Acute pain abdomen

86
ACUTE PAIN ABDOMEN DR VARUN K PG GASTROENTEROLOGY

description

pain abdomen with case scenarios

Transcript of Acute pain abdomen

Page 1: Acute pain abdomen

ACUTE PAIN ABDOMEN

DR VARUN KPG GASTROENTEROLOGY

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Definition Pain pathway Types of pain Natural history Causes of pain abdomen Clinical case scenarios Management Conclusion

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Pain less than one week duration.

Abdominal pain is the presenting complaint in 1.5 percent of office-based visits and in 5 percent of emergency department visits.

Annual incidence approx. 63/1000 ED visits.

Admission rate varies (high as 63% in pts > 65 yrs old.) 1.Woodwell DA, Cherry DK. National Ambulatory Medical Care Survey: 2002 summar. Adv Data. . 2004;

(346):1–44.

2. Kamin RA, Nowicki TA, Courtney DS, Powers RD. Pearls and pitfalls in the emergency department evaluation of abdominal pain. Emerg Med Clin North Am. 2003;21(1):61–72

DEFINITION

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PAIN PATHWAY

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Three types of pain exist:

1. Visceral

2. Parietal

3. Referred

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Visceral pain is transmitted by C fibers. Involves hollow or solid organs; midline pain

due to bilateral innvervation Steady ache or vague discomfort to

excruciating or colicky pain Poorly localized Secondary autonomic symptoms present.

VISCERAL PAIN

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Abdominal visceral nocioceptors respond to mechanical and chemical stimuli.

The principal mechanical signal to which visceral nocioceptors are sensitive is stretch.

Chemical nocioceptors are activated by substances released in response to inflammation and injury.

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Somatic-parietal pain is mediated by A-δ fibers that are distributed principally to skin and muscle.

Signals from this neural pathway are perceived as sharp, sudden, well localized pain, such as that which follows an acute injury.

These fibers convey pain sensations through spinal nerves.

PARIETAL PAIN

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Stimulation of these fibers activates local regulatory reflexes mediated by the enteric nervous system and long spinal reflexes mediated by the autonomic nervous system, in addition to transmitting pain sensation to the central nervous system.

Reflexive responses, such as involuntary guarding and abdominal rigidity, are mediated by spinal reflex arcs involving somatic-parietal pain pathways.

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Somatic A-d fibers mediate touch, vibration, and proprioception in a dermatomal distribution that matches the visceral innervation of the injured viscera and synapse with inhibitory interneurons of the substantia gelatinosa in the spinal cord.

In addition, inhibitory neurons that originate in the mesencephalon, periventricular gray matter, and caudate nucleus descend within the spinal cord to modulate afferent pain pathways.

These inhibitory mechanisms allow cerebral influences to modify afferent pain impulses.

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Referred pain is felt in areas remote from the diseased organs and results when visceral afferent neurons and somatic afferent neurons from a different anatomic region converge on second-order neurons in the spinal cord at the same spinal segment.

REFERRED PAIN

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Subdiaphragmatic irritation → ipsilateral shoulder or supraclavicular pain(kehr’s sign).

Biliary disease → right infrascapular pain MI → epigastric, neck, jaw or upper

extremity pain

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NATURAL HISTORY

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Gastritis Acute Gastroenteritis Hepatic abscess Rectal sheath hematoma Herpes Zoster UTI Tabes dorsalis Sickle cell disease Diabetes Mellitus Thyrotoxicosis Addisonians disease Poryphyria Hereditary Spherocytosis

MEDICAL CAUSES

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Acute appendicitisAcute diverticulitisAcute pancreatitisAcute cholecystitisIntestinal obstructionBilliary colicUreteric colicAcute retention of urinePerforation of peptic ulcerPerforation of appendixRuptured AAAPerforated oesophgagus

SURGICAL CAUSES

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Ectopic pregnancy PID Salpingitis Mittelschmerz Endometriosis Dysmenorrhoea Fibroid degeneration Ovarian cyst – rupture, torsion , hemorrhage

GYNAECOLOGICAL CAUSES

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LOCATION OF PAIN IMAGING Right upper quadrant Ultrasonography Left upper quadrant CT Right lower quadrant CT with iv

contrast media Left lower quadrant CT with oral and IV

contrast media Suprapubic Ultrasonography

Recommended Imaging Studies Based on Location of Abdominal Pain

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24 year healthy male with one day history of abdominal pain.

