ABS Orange Polyphenols PBF - Active Concepts,...
Transcript of ABS Orange Polyphenols PBF - Active Concepts,...
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ABS Orange Polyphenols PBF
Tomorrow’s Vision… Today!®
Slimming + Antioxidant + Superfruit + Skin Toning
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ABS Orange Polyphenols PBF
Technical Information:
Product Code: 16734
INCI Name: Water & Propylene Glycol & Citrus Aurantium Amara (Bitter Orange) Flower Extract
INCI Status: Conforms
Suggested Use Levels: 1.0–10.0%
Suggested Applications: Slimming, Antioxidant, Superfruit, Skin Toning
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Natural + Efficacious + Trendy
Addresses:
Lack of natural slimming products
Need for brand differentiation
How:
Polyphenols found in bitter orange promote natural slimming
Branding shifts towards natural products and superfruits rather than typical caffeine and green tea
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Traditional Natural Slimming Products
• Firm niche in the personal care market
• Appeals to a broad demographic
• Caffeine and green tea are typical ingredients
Benefits: Increase microcirculation Act as a diuretic Caffeine is lipolytic
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Background
• Known as “fat”
• Loose connective tissue composed of adipocites
• Accumulates in the subcutaneous layer
• Provides insulation from heat and cold
• Factors that contribute to the build-up of superficial adipose tissue:- Diet- Hormones- Circulatory insufficiency- Stress- Structure of connective tissues
Adipose Tissue:
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Background
Anatomy:
Superficial Fascial System (SFS):
• Connective tissue network extends from the sub-dermal plane to muscle fascia
• Composed of thin, horizontal membranous sheets separated by fat with interconnecting fibrous septae
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ABS Orange Polyphenols PBF
Physiology:
• SFS encases, supports, and shapes fat while holding the skin onto the underlying tissue
• Skin-superficial fat-superficial fascial system relaxes and stretches over time which results in soft tissues and cellulite• Relaxation/Stretching is influenced by estrogen and progesterone• Estrogen increases the elastic texture of collagen fibers and contributes
to adipose build-up along the thighs and buttocks
• Adipose tissue becomes swollen as a result of poor circulation in the blood and lymph nodes
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Bitter Orange
• Superfruit
• Classic component in teas, liquors, jellies, and fragrances
• Popular slimming ingredient used in dietary supplements
• Rich source of antioxidants• ABS Orange Polyphenols PBF is standardized for polyphenols
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Polyphenols
Biological activity:
• Anti-inflammatory
• Vasodilator
• Reduces capillary fragility
• Antioxidant
Slimming Effect:Polyphenols help to minimize the appearance of adipose tissue
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Modern Research
Understood to inhibit cAMP-phosphodiesterase (PDE)
cAMP mediates many different cell responses including the breakdown of glycogen and fat
Citrus polyphenols exhibit lipolyticproperties on adipocyte tissue
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ABS Orange Polyphenols PBFin-vitro Efficacy Data
Preventing conversion is important:• High levels of cAMP are important
for maximizing lipolysis
• Measure conversion of cAMP to 5’-AMP by purified human phosphodiesterase III
• In vitro method using liquid scintillation quantification
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1.0% ABS OrangePolyphenols PBF
3.0% ABS OrangePolyphenols PBF
5.0% ABS OrangePolyphenols PBF
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Inh
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Inhibition of Phosphodiesterase III Activity
Results• 1.0, 3.0 & 5.0% ABS Orange
Polyphenols PBF shown to inhibit PDE activity by 62, 92 and 98% respectively
• Indicates ABS Orange Polyphenols PBF is capable of improving lipolysis for slimming effects
Figure 1. ABS Orange Polyphenols PBF inhibits PDE activity and the level of inhibition is concentration dependent
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ABS Orange Polyphenols PBF
Technical Information:
Product Code: 16734
INCI Name: Water & Propylene Glycol & Citrus Aurantium Amara (Bitter Orange) Flower Extract
INCI Status: Conforms
Suggested Use Levels: 1.0–10.0%
Suggested Applications: Slimming, Antioxidant, Superfruit, Skin Toning