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Format for Application for Research Projects under Grant-in-Aid Scheme and Guidelines for Operation of Projects

Department of Health ResearchMinistry of Health and Family Welfare,

Government of India V. Ramalingaswami Bhawan, Ansari Nagar, Post Box No. 4911

New Delhi –110029

Tel. : 26588895, 26588980, GRAM : SCIENTIFIC26589794, 26589336

Email: hea dqua rte rs @icm r.o rg .i nFAX : 011-26588662

icm r hq d s @ s a ns a d . n ic . i n

Department of Health Research V. Ramalingawami Bhawan, Ansari Nagar, Post Box No. 4911

New Delhi - 110029APPLICATION FOR RESEARCH PROJECT UNDER GRANT-IN-AID SCHEME

(Please furnish 10 copies alongwith a CD and the font size of the content should be at least 11 pt, else the proposal will not be evaluated)

Section A GENERAL

1. Title of the Research Project2. Tick the relevant component of the scheme as identified earlier in concept research proposal

i. Research studies with emphasis on public health ii. Translational Research Projects

iii. Inter-sectoral co-ordination including funding of joint projectsiv. Cost-effectiveness analysis of health technologies through a health technology

assessment system 3. State the major discipline (for details see Annexure 1): 4. Name and Designation of

i) Principal Investigator & Email ii) Co-Investigator(s) & Email

5. Duration of Research Project

i) Period which may be needed for collecting the data

ii) Period that may be required for analyzing the data

6. Amount of grant-in-aid asked for (details are to be furnished in Section B)

SN Item- Head 1st Year(in Rs)

2nd Year(in Rs)

3rd Year(in Rs)

Total (in Rs.)

1. Staff

2. Contingencies

3. Recurring

4. Non recurring (equipment )

5. Travel

6. Overhead Charges

Total

7. Institution responsible for the research project

i. Nameii. Postal addressiii. Telephone

iv. e- mail

v. Fax No.

8. In case of Inter-sectoral research projects

i. Name(s) of the Institution (s) / Agencies

ii. Whether contributed financially

iii. Amount / Budget contributed for this project

9. Institutional ethical clearance and Project approval (Necessary documents indicating institutional ethical clearance must be enclosed for research involving human subjects as also animal experiments).

Yes No 10. Is radio tagged material proposed to be used in the project either for clinical trials or

experimental purposes? If so, clearance from Nuclear Medicine Committee, Bhabha Atomic Research Centre, Mumbai, indicating should be attached.

11. Projects involving recombinant DNA/Genetic engineering work should be examined and certificate by the Institutional Biosafety Committee (IBSC) to be enclosed. Guidelines for constitution of IBSC can be obtained from Secretary, Department of Biotechnology, CGO Complex, Lodhi Road, New Delhi-110003.

12. Approval of the institutional ethics committee(IEC) should be enclosed. Guidelines for IEC for animal experiments should follow CPCSEA requirements and for human studies should follow ICMR guidelines.

13. The Institution where the study is being done should ensure that there is no financial conflict of interest by the investigators.

14. Whether your institution (private / NGO) is registered with Department of Scientific and Industrial Research (DSIR), Government of India/ Department of Health Research (DHR) as a health research institute. If yes, certificate from DSIR/ DHR should be attached.

DECLARATION AND ATTESTATION

i. I/We have read the terms and conditions for DHR Research Grant. All necessary Institutional facilities will be provided if the research project is approved for financial assistance.

ii. I/We agree to submit within one month from the date of termination of the project the final report and a list of articles, both expendable and non-expendable, left on the closure of the project.

iii. I/We agree to submit audited statement of accounts duly audited by the auditors as stipulated by the DHR.

iv. It is certified that the equipment(s) is/ are not available in the Institute / Department or these are available but cannot be spared for the project

iv. It is further certified that the equipment(s) required for the project have not been purchased

from the funds provided by DHR for another project(s) in the Institute.

v. I/We agree to submit (online) all the raw data (along with descriptions) generated from the

project to the DHR / ICMR Data Repository within one month from the date of completion

/termination of the project.

If any equipment already exists with the Department/Institute, the investigator should justify purchase of the another equipment.

Signature of the:

a) Principal Investigator

b) Co-Investigator(s)

c) Head of the Department

Signature of the Head of the Institution with seal

Date:

P.S. DHR should be reminded if no acknowledgement is received within one month from the date of sending the application.

Section - BDETAILS OF THE RESEARCH PROJECT

Adequate information must be furnished in a brief but self-contained manner to enable the Council to assess the project.

1. Title of the project.

2. Objectives

5. Summary of the proposed research (up to 150 words) indicating overall aims of the research and importance of the research proposal. Application of the work in the context of national priorities of medical research, if any, may also be mentioned.