Pain was generalized at first, now worse in right lower abd & radiates to his right groin.

He has vomited twice today. Denies any diarrhea, fevers, dysuria or other complaints. No appetite today.

ROS otherwise negative. PMHx: negative PSurgHx: negative Meds: none Social hx: no alcohol, tobacco or drug use Family hx: non-contributory

Case #1

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Physical exam: T: 37.8, HR: 95, BP 118/76, R: 18, O2 sat:

100% room air Uncomfortable appearing, slightly pale Abdomen: soft, non-distended, tender to

palpation in RLQ with mild guarding; hypoactive bowel sounds

Genital exam: normal

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Classic presentation Periumbilical pain Anorexia, nausea, vomiting Pain localizes to RLQ Occurs only in ½ to 2/3 of patients 26% of appendices are retrocecal and cause

pain in the flank; 4% are in the RUQ A pelvic appendix can cause suprapubic pain,

dysuria Males may have pain in the testicles Addiss DG, Shaffer N, Fowler B, Tauxe RV. The epidemiology of appendicitis and

appendectomy in the United States. Am J Epidemiol 1990; 132:910-25. (Ref 21.)

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Depends on duration of symptoms Rebound, voluntary guarding, rigidity,

tenderness on rectal exam Fever (a late finding) Urinalysis abnormal in 19-40% CBC is not sensitive or specific Addiss DG, Shaffer N, Fowler B, Tauxe RV. The epidemiology of appendicitis and

appendectomy in the United States. Am J Epidemiol 1990; 132:910-25. (Ref 21.)

FINDINGS

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Abdominal xrays Appendiceal fecolith or gas, localized ileus, blurred right psoas muscle, free air CT scan

Pericecal inflammation, abscess, periappendiceal phlegmon, fluid collection, localized fat stranding

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X-RAY

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Appendicitis: CT findings

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NPO IVFs Preoperative antibiotics – decrease the

incidence of postoperative wound infections Analgesia

TREATMENT

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Alvarado Score is numerical, it has been evaluated for ruling in and ruling out appendicitis.

Studies ruling out appendicitis (using Alvarado < 3-4) have a sensitivity of 96%; studies ruling in appendicitis (using Alvarado > 6-7) have a sensitivity of 58-88%, depending on the study and score cutoffs used.

The 2007 McKay study recommends CT scan for Alvarado 4-6, surgical consultation for Alvarado ≥ 7, and for Alvarado ≤ 3, no CT for diagnosing appendicitis, as appendicitis is unlikely

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68 yo F with 2 days of LLQ abd pain, constipation, fevers/chills, nausea; vomited once at home.

PMHx: HTN, diverticulosis

PSurgHx: negative

Meds: HCTZ

Social hx: no alcohol, tobacco or drug use

Case #2

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T: 37.6, HR: 100, BP: 145/90, R: 19, O2sat: 99% room air

Gen: uncomfortable appearing, slightly pale Abd: soft, moderately tender LLQ Rectal: normal tone, guiac neg brown stool

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FINDINGS: Steady, deep discomfort in LLQ Change in bowel habits Urinary symptoms Tenesmus Paralytic ileus

Diverticulitis

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Low-grade fever Localized tenderness Rebound and guarding Left-sided pain on rectal exam Occult blood Peritoneal signs-Suggest perforation or

abscess rupture

PHYSICAL EXAMINATION

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CT scan (IV and oral contrast) Pericolic fat stranding Diverticula Thickened bowel wall Peridiverticular abscess Leukocytosis present in only 36% of

patients

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Hinchey grade I diverticulitis :localized pericolic abscess or inflammation frequently

Hinchey grade II diverticulitis: pelvic, intraabdominal, or retroperitoneal abscess.

