehow identify the small proportion but large and growing number of older patients with CKD who are most likely to experience progressive loss of renal function and benefit from aggressive efforts to slow progression and to prepare for ESRD management .
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