Acido folico
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Transcript of Acido folico
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ACIDO FOLICO
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CARACTERISTICAS
• Es una vitamina hidrosoluble, del complejo b• Oral y parenteral
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MECANISMO DE ACCION
• Bioquimicamente inactivo• Precursor de ac tetrahidrofolico y
metiltetrahidrofolico• Interconversion y metabolismo de
aminoacidos como histidina ac glutamico y serina
• Formacion de metionina a partir de homocisteina
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FUENTES NATURALES
• Hígado • Levadura• Vegetales
• Se encuentra en forma de poliglutamato, degradado a glutamato y este a monoglutamato que a su vez se degrada a metiltetrahidrofolato
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• Una suplementación adecuada disminuye el riesgo de malformaciones neurales tubulares congénitas
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PREVENCIÓN Y TRATAMIENTO DE ESTADOS CARENCIALES DE AC FOLICO
• La carencia de ac fólico:• esta asociada a una hiperhomocisteinemia • asociada a ateroesclerosis coronarias,
cerebrales y neurales tubulares• Además factor de riesgo para ca de colon,
retinopatía diabética etc.
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• La deficiencia de acido folico:• Dieta pobre de ac folico• Sindrome de mala absorcion • etc
• Estan en relacion con anemias megaloblasticas y macrociticas,
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INDICACIONES Y POSOLOGIA:
• Infancia• Embarazo• Sx mala absorcion• Esprue tropical• etc
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• Dosis: 4 mg día• Interacciones medicamentosas.
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GRACIAS
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REFERENCIAS
• Einarson A, Parshuram C, Koren G. Periconceptional use of folic acid to reduce the rates of neural tube defects: is it working? Reprod Toxicol 2000 Jul-Aug 14:4 291-2
•Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull 1999 55:3 578-92
• Lewis DP, Van Dyke DC, Stumbo PJ, Berg MJ. Drug and environmental factors associated with adverse pregnancy outcomes. Part III: Folic acid: pharmacology, therapeutic recommendations, and economics. .Ann Pharmacother 1998 Oct 32:10 1087-95
•Lewis DP, Van Dyke DC, Stumbo PJ, Berg MJ . Drug and environmental factors associated with adverse pregnancy outcomes. Part II: Improvement with folic acid. Ann Pharmacother 1998 Sep 32:9 947-61
•Scott JM, Weir DG. Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry. J Cardiovasc Risk 1998 Aug 5:4 223-7
•Hall J, Solehdin F. Folic acid for the prevention of congenital anomalies. Eur J Pediatr 1998 Jun 157:6 445-50
• Swain RA, St Clair L. The role of folic acid in deficiency states and prevention of disease. J Fam Pract 1997 Feb 44:2 138-44
•Perna AF, De Santo NG, Ingrosso D. Adverse effects of hyperhomocysteinemia and their management by folic acid. Miner Electrolyte Metab 1997 23:3-6 174-8
•Wald NJ, Hackshaw AD, Stone R, Sourial NA. Blood folic acid and vitamin B12 in relation to neural tube defects. Br J Obstet Gynaecol 1996 Apr 103:4 319-24
• Butterworth CE Jr, Bendich A. Folic acid and the prevention of birth defects. Annu Rev Nutr