Hinchey III :generalized purulent peritonitis Hinchey IV generalized fecal peritonitis.

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CT SCAN

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Fluids Correct electrolyte abnormalities Antibiotics.

TREATMENT

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46 yo M with hx of alcohol abuse with 3 days of severe boring upper abd pain radiating to back relieved on leaning forward , vomiting, subjective fevers.

Med Hx: negative Surg Hx: negative Meds: none; Social hx: heavy alcohol use, smokes 2ppd,

no drug use

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Vital signs: T: 37.4, HR: 115, BP: 98/65, R: 22, O2sat: 95% room air

General: ill-appearing, appears in pain CV: tachycardic, normal heart sounds,

pulses normal Lungs: clear Abdomen: mildly distended, moderately TTP

epigastric, +voluntary guarding Rectal: heme neg stool

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CLINICAL FEATURES Epigastric pain -Constant, boring

pain,Radiates to back. Vomiting. Fever.

ACUTE PANCREATITIS

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Patients are usually tachycardic and tachypneic.

Abdominal examination reveals hypoactive bowel sounds and marked tenderness to percussion and palpation in the epigastrium.

Abdominal rigidity is a variable finding. In rare patients, flank or periumbilical

ecchymoses (Grey-Turner’s or Cullen’s sign, respectively) develop in the setting of pancreatic necrosis with hemorrhage.

PHYSICAL FINDINGS

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Lipase -Elevated more than 3 times normal ;Sensitivity and specificity >90%

Amylase-Nonspecific USG abdomen if etiology unknown CT scan-Useful to evaluate for complications

DIAGNOSIS

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NPO IV fluid resuscitation Maintain urine output of 100 mL/hr NGT if severe, persistent nausea No antibiotics unless severe disease

TREATMENT

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72 yo M with hx of CAD on aspirin and Plavix with several days of dull upper abd pain and now with worsening pain “in entire abdomen” today. Some relief with food until today, now worse after eating lunch.

Med Hx: CAD, HTN, CHF Surg Hx: appendectomy Meds: Aspirin, Plavix, Metoprolol, Lasix Social hx: smokes 1ppd, denies alcohol or

drug use, lives alone

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CLINICAL FEATURES Burning epigastric pain leading to sudden

onset severe diffuse abdominal pain Epigastric tenderness Severe, generalized pain may indicate

perforation with peritonitis Occult or gross blood per rectum or NGT if

bleeding.

PERFORATED PEPTIC ULCER

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Acute abdominal x-ray series -Lack of free air does not rule out perforation

Broad-spectrum antibiotics Surgical consultation

Perforated Peptic Ulcer

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35 yo healthy F to ED c/o nausea and vomiting since yesterday along with generalized abdominal pain ,cramping in nature more in the periumbilical area not radiating

No fevers/chills, +anorexia. Last stool 2 days ago.

Med Hx: negative Surg Hx: s/p hysterectomy (for fibroids) Social Hx: denies alcohol, tobacco or drug use Family Hx: non-contributory

Case #5

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Crampy, intermittent pain Periumbilical or diffuse Inability to have BM or flatus Nausea and vomiting Abdominal bloating Sensation of fullness, anorexia

INTESTINAL OBSTRUCTION

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Distention Tympany Absent, high pitched or tinkling bowel sound

or “rushes” Abdominal tenderness: diffuse, localized, or

minimal

PHYSICAL FINDINGS

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CBC and electrolytes electrolyte abnormalities WBC >20,000 suggests bowel necrosis,

abscess or peritonitis Abdominal x-ray series-Air-fluid levels,

dilated loops of bowel,Lack of gas in distal bowel and rectum

CT scan-Identify cause of obstruction, Delineate partial from complete obstruction

DIAGNOSIS

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Fluid resuscitation NGT Analgesia Hospital observation for ileus or for

complete obstruction

TREATMENT

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48 yo obese F with one day hx of upper abd pain after eating, does not radiate, is intermittent cramping pain, +N/V, no diarrhea, subjective fevers. No prior similar symptoms.

