Less aggressive surgical resection. More functional preservation. Adaptive Hybrid SurgeryTM defines where surgery stops and radiosurgery begins.

ADAPTIVEHYBRID

SURGERYTM

“Benign skull base tumors present a treatment challenge since aggressive surgical resection is potentially associated with disabling morbidity. Adaptive Hybrid Surgery™ represents the best technique to objectively determine maximum safe resection in the setting of multi-modality therapy for complex tumors of the skull base.”

Igor J. Barani, MD, UCSF

Stereotactic Radiosurgery

Image Guided Surgery

Adaptive Hybrid SurgeryTM

©2011 Brainlab AG. Printed in US. NS_FL_E_AHSFlyer_0911 Q:100 ®Registered trademark of Brainlab AG in Germany and/or the US.

1. Clinical data on file.

SHIFT Today more than half of all cranial benign neoplasms are surgically

mitigated with preservation techniques. Combining surgery with

radiosurgery offers the best and most durable tumor control

while offering the same low surgical risks as preservation

surgery on its own.

brainlab.com

CONFIRM Patients suffering from cranial nerve schwannoma, cavernous sinus, ophthalmic,

jugular faramen and petroclival meningioma are ideal candidates for Adaptive Hybrid

Surgery™ and would benefit directly and immediately. Additionally, patients suffering from

any benign skull base meningioma or pituitary adenoma are suitable candidates.1

“When weighing in the advantages, it is very likely that Adaptive Hybrid Surgery™ will become standard of care for managing patients with challenging benign skull base tumors as it represents the best of neurosurgical and radiosurgical management paradigms.”

Andrew T. Parsa, MD, PhD, UCSF

“A patient treated with Adaptive Hybrid Surgery will require fewer hospitalization days, fewer imaging studies and have a faster resolution of symptoms with longer, more sustainable disease control.”

Alessandro Olivi, MD, The Johns Hopkins Hospital

“If you, as a neurosurgeon, had a vestibular schwannoma, would you want to take the risk of a complete resection and incur the facial palsy, the hearing loss, the CSF leak, the vertigo, etc., or would you prefer to have Adaptive Hybrid Surgery? I don’t think there’s any neurosurgeon around who would not prefer that approach.”

Michael Schulder, MD, North Shore-LIJ

SURVEY OF WORLDWIDE NEUROSURGEONS

GTRs FOR > 80% PATIENTS

GTRs FOR 50 - 80% PATIENTS

GTRs FOR < 50% PATIENTS

BLEND The Adaptive Hybrid Surgery application offers neurosurgeons

the confidence of a post-surgical treatment plan for their patients.

Neurosurgeons understand the need for less aggressive resections,

and require advanced tools that will allow them to perfectly

blend therapies and maximize functional benefits.Pre-OP MRI Intra-OP CT Post-OP MRI

2001

86%

28%31%

41%

13%1%

2011

MENINGIOMA CLINICAL OUTCOME 5 AND 10 YEAR ACTUARIAL RESULTS

GTR

• 93%

• 80%

5 years

10 years

70%

75%

80%

85%

90%

95%

100%

RT

• 95%

• 93%

STR+RT

• 100%

• 94%