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Advanced Czech Advanced Czech BBiotech: iotech:
Great pastGreat pastSad presentSad present
Promising futurePromising future
Peter ŠeboPeter ŠeboInstitute of Biotechnology
Academy of Sciences of the Czech Republic
Prague
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Great past:Great past:Used to be extremely strong in tradional biotechnology:Used to be extremely strong in tradional biotechnology:
Crop and animal breedingfermentation industryfermentation industry
• Famous Brewery tradition• Wine, ethanol, baker`s yeats production• Fodder yeast (Biocel Paskov)
Biotransformations:• Aminoacid production, cyclosporin A, ergot alcaloids• Vitamines, food additives etc.
Among pioneers of antibiotics production (penicilin)Among pioneers of antibiotics production (penicilin)
World famous school of continous culture technology World famous school of continous culture technology (at Institute of Microbiology of the Academy of Sciences)
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Sad present:Sad present:• Lagging behind in cuttingLagging behind in cutting--edgeedge biological research biological research
• LLimited imited and noncompetitive and noncompetitive advanced biotech researchadvanced biotech research
• Almost inextisting advanced biotech intellectual propertyAlmost inextisting advanced biotech intellectual property
• Absence and poor interest of venture capital Absence and poor interest of venture capital
• Minimal Minimal sizesize of advanced biotech industry of advanced biotech industry
4 real companies: 4 real companies: Lonza, Baxter, Contipro, ExbioLonza, Baxter, Contipro, Exbio
• Extremely limiteExtremely limited R&D in advanced biotechd R&D in advanced biotech
• Low numbers of high-tech biotech SMELow numbers of high-tech biotech SME3
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Czech advanced biotech – overall description
• 43 biotech companies*• Most companies located in
Prague and Brno metropolitan areas
• Directly employed**: 1800 -2200 people
• Combined yearly turnover**: 4-5 bil CZK (160-200 mil Euro)
• Average yearly growth rate**: 12-16%
* - traditional biotech and foreign trade representations excluded **- estimation based on a incomplete datasetsource of data: Czech Biotech Report 2008, Ernst&Young presentation at G2B conference 2006, company data in public domain
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* - traditional biotech and foreign trade representations excluded **- estimation based on a incomplete datasetsource of data: Czech Biotech Report 2008, Ernst&Young presentation at G2B conference 2006, company data in public domain
No of biotech companies* 43
Directly employed** 1800-2200
Combined yearly turnover**
4-5 bil CZK (160-200 mil Euro)
Average yearly growth rate** 12-16%
Czech advanced biotech – overall description
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Biotech companies – geographical distribution
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Selected biotech companies - Prague
Ascoprot Biotech SME (5 p.) rec. proteinsSME (5 p.) rec. proteinsBIOPREPARÁTY biological plant protectionbiological plant protectionGeneAge Technologies expression profilingexpression profilingGenomac International sequencing/genotypingsequencing/genotypingLentiKat waste water trwaste water treatmenteatment R R&D&D Top-Bio molecular biolmolecular biol.. kits producer SME ( kits producer SME (<5)<5)
Ascoprot Biotech SME (5 p.) rec. proteinsSME (5 p.) rec. proteinsBIOPREPARÁTY biological plant protectionbiological plant protectionGeneAge Technologies expression profilingexpression profilingGenomac International sequencing/genotypingsequencing/genotypingLentiKat waste water trwaste water treatmenteatment R R&D&D Top-Bio molecular biolmolecular biol.. kits producer SME ( kits producer SME (<5)<5)
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Sel. biotech companies – Central Bohemia
AppGenics SME , transgenic rabbits, hEPO SME , transgenic rabbits, hEPO recombinant recombinant