6. State the i. Novelty of your research project (in 100 words):

ii. Relevance of your research project to public health (in 100 words):iii. Relative importance of your research project in a given area (in 100 words):iv. Applicability of your research project in

(a) Short term:(b) Long term:

5. Present knowledge and relevant bibliography including full titles of articles relating to the project.

6. Preliminary work already done by the Investigator(s) on this problem, e.g. selection of subjects, standardization of methods, with results, if any.

7. Links with other DHR and ICMR projects (ad-hoc, task force or collaborative).

8. List of important publications of last 5 years of the all the investigators in the relevant fields (enclose reprints, if available).

9. Detailed research plan. (give here the design of study, indicating the total number of cases/samples/animals to be studied, the mode of selection of subjects specially in experiments involving human beings, equipments and other materials to be used, methodology/techniques to be employed for evaluating the results including statistical methods any potential to obtain patents etc.)

10. Facilities in terms of equipment, etc, available at the sponsoring institution for the proposed investigation.

11. Budget requirements (with detailed break-up and full justification): (i)Staff

(ii) ContingenciesRecurringNon-recurring(equipment) Travel

(iii) Overhead charges

Section-C BIODATA OF THE INVESTIGATORS(S)

1. Name (Dr./Kum./Smt./Shri) First name(s) Surname2. Designation:3. Complete Postal Address, Telephone Number, Fax, e-mail etc.4. Date of Birth:5. Educational Qualification : Degrees obtained (Begin with Bachelor’s Degree)

Degree Institution Field(s)Year

6. Research/Training Experience

Duration Institution Particulars of work done

7. Research specialization (Major scientific fields of interest)8. Important recent publications (last 5 years, with titles and References),

including papers In press

9. *Financial support received

1. From DHRi. in pas t

i i . *present i i i . *Pending

2. From ICMR i. Pastii. *Presentiii. *Pending

3. From other sourcesi. Pastii. *Presentiii. *Pending

* This information must be given, otherwise the application will be returned. In case no financial assistance has been received, nil should be stated. Indicate titles of the projects and reference number, if available, for DHR/ ICMR grants.

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Guidelines for Operation of Projects for Grantees of Research Projects under Grant-in-Aid (GIA) Scheme of Department of Health Research

The vision of the Department of Health Research (DHR) is to bring modern health technology to the people through innovations related to diagnostic, treatment methods and vaccines for prevention; to translate them into products and processes and , in synergy with concerned organizations, introduce these innovations into public health service. Under “ Grant-in-Aid scheme for Inter-Sectoral Convergence and Coordination for promotion and Guidance on Health Research”, the Department of Health Research provides financial assistance in the form of Grant-in-Aid for carrying out research studies to identify the existing knowledge gap and to translate the existing health leads into deliverable products. The financial assistance is provided by way of grants to scientists in regular employment in the Universities, medical colleges, postgraduate institutions, recognized research and development laboratories and NGOs (Applications from non-governmental agencies should provide documentary evidence of registration, DISR Certificate, track record etc.).

1. Proposals in fundamental/ strategic research; development and evaluation of a tool, and operational research are considered for DHR support.

2. Research grants from the DHR are essentially intended to supplement the research facilities available with the host institutions. All facilities for the conduct of research, such as basic equipment and ordinary laboratory chemicals, glassware, furniture and other assistance as may be required for the smooth working of the project shall be provided by the Institute.

3. Who Can Apply? a) Govt. Medical Institutions / Colleges / Universities

b) Private Institution/NGO (Registered with the Department of Scientific and Industrial Research (DSIR), Govt. of India)/ recognized by DHR as a health research institute

c) Individual Scientists in regular employment in the Universities, medical colleges, postgraduate institutions, recognized research and development laboratories and NGOs.

d) Professional bodies and scientific societies and associations

4. Projects Eligible for Funding: (i) Research studies with emphasis on public health: Research studies on disease burden, risk

factors, diagnosis & treatment, etc of major diseases. Studies will be limited to Non-communicable diseases only.

(ii) Translational Research Projects: Projects to translate the already identified leads into products and processes in the area of human healthcare, through coordination among the agencies involved in basic, clinical and operational research for use in the public health system. This will comprise 75 leads already available with ICMR, 25 leads from

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Extramural projects funded by ICMR and 15 leads from other Science & Technology Departments/Organisations.

(iii) Inter-sectoral co-ordination including funding of Joint Projects: To promote joint/collaborative research projects with other agencies involved in bio-medical/health research in the country for optimum use of resources and transfer of knowledge.

