JORDI LLOP ROIG

ACADEMICAL DEGREE

PhD in Inorganic Chemistry (2002)

Universitat Ramon Llull

Chemical Engineering (1997)

Institut Químic de Sarrià

Graduate in Chemistry (1996)

Universitat Ramon Llull

PROFESSIONAL EXPERIENCE

October 2007 – To date

Company CIC biomaGUNE (San Sebastián, Guipúzcoa, Spain)

Position Head of Radiochemistry Department - Group Leader

Radiochemistry -

Scientific Advisor of CIC biomaGUNE

Duties Lead and supervise all R&D projects related to the production

and/or development of radiotracers and the application in Nuclear

Imaging Techniques.

Design and production of new radiotracers labelled with PET and

SPECT isotopes.

Education of students (PhDs, post docs) and lead own research

projects.

Lead projects related to the Molecular Imaging Unit.

Facility design and start up.

June 2003 – August 2007

Company Institut Alta Tecnologia PRBB – Fundació Privada (Barcelona,

Spain)

Position Production Responsible of Radiopharmaceutical Laboratory

Duties Responsible of Radiochemistry Department – PET Laboratory

Facility design and start up

Production of PET Radiotracers labelled with 11C, 18F, 13N and 15O, including [11C]methionine, [11C]choline, [11C]raclopride,

[11C]PK11195, [11C]acetate, [11C]flumazenil, [11C]-NNC112,

[11C]-PIB, [11C]harmine, [18F]FDG, [18F]FMISO, [18F]FEAU,

[18F]F-, [13N]ammonia, [15O]water.

Production of SPECT Radiotracers labeled with 123I, including

[123I]IBZM, [123I]CNS-1261, [123I]R91150.

Qualification of the equipment and validation of manufacturing

processes for all the above-mentioned radiotracers.

Lead and supervise all R&D projects related to the production

and/or development of radiotracers.

Design and Execution of Clinical and Pre-clinical studies in

collaboration with several Pharmaceutical Companies:

GlaxoSmithKline, Esteve, Sanofi-Aventis, Advancell.

Design and Execution of Equipment-related projects in

collaboration with companies: IBA, Bioscan.

September 2004 – August 2007

Company Universitat Pompeu Fabra (Barcelona, Spain)

Position Associate Professor

Duties Teacher of the Subject: “Advanced Imaging Techniques”,

corresponding to 4th level of University degree “Human Biology”.

September 2002 – June 2003

Company Uppsala University PET Center – Uppsala Research Imaging

Solutions (Uppsala, Sweden)

Position Post-Doc Researcher

Duties Research on [11C]CO labelling strategies.

February 2002 – September 2002

Company PET Center – Clínica Universitaria de Navarra (Pamplona, Spain)

Position Post-Doc Researcher

Duties Research on 13N labelling strategies

Production of PET Radiotracers labeled with 11C, 18F and 13N,

including [11C]methionine, [11C]raclopride, [18F]FDG,

[18F]FDOPA, and [13N]ammonia.

January 1998 – February 2002

Facility Institut de Ciència de Materials de Barcelona (ICMAB-CSIC)

Position PhD student

Duties Research on boron chemistry, focusing in the development of new

mixed Cobalt sandwich compounds.

September 1996 – December 1997

Facility Institut Químic de Sarrià – Universitat Ramon Llull (Barcelona,

Spain)

Position Final Degree Project

Duties Development of new corrosion inhibitors focused to prevent

corrosion in Nuclear Power Plants.

September 1996 – December 1997

Facility Institut Químic de Sarrià – Universitat Ramon Llull (Barcelona,

Spain)

Position Half time contract (combined with Final Degree Project)

Duties Lead removing from metallic pieces. Cleaning strategies.

Water analysis and quality control of commercial reagents.

TEACHING EXPERIENCE

September 2004 – August 2007

Company Universitat Pompeu Fabra (Barcelona, Spain)

Subject Human Biology 4th level / Advanced Imaging Techniques

Duration 30 hours / year

July 2001

Company Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona,

Spain)

Subject Chemistry for Teachers

Duration 30 hours

July 2000

Company Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona,

Spain)

Subject Chemistry for Teachers

Duration 30 hours

July 1999

Company Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona,

Spain)

Subject Chemistry for Teachers

Duration 30 hours

February 1999 – May 1999

Company Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona,

Spain)

Subject Laboratory – Industrial Samples Analysis – 5th level

Duration 300 hours

October 1998 – February 1999

Company Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona,

Spain)

Subject Laboratory – Inorganic Chemistry – 2nd level

Duration 200 hours

October 1997 – May 1998

Company Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona,

Spain)

Subject Laboratory – Inorganic Chemistry – 2nd level

Duration 400 hours

October 1996 – May 1997

Company Institut Químic de Sarrià – Universitat Ramón Llull (Barcelona,

Spain)

Subject Laboratory – Inorganic Chemistry – 2nd level

Duration 400 hours

DIRECTION OF PhD’s

Student Ángel Manuel Martínez Villacorta

Project PhD

Title Translocation, biological fate and biointeractiosn of engineered

interactions with biomedical applications and for nanosafety

evaluation

Lecture date May 2018

Student Unai Cossío Arrieta

Project PhD

Title Radiolabelling and preclinical evaluation of NPs as drug delivery

systems: Application to infectious pulmonary diseases

Lecture date October 2017

Student Sameer Manohar Joshi

Project PhD

Title Synthesis of novel 13N-labelled compounds

Lecture date October 2016

Student Eunice Sofia Da Silva

Project PhD

Title Synthesis of 13N-labelled azoderivatives and evaluation as in

vivo β-amyloid markers

Lecture date October 2016

Student Larraitz Gil

Project PhD

Title Synthesis of 68Ga-labelled nanoparticles and evaluation of their

suitability as contrast agents for the early diagnose of pancreatic

cancer.

Lecture date October 2016

Student Kiran Babu Gona

Project PhD

Title Exploring new labeling strategies for boronated compounds:

towards fast development and efficient assessment of BNCT drug

candidates.

Lecture date October 2015

Student Carlos Pérez

Project PhD

Title Direct activation of metal oxide nanoparticles: application to

biodistribution studies using positron emission tomography.

Lecture date July 2014

Student Vijay Gaja

Project PhD

Title Synthesis and preclinical evaluation of 13N-labeled azo

compounds for β-amyloid imaging and synthesis of carborane derivatives for

radiolabeling with positron emitters.

Lecture date July 2014

Student Naiara Vázquez

Projec t PhD

Title Development of new D2 receptor ligands analogs labelled with

Carbon-11 and incorporating a 1,2-dicarba-closo-dodecaborane

moiety in its structure: evaluation ex vivo and in vivo.

Lecture date May 2012

Student Vanessa Gómez-Vallejo

Project PhD

Title Development of New Strategies for the Synthesis of Radiotracers

Labelled with Short-Lived Isotopes: Application to 11C and 13N.

Lecture date July 2010

DIRECTION OF FINAL DEGREE PROJECTS

Student Anna Berini

Project Final Degree Project

Title Síntesis y evaluación in vivo del radiotrazador [18F]FEAU

Lecture date February 2011

Student Patricia López

Project Final Degree Project

Title Validación del módulo de síntesis Synthera para la manufactura

del radiotrazador 2-[18F]fluoro-2-desoxi-D-glucosa en

condiciones de alta actividad

Lecture date April 2008

Student Marta Bosque

Project Final Degree Project

Title Síntesis de radiotrazadores marcados con 13N con aplicación en el

diagnóstico de patologías isquémicas

Lecture date October 2007

Student Alex Corella Frasnedo

Project Final Degree Project

Title Desenvolupament i validació de la producció de radiotraçadors

PET marcats amb 11C utilitzant com agent metilant triflat de

[11C]-metil

Lecture date August 2007

Student Vanessa Gómez -Vallejo

Project Final Degree Project

Title Síntesis y validación de trazadores marcados radiactivamente con 123I y 11C. Aplicación en el diagnóstico por imagen

Lecture date December 2005

SCIENTIFIC PUBLICATIONS

JOURNAL PAPERS

2016

- Koziorowski J, Stanciu AE, Gómez-Vallejo V, Llop J, radiolabeled

nanoparticles for cancer diagnosis and therapy. Anticancer agents in medicinal

chemistry. 2016. 16(12).

- Ruiz de Angulo A, Zabaleta A, Gómez-Vallejo V, Llop J, Mareque-Rivas J,

Microdosed Lipid-coated 67Ga_magnetite enhances antigen-specific immunity

by SPECT/CT-image tracked delivery of antigen and CpG to Lymph nodes.

ACS Nano. 2016. DOI: 10.1021/acsnano.5b07253.

- Martin A, Vázquez-Villoldo N, Gómez-Vallejo V, Padró D, Soria FN, Szczupak

B, Plaza-García S, Arrieta A, Reese T, Llop J, Domercq M, Matute C, In vivo

imaging of system sc-as a novel approach to monitor multiple sclerosis.

European Journal of nuclear medicine and molecular imaging. 2016. DOI:

10.1007/s00259-015-3275-3.

- Moraga A, Gómez-Vallejo V, Cuartero MI, Szczupak B, San Sebastian E,

Markuerkiaga I, Pradillo JM, Higuchi M, Llop J, Moro MA, Martin A,

Lizasoain I, Imaging the role of TLR4 on cell proliferation and inflammation

after cerebral ischemia by PET. Journal of cerebral blow flow and metabolism.

2016. DOI: 10.1177/0271678X15627657.

- Gómez-Vallejo V, Ugarte A, García_Barroso C, Cuadrado-Tejedor M, Szczupak

B, Dopeso-Reyes IG, Lanciego JL, García-Osto A, Llop J, Oyarzabal J, Franco

R, Pharmacokinetic investigation of sildenafil using positrón emission

tomography and determination of its effect on cerebrospinal fluid cGMP levels.

Journal of neurochemistry. 2016. 136: 403-415.