proteinsproteinsApronex SME, recombinant proteinsSME, recombinant proteins (4 p)(4 p) Baxter Czech flu vaccine production siteflu vaccine production site Biologicals SME, forensics, HCV-Y-ScreenSME, forensics, HCV-Y-ScreenEXBIO SME, Mab and reagent producer SME, Mab and reagent producer Lonza Biotec fermentation fermentation plant and R&D plant and R&D
FDA-registered pharma enzymesFDA-registered pharma enzymesProteix SME, recombinant proteins (3 p)SME, recombinant proteins (3 p)rEcoli SME,SME, recombinant proteinsrecombinant proteinsVIDIA SME, clinical diagnostic kitsSME, clinical diagnostic kits
AppGenics SME , transgenic rabbits, hEPO SME , transgenic rabbits, hEPO recombinant recombinant
proteinsproteinsApronex SME, recombinant proteinsSME, recombinant proteins (4 p)(4 p) Baxter Czech flu vaccine production siteflu vaccine production site Biologicals SME, forensics, HCV-Y-ScreenSME, forensics, HCV-Y-ScreenEXBIO SME, Mab and reagent producer SME, Mab and reagent producer Lonza Biotec fermentation fermentation plant and R&D plant and R&D
FDA-registered pharma enzymesFDA-registered pharma enzymesProteix SME, recombinant proteins (3 p)SME, recombinant proteins (3 p)rEcoli SME,SME, recombinant proteinsrecombinant proteinsVIDIA SME, clinical diagnostic kitsSME, clinical diagnostic kits
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Sel. biotech companies – South Moravia
BioVendor SME, recombinant proteins, diagnosticsSME, recombinant proteins, diagnosticsBioveta veterinary vaccines Rveterinary vaccines R&D and production&D and productionEnantis SME, recombinant dehalogenasesSME, recombinant dehalogenases
contract research in protein engineering contract research in protein engineering EPS SME, bioremediation, biogas Moravian-Biotechnology SME, custom antibody servicesSME, custom antibody servicesTEST-LINE SME, human and veterinary diagnosticsSME, human and veterinary diagnostics
BioVendor SME, recombinant proteins, diagnosticsSME, recombinant proteins, diagnosticsBioveta veterinary vaccines Rveterinary vaccines R&D and production&D and productionEnantis SME, recombinant dehalogenasesSME, recombinant dehalogenases
contract research in protein engineering contract research in protein engineering EPS SME, bioremediation, biogas Moravian-Biotechnology SME, custom antibody servicesSME, custom antibody servicesTEST-LINE SME, human and veterinary diagnosticsSME, human and veterinary diagnostics
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Sel. biotech companies – remaining regions GENERI BIOTECH SME, oligonucleotides, SME, oligonucleotides,
DNA DNA genotyping servicesgenotyping servicesContipro Group world leader in hyaluronic acidGMP recombinant defensins, wound healing GMP recombinant defensins, wound healing R&D R&D
GENERI BIOTECH SME, oligonucleotides, SME, oligonucleotides, DNA DNA
genotyping servicesgenotyping servicesContipro Group world leader in hyaluronic acidGMP recombinant defensins, wound healing GMP recombinant defensins, wound healing R&D R&D
AgroBio agrochemicals and agrobiologicalsBiocel pulp industry – fodder yeast pulp industry – fodder yeast producerproducer IVAX Pharmaceuticals , generics, ergot alcaloidsOlChemIm SME, phytohormones, antibodies (5 SME, phytohormones, antibodies (5 p)p)
AgroBio agrochemicals and agrobiologicalsBiocel pulp industry – fodder yeast pulp industry – fodder yeast producerproducer IVAX Pharmaceuticals , generics, ergot alcaloidsOlChemIm SME, phytohormones, antibodies (5 SME, phytohormones, antibodies (5 p)p)
B.P.Medical SME,SME, bioactivity testingbioactivity testing ENVISAN-GEM bioremediation GEN-TREND SME, diagnostics and SME, diagnostics and proteinsproteins
B.P.Medical SME,SME, bioactivity testingbioactivity testing ENVISAN-GEM bioremediation GEN-TREND SME, diagnostics and SME, diagnostics and proteinsproteins
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Promising futurePromising future::• Government recognizes the problem Government recognizes the problem
Advanced biotechnology and molecular biology among strategic longterm Advanced biotechnology and molecular biology among strategic longterm research orientations research orientations - funding schemes- funding schemes
More funds than competent individuals and teams available…More funds than competent individuals and teams available…