(iv) Cost effectiveness analysis of health technologies through a health technology assessment system: Development of guidelines for protocols/devices on cost effective but viable technology/process/diagnostics for managing various diseases, to facilitate public choice and controlling health care costs, while maximizing health outcomes.

5. Procedure for Receipt and Sanctioning of Proposals: i. Proposals received in response to specific advertisement as also open ended applications

will be evaluated by an Expert Committee constituted by the Secretary, DHR consisting of eminent scientists and subject specialists to assess the merit of the proposal.

ii. The funds will be released to the Head of the institute/organization and will be kept in a separate bank account. The funds will be released in installments biannually. The first installment will be sanctioned along with the approval letter. It would include the entire grant for purchase of equipment, and recurring grant for six months.

iii. The 2nd installment of the year would be released based on the submission of the Utilization Certificate (UC), along with the item-wise statement of expenditure, for at least 70% of the previously released grant, duly certified by the designated Accounts Officer of the Host Institute and the Principle Investigator.

iv. Steps to procure the approved equipment should be initiated immediately (to avoid escalation of cost) following the prescribed norms of the host institution.

v. Equipment procured through the DHR grant should bear a label "DHR funded". On completion of the study a list of all equipments procured from the project funds along with their cost, date of purchase, and suggestions for disposal should be sent to the DHR for decision.

vi. Wherever applicable, an appropriate MOU with the institute/NGO/Applicant will be signed to ensure that the interest of the DHR and public interest is protected.

vii. Once a project is approved for funding, DHR/ICMR would inform the Principal Investigator (PI) the decision that the project has been technically approved for funding and communicate the budget including the details of the staff, equipment(s), contingencies, travel etc.

viii. The PI would inform the DHR/ICMR about the following: a. His/Her acceptance of the budget and other terms and conditions. b. For all equipment approved in the project, the PI is required to give a certificate from the

Head of the Institute to the effect that equipment is not available/accessible/cannot be spared for this project work.

c. The name of the statutory auditor of the Medical College/Institute.

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d. An undertaking that the staff engaged for the project would be the responsibility of the host Institution and would have no claim to a permanent employment with the DHR/ICMR. They are not to be treated as employees of the DHR/ICMR as they will be engaged only on contract basis. They would be subject to administrative control and other rules & regulations as applicable to them, of the Institute where the project is based.

ix. The budget for each project will be available under the following heads:

i. Staff (Manpower)ii. Equipment

iii. Consumables

iv. Travel

v. Contingencies/Miscellaneous

6. Date of Start :The sanction letter would specify the date of start. It can only be a prospective date. If however no date is mentioned in the sanction letter, the project would deemed to have become operative on the day the grant is received by the Investigator. This date would have to be communicated by the host Institute to the DHR/ICMR It will in no case be later than one month after the receipt of the draft by the Institute. The date of start of a project can be changed on the request of the PI provided no expenditure has been incurred from the grant released by the Council.

7. Staff Component for the Projects:(1) The following categories of staff would be eligible to be engaged in the projects under

the scheme on fixed consolidated remuneration and contractual basis: i. Research Scientists

ii. Research Associates

iii. Sr. Research Fellows

iv. Jr. Research Fellows

v. Technical and Field staff (2) The rates of remuneration for the aforesaid staff would be reckoned with reference to the

rates as applicable at the ICMR/DST for project staff. (3) Staff would be engaged initially for a period of one year and extendable till the duration

of the project. The staff engaged in the project will not have any claim, whatsoever, for continuation of services in DHR/ICMR after completion/termination of the project.

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(4) Only those candidates can be engaged as Junior Research Fellows who have cleared the ICMR-PGI,UGC-CSIR, DBT National Eligibility Test, or equivalent .

(5) The progress of JRF and SRF working on a project will be assessed every year by a committee consisting of PI, Head of Department (where PI is HOD, the next senior of Department/Dean will be a member) and an external member who is an expert in the relevant field - not less than an Associate Professor/Professor.

8. Up-Gradation/Down-Gradation of Approved Staff: No alteration in the staff approved can be made by the institute/research Organisation without the permission of DHR/ICMR.

