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Adam Fabriwerk Processing Skids Presentation Sterile Processing
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Transcript of Adam Fabriwerk Processing Skids Presentation Sterile Processing
www.adamfabriwerk.com 1
Vishal WaghDirector
Marketing
www.adamfabriwerk.com 2
Summary
Company OverviewManufacturing Site Product ProfileProjectsInternational Presence
Indian Ethos
www.adamfabriwerk.com 3
Summary
Company OverviewManufacturing Site Product ProfileProjectsInternational Presence
Indian Ethos
www.adamfabriwerk.com 4
Company OverviewAdam Fabriwerk has been delivering quality mixing and processing machinery products to Biopharmaceutical, Pharmaceutical and Cosmetic Industries for the past 26 yearsOur corporate offices are based in Mumbai, India and our Manufacturing Facilities and R&D labs are located at Nashik,160 kms away from MumbaiStrength : 150 people
Mumbai To Nashik
Nashik Works
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Company Overview :Board of DirectorsWaman Wagh
Technical Director
Devidas ShirudeFinance Director
Sanjay ShirudeProduction Director Vishal Wagh
Marketing Director
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Summary
Company OverviewManufacturing Site Product ProfileProjectsInternational Presence
Indian Ethos
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Manufacturing SiteFabrication Facility
In house Design,Manufacturing,FAT facilitiesOrbital Welding machines with Boroscopy for TubesOverhead Cranes covering Complete Factory Bay areas for Material HandlingTotal Fabrication area availability 1800 Sq.MetresMaximum Capacity of Vessel fabrication 30000 LitresPolishing Bays separate from Fabrication and Assembly areasVessel Design as per ASME BPE-2005 and ASME Sec VIII Div 1Qualified Welders as per ASME Sec IX
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Manufacturing SiteDisplay FacilityOperator Training Modules
Prospective Clients get a first hand look at the end product
Ease of finalising specific process critical accessories and fitments
Mixing/Blending Vessels,CIP,SIP Modules and Cream Mixers on Display with Full Process Control Options with Production Scale Models
All World Class Bought outs used in Integration of the Skids on Display
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Manufacturing SiteFAT Area
Vessel Hydro TestsJacket Hydro TestsVessel/Jacket Vacuum TestsMixing Water TrialsFull BOQ/MOC Documentation Dossiers including DQ/IQ/OQ/PLC Validation Packages availableFull Operational Tests performed under FATWelding Maps with X ray ReportsSurface Finish Test with ProfilometerElectropolishing Reports Riboflavin Tests for Sprayball Efficacy
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Manufacturing SiteNew State-of-the-Art Facility
This new facility is designed for the fabrication of 100 percent stainless steel projects.
The plant will boast of a controlled environment ensuring high purity and cross contamination prevention to comply with regulatory standards.
It will also incorporate automated welding processes and advanced finishing processes as well as a designated area for factory acceptance testing.
With a height of 31 feet under hook and a 50 ton lift capacity, it is ideal for large or small tanks as well as super skids.
Unit 2
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Summary
Company OverviewManufacturing SiteProduct ProfileProjectsInternational Presence
Indian Ethos
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Product Profile : Blending Vessels
Mixing ApplicationsBacteria and Cell CulturesSuspensionsBlood fractions in Cohn fractionationVaccine suspensions containing aluminium hydrogel, salts, antibodiesDissolving glucose in water (LVP solutions)
Capacity5 to 30000 Litres
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Product Profile : Blending Vessels
Sterile Sampling System with In Situ Steam Sterilization
Sterile Flange Connections for Top dish nozzles to enhance CIP,SIP operations
Temperature/pH/Conductivity sensing through sanitary knuckle port on vessel shell
Load Cells for weight measurement
Vessel with CIP / SIP able accessories
PLC system with SCADA available for batch records
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Product Profile : Blending Vessels
General Mixing
The GMP mixer is suitable for general Mixing,Blending,Heat transfer and Shear Sensitive ApplicationsSpeed variation from 20 to 350 RPM
Upstream processing
The USM mixer is a superior alternative to top-mounted mixers in upstream mixing applicationsThe USM mixer creates medium high-shear forces and transfers much more energy into the tank than the GMP mixer, and is ideal for mixing difficult powders into a liquidSpeed variation from 300 to 1440 RPM
GMP Mixer
USM Mixer
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Product Profile : Blending Vessels
High Shear Mixing Applications
Homogenizing-Dispersing activitiesSuspension of Solid Particles in Liquid PhaseDissolving and Downsizing Particles for Suspension ManufacturingEmulsification to achieve small Droplet Size to achieve Stable EmulsionsSpeed variation from 400 to 2800 RPM
High Shear Combo Mixing
A HS mixer creates the High Shear Forces needed to create an Emulsion, while the GMP mixer is used to break the vortex and create additional agitation and balance in the tankA variety of powerful results can be achieved this way, such as controlling vortex to prevent foaming, increased agitation, etc.