•Good culture, education, enough PhDs, qualified manpowerGood culture, education, enough PhDs, qualified manpower
•National applied research support schemes (NPV )National applied research support schemes (NPV )
• Incentives for Academia collaborations with IndustryIncentives for Academia collaborations with Industry
• ERDF funds for OP R&D for Innovation and Enterprise for Innovation / pert of ERDF funds for OP R&D for Innovation and Enterprise for Innovation / pert of going to biotechgoing to biotech
• Institute of Biotechnology AS CR, v.v.i. founded on January 1, 2008Institute of Biotechnology AS CR, v.v.i. founded on January 1, 2008
• BIOCEV, CEITEC and several other major projects in preparationBIOCEV, CEITEC and several other major projects in preparation
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Biotech research - geographical distribution
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University students vs. life science students:geographical distribution
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CentersCenters of b of biotech iotech research research at Universities at Universities • Centre of Integrated Genomics: AS CR, Charles University
Institute of Chemical Technology – genomes, gene expression
• Genomics of animals: Veterinary and Pharmaceutical University Brno, South Bohemian - genomics of farm animals
• Centre of Proteomics : Military Academy in Hradec Králové
• Centre for Biocatalysis and Biotransformation: AS CR, Masaryk University, South Bohemian University – enzyme engineering
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• Centre for Molecular and Gene Biotechnology: AS CR, ICT, 5 companies – biosynthesis, biotranformation proteins
• Centre for Research of Structure and Mechanism of Action of Potential Drugs: School of Pharmacy, Hradec Králové + companies – gene therapies, biologically active substances
• Medicinal and pharmaceutical chemistry: Palacky University Olomouc – biologically active plant substances
CentersCenters of b of biotech iotech research research at Universities at Universities
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Since 2005 – major investments at Masaryk University
ILBIT
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Academy of Sciences
17
• Leading basic research institution of CR
• Funded from state budget mainly
• ~6400 employees, >50% university graduates and PhDs
• Not a University – Network of 60 institutes
All transformed to Public Research Institutes by January 1, 2007
http://www.cas.cz/en
Basic Facts and Mission of the ASCR
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Flemingovo nám. 2Prague 6, CZ-16637Czech Republic
Phone: +420 220 183 111Fax: +420 224 310 955E-mail: [email protected]
http://www.img.cas.cz
New Institute's building to completed in 2007
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INSTITUTE OF MOLECULAR GENETICS AS CR
Molecular & Cell Biology
Molecular & Applied Immunology
Developmental Biology
Virology
Molecular Genetics
Recombinant proteins
Monoclonal antibodies
Cellular vaccines
Monoclonal antibodies
Unique mouse strains
Unique chicken inbreds
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Inhibition of HIV Protease by Bizarre CompoundsInhibition of HIV Protease by Bizarre Compounds
„WIDE-OPEN“ PROTEASE IN THE COMPLEX
HIV PR dimer + 2 carborane molecules + tetrapeptide
Co
= BH
= CH
Carboranes: Boron-containing polyhedral compounds
previously used in boron neutron capture therapy
Ki = 66 nM
X-ray structure
Cigler Cigler et al.et al. (2005) PNAS 102, 15394-9 (2005) PNAS 102, 15394-9
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Dr. Ladislav Andera
http://www.img.cas.cz/[email protected]
Cell signalling and apoptosis Cell signalling and apoptosis
TRAIL induces death of tumor cells
TRAIL is produced as soluble trimer
TRAIL-based drugs in combination with other cancer therapies
Apoptosis-inducing humanized monoclonal antibodies against TRAIL receptors DR4 and DR5
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Institute of Experimental MedicineInstitute of Experimental Medicine (IEM) (IEM)
Prof.Prof. Eva Sykova, DEva Sykova, D..Sc.Sc.