9. Utilization of Travel Grant:The grant can be utilized for travel within the country by the PI, co-investigator or of Research staff working on the scheme:

a. Attending seminars/symposia/conferences within the country provided the PI himself or the project staff is presenting a research paper (based on the project work) which has been accepted. Copy of the acceptance letter should be sent to the ICMR.

b. Taking up field work/travel connected with the research work (TA/DA would be as per the entitlement) including procurement of chemicals, equipments etc.

c. Visiting the DHR/ICMR office for meetings related to the project d. Attending a training course related to the project, mainly for project staff e. The travel

grant cannot be used for foreign travel or any other expenses for visits abroad

10. Utilization of Contingent Grant :This is meant for recurring as well as non-recurring expenditure. The contingent grant can be utilized for purposes like, but not limited to:

a. Acquisition of books and documents of relevance to the research topic in case these are not available in the library, these would become the property of the Institution library and after purchase and accession may be issued to the Department/ Scientist till they are needed.

b. Charges for specialized investigations for which facilities do not exist in the host institute c. Publication charges/ reprints/ off-prints of research papers published as an outcome of the

research d. Data entry charges e. Printing of questionnaire f. Computer utilities, charges for analysis of data (computer charges) g. Typing of research reports including preparation of the final report h. POL i. Communication charges

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j. The grant cannot be used for purchase of furniture items/office equipments such as telephone, fax machine, computers etc.

(2 ) For contingency grant exceeding Rs.25,000/- per annum detailed breakup should be given.

11. Equipment: (1). Provision for equipment(s) for conduct of the study shall be provided based on the

recommendations/approval of the project by the approval by the appropriate Expert Committees. This would vary on the nature, scope and need of the project.

i. All equipments should be purchased according to the rules and procedures of the Institutions where the project is to be carried out

ii. Equipment procured through the grant should bear a label "DHR/MOHFW funded" iii. On completion of the study a list of all equipments procured from the project funds along

with their cost, date of purchase, and suggestions for disposal should be sent to the Department.

iv. Equipments costing less than Rs 20,000 are generally allowed to be retained by the Institute, while for those costing more than Rs 20,000 the Department would take decision on case to case basis.

(2) All expendable and non-expendable articles acquired for work of the project should be purchased in accordance with the procedure in vogue in the host institutions. For permanent and semi-permanent assets acquired solely or mainly out of the grant, a separate record in the form of register in prescribed Performa (Asset Register) shall be maintained by the Institute. The term "assets" means moveable property where the value exceeds Rs.1000/-. Separate assets registers for items costing more than Rs.20,000/- and less than Rs.20,000 may be maintained.

12. Overhead Expenses:Overhead expenses, if any, may be met from miscellaneous expenses as per ICMR norms.

13. Re-Appropriation of Funds:Expenditure should on no account exceed the budget sanctioned for the project. Expenditure incurred over and above the sanctioned amounts against one or more, sub-heads of expenditure such as pay & allowances, contingencies etc shall not be met without the approval of the DHR, by re-appropriation of savings under remaining sub-heads (except under sub-head ‘equipment’) by re-appropriation of money during the financial year, provided it is within over all sanctioned ceiling of the year. No expenditure shall be incurred on items not sanctioned under the scheme. Savings should also not be re-appropriated for meeting or incurring expenditure on staff that has not been sanctioned by the Department.

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14. Extension of the Project:Extension beyond the approved duration would not be entertained. If interesting/important leads emerge that need to be followed-up, a separate proposal may be submitted. Only in exceptional cases, where a valid justification exists, and recommended by the technical Evaluation Committee and Project Approval Committee an extension can be considered to complete the project.

15. Change of Principal Investigator (PI)

• PIs are encouraged to have a co-investigator in the project.

• If for any reason the PI leaves the project, an eligible co-investigator could be considered as the PI subject to recommendation of the PI, the Head of the Institution, and the approval of DHR. Such a request should be sent well in advance.

• In case the PI is shifting to any other Institution, the co-investigator could be made the new PI, or the project could be transferred to the new Institution with the mutual agreement of both Institutions and the approval of the DHR

• The host Institution has an important role to play in the above contract. The Institute/Principal Investigator will have to inform the DHR of any changes, and in consultation with DHR take steps to ensure successful completion of the project before relieving the Principal Investigator.

16. Number of Projects with the PI :Under normal conditions, a PI should not be implementing more than three research projects at a given point in time. While submitting an application for a research project, the PI should give in detail all the research projects (completed, on-going). Fresh research proposals can be considered only when the on-going research proposals are about to conclude.

17. Annual Progress Report: a) The Host Institute would be required to submit an annual progress report and also give

audited statement of expenditure by the Auditor of the research Organization/Institute etc. However, the first progress report should be submitted at least three months prior to the completion of the annual report so as to enable the evaluation and provide the grants within the completion of one year from the starting date. The subsequent annual report will be for the period of one year.

b) The financial and physical progress of the project would be evaluated by the DHR with technical support from ICMR.

c) The progress report and expenditure statement in respect of the project shall be reviewed at the time of release of subsequent grants.

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d) The Principal Investigator (PI) may be asked to present the progress at the meeting of the Committee, if considered necessary. The consolidated report of the work done to be provided to Department for evaluation and monitoring of progress and statement of expenditure.

e) The suggestion and views of the Committee and mid-course correction, if any, would be conveyed to the PI from time to time for effective conduct of the project. This would be binding on the PI.

