Action of peptides and other algesic agents on paravascular pain receptors of the isolated perfused...
Transcript of Action of peptides and other algesic agents on paravascular pain receptors of the isolated perfused...
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tomy was appiied to: 60 patients with obiitera~ ~ e arterial disease of theupper extremity, n loea l~f ionand extent of~he occlusions make reconstructive "~ascular surgery
impossible. Early postoperative results within 1-5 years ,~ere e×celIent. Best early results were obtained in functional disorders of blood flow and in cases of hyperN- drosis, I11 organic circulatory disorder the results are much better than after lumbar
onthecause of the underlying disease° • agood exposure of the sympa- metic results.
ANAESTHEStOLOGY
PNn and su~qering in ischemia. The paradox of hypnoticNUy suggested anesthesia as contradicted by reports frora the "hidden eb..server"
V J, Knox; A: H: Morga~ and E:R: Hilgard, Arch, gen: Psychiat,,30 (1974) 840-847
Verbalrep0rts of pain and suffering in ischemic pain produced by a tourniquet to the upper arm followed by exercise of the occluded hand were studied in 8 highly hypnotizable college under~aduates under conditions of normal wakefulness, hyp- nosis Without anesthesia, an4 hypnosis with suggested anesthesia.
Subjects were able to distinguish between felt sensory pain and the concomitant suffering in verbal reports on numerical scales, Suggestions of hypnotic anesthesia reduced both sensory pain and suffering(in °open' reports) about 90 ~ in the gro~p as a whole, and eliminated both completely for 3 sabjects. However, °hidden' reports of pain and suffering during hypnotic anesthesia, obtained through automatic taiking,
~nt from those obtained in the hypnosis without anesthesia ~id~e i s used ~ e b y automatic
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at dissociated interpreted as no~
s o f hypnos is in pain reduc ti o n,
. . . . . . . . . . ° n and o paravaseu~ar paie receptor8
pe &r
H. J ~ n and F. Lembeck, Naunyn-Schm!edeb~rg s Arch. exp. Path. Pha:'maco:. 283
The a!gesic effect of substances s~.~pposed to be invoived in mediation of pa~n or hyperalgesia inl!ammatory processes was measured foI!owing intraarterial ~ " to, ;. ~
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, , . . . . ° ~, ..... into rabbit. (a)by r~cerdm~ iso!ated ear, and (b)by recording intraarterial injection into the ise body of the nerve.
The order of activity of the a~gesic substances NaS: b~adykinin, subs g : P ~ >
stance~ tested ~as~ found in i adrenaline, angiotensin, vasop~essin, oxytocin inactive. Infusion of prostaglandin E~ into the aD subatances.o The vasoconstriction in the ear observed with m o s t , of the substances was not correlated with their activity in eliciting afferent impNses.
PSYCHOLOGY
Proioeged hypa~ges~a fol~owie9 'aeupt~eeture' in gnonkeys
C. J. Vi~.rck, C. G. Lineberry, P. K. Lee and H. W. Calderwood, Life Sci., 15 (1974) 1277-!289
After 'zarning to escape painful electrical stimulation oI one leg, Cebus albi- fi'ons mot~keys were presented with a random schedule of 5 intensities, and they con- sistently responded with minimal latencies to the higher inte~sities during control sessions Preceding different sets of experimental sessions, the ~ onkeys received mild e~ectrical stimulation between loci beJow the knees that were i: qended to correspond to acupancture points. Following the majority of these 'acup~nctu.re treatments' significant elevations of escape tatencies were observed a t the higlher stimNus i~nsi~ ties. The decreased0 reactivities to noxiot~s, stimuli were often dela?ted~n onset fol|ow- ing the end of acup,ancture treatments, and st~bstantial alterations of escape behavior were dete,:ted up to 70 h post-treat:mont. Regardless of the relevance of this finding to acupunct~re, it represents an unusually enduring alteration of pain sensitivity fo|low- ing stirr uiation of the body surface in a situation free frc,m suggestive influences.
ge~f-~eg=le~iee ef paBr,: the use ef Nphao~eedbaek and hypnotic trNeieg for ~ e e o e ~ r o ~ ~ ~ ehr,~eiic pain
R. r~*e~zack add .~. Perry, Exp. NeuroL, 46 (t9,5) 452-469
Patielgs s~ering chronic pain of pathological origin received alpha-feedback '~rainingo methods, in association~ with prior hgpnotic, training. Changes in the intensity and q~a!i~y of pain were measured with the McGilt Pain Questionnaire. The combined