phone:phone: +420 296 442 230+420 296 442 230fax:fax: +420 296 442 782+420 296 442 [email protected]@biomed.cas.czhttp://uemweb.biomed.cas.cz http://uemweb.biomed.cas.cz
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Stem cell research at IEM
iron nanoparticles for in vivo iron nanoparticles for in vivo NNMR imagingMR imaging of stem cells of stem cells
Biodegradable hBiodegradable hydrogelydrogelss for stem cell ingrowth into hydrogel for stem cell ingrowth into hydrogel
implants implants
in spinal cord lesion reparationin spinal cord lesion reparation
Growth of olfactory glial ensheathing cellsGrowth of olfactory glial ensheathing cells
Establishing and characterizing human embryonic stem cells Establishing and characterizing human embryonic stem cells
(Dr. P. Dvorak – among the world(Dr. P. Dvorak – among the world`s `s leaders)leaders)
[email protected]@biomed.cas.czhttp://uemweb.biomed.cas.czhttp://uemweb.biomed.cas.cz
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Invasion of axons into the hydrogel implantedinto the spinal cord injury
Institute of Experimental Medicine ASCR
E. Sykova [email protected]
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Institute of Physiology & Centre of Cardiovascular Research
Videnska 1083, 142 20 Prague 4-Krc, Czech Republic
Phone: +420 2 9644 1111Fax: +420 2 4106 2488
E-mail: [email protected]
- Bioartificial vascular tissue prostheses
- Regionally-selective cell adhesion on micropatterned surface
- Bone tissue engineering on nanostructured materials
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Innovation of clinically used vascular prosthesesInnovation of clinically used vascular prostheses: : coating with extracellular matrix (ECM) molecules and endothelializationcoating with extracellular matrix (ECM) molecules and endothelialization
Endothelial cells grow and differentiate
On the inner surface, laminin or fibrin were immobilized
Inner surface
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Bone tissue engineering Human osteoblast-like MG 63 cells
in “three-dimensional“ porous scaffolds
Cells in depth ofCells in depth of::0 – 60 0 – 60 m (blue signal)m (blue signal) 80 80 – – 160 160 m (green) m (green) 180 – 220 180 – 220 m (yellow)m (yellow) 240 – 300 240 – 300 m (orange)m (orange)320 – 400 320 – 400 m (red)m (red) 420 – 480 420 – 480 m (violet)m (violet)
400 m______
Scaffolds made of lactide and glycolide a copolymer
Average pore size and depth ~400 µm
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Institute of Microbiology Institute of Microbiology
VidenskaVidenska 1083 1083CZ-142 20 Prague 4CZ-142 20 Prague 4Czech RepublicCzech Republic
phone: +420 296 442 341phone: +420 296 442 341fax: +420 296 442 201fax: +420 296 442 201e-mail:e-mail: mbu mbu@[email protected]
http://www.biomed.cas.cz/mbu/en/http://www.biomed.cas.cz/mbu/en/
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• Pioneered continous culture research in 60Pioneered continous culture research in 60`s…`s…
• microalgae cultivation biotechnologymicroalgae cultivation biotechnology
• Biotechnological pilot plantBiotechnological pilot plant
• Targeted polymeric drugsTargeted polymeric drugs
• Biotransformation of glycansBiotransformation of glycans
• Antigen delivery tools for immunotherapy and Antigen delivery tools for immunotherapy and diagnosticsdiagnostics
Institute of Microbiology Institute of Microbiology
http://www.biomed.cas.cz/mbu/en/http://www.biomed.cas.cz/mbu/en/
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Laboratory of Laboratory of Algae Algae BiotechnologyBiotechnology
• Isotopically labelled chemicals (13C, 15N, 2H)
• Bioactive compounds for pharmaceuticals, cosmetics and nutrition
• Solar bioreactors
http://www.alga.cz/en/http://www.alga.cz/en/
[email protected]@alga.cz
Pilot plant for microalgal biomass
www.greentech.cz
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Plasma membrane
Extracellularmatrix
Endosome
Intracellularfluid
Lysosome
Targeted cancerostatic drug actionTargeted cancerostatic drug action
rihovarihova@@biomed.cas.czbiomed.cas.cz
• Targeted therapy = Reduced side effects
• Stimulation of anti-cancer immunity
• Improved efficiency
• Much better survival of treated animals
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Antigen delivery tools inducing cellular immune response Antigen delivery tools inducing cellular immune response in vaccination, immunotherapy and diagnosticsin vaccination, immunotherapy and diagnostics
Proteasome
Endosome
MHC II peptide
CD4+ T cell
Transporter associated with antigen procesing
MHC I
MHC II
Golgi
Endoplasmatic reticulum
MHC I peptide
AC
AC AC
ACAC
Ca+
AC
RepeatsAC
Translocationinto cytosol
Insertedantigen
CD8+ T cell
Repeats
?
