COMPARISON OF CALSIUM STATE IN END-STAGE RENAL DISEASE

WITH AND WITHOUT CORRECTION FOR ALBUMIN

Nurul Utami Handayani, Purwanto Adipireno

Departement of Clinical Pathology, Faculty of Medicine, Diponegoro University

Dr. Kariadi Hospital, Semarang

ABSTRACT

Background : Determination of calcium state in End-Stage Renal Disease (ESRD) very

important for clinical management because hypercalcemia and hypocalcemia state known as

independent predictor for mortality increases in patient on hemodialysis. 40% calcium in

blood bound to albumin, therefore albumin decreases can be influence measuring for calcium.

Objective : To compare calcium state in ESRD patient between two measuring which are

with and without correction for albumin.

Methods : Cross sectional study. Difference test was performed in each calcium

concentration using paired t-test and calcium state using paired sample wilcoxon test.

Consecutive sample where taken from patient with inclusion criteria (ESRD with albumin <

35 g/L).

Result : There were 36 patient with ESRD. The mean of albumin serum were 25,9 ± 5,3 g/L.

The mean of total calcium concentration with and without correction for albumin,

respectively were 2,4 ± 0,27 mmol/L and 2,1 ± 0,28 mmol/L. calcium state in ESRD patient

with and without correction for albumin, respectively were hipocalcemia 6%, normocalcemia

19%, hipercalcemia 11% dan hipocalcemia 24%, normocalcemia 11%, hipercalcemia 1%. At

statistical analysis, there are significant difference in calcium state between with and without

correction for albumin in ESRD patient (p< 0,05).

Conclusion : There are significant difference in calcium state between with and without

correction for albumin in ESRD patient.

Key word: End-Stage Renal Disease, Calcium state, Albumin