2015

- Simoes AVC, Pinto SMA, Calvete MJF, Gomes CMF, Ferreira NC, Castelo-

Branco M, Llop J, Pereira MM, Abrunhosa A, Synthesis of a new 18F labeled

porphyrin for potential application in positron emission tomography. In vivo

imaging and cellular uptake. RSC Advances. 2015. 5: 99540-99546.

- Llop J, Jiang P, Marradi M, Gómez-Vallejo V, Echeverría M, Yu S, Puigivila

M, Baz Z, Szczupak B, Pérez-Campaña C, Mao Z, Gao C, Moya SE, Visualising

dual radiolabelled poly(lactide-co-glycolide) nanoparticle degradation in vivo

using energy-discriminant SPECT. Journal of Materials Chemistry B. 2015. 3:

6293-6300.

- Gona KB, Lakshmi VPN Thota J, Baz Z, Gómez-Vallejo V, Llop J, Synthesis

and 11C-radiolabelling of 2-carboranyl benzothiazoles. Molecules. 2015. 20:

7495-7508.

- Joshi SM, de Cozar A, Gómez-Vallejo V, Koziorowski J, Llop J, Cossio F,

Synthesis of radiolabelled aryl azides from diazonium salts: experimental and

computational results permit to identify the preferred mechanism. Chem Comm.

2015. 51: 8954-8957.

- Gona KB, Lakshmi VPN Thota J, Baz Z, Gómez-Vallejo V, Llop J,

Straightforward synthesis of radioiodinated Cc-substituted o-carboranes:

towards a versatile platform to enable in vivo assessment of BNCT drug

candidates. Dalton Transactions. 2015. 44: 9915-9920.

- López de Laorden C, Beloqui A, Yate L, Calvo J, Puigivila M, Llop J, Reichardt

N, Nanostructure indium tin oxide slides for small molecules profiling and

imaging mass spectrometry of metabolites by surface-assisted laser desorption

ionization MS. Analytical Chemistry. 2015. 87: 431-440.

- da Silva ES, Gómez-Vallejo V, Llop J, López-Gallego F; Efficient nitrogen-13

radiochemistry catalyzed by a highly stable immobilized biocatalyst. Catalysis

science and technology. 2015. 5: 2705-2713.

- di Mauro PP, Gómez-Vallejo V, Baz Z, Llop J, Borrós S; Novel 18F-labeling

strategy for polyester-based NPs for in vivo PET-CT imaging. Bioconjugate

chemistry. 2015. 26(3): 582-592.

- Martin A, Szczupak B, Gómez-Vallejo V, Domercq M, Cano A, Padro D,

Muñoz C, Higuchi M, Matute C, Llop J; In vivo PET imaging of the α4β2

nicotinic acetylcholine receptor as a marker for brain inflammation after cerebral

ischemia. Journal of neurosciences. 2015. 35(15): 5998-6009.

2014

- Gómez-Vallejo V, Baz Z, Llop J; Desarrollo de nuevas sondas de imagen

molecular. RADIOPROTECCIÓN: revista de la sociedad española de

protección radiológica. 2014. 79: 60-70.

- Gona KB, Zaulet A, Gómez-Vallejo V, Teixidor F, Llop J, Viñas C; COSAN as

a molecular imaging platform: synthesis and “in vivo” imaging. Chemical

Communications. 2014. 50: 11415-11417. DOI: 10.1039/C4CC05058D.

- Cobaleda-Siles, M; Henriksen-Lacey, M; Ruiz de Angulo, A; Bernecker A,

Gómez-Vallejo V, Szczupak B, Llop J, Pastor G, Plaza-García S, Jauregui-

Osoro M, Meszaros LK, Mareque-Rivas JC; An iron oxide nanocarrier for

dsRNA to target lymph nodes and strongly activate cells of the immune system.

Small. 2014. 10(24): 5054-5067. DOI: 10.1002/smll.201401353.

- Cobaleda-Siles, M; Henriksen-Lacey, M; Ruiz de Angulo, A; Bernecker A,

Gómez-Vallejo V, Szczupak B, Llop J, Pastor G, Plaza-García S, Jauregui-

Osoro M, Meszaros LK, Mareque-Rivas JC; Theranostics: An iron oxide

nanocarrier for dsRNA to target lymph nodes and strongly activate cells of the

immune system. Small. 2014. 10(24): 5053.

- Soria FN, Pérez-Samartín A, Martin A, Gona KG, Llop J, Szczupak B, Chara

JC, Matute C, Domercq M; Extrasynaptic glutamate release through

cystine/glutamate antiporter contributes to ischemic damage. The Journal of

clinical Investigation. 2014. 124: 3645-3655.

- Infante A, Gago A, Ruiz de Eguino G, Calvo-Fernández T, Gómez-Vallejo V,

Llop J, Schlangen K, Fullaondo A, Aransay AM, Martín A, Rodríguez CI;

Prelamin A accumulation and stress conditions induce impaired Oct-1 activity

and autophagy in prematurely aged human mesenchymal stem cell; Aging. 2014.

6: 264-280.

- Gómez-Vallejo V, Gaja V, Gona KB, Llop J; Nitrogen-13: Historical review and

future perspectives; Journal of labeled compounds and radiopharmaceuticals.

2014. 57: 244-254.

- Locatelli E, Bost W, Fournelle M, Llop J, Gil L, Arena F, Lorusso V, Comes

Franchini M; Targeted polymeric nanoparticles containing gold nanorods: a

therapeutic approach; Journal of nanoparticle research. 2014. 16: 2304-2307.

- Frigell J, García I, Gómez-Vallejo V, Llop J, Penadés S; 68Ga-labeled gold

glyconanoparticles for exploring blood brain barrier permeability: Preparation,

Biodistribution Studies, and Improved Brain Uptake via neuropeptide

conjugation. Journal of American Chemical Society. 2014. 136(1): 449-457.

DOI: 10.1021/ja411096ml.

- Gaja V, Gómez-Vallejo V, Puigivila M, Pérez-Campaña C, Martin A, García-

Osta A, Calvo-Fernández T, Cuadrado-Tejedor M, Franco R, Llop J; Synthesis

and evaluation of 13N-labelled azo compounds for β-amyloid imaging in mice.

Molecular imaging and biology. 2014. 16: 538-549. DOI: 10.1007/s11307-013-

0708-x.

- Gómez-Vallejo V, Vázquez N, Gona KB, Puigivila M, González M, San

Sebastián E, Martin A, Llop J, Synthesis and in vivo evaluation of 11C-labeled

(1,7-dicarba-closo-dodecaboran-1-yl)-N-{[(2S)-1-ethylpirrolidin-2-

yl]methyl}amide. Journal of labeled compounds and radiopharmaceuticals.

2014. 57: 209-214. DOI: 10.1002/jlcr.3159.

- Llop J, Estrela-Lopis I, Ziolo RF, González A, Fleddermann J, Dorn M, Gómez-

Vallejo V, Simon-Vazquez R, Donath E, Mao Z, Gao C, Moya S.E; Uptake,

biological fate, and toxicity of metal oxide nanoparticles. Particle and Particle

and system characterization. 2014. 31: 24-35. DOI: 10.1002/ppsc.201300323.

- Vázquez N, Domercq M, Martin A, Llop J, Gómez-Vallejo V; Matute, C; P2X4

receptors control the fate and survival of activated microglia. Glia, 2014. 62(2):

171-184. DOI: 10.1002/glia.22596.

- Pérez-Campaña C, Sansaloni F, Gómez-Vallejo V, Baz Z, Martin A, Moya SE,

Lagares JI, Ziolo RF, Llop J; Production of 18F-labeled titanium nanoparticles by

proton irradiation for biodistribution and biological fate studies in rats. Particle

and particle and system characterization. 2014. 31: 134-142. DOI:

10.1002/ppsc.201300302.

2013

- Gona KB, Gómez-Vallejo V, Padro D, Llop J; [18F]Fluorination of o-carborane

via nucleophilic substitution: towards a versatile platform for the preparation of 18F-labelled BNCT drug candidates. Chemical Communications, 2013. 49(98):

11491-11493. DOI: 10.1039/c3cc46695g.

- Itsenko O, Gómez-Vallejo V, Llop J, Koziorowski J; On 11C chemistry reviews:

surveying and filling the gaps. Current Organic Chemistry, 2013. 17: 2067-

2096.

- Martín A, Szczupak B, Gómez-Vallejo V, Plaza S, Padró D, Cano A, Llop J;

PET imaging of serotoninergic neurotransmission with [11C]DASB and

[18F]altanserin after focal cerebral ischemia in rats. Journal of cerebral blood

flow and metabolism, 2013. 33: 1967-1975. DOI: 10.1038/jcbfm.2013.156.

- Pérez-Campaña C, Gómez-Vallejo V, Puigvila M, Martin A, Calvo-Fernández

T, Moya SE, Larsen ST; Gispert JD, Llop J; Assessing lung inflammation after

nanoparticle inhalation using 2-deoxy-2-[18F]-fluoro-d-glucose positron

emission tomography imaging. Molecular Imaging and biology, 2013. 16: 264-

273. DOI: 10.1007/s11307-013-0682-3.

- Llop J, Gómez-Vallejo V, Gibson N; Quantitative determination of the

biodistribution of nanoparticles: could radiolabeling be the answer?

Nanomedicine, 2013. 8(7): 1-4. DOI: 10.2217/NNM.13.91

- Pérez-Campaña C, Gómez-Vallejo V, Puigivila M, Martin A, Calvo-Fernández

T, Moya SE, Ziolo RF, Reese T, Llop J; Biodistribution of different size

nanoparticles assessed by positron emission tomography: a general strategy for

direct activation of metal oxide particles. ACS Nano, 2013. 7(4): 3498-3505.

DOI: 10.1021/nn400450p.

- Sansaloni F, Lagares JI, Llop J, Arce P, Díaz C, Pérez-Morales JM; Production

of [11C]CO2 with gas target at low proton energies. Applied radiation and

isotopes, 2013. 78: 10-15. DOI: 10.1016/j.apradiso.2013.03.002.