?
M2 integrin receptorCD11b/CD18
Ag
Ag
AgAg Ag
Ag
Antigen-specific T cells:Antigen-specific T cells:
P. Sebo P. Sebo http://l125lsx.mbu.cas.cz/Lab125/http://l125lsx.mbu.cas.cz/Lab125/ sebosebo@@biomed.cas.czbiomed.cas.cz
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Current status of antigen ACT delivery technologyCurrent status of antigen ACT delivery technologyIImmunity against virusmmunity against viruseses
Immunotherapy of transplanted tumors Immunotherapy of transplanted tumors
Protective immunity against Protective immunity against Plasmodium Plasmodium (mouse malaria model)(mouse malaria model)
Immunotherapy of Immunotherapy of experimental experimental tumorstumors (HPV16 – induced) (HPV16 – induced)
ImprovementImprovement of latent tuberculosis of latent tuberculosis diagnosing diagnosing
• PPhase I&II hase I&II clinical trial in preparation for:clinical trial in preparation for:
– melanoma melanoma treatementtreatement
– HPV16-induced cervical carcinomaHPV16-induced cervical carcinoma
((US PatentUS Patent No. 5,503,829 No. 5,503,829,, No No. . 5,679,7845,679,784,, No. 5,935,580 No. 5,935,580, , EU Patent applicationEU Patent application No. No. 03291486.303291486.3, , USUS Prov 03495, 6094 (2003)Prov 03495, 6094 (2003) ) )
http://l125lsx.mbu.cas.cz/Lab125/http://l125lsx.mbu.cas.cz/Lab125/ sebosebo@@biomed.cas.czbiomed.cas.cz
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INSTITUTE OF EXPERIMENTAL BOTANY
• Cytokinins as cell-division-inhibiting substances for cancer
treatment
• Sorted chromosomes for plant genomics
• Edible vaccines in plants
Phone: +420 220 390 453 Fax: +420 220 390 456 E-mail: [email protected]
www.ueb.cas.cz
Institute of Experimental Botany Institute of Experimental Botany Rozvojová 135 Rozvojová 135 165 00 Prague 6 - Lysolaje 165 00 Prague 6 - Lysolaje Czech Republic Czech Republic
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Senescent human fibroblasts treated (A) and untreated (B) with a cytokinin. Blue-green color is indicates ageing marker
Cytokinins Prevent Aging of Human and Plant Cells:Cytokinins Prevent Aging of Human and Plant Cells:
Synthesis and use of cytokinins and their synthetic analogs M. Strnad et.al. http://rustreg.upol.cz/
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IInhibitornhibitorss of cyclin-dependent kinases (CDK) of cyclin-dependent kinases (CDK) R-Roscovitine - R-Roscovitine - ((SSeliciclib)eliciclib)R R – phase II of clinical trials for cancer– phase II of clinical trials for cancer
C D K 2 / roscov itine co-c rys ta l
-Multiple myeloma
-B-cell Chronic Lymphocytic Leukemia
- Mantle Cell Lymphoma.