18. Final Project Completion Report (PCR):(1). At the completion of the project, the final report should be sent in the prescribed format. (2) The report should be submitted not later than three months from the date of completion

of the project. (3 ) The report should be submitted not later than three months from the date of completion of

the project. 10% grant would be withheld for release after receipt of the final report. (4) The review of any other new project sent by the same applicant for financial support from

the Department would depend upon the previous track record in terms of compliance of submission of requisite statement of Accounts and annual / final reports in time

(5) Ten copies of final report have to be submitted by the applicant along with the final audited statement of Accounts.

(6) Action taken on Project Completion Report (PCR) - The final report is reviewed by the PRC. If the report is found satisfactory, an abstract on the work done is published in the ICMR Bulletin. System of keeping PCR: A few copies are retained by the DHR and soft copies would be retained for eventual uploading on the DHR website.

19. Audit :The department would normally accept audited report from auditors as applicable to the concerned institution. Statement of accounts audited by Chartered Accountants approved by or registered with the CAG and /or Ministry of Health & Family Welfare would also be accepted. The necessary registration number should be provided for record.

20. Annual Utilization Certificate: i. The release of grants-in-aid and the terms and conditions thereof including submission of

utilization certificates shall be subject to the provisions GFRs. ii. Each year a simple statement of accounts giving the funds received and expenditure

incurred by 31st March needs to be submitted for release of the first installment for the next year duly signed by the Accounts Officer of the Institute.

iii. Unspent balance would be adjusted in the first installment for the next year iv. An audited statement would be essential for release of the second installment of the

annual grant from second year onwards.

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21.Final Settlement of the Accounts (1) The final settlement of the Accounts will be done only after the receipt of the following: a. Final audited statement of expenditureb Final utilization certificate c List of equipments procured from the project along with their cost, date of purchase, and

suggestions for disposal (2) The grant paid by the DHR shall be refunded by the institution as and when the

investigator discontinues a scheme midway or does not follow the detailed technical programme as laid down and approved by the DHR. All raw data (in all forms) should be made available/accessible to DHR if needed.

22. Publication of Results/Presentation of Papers: The research papers and publications based on the results of the research project should acknowledge assistance by the DHR. Copies/reprints of papers published should be sent along with the progress/final report.

23. Intellectual Property Rights :All new intellectual property viz., patents, designs etc. generated as part of the research supported by the DHR under the Scheme would belong to the department and other partners as per the Indian Council of Medical Research IPR policy, till any new policy is formulated by Department of Health Research.

24. Conflict of Interest : In order to maintain the objectivity in the conduct and reporting of research, it is imperative that the investigators should not have any financial or other interests that undermine scientific integrity while recording and reporting their data. Any research or other links of the investigators with industry are discouraged as such a link would compromise or likely to compromise unbiased reporting of research data. In addition, such a financial conflict of interest could lead to loss of public faith on the credibility of data being reported, especially in the light of recent reports of financial conflict of interest of investigators in drug and other clinical trials. All investigators, desirous of DHR support should declare financial conflict of interest, if any, before submitting the project for support. They should also ensure that during the conduct of the project, they would also observe the same code of conduct. If the Department comes to know of any unethical conduct on the part of investigator including improper/incomplete declaration, the project is liable to be terminated immediately.

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Annexure-1

Research studies areas to be taken-up under Grant-in-aid scheme of DHR

1. Research studies with emphasis on public health

S.N0. Priority Area of Topic of the study

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Research

1.1 Cancer 1.1.1 Estimation of State/region wise disease burden 1.1.2 Profiles of cancers1.1.3 Risk factors identification1.1.4 Development and evaluation of algorithms for

diagnosis and Management 1.1.5 Other areas relevant to the programme.

1.2 Mental Health 1.2.1 Epidemiological studies for assessing for disease burden and determinants etc.

1.2.2 Development of skills for end of life care1.2.3 Model projects under Brain Grid with NKN1.2.4 Development and evaluation of algorithms for

diagnosis and management 1.2.5 Other areas relevant to programmes.

1.3 Cardiovascular Diseases

1.3.1 Epidemiological studies for Burden estimation (regional/states)

1.3.2 Socio-behavioral, lifestyle and other risk factors1.3.3 Profile of CVS diseases1.3.4 Development and evaluation of algorithms for

diagnosis and management 1.3.5 Other areas relevant to programmes.

1.4 Environmental Health/ occupational health

1.4.1 Burden estimation1.4.2 Impact of legislation1.4.3 Air and water pollution1.4.4 Health problems related to pesticides etc1.4.5 Profile of occupational health problems of national

importance1.4.6 Other areas relevant to programmes.