- Gona KB, Gómez-Vallejo V, Llop J; Synthesis of m-carboranyl amides via

palladium-catalyzed carbonylation. Tetrahedron Letters, 2013. 54(8): 941-944.

DOI: 10.1016/j.tetlet.2012.12.019

- Torrent E, Farré M, Abasolo I, Millan O, Llop J, Gispert JD, Ruiz A, Pareto D;

Optimization of [11C]raclopride positron emission tomographic rat studies:

comparison of methods for image quantification. Molecular Imaging Journal,

2013. 12(4): 257-262. DOI: 10.2310/7290.2012.00040.

- Martín A, Gómez-Vallejo V, San Sebastián E, Padró D, Markuerkiaga I, Llarena

I, Llop J; In vivo imaging of dopaminergic neurotransmission after transient

focal ischemia in rats. Journal of Cerebral Blood Flow and metabolism, 2013.

33: 244-252.

2012

- Sansaloni F, Lagares JI, Arce P, Llop J, Pérez JM; Characterization of the proton

beam from an IBA Cyclone 18/9 with radiochromic film EBT2. AIP Conference

Proceedings, 2012. 2013: 46-50.

- Gómez-Vallejo V, González M, Llop J; Facile and improved synthesis of

[11C]Me-QNB. Journal of Labelled Compounds and Radiopharmaceuticals,

2012. 55: 470-473. DOI: 10.1002/jlcr.2979.

- Locatelli E, Gil L, Israel LL, Passoni L, Naddaka M, Pucci A, Reese T, Gómez-

Vallejo V, Milani P, Mattioli M, Llop J, Lellouche JP, Franchini MC;

Biocompatible nanocomposite for PET/MRI hybrid imaging. International

Journal of Nanomedicine, 2012. 2012(7): 6021-6033. DOI:

10.2147/IJN.S38107.

- Pérez-Campaña C, Gómez-Vallejo V, Martín A, San Sebastian E, Moya SE,

Reese T, Ziolo RF, Llop J; Tracing nanoparticles in vivo: a new general

synthesis of positron emitting metal oxide nanoparticles by proton beam

activation. Analyst, 2012. 137: 4902-4906. DOI: 10.1039/C2AN35863H.

- Gaja V, Gómez-Vallejo V, Cuadrado M, Borrell JI, Llop J; Synthesis of 13N-

labelled radiotracers using microfluidic technology. Journal of Labelled

Compounds and Radiopharmaceuticals, 2012. 55: 332-338. DOI:

10.1002/jlcr.2946.

- Gómez-Vallejo V, Martín A, Aginagalde M, San Sebastian E, Padro D, Cossio

FP, Llop J; Biodistribution and metabolism of 11C-labeled Kendine 91 in mice

and rats. Applied Radiation and Isotopes, 2012. 70: 2545-2551. DOI:

10.16/j.apradiso.2012.05.020.

- Aginagalde M, Gómez-Vallejo V, Vara Y, Cossio FP, Llop J; Synthesis of 11C-

labeled kendine-91, a histone deacetylase inhibitor. Applied Radiation and

Isotopes, 2012. 70: 2552-2557. DOI: 10.1016/j.apradiso.2012.05.016.

- Vázquez N, Gómez-Vallejo V, Llop J; Synthesis of novel pyrazole derivatives

incorporating one dicarba-closo-dodecaborane unit. Tetrahedron Letters, 2012.

53: 4743-4746. DOI: 10.1016/j.tetlet.2012.06.113.

- Martin A, San Sebastián E, Gómez-Vallejo V, Llop J; Positron emission

tomograghy with [13N]ammonia evidences long-term cerebral hyperperfusion

after 2h-transient focal ischemia. Neuroscience, 2012. 213: 47-53. DOI:

10.1016/j.neuroscience.2012.0.3.050.

2011

- Gómez-Vallejo V, Llop J; Fully automated and reproducible radiosynthesis of

high specific activity [11C]raclopride and [11C]Pittsburg compound-B using the

combination of two commercial synthesizers. Nuclear and Medicine

Communications, 2011. 32 (11): 1011-1017. DOI:

10.1097/MNM.0B013E32834B45A3.

- Catafau AM, Bullich S, Nucci G, et al; Contribution of SPECT measurements of

D2 and 5-HT2A occupancy to the clinical development of the antipsychotic SB-

773812. Journal of Nuclear Medicine, 2011. 52(4): 526-534. DOI:

10.2967/jnumed.110.081885.

- Rojas S, Martín A, Pareto D, Herance JR, Abad S, Ruiz A, Flotats N, Gispert

JD, Llop J, Gómez-Vallejo V, Planas AM; PET with 11C-Flumazenil in the rat

shows preservation of binding sites during the acute phase after 2h-transient

focal ischemia. Neuroscience, 2011. 182: 208-216. DOI:

10.1016/j.neuroscience.2011.03.013.

- Vázquez N, Gómez-Vallejo V, Calvo J, Padro D, Llop J; Synthesis of D2

receptor ligands analogs incorporating one dicarba-closo-dodecaborane unit.

Tetrahedron Letters, 2011. 52: 615-618. DOI: 10.1016/j.tetlet.2010.11.161.

2010

- Figueiras FP, Jiménez X, Pareto D, Gómez V, Llop J, Herance R, Rojas S,

Gispert JD; Simultaneous Dual-tracer PET imaging of the rat brain and its

application in the study of cerebral ischemia. Molecular Imaging and Biology,

2010. 13(3): 500-510. DOI: 10.1007/s11307-010-0370-5.

- Gómez-Vallejo V, Borrell JI, Llop J; A convenient synthesis of 13N-labelled azo

compounds: a new route for the preparation of amyloid imaging PET probes.

European Journal of Medicinal Chemistry, 2010. 45: 5318-5323. DOI:

10.1016/j.ejmech.2010.08.053.

- Gómez-Vallejo V, Kato K, Oliden I, Calvo J, Baz Z, Borrell JI, Llop J; Fully

automated synthesis of 13N-nitrosothiols. Tetrahedron Letters, 2010. 51: 2990-

2993. DOI:10.1016/j.tetlet.2010.03.122.

2009

- Catafau AM, Suarez M, Bullich S, Llop J, et al; Within-subject comparison of

striatal D2 receptor occupancy measurements using [123I]IBZM SPECT and

[11C]Raclopride PET. NeuroImage, 2009. 46: 447-458. DOI:

10.1016/j.neuroimage.2009.02.005.

- Martín A, Rojas S, Pareto D, Santalucia T, Millán O, Abasolo I, Gómez V, Llop

J, Gispert JD, Falcon C, Bargalló N, Planas AM; Depressed glucose

consumption at reperfusion following brain ischemia does not correlate with

mitochondrial dysfunction and development of infarction: an in vivo positron

emission tomography study. Current Neurovascular Research, 2009; 6(2): 82-

88.

- Gómez-Vallejo V, Kato K, Hanyu H, Minegishi K, Borrell JI, Llop J; Efficient

system for the preparation of [13N]Labeled Nitrosamines. Bioorganic and

medicinal chemistry Letters, 2009. 19: 1913-1915. DOI:

10.1016/j.bmcl.2009.02.066.

- Gómez-Vallejo V, Llop J; Specific activity of [11C]CH3I synthesized by the

“wet” method: main sources of non-radioactive carbon. Applied Radiation and

Isotopes, 2009. 67: 111-114. DOI: 10.1016/j.apradiso.2008.09.012.

- Llop J, Gómez-Vallejo V, Bosque M, Quincoces G, Peñuelas I; Synthesis of S-

[13N]Nitrosoglutathione (13N-GSNO) as a new potential PET imaging agent.

Applied Radiation and Isotopes, 2009. 67: 95-99. DOI:

10.1016/j.apradiso.2008.09.014.

2008

- Gómez V, Amador V, Gispert JD, Llop J; New Method for Routine Production

of L-[Methyl]methionine: In Loop Synthesis. Journal Labelled Compounds and

Radiopharmaceuticals, 2008. 51(1): 83-86. DOI: 10.1002/jlcr.1483.

2007

- Segura J, Fillat C, Andreu D, Llop J, Millan O, de la Torre BG, Nikolovski Z,

Gómez V, Andreu N, Pinyot A, Gispert JD, Pascual JA; Monitoring Gene

Therapy by External Imaging mRNA: Pilot Study on Murine Erytropoietin.

Therapeutic Drug Monitoring, 2007. 29(5): 612-618.

- Rojas S, Martín A, Arranz MJ, Pareto D, Purroy J, Verdaguer E, Llop J, Gómez

V, Gispert JD, Millan O, Chamorro A Planas A; Imaging Brain Inflammation

with [11C]PK11195 by PET and Induction of the Peripheral-Type

Benzodiazepine Receptor after Transient Focal Ischemia in Rats. Journal of

Cerebral Blood Flow and Metabolism, 2007. 27(12): 1975- 1986. DOI:

10.1038/sj.jcbfm.9600500.

2006

- Catafau AM, Danus M, Bullich S, Nucci G, Llop J, Abanades S, Cunningham

VJ, Eersels JL, Pavia J, Farre M; Characterization of the SPECT 5-HT2A

Receptor Ligand 123I-R91150 in Healthy Volunteers: part 2-Ketanserin

Displacement. Journal of Nuclear Medicine, 2006. 47(6): 929-937.

- Catafau AM, Danus M, Bullich S, Llop J, Perich J, Cunningham VJ, Plaza P,

Penengo MM, Eersels JL, Squassante L, Ros D, Barbanoj M; Characterization

of the SPECT 5-HT2A Receptor Ligand 123I-R91150 in Healthy Volunteers: part

1- Pseudo-equilibrium Interval and Quantification Methods. Journal of Nuclear

Medicine. 2006. 47(6): 919-928.

