Acute Cor Pulmonale
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![Page 1: Acute Cor Pulmonale](https://reader038.fdocuments.in/reader038/viewer/2022110207/55cf918d550346f57b8e60db/html5/thumbnails/1.jpg)
ECHO PATTERN OF ACUTE COR PULMONALE
Antoine Vieillard-Baron, Boulogne, France
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1- Unlike the left ventricle, the RV is able to dilate acutely under abnormal conditions.
Its diastolic function is tolerantA failed RV is dilated
2- Unlike the left ventricle, the RV not easily adapts to an acuteincrease in its afterload.
Its systolic function is sensitiveA paradoxical septal motion can be visualized in
certain conditions
ACP = Echocardiographic definitionDiastolic overload (dilatation)
+ systolic overload (paradoxical septal motion)
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I
RV DIASTOLIC FUNCTION IS TOLERANT
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No dilatation: RVEDA/LVEDA < 0.6
Moderate dilatation: RVEDA/LVEDA 0.6 - 1
Major dilatation: RVEDA/LVEDA > 1
Jardin Chest 1997
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1
0.6
0
RVEDA/LVEDA=
0.48+0.11
Healthy volunteers (n=44)
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0 0.26 0.52 0.78 1.04 1.3
0
0.26
0.52
0.78
1.04
1.3
STDVD/STDVG (A4C)
ST
DV
D/S
TD
VG
(E
TO
)
r = 0.95p<.00001
12 patients
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Normal RV function
Massive PED1
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Normal RV function
ARDS related to varicellouspneumonia
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Vieillard-Baron ICM 2006
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THE LV CONSEQUENCES OF AN ACUTE RV DILATATION
• Because of the pericardium, the sum of cardiac cavities keep constant in acute conditions.
• Any RV dilatation leads to a LV restriction which impairs its filling. This induces a pattern of relaxation impairment of the LV.
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Taylor AJP 1967
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45
40
35
30
25
20
15
10
5
ACP = 0 ACP = 1
100
90
80
70
60
50
40
30
20
ACP = 0 ACP = 1
EDA RV+LV(cm2)
LVEDV(cm3)
Vieillard-Baron CCM 2001
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TEE study at D375 SDRA (1996-2001)
Gr I (56 patients) Gr II (19 patients)no ACP (75 %) ACP (25 %)
LVEDV 60 ± 16 50 ± 15* (cm3/m2)E/A mit 1.3 ± 0.4 0.8 ± 0.2*
SI 32± 9 25 ± 9* (cm3/m2)HR 96 ± 19 112 ± 16* (bt/mn)
Vieillard-Baron CCM 2001
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P/F 80Crs 25 mL/cmH2O
P/F 40Crs 20 mL/cmH2ONE 0.6 µg/kg/min
P/F 35Crs 11 mL/cmH2ONE 1.5 µg/kg/min
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II
RV SYSTOLIC FUNCTION IS SENSITIVE
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Redington Br Heart J 1990
1: Opening of the pulmonic valve
2: Beginning of relaxation
3: Closing of pulmonic valve
1
2
3
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Elzinga 1990
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Jardin N Engl J Med 1981
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Normal RV function
Massive PED1
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Normal RV function
ARDS related to varicellous pneumonia
Vieillard-Baron AJRCCM 2002
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Ryan JACC 1985
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Vieillard-Baron AJRCCM 2002
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INCIDENCE OF ACP IN ICU
CCM 2001ICM 2001
• 75 ARDS submitted to a protective ventilation
– TEE at D3– Incidence of ACP: 25%
• 161 massive PE– TTE at D1– Incidence of ACP: 61%