Med hx: denies Surg hx: denies No meds or allergies Social hx: no alcohol, tobacco or drug use

Case #6

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T: 100.4, HR: 96, BP: 135/76, R: 18, O2 sat: 100% room air

General: moderately obese, no acute distress

CV: normal Lungs: clear Abd: moderately tender RUQ, +Murphy’s

sign, non-distended, normal bowel sounds

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RUQ or epigastric pain Radiation to the back or shoulders Dull and achy Pain lasting longer than 6 hours Nausea,Vomiting,anorexia Fever, chills.

ACUTE CHOLECYSTITIS

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Epigastric or RUQ pain Murphy’s sign Peritoneal signs suggest perforation

PHYSICAL FINDINGS

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USG ABOMEN

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RUQ US Thicken gallbladder wall Pericholecystic fluid Gallstones or sludge Sonographic murphy sign HIDA scan-more sensitive & specific than US

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Surgical consult IV fluids Correct electrolyte abnormalities Analgesia Antibiotics NGT if intractable vomiting

TREATMENT

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Sudden onset of acute, severe abdominal pain localized to the midabdomen or paravertebral or flank areas.

The pain is tearing in nature and associated with prostration,lightheadedness, and diaphoresis.

Physical examination reveals a pulsatile, tender abdominal mass in about 90% of cases. The classic triad of hypotension, a pulsatile mass,

and abdominal pain is present in 75% of cases and mandates immediate surgical intervention.

ABDOMINAL AORTIC ANEURYSM

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Consider this diagnosis in all elderly patients with risk factors Atrial fibrillation, recent MI,Atherosclerosis, CHF, digoxin therapy Hypercoagulability, prior DVT, liver disease.

Severe pain, often refractory to analgesics Relatively normal abdominal exam Embolic source: sudden onset (more

gradual if thrombosis) Nausea, vomiting and anorexia are common

MESENTERIC ISCHEMIA

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50% will have diarrhea Eventually stools will be guiaic-positive Metabolic acidosis and extreme leukocytosis

when advanced disease is present (bowel necrosis)

Diagnosis requires mesenteric angiography or CT angiography

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It is defined as pathologic elevation of intraabdominal pressure.

An elevated intra-abdominal pressure may develop in a patient who survives massive volume resuscitation with resulting visceral edema or who has a disease such as severe pancreatitis that can cause visceral or retroperitoneal edema.

ABDOMINAL COMPARTMENT SYNDROME

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The World Society for Abdominal Compartment Syndrome has established a consensus grading scheme for ACS based on the measured bladder pressure.

A normal value for bladder pressure is less than 7 mm Hg.

Grade I ACS is defined as a pressure of 12 to 15 mm Hg.

Grade II as 16 to 20 mm Hg, Grade III as 21 to 25 mm Hg and Grade IV as greater than 25 mm Hg. An G, West M. Abdominal compartment syndrome: A concise clinical review. Crit Care

Med 2008; 36:1304-10

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Nonsurgical options for treating low-grade ACS include gastric decompression, sedation, neuromuscular blockade, placing the patient in a reverse Trendelenburg position while allowing the hips to remain in a neutral position, and diuretics.

In a patient with high grade ACS, particularly when renal and respiratory function is compromised, laparotomy and creation of an open abdomen is most effective.

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Mortality rate for abdominal pain in the elderly is 11-14%

Perception of pain is altered Altered reporting of pain: stoicism, fear,

communication problems

Abdominal Pain in the Elderly

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Most common causes: Cholecystitis Appendicitis Bowel obstruction Diverticulitis Perforated peptic ulcer Don’t miss these: AAA, ruptured AAA Mesenteric ischemia Myocardial ischemia Aortic dissection

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Appendicitis – do not exclude it because of prolonged symptoms. Only 20% will have fever, N/V, RLQ pain and ↑WBC

Acute cholecystitis – most common surgical emergency in the elderly.

