OsteoWarriors HQ Happenings(page 8)

AGENDA: THURSDAY, FEBRUARY 27TH10:00 AM - 4:00 PMAMBASSADOR AGENT TRAINING Ambassador Agent Training lunch from 12-12:30 PM

12:00 - 6:00 PMREGISTRATION OPENS Near the hotel lobby

4:00 - 4:30 PMMIB FAMILY FUND HOLDERS MEETINGBy invitation only

4:30 - 5:00 PMCOOPERATIVE OSTEOSARCOMA FUNDRAISING All registered FACTOR guests are welcome

5:00 - 6:00 PMWELCOME RECEPTION All registered FACTOR guests are welcome

5:00 - 5:20 PMOSTEOWARRIOR VS. DOCTOR CHALLENGE All registered FACTOR guests are welcome

6:00 PMDINNER ON OWN - KITCHEN WESTMIB section available for community dining

6:15 PMSHUTTLE DEPARTURE FOR SPEAKER DINNERMeet at the McDowell Building

7:00 - 9:00 PMSPEAKER DINNER Off-site at Wrigley Mansion Sponsored by the Childhood Cancer Project

CORONADO I, II, III

CORONADO IV

CORONADO V

BENNIE’S COURTYARD

SUNSET/ PALM COURT

VISTA VERDE

MCDOWELL MERCANTILE

GARDEN COURT

PARADISE LAWN PARK

COMMUNITY LAWN

SUNSET PLAZA

COMMUNITY LAWN

6:45 - 7:45 AM BREAKFAST AND REGISTRATION Sponsored by St. Baldrick’s

8:00 - 8:10 AMWELCOME AND OPENING REMARKSAnn Graham, MIB AgentsMatteo Trucco, MD, MIB Agents, Cleveland Clinic

8:10 - 8:20 AMSESSION 1: NEW TARGET AND APPROACHESJoshua Schiffman, MD University of Utah, Huntsman Cancer Institute

8:20 - 8:40 AMOUTSMARTING OS WINNER 2017 - EP53 PROTEIN LOADED NANOPARTICLE FOR OS - UPDATEJoshua Schiffman, MD University of Utah, Huntsman Cancer Institute

8:40 - 9:00 AMTARGETING IGF2R IN OS WITH RADIOIMMUNOTHERAPY - COMPARATIVE ONCOLOGY APPROACH Ekatarina Dadachova, PhDUniversity of Saskatchewan, Fedoruk Center for Nuclear Innovation

9:00 - 9:20 AMMAKING THE MOST OF TISSUE SAMPLES TO SUPPORT RESEARCH AND CLINICAL CAREAlanna Church, MD, MSc, FRCPCHarvard Medical School, Boston Children’s Hospital

9:20 - 9:40 AM POSTER SESSION* & BREAK Sponsored by OS Collaborative

9:40 - 10:00 AMUHRF1 AS A THERAPEUTIC TARGET IN OSClaudia Benavente, PhDUniversity of California, Irvine, Chao Comprehensive Cancer Center

10:20 - 10:40 AMCOUNT ME IN; LAUNCHING THE OS PROJECTCorrie Painter, PhDThe Broad Institute of MIT & Harvard, Count Me In

10:40 - 11:00 AMMAKE THE WANDERING TUMOR CELLS UNCOMFORTABLERyan D. Roberts, MD, PhDNationwide Children’s Hospital

11:00 - 11:10 AMPANEL DISCUSSIONModerator: Schiffman Dadachova, Church, Benavente, Painter, Roberts

11:10 - 11:20 AM GROUP PHOTO

11:20 - 12:30 PM LUNCH Sponsored by Matthew Lehrman Osteosarcoma Fund

12:30 - 12:40 PMSESSION 2: NEW CHEMOTHERAPY TRIALS FOR OSRichard Gorlick, MDUniversity of Texas at MD Anderson, Children’s Cancer Hospital

12:40 - 1:00 PMOUTSMARTING OS WINNER 2018 - DISULFIRAM TO OVERCOME CHEMOTHERAPY RESISTANCE IN SARCOMASMatteo Trucco, MDCleveland Clinic, Children’s Cancer Innovative Therapy Program

1:00 - 1:20 PMCHILDREN’S ONCOLOGY GROUP OS CLINICAL TRIALS PAST, PRESENT, AND FUTUREKatherine A. Janeway, MD, MMScHarvard Medical School, Dana-Farber/Boston Children’s Cancer