Phase II clinical trial for Non-Small Cell Lung Cancer treatment
M. Strnad et.al. http://rustreg.upol.cz/
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Institute of Biotechnology Institute of Biotechnology
Founded by Academy of Sciences Founded by Academy of Sciences January 1, 2008January 1, 2008
37
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IBTIBT seeding groups 2007-2010 seeding groups 2007-2010
• 2008: IBT/Sebo2008: IBT/SeboP. BartůněkP. Bartůněk - Chemical genetics- Chemical geneticsM. KubistaM. Kubista - Single cell expression profiling- Single cell expression profilingJ. NeužilJ. Neužil - Molecular and recombinant therapeutics- Molecular and recombinant therapeuticsJ. PěknicováJ. Pěknicová - Diagnostics for reproductive medicine- Diagnostics for reproductive medicineR. SedláčekR. Sedláček - Transgenic Animals- Transgenic AnimalsŠ. Růžičková Š. Růžičková - Diagnostics of autoimmune diseases - Diagnostics of autoimmune diseasesP. ŠeboP. Šebo - Recombinant binding proteins (ligands)- Recombinant binding proteins (ligands)
• 2009:2009:• G. PavlinkovaG. Pavlinkova - gene expression regulation in diabetic - gene expression regulation in diabetic
embryopathyembryopathy• New recruitmentsNew recruitments
• 20010 / 2011 Evaluation/new recruitements• 2012 Recruitement of new groupleaders
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S78E or S78A or S78G
A186F or A186Y or A186W
I166E or I166Q or I166N or I166D
Setting-up the ribosome display technology on the Setting-up the ribosome display technology on the model of Improvement of IFNmodel of Improvement of IFN receptor binding site receptor binding site
Calculations and rational design: J. Vondrášek
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Vestec at Prague
Regional development and competitiveness Regional development and competitiveness tthrough hrough promotion ofpromotion of cutting-edge biotechnology and cutting-edge biotechnology and
biomedical R&D in Czech Republicbiomedical R&D in Czech Republic
European Regional Development FundEuropean Regional Development FundOperational Program R&D for InnovationOperational Program R&D for Innovation
2007 - 20132007 - 2013
Biotech Biotech && Biomed Research CenterBiomed Research Center of Academy of Sciences and Charles Universityof Academy of Sciences and Charles University
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Biotech&Biomed Res. Center of Academy of Sciences and Charles University
20 000 m20 000 m2 2 of Rof R&&D facilitiesD facilities
450 researchers450 researchers
150 students and postdocs150 students and postdocs
~~100100 M M€€
2012 – the true START!2012 – the true START!
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Biotech&Biomed Res. Center of Academy of Sciences and Charles University
Center of Molecular BiotechnologiesCenter of Molecular Biotechnologies
Emphasis on:Emphasis on: protein research and protein research and
engineering engineering - - Structural BiologyStructural Biology
Openings for discovering new Openings for discovering new interesting molecules for therapy interesting molecules for therapy and diagnosticsand diagnostics
Processes for producing Processes for producing recombinant therapeutic and recombinant therapeutic and diagnostic proteins diagnostic proteins of extremely of extremely high added valuehigh added value
qRT/PCR for clinical and qRT/PCR for clinical and research applications research applications
Licensing to biotech companiesLicensing to biotech companies
Start-up and spin-off biotechsStart-up and spin-off biotechs
Transgenic cells, animals Transgenic cells, animals and plants and plants
Genetic manipulation of producing cells Genetic manipulation of producing cells
Culture techniques for bacteria and yeastsCulture techniques for bacteria and yeasts
AAdvanced cell culture techniquesdvanced cell culture techniques
Advanced biomacromolecule (protein) Advanced biomacromolecule (protein) separation and purificationseparation and purification
Cutting-edge biomacromolecule analysis and Cutting-edge biomacromolecule analysis and characterization methodscharacterization methods
SStructural biology and protein engineeringtructural biology and protein engineering
BBioinformatics and modelingioinformatics and modeling
Nanobiotechnologies – molecular motorsNanobiotechnologies – molecular motors
BiosensorsBiosensors
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Biotech&Biomed Res. Center of Academy of Sciences and Charles University
•Tissue engineering and therapies•Cellular therapies using stem cells •Immunobiology of stem cells•Application of stem cells in:
• neurology, cardiology, diabetology and hepatology•ophthalmology, stomatology a otolaryngology
•Stem cell use on scaffolds for bone and cartilage reconstruction•Biomaterials•Nanotechnologies for cell and tissue imaging•Nanotechnologies for therapy and diagnostics
Center of Regenerative Medicine
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Academy of SciencesPublic research institutes:
Charles University
BBinstitute of Biotechnologyinstitute of Biotechnology ((foundedfounded 1.1.2008) 1.1.2008)
Institute of PhysiologyInstitute of Physiology
Institute of MicrobiologyInstitute of Microbiology
Institute of Experimental MedicineInstitute of Experimental Medicine