2005

- Catafau AM, Perez V, Penengo MM, Bullich S, Danús M, Puigdemont D,

Pascual JC, Corripio I, Llop J, Perich J, Álvarez E; SPECT of Serotonin

Transporters Using 123I-ADAM: Optimal Imaging Time After Bolus Injection

and Long-Term Test-Retest in Healthy Volunteers. Journal of Nuclear

Medicine. 2005; 46: 1301-1309.

- Viñas C, Llop J, Teixidor F, Kivekäs R, Sillanpää R; Restricted Rotation in

Unbridged Rotational Behaviour of closo-[Co(η5-NC4H4)(C2B9H11)]

Derivatives. Chem. Eur. J. 2005; 11:1933-1941. DOI:

10.1002/chem.200400445.

2004

- Rahman O, Llop J, Langström B; Organic Bases as Additives to Improve the

radiochemical Yields of [11C]Ketones Prepared by the Suzuki Coupling

Reaction. Eur. J. Org. Chem. 2004; 2674-2678. DOI: 10.1002/ejoc.200400038.

2003

- Llop J, Masalles C, Teixidor F, Viñas C, Sillanpää R, Kivekäs R; The [3,3-

Co(1,2-C2B9H11)2]- Anion as Platform for New Materials: Synthesis of its

Functionalized Monosubstituted Derivatives Incorporating Synthons for

Conducting Organic Polymers. J. Chem. Soc. Dalton Trans. 2003; 556-561.

DOI: 10.1039/b211860m.

2002

- Llop J, Viñas C, Teixidor F, Victori L; Coordinating Properties of Mixed

Pyrrolyl/Dicarbollyde Cobalt Metallocene-type Complexes. J. Chem. Soc.,

Dalton Trans. 2002; 8:1559-1565. DOI: 10.1039/b110918a.

- Llop J, Viñas C, Oliva JM, Teixidor F, Flores MA, Kivekäs R, Sillanpää R;

Modulation of the C-C Distance in Disubstituted 1,2-R2-o-Carboranes. Crystal

Structure of closo-1,2-(SPh)2-1,2-C2B10H10. Journal of Organometallic

Chemistry. 2002; 657(1-2): 232-238.

- Llop J, Viñas C, Teixidor F, Kivekäs R, Sillanpää R; Frozen-Out Rotamers of

Mixed Cobaltacarborane Complexes. Organometallics. 2002; 21(2):355-361.

DOI: 10.1021/om010711l.

- Llop J, Viñas C, Teixidor F, Victori L, Kivekäs R, Sillanpää R; Redox Potential

Modulation in Mixed Sandwich Pyrrolyl/Dicarbollide Complexes. Inorganic

Chemistry. 2002; 41(13): 3347-3352. DOI: 10.1021/ic011285z.

- Masalles C, Llop J, Viñas C, Teixidor F; Extraordinary Overoxidation

Resistance Increase in Self-Doped Polypyrroles by Using Non-Conventional

Low Charge-Density Anions. Advanced Materials. 2002; 14(11): 826-829.

2001

- Llop J, Viñas C, Teixidor F, Victori L, Kivekäs R, Sillanpää R; C-C Plasticity in

Boron Chemistry: Modulation of the Cc…Cc Distance in Mixed

Pyrrolyl/Dicarbollide Complexes. Organometallics. 2001; 20:4024-4030. DOI:

10.1021/om010511.

- Sillanpää R, Llop J, Viñas C, Teixidor F; Kivekäs, R; n5-(3)-1-methyl-1,2-

dicarbollyl-n5-2’,5’-dimethylpyrrolylcobalt(III). Acta crystallographica. 2001;

C57:900-901.

BOOK CHAPTERS

- Llop J, Gómez-Vallejo V, Gibson PN; Isotopes in nanoparticles: Fundamentals

and applications. Isotopes in nanoparticles. Fundamentals and applications.

2016. 1-513.

- Reese T, Gómez-Vallejo V, Ferreira P, Llop J; Health and safety considerations

for radiolabelled nanoparticles. Isotopes in nanoparticles. Fundamentals and

applications. 2016. 493-512.

- Gil Iceta L, Gómez-Vallejo V, Koziorowski JM, Llop J; Radiochemical stability

studies of radiolabelled nanoparticles. Isotopes in nanoparticles. Fundamentals

and applications. 2016. 429-454.

- Cossío U, Gómez-Vallejo V, Llop J, Laverman P; Radiolabelling of liposomes.

Isotopes in nanoparticles. Fundamentals and applications. 2016. 261-286.

- Llop J, Gómez-Vallejo V, García Martín I, Marradi M; Radiolabelling of

nanoparticles using radiohalogens, 13N, and 11C. Isotopes in nanoparticles.

Fundamentals and applications. 2016. 231-260.

- García Martín I, Frigell J, Llop J, Marradi M; Radiolabelling of NPs using

radiometals: 99mTc, 68Ga, 67Ga, 89Zr, and 64Cu. Isotopes in nanoparticles.

Fundamentals and applications, 2016. 183-230.

- Gómez-Vallejo V, Llop J, Lagares JI; A brief overview of radioactivity. Isotopes

in nanoparticles. Fundamentals and applications, 2016. 143-162.

- Gómez-Vallejo V, Jiménez M, Llop J, Reese T; New molecular and functional

imaging techniques. Functional imaging in oncology. 2014. 491-522.

- Gómez-Vallejo V, Gaja V, Zoziorowski J, Llop J; Specific activity of 11C-

labelled radiotracers: a big challenge for PET chemists. Positron Emission

Tomography: Current Clinical and Research Aspects, 2012. Cap. 7, 183-208.

- Llop J, Teixidor F, Viñas C, Kivekäs R, Sillanpää R; Pyrrole and o-carborane.

Contemporary Boron Chemistry. Ed. R.S.C. 2000; 308-315.

PATENTS

- Rahman O, Langström B, Kihlberg T, Llop J; Methods for Carbon Isotope

Labeling Synthesis of Ketones and Amines by Suzuki Coupling Reactions Using

Carbon-Isotope Monoxide. Registry Number: Application Number

PCT/IB2004/004199. International Publication Number: WO 05/066100 A1.

Priority Date: December, 24th 2003. Owner: GE Healthcare Limited. Priority

Countries: US. Other Countries: US.

ADDITIONAL FORMATION

2013

- 12th FELASA/SECAL Congress 2013.

Accredited by: FELASA

- Congreso Sociedad Española Medicina Nuclear e Imagen Molecular

Accredited by: Semnim

2012

- Curso de Revisión y Actualización de las Normas de Protección Radiológica

Accredited by: ACPRO

- Curso de Revisión y Actualización de GMPs.

Accredited by: IBA Molypharma

- Curso Manipulación y Experimentación animal. Categoría B.

Accredited by: Animalaria

2011

- I Jornadas de NeuroImagen y VIII Jornadas del Grupo PET

Accredited by: Semnim

- 19th International Symposium on Radiopharmaceutical Sciences

Accredited by: Society of Radiopharmaceutical Sciences

2010

- IV Jornadas de Formación Teórico-Práctica en MRI/MRS: Aplicación en

animales de laboratorio

Accredited by: UAB

2009

- IBA Users Meeting

Accredited by: IBA

- 18th International Symposium on Radiopharmaceutical Sciences

Accredited by: Society of Radiopharmaceutical Sciences

- IBA Hands on – Cyclotron Training

Accredited by: IBA

2008

- XIII Imeboron – International Conference on Boron Chemistry

Accredited by: CSIC

- World Molecular Imaging Congress 2008

Accredited by: Academy of Molecular Imaging

- XI TurkuPET Symposium

Accredited by: University of Turku

- 14th European Symposium on Radiopharmacy and Radiopharmaceuticals

Accredited by: European Association of Nuclear Medicine

2007

- Workshop en Imagen Molecular

Accredited by: Consejería de Sanidad de la Comunidad de Madrid

2006

- Training in risk prevention and emergency plan

Accredited by: CYCLOPS, Servicio de Prevención

- cGMPs aplicada a Radiofármacos

Accredited by: SVS (Sociedad de Validación de Sistemas)

2004

- Changes Control and Re-validation

Accredited by: SVS (Sociedad de Validación de Sistemas)

- Training program consisted on Hands-on sessions pertaining to the

operation and Maintenance of the Cyclone 18/9TM cyclotron

Accredited by: IBA (Ion Beam Applications)

2003

- Radioactive Facility Supervisor in Nuclear Medicine Area

Accredited by: INTE (Institut de Tècniques Energètiques de la Unversidad

Politécnica de Cataluña)

- Termochemical Risks

Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

- Reometry and Reology

Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

- Advanced Surface Characterization Techniques

Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

- X-Ray Diffraction – Single Crystal Structure Analysis

Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

2002

- Radio-element and their use: Radiochemistry

Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

- Advanced Quantum Chemistry

Accredited by: Institut Químic de Sarrià – Universitat Ramon Llull

SCIENTIFIC MEETINGS CONTRIBUTIONS

2016

- Benito AB, Aiertza MK, Marradi M, Gil L, Alonso E, Jiménez-González M,

Reese T, Scanziani E, Passoni L, Oreinstein A, Oron-Herman M, Shekther T,

Gazit E, Cabañero G, Grande HJ, Gómez-Vallejo V, Llop J, Ionaz I; Functional

single chain polymer nanoparticles: targeting and imaging pancreatic tumors in

vivo. Poster. 10th World biomaterilas congress. Montreal, Canada. May, 2016.

2015

- Gómez-Vallejo V, Ríos X, Al Harari F, Arsequell G, Valencia G, Llop J; 18F-

labeling and in vivo studies of transthyretin amyloid formation inhibitor

iododiflunisal. Comunicación Oral. International Molecular Imaging

Workshop. San Sebastian, Spain. November, 2015.

- Gil L, Jiménez-González M, Shekther T, Gómez-Vallejo V, Gazit E, Reese T,

Llop J; Tumor targeting efficiency studies of radiolabeled PTR peptides for

pancreatic cancer. Poster. International Molecular Imaging Workshop. San

Sebastian, Spain. November, 2015.