1:20 - 1:40 PMTOWARD GENOME-INFORMED COMBINATION THERAPY FOR OSAlejandro Sweet-Cordero, MDBenoiff UCSF, University of California, San Francisco

1:40 - 2:00 PMEUROPEAN CLINICAL TRIALS & APPROACHES TO OSStefan Bielack, MDStuttgart Cancer Center

2:00 - 2:20 PMIMPACT OF ADJUVANT SIROLIMUS ON METASTATIC PROGRESSION IN CANINE OSAmy LeBlanc, DVMNational Cancer Institute’s Comparative Oncology Program

2:20 - 2:40 PMREGULATORY LANDSCAPE AND IT’S IMPACT ON PHARMACEUTICAL COMPANY’S APPROACH TO PEDIATRIC CLINICAL TRIALSMark Kieran, MD, PhDBristol-Myers Squibb

2:40 - 2:50 PMPANEL DISCUSSIONModerator: Gorlick Trucco, Janeway, Sweet-Cordero, Bielack, LeBlanc, Kieran

2:50 - 3:10 PM POSTER SESSION* & BREAK Sponsored by MSK Kids, Memorial Sloan Kettering Cancer Center

3:10 - 3:20 PMSESSION 3: OUTSMARTING OSTEOSARCOMA FINALISTSJohn Healey, MDMemorial Sloan Kettering Cancer Center

3:20 - 3:40 PMCLONALITY AND MECHANISMS OF RESISTANCE TO TARGETED THERAPY IN OSRichard Gorlick, MDUniversity of Texas at MD Anderson, Children’s Cancer Hospital

3:40 - 4:00 PMMODELING AND TARGETING MYC-DRIVEN OSJason Yustein, MD, PhDBaylor College of Medicine, Texas Children’s Cancer Center

4:00 - 4:20 PMDEFINING THE IMMUNE ATLAS IN OS LUNG METASTASESJ. Andrew Livingston, MD, MSUniversity of Texas at MD Anderson, Children’s Cancer Hospital

4:20 - 4:30 PMCLOSING REMARKSMatteo Trucco, MDMIB Agents Cleveland Clinic, Children’s Cancer Innovative Therapy Program

END OF SESSIONS - VOTING FOR OUTSMARTING OS WINNER NOW OPEN THROUGH SATURDAY AT NOON

6:00 - 7:00 PMBEREAVED PARENT’S SESSIONSandra Howlett, EdD

7:00 - 9:00 PMBEREAVED PARENT’S DINNERPrivate Event, Prayer by Deacon Smith

7:10 - 9:10 PM DINNERAll registered FACTOR guests are welcome Prayer by Deacon Smith

*Poster Session sponsored by Vuja De Sciences

AGENDA: FRIDAY, FEBRUARY 28TH

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AGENDA: SATURDAY, FEBRUARY 29TH6:45 - 7:45 AM BREAKFAST

8:00 - 8:05 AMOPENING REMARKSMatteo Trucco, MD, MIB Agents, Cleveland Clinic

8:05 - 8:10 AMSESSION 4: INTRODUCTION OF KEYNOTE SPEAKER ALEX HUANG, MD, PHDMatteo Trucco, MDCleveland Clinic, Children’s Cancer Innovative Therapy Program

8:10 - 8:30 AMKEYNOTE SPEECH: OUTSMARTING OS 2019 WINNER - CONDITIONING THE IMMUNE ENVIRONMENT FOR EFFECTIVE THERAPIES FOR METASTATIC PULMONARY OSAlex Huang, MD, PhDCase Western Reserve University School of Medicine, Rainbow Babies & Children’s Hospital

8:30 - 8:40 AMKEYNOTE SPEECH: Q & AAlex Huang, MD, PhDCase Western Reserve University School of Medicine, Rainbow Babies & Children’s Hospital

8:40 - 9:00 AM POSTER SESSION* & BREAK

9:00 - 9:10 AMSESSION 5: IMMUNOTHERAPY & MICROENVIRONMENT/ METASTATIC DISEASEAlex Huang, MD, PhDCase Western Reserve University School of Medicine, Rainbow Babies & Children’s Hospital

9:10 - 9:30 AMCAR-T CELL THERAPY FOR OS AND PEDIATRIC SOLID TUMORSRobbie Majzner, MDStanford University, Stanford University Medical Center