Combo Mixing
HS Mixer
Rotor
Stator
Drive
Tank Plate
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Product Profile : Blending Vessels
Valve Configurations
Take Off ValvesUsed in PW and WFI Loops, free of Dead Legs and No Pressure Drop over the valve in the main line
Tank Outlet ValvesTruly Zero Dead Leg with Multiple ports and Actuation options
Shut Off ValvesPositive Sealing with no cavities, Full Drainability and Low Pressure Drop
Flow Through ValvesManifold, Take Off and Drainage Valves in Aseptic Applications
Take Off
Shut Off Flow Through
Tank Outlet
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LVP Project Profiling
Photo Courtesy:Charak Pharmaceuticals
Product Profile : Blending Vessels
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Product Profile : Blending Vessels
LVP Project Profiling
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LVP Preparation tanks
Jacketed/Insulated/Cladded VesselBottom Entry Propeller Mixer for vigorous MASS MOVEMENT within the vesselBottom Entry Magnetic mixer mounted within the vesselLug Mounted Vessel on Platform with Load cells
Product Profile : Blending Vessels
Mixing of 10000 litres of water
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Transfer Panels
Panel Design
Jumper DesignJumper HoldersPort CapsDrain PanProximity SwitchesPanel SupportPanel and Port Labeling
Photo Courtesy: Johnson & Johnson
Product Profile : Blending Vessels
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Applications : Cleaning In Place of
Cream Manufacturing VesselIntermediate Preparation VesselsStorage Vessels Product Transfer lines
Photo Courtesy: Encube Ethicals
Product Profile : CIP System
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Completely Automated Process Cycles of Pre Wash/Air blow/Detergent Wash/Rinse /Drying
On line display of process parameters with P & I of Operating System
Real Time Recording and Print /Communication of Process Parameters
Detergent / Acid / Alkali Automated Dosing system
On Line pH,Conductivity, TOC Sensing
CIP is designed in accordance with ASME BPE guidelines
PLC-based, with Touch Screen MMI and SCADA Packages
Product Profile : CIP System
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Key Benefits of CIP Process
Validatable process for cleaning of process equipment
Lower facility operating costs
Minimal dismantling of equipment and piping
Reduced turnaround time for cleaning
WFI requirements for cleaning reduced significantly
Exposure to hazardous activities or entry into tanks, is eliminated
Product Profile : CIP System
Cleaning In Place Cycle
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Key Benefits of CIP Process
Validatable process for cleaning of process equipment
Lower facility operating costs
Minimal dismantling of equipment and piping
Reduced turnaround time for cleaning
WFI requirements for cleaning reduced significantly
Exposure to hazardous activities or entry into tanks, is eliminated
Product Profile : CIP System
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Flow Characteristics and Measurement
Sanitary Flow meter
Product Profile : CIP System
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PIDOf
Plant wideCIP
System
Product Profile : CIP System
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HMI Screens : Manufacturing Vessel
Automation
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HMI Screens : Phase Preparation Vessel
Automation
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HMI Screens : Product Preparation Steps
Automation
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HMI Screens : CIP System
Automation
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HMI Screens : CIP System Steps
Automation
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Summary
Company OverviewManufacturing Site Product ProfileProjectsInternational PresenceTrade Shows
Indian Ethos
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Sterile Processing Projects
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Sterile Processing Projects
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Sterile Processing Projects
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ProjectsReliance Lifesciences
IndiaBlood Plasma Products
Sanofi AventisEgypt
Semi Solids Processing Plant
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ProjectsSerum Institute Of India
IndiaDSP Area Blending Vessels for
HIB Vaccine Project
EIMCEgypt
Vaccine Formulation Vessels
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ProjectsJohnson & Johnson
IndiaFully Integrated SCADA Controlled Semi Solids-Liquids
Facility
Encube EthicalsIndia
Fully Automated Semi Solid/Emulsions Processing Facility
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Summary
Company OverviewManufacturing Site Product ProfileProjectsInternational Presence
Indian Ethos
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International PresenceInterphex Singapore 2005 CPHI India 2006 Interphex New York 2007
Interphex India 2007 Interphex Philadelphia 2008 Interphex Canada 2008