- Gil L, Jiménez-González M, Szczupak B, Gómez-Vallejo V, Reese T, Llop J; 18F-FDG biodistribution differences depending upon different anesthesia

conditions in tumor bearing mice. Poster. International Molecular Imaging

Workshop. San Sebastian, Spain. November, 2015.

- Cossío U, Asensio M, Montes A, Akhtar S, te Welscher Y, van Nostrum R,

Gómez-Vallejo V, Llop J; Biodistribution studies of 67Ga-loaded liposomes

administered by a new aerosol inhalation system. Comunicación oral.

International Molecular Imaging Workshop. San Sebastian, Spain.

November, 2015.

- Joshi S, Gómez-Vallejo V, Llop J; Preparation of 13N-labelled biologically

active polysubstituted triazoles via Huisgen cycloaddition. Poster. International

Molecular Imaging Workshop. San Sebastian, Spain. November, 2015.

- Da Silva E, Gómez-Vallejo V, Llop J, López-Gallego F; Efficient and

sustainable synthesis of L-[13N]alanine catalyzed by heterogenous biocatalysts.

Comunicación Oral. International Molecular Imaging Workshop. San

Sebastian, Spain. November, 2015.

- Da Silva E, Gómez-Vallejo V, Llop J, López-Gallego F; Efficient and

sustainable synthesis of L-[13N]alanine catalyzed by heterogenous biocatalysts.

Comunicación Oral. International Molecular Imaging Workshop. San

Sebastian, Spain. November, 2015.

- Cossío U, Asensio M, Montes A, Akhtar S, te Welscher Y, Gómez-Vallejo V,

Llop J; Radiolabelling of liposomes with 67Ga and biodistribution studies after

administration by an aerosol inhalation system. Comunicación Oral. bioMAPP.

San Sebastian, Spain. October, 2015.

- Joshi S, Gómez-Vallejo V, Llop J; Preparation of 13N-labelled biologically

active polysubstituted triazoles via Huisgen cycloaddition. Comunicación Oral.

bioMAPP. San Sebastian, Spain. October, 2015.

- Gil L, Gómez-Vallejo V, Jiménez-González M, Benito A, Shekther T, Gazit E,

Loinaz I, Reese T, Llop J; Influence of different targeting moieties on SCPNs by

SPECT/CT imaging for triggering pancreatic cancer. Poster. bioMAPP. San

Sebastian, Spain. October, 2015.

- Da Silva ES, Gómez-Vallejo V, Llop J, López-Gallego F; Biocatalyzed

synthesis of L-13N-alanine by L-alanine dehydrogenase from Bacilus subtilis.

Poster. bioMAPP. San Sebastian, Spain. October, 2015.

- Gago B, Garcia-Garcia D, Marin C, Jumenez-Urbieta H, Oregui A, Gómez-

Vallejo V, Llop J, Mengod G, Corted R, Delgado-Alvarado M, Rodríguez-Oroz

MC; Apomorphine-induced dyskinesias in parkinsonian rats: PET and

histological studies. Poster. 16 Congreso Nacional de las Sociedad Española

de Neurociencias. Granada, Spain. September, 2015.

- Martín A, Gómez-Vallejo V, Szczupak B, Arrieta A, Cano A, Muñoz C, Padró

D, Damont A, Dollé F, Llop J; Novel approaches to image the neuroinflamatory

response after stroke by PET. Poster. Euroglia 2015. Bilbao, Spain. July, 2015.

- Domercq M, Martín A, Vázquez-Villoldo N, Padró D, Gómez-Vallejo V, Soria

F, Szczupak B, Plaza S, Arrieta A, Reese T, Llop J, Matute C; A novel imaging

approach to monitor multiple sclerosis. Poster. Euroglia 2015. Bilbao, Spain.

July, 2015.

- Benito A, Aiertza MK, Marradi M, Gil L, Alonso Guerrero E, Jiménez M, Reese

T, Escanziani E, Passoni L, Orenstein A, Oron.Herman M, Cabañero G, Grande

HJ, Gómez-Vallejo V, Llop J, Loinaz I; Functional single chain polymer

nanoparticles: targeting and imaging pancreatic tumors in vivo. Poster.

CLINAM 2015. Basel, Switzerland. June, 2015.

- Gómez-Vallejo V, Marradi M, Echeverría M, Szczupak B, Puigivila M, Moya

SE, Llop J; Determinación de la biodistribución y estabilidad de NPs in vivo

mediante marcaje doble y SPECT con discriminación energética. Oral

Communication. 35º SEMNIM. Burgos, Spain. June, 2015.

- Gómez-Vallejo V, de Cózar A, Joshi SM, Koziorowski J, Llop J, Cossío FP;

Aplicación del nitrógeno-13 al estudio mecanístico de reacciones: formación de

azidas aromáticas. Oral Communication. 35º SEMNIM. Burgos, Spain. June,

2015.

- Gómez-Vallejo V, Gil L, Errasti M, González M, Lekuona A, Llop J;

Producción semiautomática de 89Zr. Oral Communication. 35º SEMNIM.

Burgos, Spain. June, 2015.

- da Silva Fernandes E, Gómez-Vallejo V, Llop J, López-Gallego F; Efficient

[13N]nitrate reduction catalyzed by Aspergillus niger nitrate reductase

immobilized on positively charged carrier. Poster. 21st ISRS (International

Symposium on Radiopharmaceutical Sciences). Columbia, Missouri. May,

2015.

- Cossío U, Gómez-Vallejo V, Pini A, Falciani C, Llop J; Promising anti-Gram-

negative antimicrobial peptides (AMPs): Radiolabeling and biodistribution

profiles. Poster. 21st ISRS (International Symposium on

Radiopharmaceutical Sciences). Columbia, Missouri. May, 2015.

- Joshi S, Gómez-Vallejo V, Llop J; Preparation of 13N-labelled polysubstituted

triazoles via Huisgen cycloaddition. Poster. 21st ISRS (International

Symposium on Radiopharmaceutical Sciences). Columbia, Missouri. May,

2015.

- Gona KB, Gómez-Vallejo V, Llop J; Synthesis of radiolabelled boron-rich

functionalized NPs as boron carriers for boron neutron capture therapy. Poster.

21st ISRS (International Symposium on Radiopharmaceutical Sciences).

Columbia, Missouri. May, 2015.

2014

- Weis C, Plaza-García S, Jiménez-González M, Strauss A, Reese T, Llop J, Felix

K, Szczupak B, Rosenberger I, Israel LL, Kreuter J, Lellouche JPM, Werner J,

Hans-Ulrich K, Grenacher L; Increasing MRI’s sensitivity: how phase analysis

improves the detection of iron-loaded nanoparticles in-vivo. Poster. World

Molecular Imaging Conference. Seoul, Korea. September, 2014.

- Strauss A, Jiménez-González M, Szczupak B, Plaza-García S, Weis C, Llop J,

Reese T, Gómez-Vallejo V, Gil L, Knoll P, Mirzaei S, Israel LL, Lellouche

JPM, Felix K, Dobiash F, Werner J, Rosenberger I, Kreuter J, Hans-Ulrich K,

Grenacher L; Homing-analysis of different iron loaded nanoparticles targeted

against PaCa using 11.7T MRI and SPECT-CT. Poster. World Molecular

Imaging Conference. Seoul, Korea. September, 2014.

- Jiménez-González M, Plaza-García S, Pastor G, Llop J, Reese T; Visualization

of nearby lymph nodes in a xenograft tumor model using MRI imaging at 11.7

Tesla. Poster. World Molecular Imaging Conference. Seoul, Korea.

September, 2014.

- Pastor G, Jiménez-González M, Plaza-García S, Llop J, Reese T; Zoomed

displaced U-FLARE utilized for relaxation time mapping of tumors in mice at

11.7T. Poster. World Molecular Imaging Conference. Seoul, Korea.

September, 2014.

- Joshi SM, da Silva ES, Gómez-Vallejo V, Llop J; Fenilazidas marcadas con

nitrógeno-13: precursores para la preparación de triazoles polisustituidos. Oral

Communication. 34º Congreso de la Sociedad Española de Medicina Nuclear

e Imagen Molecular (SEMNIM). Madrid, Spain. May, 2014.

- Elizalde J, Berganzo J, Ruano-López JM, Gómez-Vallejo V, Gona KB,

Rodríguez B, Llop J; Diseño e implementación de un sistema de microfluidos

para la síntesis de [18F]FDG mediante reacción en fase sólida. Oral

Communication. 34º Congreso de la Sociedad Española de Medicina Nuclear

e Imagen Molecular (SEMNIM). Madrid, Spain. May, 2014.

- Sansaloni F, Gómez-Vallejo V, Errasti M, Lecuona A, Koziorowski J, Lagares

JI, Llop J; Direct determination of specific activity of the cyclotron-produced

[11C]CO2 using GC-MS. Oral communication. 17th European symposium on

Radiopharmacy and Radiopharmaceuticals-ESRR’14. Pamplona, Spain.

April, 2014.

- Cobaleda-Siles M, Gómez-Blanco N, González M, Gómez-Vallejo V, Llop J,

Mareque-Rivas JC; Intrinsically labelled magnetite- and quantum dot-filled

micelles improving specific activity of labelled nanoparticles. Poster. 17th

European symposium on Radiopharmacy and Radiopharmaceuticals-

ESRR’14. Pamplona, Spain. April, 2014.

- Gona KB, Gómez-Vallejo V, Puigivila M, Lekuona A, Zaulet A, Viñas C, Llop

J; Teixidor F; Synthesis and biodistribution of 124I- and 125I-labelled

cobaltabisdicarbollides. Oral communication. 17th European symposium on

Radiopharmacy and Radiopharmaceuticals-ESRR’14. Pamplona, Spain.

April, 2014.