9:30 - 9:50 AMTUMOR VACCINE FOR CANINE OSBrian K. Flesner, DVM, DACVIMUniversity of Missouri, College of Veterinary Medicine

9:50 - 10:10 AMDC VACCINE AND TGFB AS IT MAY RELATE TO OSJohn Letterio, MDCase Western Reserve University School of Medicine, Rainbow Babies & Children’s Hospital

10:10 - 10:30 AMEMERGING CELLULAR THERAPIES FOR OSKris Mahadeo, MD, MPHUniversity of Texas at MD Anderson, Children’s Cancer Hospital

10:30 - 10:40 AMPANEL DISCUSSIONModerator: HuangMajzner, Flesner, Letterio, Mahadeo

10:40 - 11:35 AMSESSION 6: ALL THINGS MIB AGENTSLiz Vallejo, Casey Crossan, Maureen Smart, LCSW, Sean Brosnan, Bentley Dyer, Tim Songster, Matthew Allen, Alexis Johnson, Ryan Kennington, and Christina Ip-TomaMIB Agents

11:35 - 12:45 PM LUNCH

12:45 - 1:00 PMSESSION 7: THE OS INSTITUTE: WHO WE ARE, WHAT WE DO, AND WHERE WE ARE GOINGLee Helman, MDUSC Keck School of Medicine, Children’s Hospital of Los Angeles

1:00 - 1:20 PMTARGETING METASTATIC DEPENDENCIES IN OSPeter Scacheri, PhDCase Western Reserve University

1:20 - 1:40 PMCD73 - THE NEXT IMMUNOTHERAPY TARGET IN OSJ. Andrew Livingston, MD, MSUniversity of Texas at MD Anderson, Children’s Cancer Hospital 1:40 - 2:00 PMGENOME-INFORMED COMBINATION THERAPY IN OSKatherine A. Janeway, MD, MMScHarvard Medical School, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center

2:00 - 2:10 PMPANEL DISCUSSIONModerator: Helman Scacheri, Livingston, Janeway

2:10 - 2:30 PM POSTER SESSION* & BREAK

2:30 - 2:40PMSESSION 8: SUPPORTIVE CARE AND MINIMIZING TOXICITYPeter Anderson, MD, PhD Cleveland Clinic, Children’s Cancer Innovative Therapy Program

2:40 - 3:00 PMPARENTAL REGRET, DECISION MAKING AND COMMUNICATIONBryan Sisk, MD Washington University School of Medicine 3:00 - 3:20 PMSURGICAL DECISION AID FOR THE TREATMENT OF OS IN THE LOWER EXTREMITYJanet Panoch, MA Amputee Colilition 3:20 - 3:40 PMSURVIVING AND THRIVING: PHYSICAL AND OCCUPATIONAL THERAPY FOR PATIENTS WITH OSChristine Zwick, DPT & Chelsea Derkacz, OTR Nemours/Alfred I. duPont Hospital for Children

3:40 - 4:00 PMCARING FOR THE HEALTHCARE TEAM Kate Eshelman, PsyD Cleveland Clinic Children’s Hospital 4:00 - 4:20 PMPROMOTING QOL OUTCOMES FOR OS PATIENTS THROUGH SMART AUDIO COMPANIONSHIPSimon Holland Elly Health 4:20 - 4:30 PMPANEL DISCUSSION Moderator: AndersonSisk, Panoch, Zwick, Derkacz, Eshelman, Holland 4:30 - 4:40 PMBELIEVE IN BETTERLauren RamerOsteoWarrior

4:40 - 4:55 PMSESSION 9: ANNOUNCEMENT OF OUTSMARTING OS WINNERMatteo Trucco, MD and MIB Family Fund Holders

4:55 - 5:00 PMCLOSING REMARKS Ann Graham and Matteo Trucco, MDMIB Agents

6:00 - 8:00 PMVOLUNTEER APPRECIATION AND OUTRUNNING OSTEOSARCOMA DINNERFee of $32.00 to attend

*Poster Session sponsored by Vuja De Sciences

AGENDA: SUNDAY, MARCH 1ST7:00 - 7:30 AM

OUTRUNNING OSTEOSARCOMA 5K REGISTRATIONAll runners

7:30 - 8:00 AMWARM UP AND STRETCH

All are welcome!

8:00 - 10:00 AMKID DASH AND 5K

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