AARHUS UNIVERSITY Partikel terapi accelerator (Siemens)
Transcript of AARHUS UNIVERSITY Partikel terapi accelerator (Siemens)
Cancer and radiation therapySøren Pape Møller
23 NOVEMBER, 2009AARHUSUNIVERSITY
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Partikel terapi accelerator (Siemens)
Cancer and radiation therapySøren Pape Møller
23 NOVEMBER, 2009AARHUSUNIVERSITY
Dose and intensity
• Range of 30 cm →• Proton energy: (50-)250 MeV• Carbon energy: (100-)430 MeV/u=5GeV
• Dose of 2 Gy (=J/kg) in 2(10) l in 2 min. →• Particle intensity 6⋅1011 p in 2 min• or 2⋅1010 C in 2 min
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SIEMENS/DANFYSIK PT system
10m
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PT RKASiemens facility in Marburg
Siemens: Also PT iKiel and Shanghai
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Kiel facility
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Rhön-Klinikum Marburg
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Rhön-Klinikum Marburg
7First accelerator installation in nov. 2008
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Building Layout
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Proton energy range 48-250 MeV/u
Carbon ion energy range 88-430 MeV/u
Time to change between ion species <10 s
Ramping time of synchrotron to highest magnetic field <1 s
Extraction time from synchrotron <10 s (up to 30 s)
Time for energy change (stop extraction to start extraction) <5 s
Time to switch beam from room to room <8 s
System uptime >95-98%
Maximum number of protons at end of HEBT per spill 4⋅1010
Maximum number of carbon ions at end of HEBT per spill 1⋅109
Intensity variation 0.001-1
Stability during spill
Extracted intensity (300 ms) sampling <+30%/-50%
Max/min intensity for faster sampling (down to 10 µs) <3
Beam width at variations at isocenter <20%
Position variations at isocenter (including feedback) <0.5 mm
Integral intensity (fill) <30%
Variations in mean energy from synchrotron <0.1%
Main specs. to the PT accelerator system
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10 m
RKA i Marburg
Ion source
Low-energypreaccelerator
RadioFrequencyQuadrupole
Linac
Focusingquadrupole
Deflectionmagnet
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ECR Ion Source
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Beam after ion source
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LEBT
•Macro-pulse chopper
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Solenoide
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LINAC quadrupoles
Ramped lenses with 5Hz
15ms ramp-up-time, 3ms flat-top, 25ms ramp-down-time
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Radial Envelopes
0 100 200 300 400 500 600
-5
0
5
radi
al e
nvel
opes
x a
nd y
[mm
]
z[cm] beamaxis
-35° -35° -35°0° 0° 0°
L L
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MEBT
Vertical correctors
chopper
Injection septum
Stripper foil
debuncher
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MEBTHorizontal beam envelope [m] versus distance [m]
Vertical beam envelope [m] versus distance [m]
Note: Linear optics
0.000
0.000
14.574
14.574
0.025000
0.025000
-0.025000
-0.025000
Betatron envelope Momentum envelope
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Chopper
slit
bend chop bend
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Charge separation
The most closely spaced ions, from a not complete stripping process, will be O7+ and O8+.
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MEBT 25° dipole
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Debuncher
Beam at the stripper:
After the debuncher:
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10 m
RKA i Marburg
Synchrotron cavity2.5 kV, 1-7 MHz, Rev. freq. 0.5-3.5 MHz
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DF synchrotron
Bumper
Elektrostatiskinjektions
Elektrostatiskekstraktionsseptum
Magnetiskekstraktiosepta
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Synchrotron dipole
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Synchrotron sextupole
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Non-linear EFB variation, Pre-prototype exit, y=0, 100%
-0.00100
-0.00080
-0.00060
-0.00040
-0.00020
0.00000
0.00020
0.00040
0.00060
0.00080
0.00100
-100 -80 -60 -40 -20 0 20 40 60 80 100
x (mm)
dLre
s/Lh
alf (
T)
dLres/LhalfdInt_Rel Calculated
Maximum field, Pre-prototype exit, y=0, 100%
-0.00500
-0.00400
-0.00300
-0.00200
-0.00100
0.00000
0.00100
0.00200
0.00300
0.00400
0.00500
-100 -80 -60 -40 -20 0 20 40 60 80 100
x (mm)
dB0/
B0
(T)
dB0/B0dB/B0 Calculate
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Electrostatic injection septum
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Electrostatic extraction Septum
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Multi-Turn-Injection
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Magnetic extraction septum
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Extraction straight section
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Synchrotron cycle
•0
•0,2
•0,4
•0,6
•0,8
•1
•1,2
•0 •1 •2 •3 •4 •5 •6 •7
•time (s)
•B/B
max
•low-energy protons•high-energy protons•low-energy carbon•high-energy carbon
•"chimney"
•dB•/•dt•/•Bmax •=1/s
•Extraction•1-10s
•Injection
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Beam envelope at injection
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Injection bump
Bumper magnet #1 #2 #33.2 mrad. 6.3 mrad. 7.6 mrad.
septum
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Bumper supply
time
Magnetic field
18 μs
Turn 4 15
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Synchrotron dump
Vertical beam envelope [m] versus distance [m]
Note: Linear optics
11.220 18.422
0.040000
-0.040000
Betatron envelope Momentum envelope
Note: Linear optics
0.000 64.800
0.025000
-0.025000
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Slow Extraction
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HEBT
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HEBT
Survey-Plot [mm] 108000
HC
HS1
HC
VS1
HC
HS2
HC
VS2
HC
PG
1
HC
HS3
HC
HS4
HC
VS4
HC
PG
2
HC
PG
3
HC
HS
5
HC
VS
5H
CP
G4
H1PGT
H2PGT
H3PGT
H4H
S1
H4V
S1
H4H
S2
H4V
S2
H4P
G2
H4HS3
H4VS3
H4PGT
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Fast Beam Abort System
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HEBT
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HEBT quadrupole
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TR-1
TR-2
TR-3
TR-4
10 m
RKA i Marburg
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Udfordringer ved et PT anlæg
› Kompleksitet
› Pålidelighed - QA
› Økonomi
› Logistik
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Billeder fra Marburg
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