- Joshi SM, Gómez-Vallejo V, Llop J; Synthesis of 13N-labelled phenyl azide via

dutt-wormall reaction. Poster. 17th European symposium on Radiopharmacy

and Radiopharmaceuticals-ESRR’14. Pamplona, Spain. April, 2014.

- Elizalde J, Ruano-López JM, Berganzo J, Gómez-Vallejo V, Gona KB,

Rodríguez B, Lima A, da Silva ES, Llop J; Automated synthesis box based on

microfluidics for solid phase supported synthesis: application to 18F and 13N.

Poster. 17th European symposium on Radiopharmacy and

Radiopharmaceuticals-ESRR’14. Pamplona, Spain. April, 2014.

2013

- Gago B, Marin C, Garcia-Garcia D, Jiménez-Urbieta H, Oregui A, Gómez-

Vallejo V, Llop J, Rodriguez-Oroz MC; Apomorphine-induced diskenias in

unilateral 6-hydroxidopamine-lesioned rats: quetiapine dose response effects.

Poster. 15 Congreso de la Sociedad Española de Neurociencia. Oviedo,

Spain. September, 2013.

- Martin A, Szczupack B, Gómez-Vallejo V, Plaza S, San Sebastián E, Padró D,

Makuerkiagi I, Llop J; In vivo imaging of dopaminergic and serotoninergic

neurotransmission following long-term ischemia. Poster. NeuroGUNE. Bilbao,

Spain. July, 2013.

- Gago B, Marin C, Garcia-Garcia D, Jiménez-Urbieta H, Oregui A, Gómez-

Vallejo V, Llop J, Rodriguez-Oroz M; Apomorphine-induced abnormal

involuntary movements in unilateral 6-hydroxidopamine-lesioned rats:

quetiapine effects. Poster. NeuroGUNE. Bilbao, Spain. July, 2013.

- Errasti M, González-Esparza M, Lekuona A, Gómez-Vallejo V, Llop J;

Determination of the specific activity of cyclotron produced [11C]CO2 by GC-

MS. Where is cold CO2 coming from? Oral Comunication. IBA Users meeting..

Copenhage, Denmark. June, 2013.

- González-Esparza M, Gómez-Vallejo V, Errasti M, Lekuona A, Llop J; Diseño e

implementación de un sistema para la determinación de CO2 generado durante el

proceso de producción de [11C]CO2. Oral Comunication. 33º Congreso de la

Sociedad Española de Medicina Nuclear e Imagen Molecular. Murcia, Spain.

June, 2013.

- Babu Gona K, Puigivila M, Calvo-Fernández T, Oyarzabal J, García-Osta A,

Cuadrado-Tejedor M, Franco R, Gómez-Vallejo V, Llop J; Síntesis y estudio

farmacocinético de [11C]sildenafilo. Oral communication. 33º Congreso de la

Sociedad Española de Medicina Nuclear e Imagen Molecular. Murcia, Spain.

June, 2013.

- Gómez-Vallejo V, Gaja V, Puigivila M, Gona KB, Calvo-Fernández T, García-

Osta A, Cuadrado-Tejedor M, Franco R, Llop J; Síntesis de [13N]azoderivados y

evaluación como marcadores de placa β-amiloide. Poster. 33º Congreso de la

Sociedad Española de Medicina Nuclear e Imagen Moleacular. Murcia,

Spain. June, 2013.

- Simoes A, Calvete MJF, Llop J, Gómez-Vallejo V, Abrunhosa AJ;

Radiosynthesis of new F-18-labelled meso-tetraphenylporphyrins as potential

tracers for in vivo molecular imaging with PET. Poster. The 20th international

symposium on radiopharmaceutical sciences. Jeju, Korea. April, 2013.

- Babu Gona K, Gómez-Vallejo V, Llop J; Selective mono-fluorination of o-

carborane and further derivatization: a potential tool for the evaluation of newly

developed BNCT. Oral Comunication. The 20th international symposium on

radiopharmaceutical sciences. Jeju, Korea. April, 2013.

- Gaja V, Gómez-Vallejo V, Puigivila M, Babu Gona K, Cuadrado-Tejedor M,

Franco R, Llop J; Synthesis and evaluation of 13N-labelled azo compounds as

potential small animal PET imaging agents for β-amyloids plaques. Poster. The

20th international symposium on radiopharmaceutical sciences. Jeju, Korea.

April, 2013.

2012

- Gago B, Marin C, Garcia-Garcia D, Jiménez-Urbieta H, Gómez-Vallejo V, Llop

J, Rodriguez-Oroz M; Disquenias en el modelo animal de enfermedad de

Parkinson de la rata lesionada unilateralmente con 6-OHDA: efecto de la

quetiapina. Oral Comunication. XXXIII Reunión Annual del grupo español

de neurotransmission y neuroprotección. Guipúzcoa, Spain. December, 2012.

- Gago B, Marin C, Garcia-Garcia D, Gómez-Vallejo V, Llop J, Rodriguez-Oroz

M; Quetiapine effects on apomorphine-induced abnormal involuntary

movements in unilateral 6-hydroxydopamine-lesionedrats. Poster. Neuroscience

2012. New Orleans, USA. October, 2012.

- Martín A, Gómez-Vallejo V, San Sebastián E, Padró D, Makuerkiaga I, Llop J;

PET Imaging of metabolism, perfusión and dopamine receptor after stroke.

Poster. 2012 World Molecular Imaging Conference. Dublin, Ireland.

September, 2012.

- Martín A, Moraga A, San Sebastián E, Szczupak B, Gómez-Vallejo V,

Makuerkiaga I, Padró D, Llop J, Lizasoaín I; Role of Toll-like receptor-4 in

neuroinflammation using positron emission tomography after cerebral ischemia.

Poster. 2012 World Molecular Imaging Conference. Dublin, Ireland.

September, 2012.

- Martín A, San Sebastián E, Gómez-Vallejo V, Llop J; Positron Emission

Tomography with [13N]Ammonia evidences long-term cerebral hyperfusion

after 2h-transient focal ischemia. Poster. 2012 World Molecular Imaging

Conference. Dublin, Ireland. September, 2012.

- Sansaloni F, Lagares JI, Arce P, Llop J; Characterization of the proton beam

from an IBA cyclone 18/9 with radiochromic film EBT. Poster. 14th

International Workshop on Targetry and Target Chemistry. Cancun,

Mexico. August, 2012.

- Pérez-Campaña C, Puigivila Viñeta M, Gómez-Vallejo V, Llop J; Synthesis,

characterization and biodistribution of metal oxide nanoparticles by means of

Positron Emission Tomography (PET). Poster. 9th World Biomaterials

Congress. Chengdu, China. June, 2012.

- González Esparza M, Gómez-Vallejo V, Llop J; Síntesis, purificación y control

de calidad de [11C]PE2I y [18F]altanserina para su utilización en un estudio

preclínico. Poster. 32º Congreso de la Sociedad Española de Medicina

Nuclear e Imagen Molecular (SEMNIM). Cádiz, Spain. June, 2012.

- Pérez-Campaña C; Puigivila Viñeta M, Gómez-Vallejo V, Llop J; Síntesis,

caracterización y biodistribución de nanopartículas de óxidos metálicos

mediante Tomografía por Emisión de Positrones. Poster. 32º Congreso de la

Sociedad Española de Medicina Nuclear e Imagen Molecular (SEMNIM).

Cádiz, Spain. June, 2012.

- Gómez-Vallejo V, Gaja V, Llop J; Síntesis de azoderivados marcados con

nitrógeno-13 mediante microfluidos: evaluación como marcadores de placa β-

amiloide. Oral Communication. 32º Congreso de la Sociedad Española de

Medicina Nuclear e Imagen Molecular (SEMNIM). Cádiz, Spain. June, 2012.

- Puigivila M, Vázquez N, Gómez-Vallejo V, Llop J; Síntesis de 1-(N-(1-[metil-11C]-2-metilen-pirrolidin)-formamida)-1,7-dicarba-closo-dodecaborano:

Evaluación como ligando de receptores dopaminérgicos D2. Poster. 32º

Congreso de la Sociedad Española de Medicina Nuclear e Imagen

Molecular (SEMNIM). Cádiz, Spain. June, 2012.

- Gaja V, Gómez-Vallejo V, Llop J; Synthesis of 13N-labelled radiotracers using

microfluidic technology. Oral Communication. 16th European Symposium on

Radiopharmacy and Radiopharmaceuticals (ESRR). Nantes, France. April,

2012.

2011

- Yordanov A, Shulman S, Gómez-Vallejo V, Llop J; Is there future for comercial

C-11 PET drug manufacturing using disposable kits?; Poster. 19th International

Symposium on Radiopharmaceutical Sciences (ISRS). Amsterdam,

Netherlands. August, 2011.

- Llop J; Synthesis of radiolabelled nanoparticles for biodistribution studies in

animal models; Oral communication Safety issues of nanomaterials along

their life cycle. Barcelona, Spain. May, 2011.

- Gómez-Ros JM, Romero A, Belogni R, Esposito A, Moraleda M, Lagares JI,

Sansaloni F, Arce P, Llop J; Verificación experimental de un nuevo

espectrómetro de neutrones para dosimetría ambiental y de área; Poster. II

Congreso Conjunto SEFM-SEPR. Seville, Spain. May, 2011.

- Llop J, Pérez Campaña C, Gómez-Vallejo V, San Sebastián E, Martín A, Reese

T, Ziolo FR, Moya SE; Synthesis of positron emitter labeled metal oxide

nanoparticles for biodistribution studies by direct activation with high energy

protons; Oral Communication. ImagineNano. Bilbao, Spain. April, 2011.

- Pérez Campaña C, Gómez-Vallejo V, Ziolo FR, Reese T, Moya SE, Llop J;

Synthesis, characterization and activation of metal oxide nanoparticles; Poster.

ImagineNano. Bilbao, Spain. April, 2011.

2010

- Gómez-Vallejo V, Borrell JI, Llop J; A convenient synthesis of 13N-labelled

azo compounds: a new route for the preparation of amyloid PET probes; Oral

Communication. International Workshop on Biomedical Applications for

microPET. Seville, Spain. September, 2010.