Perforated peptic ulcer – only 50% report a sudden onset of pain. In one series, missed diagnosis of PPU was leading cause of death.

Mesenteric ischemia – we make the diagnosis only 25% of the time. Early diagnosis improves chances of survival. Overall survival is 30%.

Increased frequency of abdominal aortic aneurysms AAA may look like renal colic in elderly patients

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Pregnant women develop acute appendicitis and cholecystitis at the same rate as their nonpregnant counterparts.

A number of additional diagnoses, such as placental abruption and pain related to tension on the broad ligament, must be distinguished from nonobstetric diagnoses.

PIAN ABDOMEN IN PREGNANCY

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Appendicitis occurs in approximately 1 in 2000 pregnancies and is equally distributed among the three trimesters.

Biliary tract disease is also common during pregnancy.

Open or laparoscopic management of these diseases is safe but is associated with a rate of preterm delivery of approximately 12% for appendectomy and 11% for cholecystectomy.

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Immunocompromised hosts may manifest with acute abdominal pain, including neutropenic enterocolitis, drug-induced pancreatitis, graft-versus-host disease, pneumatosis intestinalis, and cytomegalovirus (CMV) and fungal infections.

PAIN ABDOMEN IN HIV

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In general, immunocompromised patients may lack the definitive signs of an acute abdominal crisis usually seen in immunocompetent persons; an elevated temperature, peritoneal signs, and leukocytosis may be absent in these cases.

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Acetaminophen Non-steroidal anti-inflammatory drugs

(NSAIDs) Opioids Treatment of cause.

TREATMENT

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In order to obtain the best therapeutic effect while minimising side effects, many analgesic drugs require careful titration and individualisation of dose regimens.

Multimodal analgesia (that is, the concurrent use of different classes of analgesics) improves the effectiveness of acute pain management.

Drug administration can be by oral,

subcutaneous, intramuscular, intravenous, epidural, intrathecal, inhalational, rectal, transdermal or transmucosal routes

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Some specialised analgesia delivery techniques require greater medical and nursing knowledge and expertise like Patient-controlled analgesia, Epidural and intrathecal analgesia ,Other regional analgesic procedures, Continuous infusions of opioids, local anaesthetics, ketamine and other drugs.

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NON-PHARMACOLOGICAL THERAPIES Non-pharmacological therapies must be

considered as complementary to pharmacological therapies.

Psychological interventions, acupuncture,

transcutaneous electrical nerve stimulation and physical therapy may be effective in some acute pain settings.

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Sir Zachary Cope stated that “Morphine does little or nothing to stop serious intra-abdominal disease, but it puts an efficient screen in front of the symptoms.

Six studies in which the early administration of analgesia was compared with administration of placebo in patients with acute abdominal pain have shown that the patients who receive analgesics are more comfortable and do not experience a delay in diagnosis.

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Significant abdominal tenderness should never be attributed to gastroenteritis

Incidence of gastroenteritis in the elderly is very low Always perform genital examinations when lower

abdominal pain is present – in males and females, in young and old

In older patients with renal colic symptoms, exclude AAA

Severe pain should be taken as an indicator of serious disease

Pain awakening the patient from sleep should always be considered signficant

Abdominal Pain Clinical Pearls

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Sudden severe pain suggests serious disease Pain almost always precedes vomiting in surgical

causes; converse is true for most gastroenteritis and NSAP

Acute cholecystitis is the most common surgical emergency in the elderly

A lack of free air on a chest xray does NOT rule out perforation

Signs and symptoms of PUD, gastritis, reflux and nonspecific dyspepsia have significant overlap

If the pain of biliary colic lasts more than 6 hours, suspect early cholecystitis

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