1.5 Stroke and neurological disorders

1.5.1 State and regional data1.5.2 Type of strokes1.5.3 Risk factors estimations1.5.4 Development and evaluation of algorithms for

diagnosis and management 1.5.5 Other areas relevant to programmes.

1.6 Diabetes 1.6.1 State and regional data1.6.2 Risk factors estimations1.6.3 Strategies for management at various levels1.6.4 Other areas relevant to programmes.

1.7 Metabolic disorders 1.7.1 State and regional data along with risk factors1.7.2 Development and evaluation of algorithms for

diagnosis and management 1.7.3 Other areas relevant to programmes.

1.8 Congenital Malformations and Genetics

1.8.1 State and regional data including classification1.8.2 Risk factors estimations1.8.3 Development and evaluation of algorithms for

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diagnosis and management 1.8.4 Other areas relevant to programmes

1.9 Kidney and liver disorders

1.9.1 State and regional data and types1.9.2 Risk factors estimations1.9.3 Development and evaluation of algorithms for

diagnosis and management 1.9.4 Other areas relevant to programmes.

1.10 Physical Health problems specifically related to women regarding top 5 problems:

Heart diseases, Breast

cancer/cervix Osteoporosis Depression Autoimmune

diseases

1.10.1 Studies on various aspects such as:1.10.2 Vulnerability to diseases1.10.3 Socio-cultural factors1.10.4 Education and access to information1.10.5 Gender specific public health interventions

1.11 Maternal health 1.11.1 Estimating morbidity and mortality patterns1.11.2 Nutritional disorders1.11.3 Tools for reducing MMR1.11.4 Reproductive health 1.11.5 Health care seeking behavior1.11.6 Other areas relevant to programmes.

1.12 Child health 1.12.1 Estimating morbidity and mortality patterns1.12.2 Nutritional disorders (malnutrition and obesity)1.12.3 Diarrhoeal and respiratory disorders 1.12.4 Factors affecting pre-term, LBW 1.12.5 Immunization1.12.6 Other areas relevant to programmes.

1.13 Low child sex ratio and other Gender and Health

1.13.1 Factors influencing female feticide 1.13.2 Social beliefs1.13.3 Qualitative research studies1.13.4 Domestic violence1.13.5 Other areas relevant to programmes.

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2. Translational Research Projects

Item Topic of the Study 2.1 Leads identified by ICMR Institutes and partly developed

The technologies targeted for 2013-14 include : (i) diagnostic assays/ reagents/ devices for diabetes

mellitus; cervical cancer; thallesemia ; infectious diseases such as tuberculosis, leptospirosis, hepatitis E, rotavirus diarrhoea, food borne pathogens, Chlamydia infections, kala- azar, malaria, filarial and lung fluke;

(ii) vaccines for Japanese encephalitis, hepatitis E, ;

(iii) nutrition: assays for bioavailability of iron , vitamin A estimation;

(iv) Others: cooling garment to prevent and manage heat effects; ergonomically designed rickshaw; test for determination of viability of sperms; molecules, metabolites / organisms for biological control of mosquitoes.

31-75 : Leads identified as second priority likely to take 3-4 years to develop prototype/ technologies

2.2 Leads identified from extramural projects2.3 Leads identified by other agencies/ requiring inter-departmental collaboration with like DST, DBT, DSIR, DRDO etc.

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3. Inter-sectoral Co-ordination including funding of joint projects

S.N0. Purpose of studyJoint projects with DBT /DST/DRDO on diagnostics & vaccine3.1 3.1.1 Diagnostics in area of Cancer, Stroke, Diabetes, Vector borne diseases,

Tuberculosis, Leishmaniasis etc.3.1.2 Vaccines for Vector borne diseases, Leishmaniasis etc.3.1.3 Basic biology, polymers, devices, bio-instrumentation and other life science

related areas like nanotechnology etc. Joint projects with DBT /DST/CSIR/ on New drug discovery 3.2 3.2.1 Drug discovery in the areas of Cancer, Stroke, Diabetes, Vector borne

diseases, Tuberculosis, Leishmaniasis etc.3.2.2 Diagnostics, devices and therapeutics with DST, DBT, CSIR, DRDO,

Information TechnologyJoint projects with AYUSH New drug discovery / Treatment3.3 3.3.1 Drug discovery / new treatment in the areas of Cancer, Stroke, Diabetes,

Vector borne diseases, Tuberculosis, Leishmaniasis, cardiovascular diseases, Mental disorders, arthritis, skin disorders etc.