Institute of macromolecular ChemistryInstitute of macromolecular Chemistry
Institute of Molecular GeneticsInstitute of Molecular Genetics
Faculty of ScienceFaculty of Science
11stst Medical School Medical School
Biotech&Biomed Res. Center of Academy of Sciences and Charles University
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Pros and cons for the future
Strong points Weak points
long tradition in classic biotechnology
lag in cutting-edge molecular biotechnology
established education system; well qualified and cheap manpower
insufficient interaction of academia with industry; brain-drain
improved infrastructure in R&D; restructuring research organizations
missing tradition of spin-offs; lack of managers trained in science
growing awareness on intellectual property protection in academia
lack of funding for patenting in academia; lack of venture capital
increasing funding to R&D; long-term funding
growing bureaucracy; complex rules for the use of funding
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Summary of pros and cons for the future
Strong points Weak points
long tradition in classic biotechnology Lagging behind in cutting-edge molecular biotechnologies
established education system; well qualified and cheap manpower
insufficient interaction of academia with industry; brain-drain
improved infrastructure in R&D; restructuring research organizations
missing tradition of spin-offs; lack of managers trained in science
growing awareness on intellectual property protection in academia
lack of funding for patenting in academia; lack of venture capital
increasing funding to R&D; long-term funding
growing bureaucracy; complex rules for the use of funding
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Strong points Weak points
long tradition in classic biotechnology Lagging behind in cutting-edge molecular biotechnologies
established education system; well qualified and affordable manpower
insufficient interaction of academia with industry; past brain-drain
improved infrastructure in R&D; restructuring research organizations
missing tradition of spin-offs; lack of managers trained in science
growing awareness on intellectual property protection in academia
lack of funding for patenting in academia; lack of venture capital
increasing funding to R&D; long-term funding
growing bureaucracy; complex rules for the use of funding
Summary of pros and cons for the future
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Strong points Weak points
long tradition in classic biotechnology Lagging behind in cutting-edge molecular biotechnologies
established education system; well qualified and affordable manpower
insufficient interaction of academia with industry; past brain-drain
improved infrastructure in R&D; restructuring research organizations
missing tradition of spin-offs; lack of managers trained in science
growing awareness on intellectual property protection in academia
lack of funding for patenting in academia; lack of venture capital
increasing funding to R&D; long-term funding
growing bureaucracy; complex rules for the use of funding
Summary of pros and cons for the future
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Strong points Weak points
long tradition in classic biotechnology Lagging behind in cutting-edge molecular biotechnologies
established education system; well qualified and affordable manpower
insufficient interaction of academia with industry; past brain-drain
improved infrastructure in R&D; restructuring research organizations
missing tradition of spin-offs; lack of managers trained in science
growing awareness on intellectual property protection in academia
lack of funding for patenting in academia; lack of venture capital
increasing funding to R&D; long-term funding
growing bureaucracy; complex rules for the use of funding
Summary of pros and cons for the future
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Strong points Weak points
long tradition in classic biotechnology Lagging behind in cutting-edge molecular biotechnologies
established education system; well qualified and affordable manpower
insufficient interaction of academia with industry; past brain-drain
improved infrastructure in R&D; restructuring research organizations
missing tradition of spin-offs; lack of managers trained in science
growing awareness on intellectual property protection in academia
lack of funding for patenting in academia; lack of venture capital
increasing funding to R&D; long-term funding
growing bureaucracy; complex rules for the use of funding
Summary of pros and cons for the future
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Special Thanks:Special Thanks:
Jiří DamborskýJiří Damborský
Michal KostkaMichal Kostka
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Contact:Contact:
[email protected]@biomed.cas.cz
Peter Sebo, PhD.Peter Sebo, PhD.
BIOCEV coordinatorBIOCEV coordinator
Institute of Biotechnology AS CR, v.v.i.Institute of Biotechnology AS CR, v.v.i.
Academy of Sciences of the Czech RepublicAcademy of Sciences of the Czech RepublicVidenska 1083Videnska 1083
142 20 Prague 4142 20 Prague 4Czech RepublicCzech Republic
GSM: (+420) 774 798 121GSM: (+420) 774 798 121office: (+420) 241 062 762office: (+420) 241 062 762
http://www.http://www.ibtibt.cas.cz.cas.cz
http://125lsx.mbu.cas.cz/Lab125/http://125lsx.mbu.cas.cz/Lab125/