2009

- Gómez-Vallejo V, Kato K, Hanyu M, Minegishi K, Borrell JI, Llop J; Efficient

method to synthesize [13N]-Nitrosamines; Poster. 18th International

Symposium on Radiopharmaceutical Sciences. Edmonton, Canadá. July,

2009.

2008

- Catafau AM, Suarez M, Bullich S, Gunn R, Rabiner E, Llop J, Laruelle M;

Within-subject Comparison of Striatal D2 Receptor Occupancy Measurements

using 123I-IBZM SPECT and 11C-Raclopride PET; Oral Communication. SNM

Annual Meeting. New Orleans, LA (USA). 2008.

- Catafau AM, Bullich S, Suarez M, Cot A, Gunn R, Gallego J, Pavia J, Llop J,

Rabiner E, Ros D, Laruelle M; Striatal Dopamine D2 Receptor Occupancy

Measurements using [123I]IBZM SPECT and [11C]Raclopride PET: A Within-

Subject Comparison Study; Oral Communication. 7th International

Symposium on Functional Neuroreceptor Mapping of the Living Brain.

Pittsburg (USA). July, 2008.

2007

- Gómez V, Millán O, Llop J, Gispert JD, Andreu N, Pinyot A, Nikolovsky Z, de

la Torre BG, Pascual JA, Andreu D, Fillat C, Segura J; Isotope-based imaging of

erythropoietin mRNA; Poster. AMI Annual Conference. Rhode Island, USA.

September, 2007.

- Gómez V, Cebrián P, Doutres A, Gispert JD, Amador V, Llop J; Nuevo método

para la producción rutinaria de 11C-Metionina mediante captura y reacción en

loop; Oral Communication. XXVIII Congreso de la Sociedad Española de

Medicina Nuclear. León, Spain. June, 2007.

- Llop J, Cebrián P, Doutres A, Gómez V; Búsqueda de las fuentes de CO2 no

radiactivo en la manufactura de radiotrazadores marcados con carbón-11; Poster.

XXVIII congreso de la Sociedad española de Medicina Nuclear. León, Spain.

June, 2007.

2006

- Gispert JD, Pareto D, Llop J, Gómez V, Rojas S, Martín A, Planas AM, Millán

O; Simultaneous dual-isotope PET imaging; Poster. AMI Annual Conference.

Florida, USA. September, 2006.

- Llop J, Rodríguez S, Brosa C, Gómez V; Puesta a punto de la síntesis,

purificación y formulación de 18F-Fluoromisonidazol (18F-FMISO); Oral

Communication. XXVII Congreso de la Sociedad Española de Medicina

Nuclear. Granada, Spain. June, 2006.

- Corella A, Gómez V, Brosa C, Llop J; Comparativa del marcaje de 11C-

Racloprida utilizando como agente metilante 11C-CH3I y 11C-CH3OTf; Poster.

XXVII Congreso de la Sociedad Española de Medicina Nuclear. Granda,

Spain. June, 2006.

- Gispert JD, Pareto D, Llop J, Gómez V, Rojas S, Martín A, Planas AM, Millán

O; Imagen PET simultánea de dos radiotrazadores; Poster. XXVII Congreso de

la Sociedad Española de Medicina Nuclear. Granada, Spain. June, 2006.

- Gómez V, Borrell JI, Rojas S, Martín A, Planas AM, Gispert JD, Millán O, Llop

J; Síntesi i validació d’un radiotraçador per a receptors benzodiazepínics

perifèrics: 11C-PK11195; Oral Communication. Quarta Trobada de Joves

Investigadors dels Països Catalans. Lleida, Spain. January, 2006.

2005

- Gómez V, Llop J, Gispert JD, Martínez M, Martín A, Rojas S, García S, Planas

A, Dierssen M, Sanfeliu C, Millán O; PET technology for the study of CNS:

First steps at IAT-PRBB; Poster. 4th Annual Meeting Mouse Models of

Neuroscience Research. Barcelona, Spain. December, 2005.

- Gómez V, Doutres A, Miralles E, Llop J; Puesta a punto del método de síntesis,

purificación, acondicionado y control de calidad de radiotrazadores PET

marcados con carbono-11; Oral Communication. XXVI Congreso de la

Sociedad Española de Medicina Nuclear. Gran Canaria, Spain. June, 2005.

2004

- Llop J; Aspectos Generales de la Radioquímica con Emisores de Positrones;

Oral Communication. PET-Tomografía por Emisión de Positrones:

Aplicaciones en Investigación Clínica. Barcelona, Spain. 2004.

2000

- Llop J, Teixidor F, Viñas C, Kivekäs R, Sillanpää R; Pirrol y o-carborano.

Poster. IX Reunión Científica Plenaria de Química Inorgánica-QIES2000.

Bilbao, Spain. September, 2000.

1998

- Masalles C, Tutusaus O, Llop J, Teixidor F, Viñas C, Borrós S; Elaboration de

Nouvelles Membranes Capteuses de Cations à Partir du Polypyrrole Dopé Avec

des Composés Sándwich du Cobaltacarborane. Poster. 8me Tournée Chimie

Grand Sud-Ouest. Pau, France. 1998.

RESEARCH PROJECTS

PUBLIC FOUNDATION

PROJECT TITLE Imagen multimodal y traslacional (IMUTRANS)

FUNDING MINECO

FROM 2015 TO 2017

PI Borja Ibáñez y Luis Liz-Marzán

PROJECT TITLE PET Imaging in drug design and development (PET3D)

FUNDING UE

FROM 2016 TO 2020

PI Matteo Zanda

PROJECT TITLE Translocation, biological fate, stability and effective dose of

engineered NMs for nanosafety studies (FATENANO)

FUNDING ERANET-MINECO

FROM 12/2015 TO 11/2018

PI Sergio Moya

PROJECT TITLE HYMADE: hybrid drug delivery systems upon mesoporous

materials, self assembled therapeutics and virosomes

FUNDING European Community

FROM 01/02/2015 TO 31/01/2019

PI Jordi Llop, Sergio Moya y Luis Liz Marzán

PROJECT TITLE Translocación, destino biológico y biointeracciones de

nanomateriales con aplicaciones biomédicas e industriales para su evaluación

toxicológica

FUNDING Gobierno Vasco

FROM 2015 TO 2018

PI Jordi Llop y Sergio Moya

PROJECT TITLE Setting a rational screening program for transthyretin-Aβ binding

stabilizing compounds that may lead to potential Alzheimer’s disease modulating drugs

FUNDING Fundació La Marató de TV3

FROM 2015 TO 2018

PI Gemma Arsequell (PI subproject)

PROJECT TITLE Translocación, destino biológico y biointeracciones de

nanomateriales con aplicaciones biomédicas e industriales para su evaluación

toxicológica

FUNDING MINECO

FROM 01/01/2014 TO 31/12/2017

PI Jordi Llop y Sergio Moya

PROJECT TITLE PneumoNP: nanotherapeutics to treat antibiotic resistant gram

negative bacteria caused neumonia infections

FUNDING European Union

FROM 01/01/2014 TO 31/12/2017

PI Mentxu Aiertza

PROJECT TITLE RADIOMI: Innovative radiochemistry to advance molecular

imaging

FUNDING European Union

FROM 01/11/2012 TO 31/10/2016

PI Jordi Llop (PI subproject)

PROJECT TITLE Desarrollo de chaperonas farmacológicas para el tratamiento de

enfermedades raras neurometabólicas

FUNDING Ministerio de Economía y Competitividad

FROM 08/2012 TO 07/2015

PI Salvador Borrós

PROJECT TITLE Biological Foundation for the Safety Classification of Engineered

Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of

ENM with Living Organisms and the Environment

FUNDING European Union (FP7-NMP-2012-LARGE-6)

FROM April 2013 TO March 2016

PI Kai Savolainen

PROJECT TITLE Estudio del papel de los receptores dopaminérgicos y los

transportadores serotoninérgicos en el proceso de la recuperación funcional cerebral del

ictus isquémico experimental mediante técnicas de neuroimagen multimodal

FUNDING Departamento de educación, universidades e investigación, dirección de

política científica, proyectos de investigación (Gobierno Vasco)

FROM 01/01/2011 TO 31/12/2013

PI Abraham Martín

PROJECT TITLE SaveMe: A Modular Active Nano-Platform for Advanced Cancer

Management: Core nanosystems, tumor targeting and penetration, Molecular

Imaging and Degradome based Therapy

FUNDING European Union (FP7/NMP-2010-4.0-1)

FROM 01/03/2011 TO 28/02/2015

PI Jordi Llop (subproject PI)

PROJECT TITLE QNano: A pan-European infrasctructure for quality in

nanomaterials safety testing

FUNDING European Union

FROM January 2010 TO January 2015

PI NA

PROJECT TITLE AMIT: Advanced Molecular Imaging Tecnologies

FUNDING Ministerio de Ciencia e Innovación

FROM 01/11/2011 TO 31/12/2013

LEADER COMPANY SEDECAL

PROJECT TITLE RADIOBORON: Síntesis de radiotrazadores PET con aplicación

en BNCT

FUNDING Ministerio de Economía y Competitividad

FROM 01/01/2010 TO 31/12/2012

PI Jordi Llop Roig

PROJECT TITLE HINAMOX: Health Impact of Engineered Metal and Metal Oxide

Nanoparticles: Response, Bioimaging and Distribution at Cellular and Body Level

FUNDING European Union

FROM October 2009 TO October 2012

PI Sergio Moya

PROJECT TITLE PHECOMP: Phenotypical Characterisation of Animal Models for

Neuropsychiatric Disorders Related to Compulsive Behaviour

FUNDING European Union

FROM January 2007 TO December 2009

PI Olga Millán Portillo (Sub-project PI)

PROJECT TITLE DOPAGEN: Detección del Dopaje Genético por Factores de

Crecimiento en un Modelo Animal (2). (Sub-project of a Coordinate Project with the

same name)

FUNDING Ministerio de Educación y Ciencia (MEC)

FROM January 2007 TO December 2009

PI David Andreu Martínez (Sub-project PI)

PROJECT TITLE Neuroimagen Molecular en el Temblor Esencial: Estudio PET

Multi-Trazador

FUNDING Instituto de Salud Carlos III – Ministerio de Sanidad (FIS)

FROM January 2006 TO December 2007

PI Alejandro Gironell

PROJECT TITLE Imagen Médica Molecular y Multimodal

FUNDING Instituto de Salud Carlos III – Ministerio de Sanidad (FIS)

FROM January 2006 TO December 2006

PI Juan Domingo Gispert

PROJECT TITLE Evaluación de SPECT cerebral con 123I-ADAM para la imagen y

cuantificación de transportadores de serotonina en humanos

FUNDING Fundació La Marató de TV3

FROM May 2003 TO December 2004

PI Ana M. Catafau

RESEARCH PROJECTS

PRIVATE FOUNDATION

PROJECT TITLE 11C-Specific activity (SA) and yield in a new lined target

FUNDING IBA

FROM 05/2014 TO 05/2015

PI Jordi Llop

PROJECT TITLE Determinación el efecto de la dieta en el proceso de

envejecimiento en roedores: determinación del volumen de hipocampo y metabolismo

glicídico en cerebro mediante Imagen por Resonancia Magnética y Tomografía por

Emisión de Positrones.