3.3.2 Role of Yoga in cardio-vascular diseases, diabetes, stroke and neurological disorders etc.Other alternate therapies

Joint projects with Department of Environment3.4 3.4.1 Effect of climate change on vector borne diseases, and other communicable

diseases and impact of transgenic/ recombinant technology on health3.4.2 Indoor and outdoor air pollution3.4.3 Noise heat, radiation pollution etc3.4.4 Pollution due to chemicals, pesticides, other toxic waste etc. 3.4.5 Development of disaster management tools

Joint projects with DARE/ ICAR3.5 3.5.1 Diagnostics, treatment and control of diseases on Zoonosis

3.5.2 Improvement of nutritional status Nutritional safety –use of pesticides; other toxic contaminants etc

Joint projects with Department of Space3.6 3.6.1 GIS mapping of Vector borne diseases with geo-climatic factors

3.6.2 GIS mapping of cardio-vascular, cancer, diabetes diseases with population density, industry, agricultural produce etc.

Joint projects with M/o of Women & Child Development, Department of Health & FW and ICSSR/ Department of information technology/ labour etc.

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3.7 3.7.1 Nutritional patterns and developing interventions with WCD, Nutritional institutes

3.7.2 Socio-behavioural factors related with maternal health with ICSSR3.7.3 Health education with WCD3.7.4 Public health interventions with Department of Health and women and child

development, social justice3.7.5 Under-five morbidity pattern with ICDS3.7.6 Nutritional interventions with schools, WCD3.7.7 Studies with ICSSR on Low Child sex ratio, female feticide, domestic

violence and sexual violence at work place 3.7.8 Model projects on implementation of Knowledge management policy; 3.7.9 Other model projects related to national programmes including health

systems research and socio-behavioural interventions

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4. Cost effectiveness analysis of health technologies through a health technology assessment system

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S.N0. Area of Research

Sub-areas Topics of the study

4.1 Cancer 4.1.1 Methods for effective and early diagnosis4.1.2 Impact of health services for cancer management 4.1.3 Efficacy of different regimens4.1.4 Development of guidelines for diagnosis and management

4.2 Mental Health 4.2.1 Scales and tools for assessment of Mental Health4.2.2 Evaluation of newer modalities of treatment like ECT etc4.2.3 Development of guidelines for diagnosis and management

4.3 Cardiovascular Diseases 4.3.1 Assessment of promotive models for prevention of risk factors4.3.2 Efficacy of newer diagnostic tests4.3.3 Models of early treatment to reduce mortalities 4.3.4 Health informatics and health technology assessments4.3.5 Development of guidelines for diagnosis and management

4.4 Stroke and neurological disorders 4.4.1 Newer diagnostics4.4.2 Newer treatment modalities4.4.3 Preventive models4.4.4 Development of guidelines for diagnosis and management

4.5 Diabetes 4.5.1 Newer diagnostics4.5.2 Newer management strategies4.5.3 Health promotive and preventive models4.5.4 Development of guidelines for diagnosis and management

4.6 MalariaDengueChikungunyaJapanese Encephalitis (Vector Borne Diseases)

4.6.1 Efficacy of alternate drugs4.6.2 Newer vaccines4.6.3 Newer drugs including larvicidals4.6.4Preventive technologies4.6.5 Use of technologies for prevention and cure4.6.6 Development of guidelines for diagnosis and management

4.7 Tuberculosis / Leprosy Other Mycobacterial diseases

4.7.1 Multidrug resistance4.7.2 Newer diagnostics4.7.3 Newer drugs and combinations4.7.4 Development of guidelines for diagnosis and management

4.8 Leishmaniasis / Kalazar 4.8.1 Newer diagnostics4.8.2 Newer drugs

4.9 Zoonoses 4.9.1 Newer diagnostics4.9.2 Newer drugs

4.10 Guidelines for management of important maternal and child health problems; region specific guidelines for nutrition; enteric infections, acute fevers; PUO; genetic disorders, blood disorders etc;

Annexure 2

Cost details of permanent equipment/assets

(Please use a separate sheet for each equipment)

1. Name of equipment/ asset with model, name etc. and date of procurement2. Sanctioned amount:3. Actual expenditure (this should include only the cost of equipment, insurance, freight

charges and octroi etc.)4. Other expenses, if any (expenses such Bank charges, agency commission etc.,

should be avoided through appropriate negotiations. If unavoidable expensesincurred, the same may be indicated

5. Utilization rate (%)

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Annexure-3

FORMAT FOR ANNUAL PROGRESS REPORT

Proposal ID:

1. Project title

2. PI (name & address)

3. Co-PI (name & address)

4. Date of start

5. Duration

6. Objectives of the proposal

7. Methodology

8. Interim modification of objectives/methodology (with justifications)

9. Summary on progress (during the period of report)

10. Applied value of the project

11. Research work which remains to be done under the project

12. Any publications.

13. Any patents applied for

14. If additional budget or staff is required for the remaining part of the research work, please give justifications and details.

