3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 1

WELCOME

Under the guidelines of Dr. Ashalatha MProfessor and HODDept of DravyagunaGAMCBangalore- 09

ByDr. Thriveni D.P.Final year MDDept. of DravyagunaGAMCBangalore-09

3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 2

RESEARCH UPDATES ON DRUGS IN  MUKHADOOSHIKA(ACNE VULGARIS)

Content

Introduction

Acne treatment modalities and kind of drugs

Ayurvedic perspective

Bioactive compounds in Acne

Researches

Few herbal drugs

Conclusion

3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 3

Introduction

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Classical references

‘Kshudra Rogas’ (SU.Ni.13)

Kshudraroga pratisheda (A.H.U.31,32)

Varnya, Vayasthapana (Ch.Su.4/8).

Shasti Upkramas (SU.Chi.1/68- 78).

Kshudraroga chikitsa-Chakradata

Sarangdhara Samhita - certain special Lepas

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Kind of drugs useful in MUKHADOOSHIKA

Varnya

gana

Shothahara

Pandukarana

Mrudukarana

Darunikarana

Avasadana

Utsadana

Vranaropana

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Treatment modality of Acne vulgaris1.   To counteract excess sebum and androgen‐

‐

Sebostatics,Antiandrogen

2.   To get rid of P.acne ‐

Antibiotics

3.   To treat lesion                 ‐

Comedolytics,Anti‐inflammatory

4. For regenerative               ‐

SteroidAntioxidants

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Bioactive compoundsGlycoside(Phenolic,Flavonoids)

Antioxidant, Antibiotic, Anti- inflammatory

Tannin(hydrosible)

Condensed tannin(Isoflavones)

-Antimicrobial, Anti- inflammatory, Antipruritic effects-Anti-cellulite , Viscoelastic properties

Fatty acids (Omega-3& omega-6) optimizes permeability in the skinVolatile oil

TerpenoidSesquiterpene

-Antibacterial, increases the permiabillity, healing-Anti-inflammatory-Antimicrobial

Vitamin A Sebostatic, Anti-inflammatory Vitamin E Antioxidant

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Researches

Rathod Suresh- The study of Shalmali w.s.r.to its efficacy on Mukhadooshika 2002, Tilaka Ayurveda College Pune.

Agravat H.P - Yuvan Pidaka and role of Lodhradi Lepa there in (Acne )

Sandeep Sagare - Comparative study on Vachadi Lepa and Mruttika Lepa in Mukhadooshika with special reference to Acne Vulgaris.

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Lodhra- Symplocos racemosa

Part used ‐

Stembark

Action‐

vranaropana,grahi

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Constituents ActionPhenolic glycoside- symploracemoside

Anti-inflammatory

Alkaloid- loturine,collutrine

Antiseptic, Antioxidant

(Ref‐Kerala Ayurveda vaidyam)

Vacha- Acorus calamus

Part used‐

Rhizome

Action‐

lekhana

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Constituent Action

MonoterpeneTerpineol

Anti‐ inflammatory

(Ref;Birla

Institute of technology and 

science,Pharmacy

group)

Yasti – Glycirrhiza glabra

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Part used- rootAction- vranaropana,

raktadoshahara

Constituent Action

Gycyrrhizin Anti‐inflammatory

GlabridinLiquiritin

Hinders   melanogenesis

(Ref;Birla

Institute of technology and science,Pharmacy

group)

Manjista- Rubia cordifolia

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Part used- rootAction- varnya,raktaprasadana

Constituents ActionManjistin Anti-inflammtoryAnthroquinone Antibacterial

Antioxidant

(Ref; Review of Articles on Ayurveda and natural 

products )

Part used- spines

Action – grahi,pittasranashana

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Constituent Action

Shamimin

Oxalate

‐Antimicrobial

‐Disintegrates  hard tissue

Shalmali- Bombax ceiba

(Ref‐

Himalaya drug company,Bangalore)

Kola- Zizyphus jujuba

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Part used‐

FruitpulpAction – grahi,

Constituent ActionTriterpinoid Anti‐

inflammatoryFlavaonoid AntioxidantSaponin Enhances the 

penetration Essential oil Healing

(Ref;Kerala

Ayurveda vaidyam)

Conclusion

Ayurveda also given importance to cosmetics with therapeutics

There are lot of researches done and carrying out on 

Mukhadooshika

to find still more effficient

one.

Further there is a scope for studying these dravyas

in 

more detail  with respect to pharmacokinetics.

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THANKING                  YOU