FUNDING Abbott Nutritional

FROM 14/11/2011 TO 31/08/2012

PI Jordi Llop/Torsten Reese

PROJECT TITLE Cría y mantenimiento de ratas con dos dietas y evaluación de sus

efectos cognitivos

FUNDING Abbott Nutritional

FROM 07/10/2011 TO 30/04/2011

PI Jordi Llop/Torsten Reese

PROJECT TITLE Medidas del volumen del cerebro e hipocampo mediante

resonancia magnética de imagen en ratas

FUNDING Abbott Nutritional

FROM 01/08/2011 TO 31/08/2011

PI Jordi Llop/Torsten Reese

PROJECT TITLE Evolución de 2 formulaciones subcutáneas formantes de

“DEPOT” mediante Imagen por Resonancia Magnética Nuclear en rata

FUNDING CRC CIM

FROM 01/10/2010 TO 01/03/2011

PI Jordi Llop

PROJECT TITLE IMAGENE. Non Invasive Molecular Imaging of Gene Expression

Useful for Doping Control: Pilot Study in Animals after Erythropoietin Gene Transfer

FUNDING WADA (World Anti-Doping Agency)

FROM January 2005 TO December 2006

PI Jordi Segura

PROJECT TITLE Development and Implementation of the Synthesis and

Purification of Known 11C Radioligands for Neurotransmission PET Imaging

FUNDING GlaxoSmithKline (GSK)

FROM June 2004 TO May 2005

PI Jordi Llop Roig

PROJECT TITLE Development of Iodination Syntheses Procedures for Preparation

of 123I-Labelled SPECT Ligands

FUNDING GlaxoSmithKline (GSK)

FROM June 2004 TO May 2005

PI Jordi Llop

PROJECT TITLE Estudio Abierto para Caracterizar la Unión in-vivo a los

Receptores 5HT2A del Radioligando 123I-R91150 y su Desplazamiento por Ketanserina

en Voluntarios Sanos.

FUNDING GlaxoSmithKline (GSK)

FROM February 2004 TO July 2004

PI Ana M. Catafau

STAYS IN OTHER CENTERS

CENTER National Institute of radiological Sciences (NIRS). Chiba, Japan

FROM October 2008 TO December 2008

SUBJECT Development of new radiotracers labelled with nitrogen-13 using 13N-

NO2- as a radioactive precursor.

CENTER Centro Nacional de Aceleradores (CNA). Sevilla, Spain

FROM October 2007 TO December 2007

SUBJECT Development and implementation of the synthesis and purification of

known 18F radioligands.

CENTER Uppsala Research Imaging Solutions AB. Uppsala, Sweden

FROM September 2002 TO May 2003

SUBJECT Synthesis of labelled compounds with carbon-11 from carbon monoxide

using the Suzuki coupling reaction.

CENTER Clínica Universitaria de Navarra. Pamplona, Spain

FROM March 2002 TO September 2002

SUBJECT Synthesis of labelled compounds with carbon-11 from carbon monoxide

using the Suzuki coupling reaction.

OTHER MERITS

- Member of the Coordination Committee of ReDIB.

- Member of the Panel in more than 5 PhD Thesis.

- Best Oral Communication awarded in the 34º Congress of SEMNIM.

- Co-editor of a book entitled “Synthesis of radiolabeled nanoparticles”. Estimated

publication: 2016.

- Member of International Society of Radiopharmaceutical Sciences (ISRS) (From

2013 to now).

- Reviewer of some International Journals such us ACS Nano, European Journal of

Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters and Journal of

Labelled Compounds and Radiopharmaceuticals.

- Advisor of BIG (Barcelona Imaging Group S.L.). Barcelona, Spain (From March

2012 to March 2013).

- Member of Sociedad Española Medicina Nuclear e Imagen Molecular (SEMNIM)

(From March 2012 to now).

- Member of scientific committee of CIC biomaGUNE. San Sebastián, Spain (From

October 2011 to now).

- Scientific Advisor of ICNAS – Produção Unipessoal. Coimbra, Portugal (From

August 2010 to now).

- Scientific Advisor of FGUMA PET center. Málaga, Spain (From January 2010 to

December 2011).

- Radioprotection Officer of the Radioactive Facility at CIC biomaGUNE (From

October 2007 to December 2011).

- Member of the scientific committee of the Singular Scientific-Technique Facility (in

Spanish, ICTS) of the Molecular Imaging Platform at CIC biomaGUNE (From

November 2006 to now).

- Advisor to create the Molecular Imaging Unit at CIC biomaGUNE (From November

2006 to August 2007).

INVITED LECTURES

2015

- Nanomedicina y la eterna promesa: qué puede hacer un alquimista? X Congreso

de estudiantes de Farmacia de Alicante. Alicante, España. October 2015.

- Radiochemistry: something else than radio and chemistry. biomaPP15. San

Sebastian, Spain. October 2015.

- Molecular Imaging in drug development: specific applications to boron clusters.

Medicinal chemistry of boron compounds. Oropesa, Spain. October 2015.

- Radiochemical integrity of labelled NPS: a key ( and usually forgotten) property

of diagnostic, therapeutic and theragnostic NPs. TnT Conference. Lisbon,

Portugal. July 2015.

- Nuevas tendencias y tecnologías en síntesis PET. XVI Curso teórico-práctico

PET. Pamplona, Spain. April 2015.

2014

- Nanomedicine: two decades inspiring the next. Can radiochemistry lend a hand?

Christmas Lecture CIC biomaGUNE-CIC bioGUNE. Bilbao, Spain. December

2014.

- New trends in nuclear imaging: a radiochemistry perspective. Radiochemistry

Workshop. Coimbra, Portugal. July 2014.

- 13N-radiochemistry revisited: synthesis and utilisation. XIII Turku PET

Symposium. Turku, Finland. May 2014.

- Nitrogen-13: History, new synthetic strategies and future challenges. Opening

Lecture. 17th symposium on radiopharmacy and radiopharmaceuticals.

Pamplona, Spain. April 2014.

- Nuevas tendencias y tecnologías en síntesis PET. XV Curso Teórico-Práctico

PET. Pamplona, Spain. April 2014.

- Radioquímica e Imagen Molecular: aplicaciones en biomedicina. Invited

Lecture. Organic Chemistry Department. UPV. Bilbao, Spain. March 2014.

- Radiolabelling of nanoparticles for nanosafety evaluation: direct beam

activation. NANOPORTUGAL 2014. Nanoscience and nanotechnology

conference. Porto, Portugal. February 2014.

2013

- Occupational health and safety program in an animal imaging facility. 12th

FELASA/SECAL CONGRESS 2013. Barcelona, Spain. June 2013.

- Carbono-11: ¿Sabías que...33º Congreso de la Sociedad Española de Medicina

Nuclear e Imagen Molecular. Murcia, Spain. June 2013.

- Radiomarcaje de nanopartículas. XIV Curso Teórico-Práctico PET. Pamplona,

Spain. April 2013.

- Ciclotrón: producción de precursores primarios. Curso de radiofármacos

fluorados, aula virtual de radiofarmacia. 2013.

2012

- Radiolabelled NPs: physicochemical aspects and applications. IVICFA mini-

workshop, medical physics. Valencia, Spain. October 2012.

- Assessment of the biodistribution pattern and inflammatory response after acute

administration of metal oxide Nps using Positron Emission Tomography. Safety

Issues and Regulatory Challenges of Nanomaterials. San Sebastián, Spain.

May, 2012.

- Nitrogen-13: History, new synthetic strategies and future challenges.

Radiochemistry Meeting Malmoe 2012. Malmoe, Sweden. March, 2012.

2011

Synthesis of Radiolabeled NPs for Biodistribution Studies in Animal Models.

Safety issues of Nanomaterials along their life cycle Symposium. Barcelona,

Spain. May, 2011.

PET chemistry: from general perspective to particular applications.

Radiochemistry Workshop. Coimbra, Portugal. November, 2011.

The other imaging technologies: complements for a multimodal approach?

Workshop in Tissue Imaging. La Coruña, Spain. November, 2011.

2010

- Nuevos trazadores sobre las enfermedades por depósito de proteínas del Sistema

Nervioso central: aplicaciones clínicas y para la investigación. Neurociencia y

biotecnología aplicadas: una mirada hacia las terapias neuroregeneradoras.

San Sebastián, Spain. July, 2010.

2006

- Ciclotrón: Síntesis de Radiofármacos. European Seminar on NeuroImaging

and addiction. Barcelona, Spain. July, 2006.