Date : Signature

Designation

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14Annexure-4

Format for Annual Statement of Accounts to accompany request for release of First Installment

(Year means Financial Year i.e. 1st April to 31st March of next year)

1. Sanction letter No. :....................... ……………

2. Total Project Cost : Rs………………………

3. Sanction /Revised Project cost(if applicable) :Rs………….......................

4. Date of Commencement of Project :…………….......................

5. Statement of Expenditure :………….…......................

S.No. Sanctioned/Heads FundsAllocated

ExpenditureIncurred

Balanceas on(Date)

Requirementof Funds upto31

st March

Remarks

IYear

IIYear

IIIYear

1. Salaries2. Permanent

Equipments3. Supplies &

Materials4. Travel5. Contingencies6. Overhead 7. Others (if any)8. Total

Signature of Principal Investigator Signature of Accounts Officer with date With date

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Annexure-5

Check list for covering note to accompany Utilization Certificate of grant for the project for the period ending 31st March, 20 __)

1) Title of the project

2) Name of the Institutions

3) Principal Investigator

4) DHR letter No. and date sanctioning the project.

5) Head of account as given in the original sanction letter

6) Amount received during the financial year (Please give No. & Date of DHR's sanction letter for the amount)

7) Total amount that was available for expenditure (excluding commitments)during the financial year (SI.No.6+7)

8) Actual expenditure (excluding commitments) incurred during the financial year(upto 31st March).

9) Balance amount available at the end of the financial year.

10) Amount already committed, if any.

11) Amount to be carried forward to the next financial year (if applicable). Indicate the amount already committed with supporting documents.

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Annexure 6

FORMAT FOR UTILISATION CERTIFICATE

(ANNUAL/FINAL)

Proposal ID:

Certified that out of Rs .................... of grants-in-aid sanctioned during the year………............

in favour of ............................………. under DHR Letter No………........................... and Rs

................................on account of unspent balance of the previous year, a sum of Rs ................. has

been utilized for the purpose of …………........................... for which it was sanctioned and that

the balance of Rs. ............. remaining unutilised at the end of the year has been surrendered to

DHR /ICMR(vide cheque No ........................... Dated…............/will be adjusted towards the grants-in-aid

payable during the next year i.e ............................................

Signature of Signature of Registrar/ Signature of Accounts Principal Investigatorwith date

of the Institute with date of the Institute with date

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FORMAT FOR FINAL REPORTAnnexure-7

Proposal ID:

1. Title of the Project:

2. Principal Investigator and Co-Investigators

3. Implementing Institution and other collaborating Institutions

4. Date of commencement

5. Duration

6. Date of completion

7. Objectives as approved

8. Deviation made from original objectives if any, while implementing the project and reasons thereof.

9. Experimental work giving full details of experimental set up, methods adopted, data collected supported by necessary tables, charts, diagrams and photographs.

10. Detailed analysis of results indicating contributions made towards increasing the state of knowledge in the subject.

11. Conclusions summarizing the achievements and indication of scope for future work.

12. S&T benefits accrued:

I. List of research publications with complete

details: Authors, Title of paper, Name of

Journal, Vol., page, year

II Manpower trained on the project:a. Research Scientists or Research Fellows b. No. of PhDs producedc. Other Technical Personnel trained

III. Patents taken, if any:

IV Products developed, if any.

13. Abstract (300 words for possible publication in DHR/ ICMR Bulletin).

14. Procurement/usage of

17

Equipment a.S.No.

Name ofEquipment

Make/Model

CostFE/Rs

Date ofInstallation

Utilisationrate %

Remarks regardingmaintenance/breakdown

b. Suggestions for disposal of equipment(s) Name and signature with

date

1. (Principal Investigator)

2. (Co-Investigator)

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Annexure 8FORMAT FOR FINAL STATEMENT OF EXPENDITURE

(to accompany the Final Report)

1) Sanction letter No.2) Total project cost

(Sanctioned/revised project cost, if applicable)3) Date of commencement of project:4) Date of completion of project:5) Grant revised in each year (financial):

S.No.

SanctionedHeads

FundsAllocated

Expenditure IncurredFinancial year-wise

Balance(if any)

Remarks

Ist

yr IInd

yr IIIrd

yr IVth

yr Tota l

1 2 3 4 5 6 7 8 9 101 Salaries2 Equipment3 Consumables4 Travel5 Contingencies6 Overhead

Expenses7 Others

(if any)8 Total

Amount to be refunded/reimbursed (whichever is appropriate): Rs.

Name & Signature Principal Investigator With date

Signature of Competent Financial/audit authority With date