Advanced Bone Grafting, Built on a Strong Foundation e m i n e r ali z e d r B o n e M a t r i x F...
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D e m i n e r a l i z e d B o n e M a t r i x ( D B M ) Smarter thinking. Simpler design. ™ Advanced Bone Grafting, Built on a Strong Foundation B o n e P r o t e i n s Accell ® combines DBM, Reverse Phase Medium (Poloxamer) with Accell Technology to create Accell Bone Matrix (ABM), a patented dispersed form of DBM which offers a significant increase in surface area providing access to natural bone proteins delivering osteoinductive propeties. • ABM is an open-structured, dispersed form of DBM, which provides immediate and sustained accessibility to bone proteins without the need to be broken down. • Meets the needs of challenging surgical applications where robust handling is essential • Delivered in an easy-to-use syringe—no mixing or special storage Accell vs. First Generation DBM after 4 weeks 1 Control Minimal bone regeneration observed at 4 weeks. Healing limited to area adjacent to host bone. Skeletally mature sheep model. Cylindrical 5 mm metatarsal defect created in tibial diaphysis. 1 st Generation DBM Bone regeneration occurs throughout the defect, caused by the presence of DBM particles. The inert carrier has been metabolized. (DynaGraft II ® ) More bone formation is evident immediately adjacent to the bone repair surfaces and within the interior of the defect. Accell delivers naturally- occurring growth factors. ® N a t u r a l l y O c c u r r i n g G r o w t h F a c t o r s ®
Transcript of Advanced Bone Grafting, Built on a Strong Foundation e m i n e r ali z e d r B o n e M a t r i x F...
Demineralized Bone M
atrix (DBM
)
Smarter thinking. Simpler design.™
Advanced Bone Grafting, Built on a Strong Foundation
Bone Proteins
Accell® combines DBM, Reverse Phase Medium (Poloxamer) with Accell Technology to create Accell Bone Matrix (ABM), a patented dispersed form of DBM which offers a significant increase in surface area providing access to natural bone proteins delivering osteoinductive propeties.
• ABM is an open-structured, dispersed form of DBM, which provides immediate and sustained accessibility to bone proteins without the need to be broken down.
• Meets the needs of challenging surgical applications where robust handling is essential• Delivered in an easy-to-use syringe—no mixing or special storage
Accell vs. First Generation DBM after 4 weeks1
ControlMinimal bone regeneration observed at 4 weeks. Healing limited to area adjacent to host bone.
Skeletally mature sheep model. Cylindrical 5 mm metatarsal defect created in tibial diaphysis.
1st Generation DBMBone regeneration occurs throughout the defect, caused by the presence of DBM particles. The inert carrier has been metabolized. (DynaGraft II®)
More bone formation is evident immediately adjacent to the bone repair surfaces and within the interior of the defect. Accell delivers naturally-occurring growth factors.
®
Naturally Occurring Grow
th Factors®
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The DBM is divided into two equal parts, and one part is entered into the Accell® process.
Step #1: DBM is dissolved using a proprietary process, creating a solution from which small collagen fragments, naturally occurring growth factors, and bone proteins are isolated and extracted.
Step #2: The extract is then combined with the DBM and Reverse Phase Medium, creating an advanced bone graft product.
E-Beam Sterilization: Every lot is sterilized using a low-dose electron beam, a process that has been shown to preserve the osteoinductive potential of DBM.2
Final Formulation
DBM
B A
AccellDBM
Solubilization
Lot Division
Final Product Con�guration
Sterilization
Soluble DBM
1. Effective Design of Bone Graft Materials Using Osteoinductive and Osteoconductive Compnents. Kay, JF; Khaliq; SA, Nguyen, JT. ISOTIS ORTHOBIOLOGICS, Irvine, CA. Presented at: Biomaterials in Regenerative Medicine, Philadelphia, PA, October 16-18, 2004.
2. Influence of irradiation on the osteoinductive potential of demineralized bone matrix. Wientroub S, Reddi AH. Calif Tissue Int 1988;42:255-60.
ORDERING INFORMATION
Product Description Part Number
Accell Connexus® 0.5cc 10.310.1050
Accell Connexus® 1.0cc 10.310.1060
Accell Connexus® 2.5cc 10.310.1070
Accell Connexus® 5.0cc 10.310.1080• Moldable, easy to pack into any shape defect
• Proprietary carrier Reverse Phase Medium thickens at body temperature, allowing for better graft containment
How Bone Proteins and Naturally Occurring Growth Factors are Delivered with Accell Connexus
Ready and Easy to Use
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