Academic Centers Academic Centers Research Node of Research Node of

PECARNPECARN ((“ACORN”“ACORN”))

Supported by Project #U03 MC00001-01 from Supported by Project #U03 MC00001-01 from the Maternal and Child Health Bureau, Health the Maternal and Child Health Bureau, Health

Resources and Services Administration, Resources and Services Administration, Department of Health and Human Services Department of Health and Human Services

Who We AreWho We AreUniversity of California, Davis Medical Center,University of California, Davis Medical Center,University of California, Davis School of MedicineUniversity of California, Davis School of Medicine

Children’s Hospital of Wisconsin,Children’s Hospital of Wisconsin,Medical College of WisconsinMedical College of Wisconsin

Children’s Hospital of Philadelphia,Children’s Hospital of Philadelphia,University of Pennsylvania School of MedicineUniversity of Pennsylvania School of Medicine

St. Louis Children’s Hospital,St. Louis Children’s Hospital,Washington University School of MedicineWashington University School of Medicine

Primary Children’s Medical Center,Primary Children’s Medical Center,University of Utah School of MedicineUniversity of Utah School of Medicine

Children’s Hospital Medical Center,Children’s Hospital Medical Center,University of Cincinnati School of MedicineUniversity of Cincinnati School of Medicine

University of California, Davis Medical CenterUniversity of California, Davis Medical CenterUniversity of California, DavisUniversity of California, Davis

Nathan Kuppermann, MD, MPH Nathan Kuppermann, MD, MPH

Chair, Department of Emergency Medicine,Chair, Department of Emergency Medicine,

Professor of Emergency Medicine/PediatricsProfessor of Emergency Medicine/Pediatrics

Emily Kim, MPHEmily Kim, MPH

ACORN Node AdministratorACORN Node Administrator

James Holmes Jr., MD, MPHJames Holmes Jr., MD, MPH

Trauma ConsultantTrauma Consultant

Associate Professor of Emergency Medicine/PediatricsAssociate Professor of Emergency Medicine/Pediatrics

Children’s Hospital of Children’s Hospital of Wisconsin, Wisconsin,

Medical College of WisconsinMedical College of Wisconsin

Marc Gorelick, MD, MSCEMarc Gorelick, MD, MSCEMedical Director, Emergency Department, Medical Director, Emergency Department,

Professor of Pediatrics and Emergency Professor of Pediatrics and Emergency Medicine Medicine

Children’s Hospital of Children’s Hospital of Philadelphia, University of Philadelphia, University of

PennsylvaniaPennsylvania

Elizabeth Alpern, MD, MSCEElizabeth Alpern, MD, MSCEAssistant Professor of PediatricsAssistant Professor of Pediatrics

Kathy Shaw, MD, MSCEKathy Shaw, MD, MSCEDivision Chief, Pediatric Emergency Division Chief, Pediatric Emergency

Medicine,Medicine,

Professor of PediatricsProfessor of Pediatrics

Evaline Alessandrini, MD, MSCEEvaline Alessandrini, MD, MSCEAssociate Professor of PediatricsAssociate Professor of Pediatrics

St. Louis Children’s Hospital, St. Louis Children’s Hospital, Washington University in St. Louis School of Washington University in St. Louis School of

MedicineMedicine

David Jaffe, MDDavid Jaffe, MDMedical Director of Emergency Services,Medical Director of Emergency Services,

Professor of PediatricsProfessor of Pediatrics

Walton Schalick, MD, PhDWalton Schalick, MD, PhDEthics ConsultantEthics ConsultantAssistant Professor of Bioethics, Medical Assistant Professor of Bioethics, Medical

History, PediatricHistory, PediatricOrthopedics & RehabilitationOrthopedics & Rehabilitation

University of Wisconsin-MadisonUniversity of Wisconsin-Madison

Primary Children’s Medical Center, Primary Children’s Medical Center, University of UtahUniversity of Utah

Douglas Nelson, MDDouglas Nelson, MD

Professor of PediatricsProfessor of Pediatrics

Associate Chief, Emergency Pediatric Associate Chief, Emergency Pediatric MedicineMedicine

