Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical...
-
Upload
claire-cameron -
Category
Documents
-
view
214 -
download
0
description
Transcript of Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical...
![Page 1: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/1.jpg)
Aaron Manning
![Page 2: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/2.jpg)
OverviewAlso called American trypanosomiasis and
the Kiss of DeathA tropical parasitic disease caused by the
flagellate protozoan Trypanosoma cruzi.Spread to humans through the bite of an
insect vector
![Page 3: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/3.jpg)
Signs and SymptomsAcute Stage
Nonspecific symptoms i.e. fever, diarrhea, vomiting
Swelling and inflammationRomaña's sign
![Page 4: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/4.jpg)
Signs and SymptomsChronic Stage
About 30% develop medical problemsCardiac damageDigestive system damageNeurological disorders
Potentially fatal if untreated
![Page 5: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/5.jpg)
DiagnosisT. cruzi in blood smearsPCR to ID strains
![Page 6: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/6.jpg)
DiscoveryBrazilian physician Carlos Chagas - 1909Chagas’ work uniqueDarwin
![Page 7: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/7.jpg)
Epidemiology1960s16–18 million people affected as of
2008~100 million at riskKills around 20,000 annually
![Page 8: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/8.jpg)
18 countries from US to ArgentinaOccurs almost exclusively in rural areas
Why?
![Page 9: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/9.jpg)
The VectorBlood-sucking insects of the subfamily
Triatominaevinchuca, barbeiro, chinche, the kissing bug
![Page 10: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/10.jpg)
TransmissionA triatomine becomes infectedHides during dayEmerges at nightBites, feeds, then defecates
![Page 11: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/11.jpg)
TransmissionScratchingBlood transfusions, organ transplants, or
breast milkCongenital Transmission
13% of stillborn deaths in parts of Brazil
![Page 12: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/12.jpg)
![Page 13: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/13.jpg)
Clinical ManifestationsCell death in target tissuesInflammatory response
![Page 14: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/14.jpg)
Treatment and Prevention
![Page 15: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/15.jpg)
PreventionMost effective approachInsecticidesImproving housing conditionsTesting of blood donorsNo vaccine
![Page 16: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/16.jpg)
Treatment and ManagementTwo approaches
Antiparasitic treatment Symptomatic treatment
![Page 17: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/17.jpg)
Antiparasitic TreatmentMost effective early Drugs include azole or nitro derivativesResistance
![Page 18: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/18.jpg)
Symptomatic TreatmentDisease cannot be cured in chronic phaseManaging the clinical manifestationsPacemakers and anti-arrhythmia drugsSurgery for megaintestine. Heart transplantation surgery
![Page 19: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/19.jpg)
On the HorizonNew DrugsNew vaccines being testedStem cell therapy
![Page 20: Aaron Manning. Overview Also called American trypanosomiasis and the Kiss of Death A tropical parasitic disease caused by the flagellate protozoan Trypanosoma.](https://reader036.fdocuments.in/reader036/viewer/2022070610/5a4d1b9c7f8b9ab0599c5db5/html5/thumbnails/20.jpg)
Resources Antonio RL Teixeira; Nascimento; Sturm. Evolution and pathology in Chagas disease - a
review . Mem. Inst. Oswaldo Cruz vol.101 no.5 Rio de Janeiro Aug. 2006Centers for Disease Control. http://www.cdc.gov/chagas/ Prata A. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis. 2001
Sep;1(2):92-100.Vanessa Leiria Campo, Carvalho, Allman, Davis and Robert A. Field. Chemical and
chemoenzymatic synthesis of glycosyl-amino acids and glycopeptides related to Trypanosoma cruzi mucins Org. Biomol. Chem., 2007, 5, 2645
Wikipedia. http://en.wikipedia.org/wiki/Chagas_diseaseWorld Health Organization. www.who.int/tdr/svc/diseases/chagas