Cincinnati Children’s Cincinnati Children’s Hospital Medical Center, Hospital Medical Center, University of Cincinnati University of Cincinnati

College of MedicineCollege of Medicine

Richard Ruddy, MDRichard Ruddy, MDDirector, Division of Emergency Medicine,Director, Division of Emergency Medicine,

Professor of Clinical PediatricsProfessor of Clinical Pediatrics

Where We Are Located Where We Are Located

ACORN Organizational ACORN Organizational Structure Structure

Key Features of the ACORN Key Features of the ACORN NodeNode

• Comprised of Three HEDA Cores Comprised of Three HEDA Cores

AdministrativeAdministrative

Ethics/ Human SubjectsEthics/ Human Subjects

Epidemiological/BiostatisticsEpidemiological/Biostatistics

Key Features of the ACORN Key Features of the ACORN NodeNode

• HEDA Cores HEDA Cores

AdministrativeAdministrative• Overall nodal organizational responsibilityOverall nodal organizational responsibility• Oversee generation of nodal research priority listOversee generation of nodal research priority list• Oversee the conduct of nodal researchOversee the conduct of nodal research• Oversee intranodal, internodal communicationsOversee intranodal, internodal communications• Build partnerships with the MCHB/EMSCBuild partnerships with the MCHB/EMSC

Key Features of the ACORN Key Features of the ACORN NodeNode

• HEDA Cores HEDA Cores

Ethics / Human SubjectsEthics / Human Subjects• Insure the protection of human subjectsInsure the protection of human subjects• Review ethical content of all nodal research by Review ethical content of all nodal research by

committeecommittee• Advise nodal investigators regarding all ethical issues Advise nodal investigators regarding all ethical issues

pertaining to nodal research prior to submission to pertaining to nodal research prior to submission to PECARNPECARN

• Review IRB issues at nodal HEDAs and help coordinate Review IRB issues at nodal HEDAs and help coordinate activities which require cooperation between IRBs activities which require cooperation between IRBs

Key Features of the ACORN Key Features of the ACORN NodeNode

• HEDA CoresHEDA Cores Epidemiology / BiostatisticsEpidemiology / Biostatistics• Review nodal research proposals and provide Review nodal research proposals and provide

specific feedback to investigators on issues of specific feedback to investigators on issues of study design, sources of bias and confounding, study design, sources of bias and confounding, sample size and power, logistics and feasibilitysample size and power, logistics and feasibility

• Assist in the development of surveys and other Assist in the development of surveys and other data collection instrumentsdata collection instruments

• Assist with statistical analysis of completed nodal Assist with statistical analysis of completed nodal research, including multivariable statistical models research, including multivariable statistical models and techniques for validationand techniques for validation

• Assist with preparation of research presentations Assist with preparation of research presentations and manuscriptsand manuscripts

ACORN Proposal Generation ACORN Proposal Generation & Review Process& Review Process

ACORN ResearchACORN ResearchApproved Projects:Approved Projects:• Randomized Trial of Oral Dexamethasone in Randomized Trial of Oral Dexamethasone in

Acute BronchiolitisAcute Bronchiolitis• PECARN Core Data Project (with CARN)PECARN Core Data Project (with CARN)• Head Injury ProjectHead Injury Project• Cervical Spine Injury ProjectCervical Spine Injury Project• Intra-abdominal Injury ProjectIntra-abdominal Injury Project• Patient Safety Project (with CARN)Patient Safety Project (with CARN)• Quality Measures ProjectQuality Measures Project

Concluding StatementConcluding Statement

The ACORN Node of PECARN is committed The ACORN Node of PECARN is committed to applying our strengths and expertise to to applying our strengths and expertise to the study of the prevention and treatment the study of the prevention and treatment of acutely ill and injured children. of acutely ill and injured children.

We will forge strong collaborations with all We will forge strong collaborations with all other Nodes of PECARN and the other Nodes of PECARN and the MCHB/EMSC. MCHB/EMSC.

We are confident that the strong We are confident that the strong commitment of all the Nodes of PECARN commitment of all the Nodes of PECARN will insure the success of this novel and will insure the success of this novel and exciting network.exciting network.